CONSTRUYENDO EL FUEGO. FALLAS INFANTILES DE MADERA

Este trabajo final de grado es un estudio teórico y práctico sobre las fallas, en concreto las infantiles. Las fallas se han ido adaptando a los nuevos tiempos en cuanto a temáticas, estética y materiales, sin embargo, en este documento nos enfocamos en analizar la madera como material principal en la construcción de las fallas infantiles. Las fallas de pequeño formato están desarrollando un cambio estético y conceptual, así mismo, podemos encontrar en los últimos años un auge de artistas que debutan en esta disciplina, con una formación artística que les precede y que están revolucionando el mercado de las fallas infantiles en todos los ámbitos. Todo el apartado teórico-histórico será complementado con la construcción del monumento adulto e infantil de la falla Avingunda Tarongers- Universitat Politècnica de València 2019, donde la madera en ambos monumentos, grande e infantil, tiene un papel clave.This final project involves theoretical and practical study of children¿s fallas. Fallas have been gradually developing questions about topics, estetics or materials. But in this poject, we focus on analysing children¿s fallas which are built with wood. Children¿s fallas are envolving thanks to artist who studied Fine Arts. For this reason, they are revolutionising the realm of fallas. The section teorical- historical is supplemented with the creation of fallas Avinguda Tarongers- Universitat Politècnica de València, where wood has of great importance in fallero monuments.Cuevas Saez, S. (2019). CONSTRUYENDO EL FUEGO. FALLAS INFANTILES DE MADERA. http://hdl.handle.net/10251/12549

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio