La reconstrucción de la biblioteca hipotética de Francisco de Quevedo: Viejos problemas y nuevos hallazgos

RESUMEN: En este trabajo se estudian los diversos problemas que plantea el proceso de reconstrucción de la biblioteca hipotética de Francisco de Quevedo a partir de los inventarios post morten del escritor madrileño y del VII duque de Medinaceli, junto a los índices de la biblioteca del monasterio de San Martín de Madrid. Además se da noticia de un nuevo conjunto de ejemplares impresos de la colección bibliográfi ca de Quevedo.ABSTRACT: This paper studies various problems linked with the hypothetical reconstruction of the library of Francisco de Quevedo. It is based on the inventories made after the death of the writer, both of his own books and of those of the 7th Duque de Medinaceli. We use, as well, the indexes of the library of Monasterio de San Martín, in Madrid. Furthermore, we give information about a new set of printed copies of Quevedo’s bibliographic collection

Francisco de Quevedo y el VII duque de Medinaceli en su correspondencia: Cajón de sastre noticiero

Este trabajo se ha realizado el el marco de los proyectos FFI2015-65779-P y HAR2015-68946-C3-1-P, financidados por el Ministerio de Economía y Competitividad del Gobierno de España y el Fondo Europeo de Desarrollo Regional (FEDER) desde el 01/01/2016 hasta el 31/12/201

Algunos casos de atribuidos y apócrifos en las ediciones de la poesía de Quevedo

En este artículo se ha pretendido realizar una revisión de los textos apócrifos y atribuidos que han sido recogidos en las ediciones de la poesía completa de Quevedo. Para ello se ha reunido la bibliografía existente y consultado varios testimonios manuscritos, con la finalidad de analizar y valorar los textos espurios o de dudosa autoría adjudicados al escritor madrileño. In this article, it has been pretended to make a review of the apocryphal and attributed texts that have been recollected in the complete poetry edition of Quevedo. For that purpose, the existent bibliography has been reunited as well as consulted some manuscript testimonies to analyse and validate the spurious and doubtful authored texts attributed to the Madrilenian writer

Las lecturas de Quevedo a la luz de algunos impresos de su biblioteca

En este trabajo se realiza un primer acercamiento a la configuración del catálogo de la posible biblioteca a la que tuvo acceso Quevedo (ya fuera en ejemplares suyos o del Duque de Medinaceli). La reconstrucción de esta «biblioteca imaginaria» se realiza a partir de los índices de libros del Monasterio de San Martín de Madrid. Por ello, se ha procedido a una primera cala en dichos índices con la finalidad de identificar ediciones de autores leídos y citados por Quevedo: Arias Montano, Botero, Lipsio, Petrarca, padre Mariana, entre otros. También se presenta el hallazgo de una obra de Carpentier propiedad de Quevedo, que se añade a los más de 25 impresos ya conocidos de su biblioteca. The present work constitutes a preliminary approach to the possible catalogue of a potential library that could have been accessible to Quevedo, either through their own books or through those of the Duke of Medinaceli. The reconstruction of this «imaginary library» is based on the indexes of the library of the Monasterio de San Martín, Madrid. A first screening of those indexes have been performed in order to identify printed books which Quevedo read and cited from, among others, Arias Montano, Botero, Lipsio, Petrarca and Mariana. A couple of works from Carpentier have been also identified as being property of Quevedo. These works must now be added to those already known printed books from his library, more than 25 pieces of work until no

Esbozos de retratos en las cartas de Francisco de Quevedo

Reading Quevedo’s correspondence gives us the opportunity of looking at his literary production from a new perspective, which completes and helps defining its many different facets. The point of departure in this occasion is his letters. Based on them we study the portraits of persons represented there. Their presence in the letters aims at very different objectives, depending on the person depicted and the addressee of the letter. Very often, these portraits are only sketches, made out of a few strokes, which need an intelligent reading by the addressee to be fully understood. This can explain why some of these portraits seem to us dark and too short: probably, they are supposed to be clear only to the person to whom they are addressed.La lectura de la correspondencia de Quevedo ofrece una perspectiva que ayuda a completar y matizar las muchas que presenta su obra. En esta ocasión se parte de su Epistolario para estudiar los retratos y las figuras que en él se deslizan, y su finalidad varía atendiendo a las circunstancias y corresponsal al que dirige Quevedo la carta. Estos retratos y figuras en repetidas ocasiones no son más que esbozos construidos con leves pinceladas que necesitan de la lectura cómplice del destinatario de la carta, lo que puede explicar la brevedad y la oscuridad de algunas pinturas, posiblemente solo llenas de claridad para la persona a la que van dirigidas

Diferencias morfométricas entre la abeja apis mellifera iberica y la abeja rusa de la región de primorsky

It has been proved that the Russian bees of the region of Primorsky have a great tolerance to Varroa. In the present work we have made a comparative study of these bees and Apis mellifera iberica, by means of a morphometric study, putting under the values obtained a descriptive statistical research, evaluating the normality of the distribution by means of the test of Kolmogorov-Smirnov and the differences between the two populations of bee by means of tests parametric (t´Student) or nonparametric (U of Mann-Whitney), according to the type of distribution

Study of the anticancer properties of optically active titanocene oximato compounds

New water soluble and optically active cyclopentadienyl titanium derivatives [(η5-C5H5)2Ti{(1R,4S)-ĸON,(R)NH}Cl] (R = Bn (Benzyl) 1a’, 2-pic (2-picolylamine) 1b’) have been synthesized. The novel compounds along with those previously described [(η5-C5H5)2Ti{(1S,4R)-ĸON,(R)NH}Cl] (R = Bn 1a, 2-pic 1b) were evaluated by polarimetry, ultra-violet and circular dichroism spectroscopy. The structure of 1b was determined by single crystal X-ray crystallography and showed a unique terminal monohapto Tisingle bondO disposition of the oximato ligand. All enantiomers have been tested against several cancer cell lines in vitro: prostate PC-3 and DU-145, lung A-549, pancreas MiaPaca-2, colorectal HCT-116, leukemia Jurkat and cervical HeLa. In addition, 1a, 1b and 1b’ were tested against non-tumorigenic prostate RWPE-1 cell line. After 24 h of incubation, 1b and 1b’ were moderately active against Jurkat and A-549 cells. The anti-proliferative effect of titanium compounds on prostate PC-3, DU-145 and RWPE-1 cell lines was also assessed after 72 h of drug exposure. The cytotoxic profile of the enantiomers was similar, exception made for the PC-3 cells, with S,R-isomers exhibiting cytotoxicities 2 to 3 times higher than R,S-compounds. Under these conditions, derivative 1b showed calculated IC50 values better than those of Tacke's Titanocene-Y (bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dichloride) on both the prostate PC-3 and DU-145 cells. 1a and 1b cytotoxic behaviour shows certain selectiveness, with activities 2–4 times lower on normal prostate RWPE-1 than on cancer PC-3 cells. Furthermore, 1b produces higher cytotoxicity on prostate PC-3, DU-145 and RWPE-1 cells than the additive dose of titanocene dichloride and pro-ligand b·HCl. Additionally, compound-DNA interactions have been investigated by equilibrium dialysis, Fluorescence Resonance Energy Transfer (FRET) melting assays and viscometric titrations, which suggest that these metal complexes and/or their hydrolysis products bind DNA either in the minor groove or externally.Ministerio de Economía y CompetitividadComunidad Autónoma de MadridUniversidad de Alcal

Early Events in Retinal Degeneration Caused by Rhodopsin Mutation or Pigment Epithelium Malfunction: Differences and Similarities

To study the course of photoreceptor cell death and macro and microglial reactivity in two rat models of retinal degeneration with different etiologies. Retinas from P23H-1 (rhodopsin mutation) and Royal College of Surgeon (RCS, pigment epithelium malfunction) rats and age-matched control animals (Sprague-Dawley and Pievald Viro Glaxo, respectively) were cross-sectioned at different postnatal ages (from P10 to P60) and rhodopsin, L/M- and S-opsin, ionized calcium-binding adapter molecule 1 (Iba1), glial fibrillary acid protein (GFAP), and proliferating cell nuclear antigen (PCNA) proteins were immunodetected. Photoreceptor nuclei rows and microglial cells in the different retinal layers were quantified. Photoreceptor degeneration starts earlier and progresses quicker in P23H-1 than in RCS rats. In both models, microglial cell activation occurs simultaneously with the initiation of photoreceptor death while GFAP over-expression starts later. As degeneration progresses, the numbers of microglial cells increase in the retina, but decreasing in the inner retina and increasing in the outer retina, more markedly in RCS rats. Interestingly, and in contrast with healthy animals, microglial cells reach the outer nuclei and outer segment layers. The higher number of microglial cells in dystrophic retinas cannot be fully accounted by intraretinal migration and PCNA immunodetection revealed microglial proliferation in both models but more importantly in RCS rats. The etiology of retinal degeneration determines the initiation and pattern of photoreceptor cell death and simultaneously there is microglial activation and migration, while the macroglial response is delayed. The actions of microglial cells in the degeneration cannot be explained only in the basis of photoreceptor death because they participate more actively in the RCS model. Thus, the retinal degeneration caused by pigment epithelium malfunction is more inflammatory and would probably respond better to interventions by inhibiting microglial cells.Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15) and the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa” ISCIII-FEDER PI16/00380, PI16/00031, RD16/0008/0026, RD16/0008/0016, SAF2015-67643

Biological evaluation of water soluble arene Ru(II) enantiomers with amino-oxime ligands

New water soluble, enantiopure arene ruthenium compound SRuSN-(1R,4S)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (Bn = benzyl, 1a′) has been synthesized. The novel compound along with that previously described RRuRN-(1S,4R)-[(η6-p-cymene)Ru{ĸNH(Bn),ĸNOH}Cl]Cl (1a) was evaluated by polarimetry, ultra-violet and circular dichroism spectroscopy. The structure of novel ruthenium derivative 1a′ was determined by single crystal X-ray crystallography. Both enantiomers have been tested against several cancer cell lines in vitro: prostate PC-3, lung A-549, pancreas MIA PaCa-2, colorectal HCT-116, leukemia Jurkat and cervical HeLa. Both enantiomers are active and versatile cytotoxic agents, showing IC50 values from 2 to 12 times lower than those found for cisplatin in the different cell lines evaluated. The mechanism of cell death induced by the metal compounds was analyzed in A-549 and Jurkat cell lines. Derivatives 1a and 1a′ induced apoptotic cell death of A-549 cells while dose-dependent cell death mechanisms have been found in the Jurkat cell line. Compound-DNA interactions have been investigated by equilibrium dialysis, Fluorescence Resonance Energy Transfer (FRET) melting assays and viscometric titrations, revealing moderate binding affinity of 1a and 1a′ towards duplex DNA. Finally, the efficacy of 1a in a preliminary in vivo assay of PC-3 xenografts in nude mice has been evaluated, resulting in a promising inhibition of tumor growth by 45%. Analysis of tumor tissue also showed a significant decrease of levels of crucial molecules in the invasive phenotype of PC-3 cells.Ministerio de Economía y CompetitividadComunidad Autónoma de MadridUniversidad de Alcal