Minisatellite mutation rates increase with extra-pair paternity among birds

<p>Abstract</p> <p>Background</p> <p>Amos <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> suggested recently that a previously reported positive relationship between minisatellite mutation rates and extra-pair paternity among species of birds <abbrgrp><abbr bid="B2">2</abbr></abbrgrp> was confounded by transcription errors and selective inclusion of studies. Here we attempted to replicate the results reported by Amos <abbrgrp><abbr bid="B1">1</abbr></abbrgrp>, but also tested for the relationship by expanding the data base by including studies published after our original paper.</p> <p>Results</p> <p>We were able to replicate the positive association between mutation rate and extra-pair paternity in birds, even after controlling statistically for the confounding effecs of mean number of bands scored, using 133 species, compared to 81 species in our first report <abbrgrp><abbr bid="B2">2</abbr></abbrgrp>. We suggest that Amos <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> failed to reach a similar conclusion due to four different potential causes of bias. First, Amos <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> missed 15 studies from the literature that we were able to include. Second, he used estimates of mutation rates that were based on both within- and extra-pair offspring, although the latter will cause bias in estimates. Third, he made a number of transcription errors from the original publications for extra-pair paternity, mutation rates, number of novel bands, and mean number of bands scored per individual. Fourth, he included <it>Vireo olivaceus </it>although the mutation rate estimate was based on one single offspring!</p> <p>Conclusion</p> <p>There was a positive association between mutation rates and extra-pair paternity in birds, accounting for an intermediate effect size that explained 5–11% of the variance; estimates that are bound to be conservative due to many different causes of noise in the data. This result was robust to statistical control for potentially confounding variables, highlighting that it is important to base comparative studies on all available evidence, and that it is crucial to critically transcribe data while simultaneously checking published estimates for their correctness.</p

Pay-as-bid pricing in combined pool / bilateral electricity markets

In the context of combined pool/bilateral operation of electricity markets, this paper compares two pricing strategies; pay-as-bid strategy defines three types of services: bilateral contract generation, transmission loss and congestion management required by the bilateral contracts, and pool demand generation including associated transmission loss and congestio

Effects of high volume saline enemas vs no enema during labour – The N-Ma Randomised Controlled Trial [ISRCTN43153145]

BACKGROUND: Enemas are used during labour in obstetric settings with the belief that they reduce puerperal and neonatal infections, shorten labour duration, and make delivery cleaner for attending personnel. However, a systematic review of the literature found insufficient evidence to support the use of enemas. The objective of this RCT was to address an identified knowledge gap by determining the effect of routine enemas used during the first stage of labour on puerperal and neonatal infection rates. METHODS: Design: RCT (randomised controlled trial; randomized clinical trial). Outcomes: Clinical diagnosis of maternal or neonatal infections, labour duration, delivery types, episiotomy rates, and prescription of antibiotics Setting: Tertiary care referral hospital at the Javeriana University (Bogotá, Colombia) that attended 3170 births during study period with a caesarean section rate of 26%. Participants: 443 women admitted for delivery to the obstetrics service (February 1997 to February 1998) and followed for a month after delivery. Inclusion criteria were women with: low risk pregnancy and expected to remain in Bogotá during follow up; gestational age ≥ 36 weeks; no pelvic or systemic bacterial infection; intact membranes; cervix dilatation ≤7 cm. Intervention: 1 litre saline enema, versus no enema, allocated following a block random allocation sequence and using sealed opaque envelopes. RESULTS: Allocation provided balanced groups and 86% of the participants were followed up for one month. The overall infection rate for newborns was 21%, and 18% for women. We found no significant differences in puerperal or neonatal infection rates (Puerperal infection: 41/190 [22%] with enema v 26/182 [14%] without enema; RR 0.66 CI 95%: 0.43 to 1.03; neonatal infection 38/191 [20%] with enema v 40/179 [22%] without enema; RR 1.12, 95% CI 95% 0.76 to 1.66), and median labour time was similar between groups (515 min. with enema v 585 min. without enema; P = 0.24). Enemas didn't significantly change episiorraphy dehiscence rates (21/182 [12%] with enema v 32/190 [17%] without enema; P = 0.30). CONCLUSION: This RCT found no evidence to support routine use of enemas during labour. Although these results cannot rule out a small clinical effect, it seems unlikely that enemas will improve maternal and neonatal outcomes and provide an overall benefit

Twin disc assessment of wear regime transitions and rolling contact fatigue in R400HT – E8 pairs

Twin disc tests were carried out to evaluate the wear resistance and Rolling Contact Fatigue (RCF) of premium R400HT rail samples in contact with E8 wheel samples. The wear rate and friction coefficient were correlated with the frictional work expended at the contact interface (the Tgamma approach). Accelerated RCF tests were also carried out on the premium R400HT rail and the results were compared to those obtained for standard R260 rail. The wear rates of rail samples were consistently lower than those reported in the literature for other contacting pairs in which the rail material studied is softer than R400HT. Also, the energy needed for the transition from the moderate to severe wear regime significantly increased for the hardened rail. Fatigue cracks were shallower for R400HT when compared with standard rail material. Hardened rails also showed lower mean spacing between fatigue cracks. This new information can be used to improve wear simulations of wheels and rails by using more realistic wear equations

Dispersive ππ→KKˉ\pi\pi\rightarrow K\bar K amplitude and giant CP violation in B to three light-meson decays at LHCb

The LHCb collaboration has recently reported the largest CP violation effect from a single amplitude, as well as other giant CP asymmetries in several $B$-meson decays into three charmless light mesons. It is also claimed that this is predominantly due to $\pi\pi\rightarrow K\bar K$ rescattering in the final state, particularly in the 1 to 1.5 GeV region. In these analyses the $\pi\pi\rightarrow K\bar K$ amplitude is by default estimated from the $\pi\pi$ elastic scattering amplitude and does not describe the existing $\pi\pi\rightarrow K\bar K$ scattering data. Here we show how the recent model-independent dispersive analysis of $\pi\pi\rightarrow K\bar K$ data can be easily implemented in the LHCb formalism. This leads to a more accurate description of the asymmetry, while being consistent with the measured scattering amplitude and confirming the prominent role of hadronic final state interactions, paving the way for more elaborated analyses.Comment: 9 pages, 6 figures. Minor corrections and discussions were added. Extended appendix with an additional improved model of the S-wave. Final version to appear in Phys.Rev.Let

The United Nations' Sustainable Development Goals: Pros and Cons for Managers of Multinationals

The UN Sustainable Development Goals (SDGs) are becoming a crucial mechanism for coordinating governments' efforts to address global challenges. However, their implementation by managers is challenging. In this article, we offer an overview of the pros and cons of the SDGs as mechanisms for managers of multinationals to help contribute to sustainable development. On the pro side, the SDGs are comprehensive and actionable. On the con side, they are vague, complex and may lend themselves to "rainbow-washing." We provide suggestions for managers to help them respond to these challenges by avoiding cherry-picking SDGs, using the SDGs to assess sustainability, and pursuing SDG projects via partnerships

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that expression of granulin peptides, the cleavage products of the neurodegenerative disease protein progranulin, enhance the accumulation and toxicity of TAR DNA binding protein 43 (TDP-43) in Caenorhabditis elegans (C. elegans). In this study we show that C. elegans granulins are produced in an age- and stress-dependent manner. Granulins localize to the endolysosomal compartment where they impair lysosomal protease expression and activity. Consequently, protein homeostasis is disrupted, promoting the nuclear translocation of the lysosomal transcription factor HLH-30/TFEB, and prompting cells to activate a compensatory transcriptional program. The three C. elegans granulin peptides exhibited distinct but overlapping functional effects in our assays, which may be due to amino acid composition that results in distinct electrostatic and hydrophobicity profiles. Our results support a model in which granulin production modulates a critical transition between the normal, physiological regulation of protease activity and the impairment of lysosomal function that can occur with age and disease

Alterations in executive functions in inmates convicted for violent behavior : a systematic review

The growth of the prison population and the high recidivism rates of inmates represent a major public safety problem. This systematic review explored executive functions in inmates convicted of violent behavior compared with inmates convicted of non-violent behavior and healthy controls (HCs). Systematic searches were carried out using five databases (PubMed, Scopus, Web of Science, EBSCO, and Embase) until March 6th, 2023. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, two reviewers independently performed the screening, data extraction, and risk of bias assessment of the 8 studies included. The protocol of this study was registered in Prospective Register of Systematic Reviews (PROSPERO), under registration number CRD42021252043. Consistently, inmates convicted of violent behavior exhibited a greater alteration in inhibition than inmates convicted of non-violent behavior (four out of four studies) and HCs (two out of two studies). In addition, inmates convicted of violent behavior showed greater impairments in cognitive flexibility (two out of three studies) and working memory (two out of three studies) than HCs. Although with limited evidence (only one study), they also showed worse performance in set shifting and planning than HCs. This study provides evidence of alterations in inhibition in inmates convicted of violent behavior compared to inmates convicted of non-violent behavior and HCs. Even though inmates convicted of violent behavior showed greater impairments in planning and set shifting than HCs, these findings were supported in only one study. In general, more robust evidence is needed to confirm alterations in inmates convicted due to violent behavior. These findings highlight the importance of designing and promoting specific cognitive interventions that contribute to the reintegration of inmates into society