Stopping a reaction-diffusion front

We revisit the problem of pinning a reaction-diffusion front by a defect, in particular by a reaction-free region. Using collective variables for the front and numerical simulations, we compare the behaviors of a bistable and monostable front. A bistable front can be pinned as confirmed by a pinning criterion, the analysis of the time independant problem and simulations. Conversely, a monostable front can never be pinned, it gives rise to a secondary pulse past the defect and we calculate the time this pulse takes to appear. These radically different behaviors of bistable and monostable fronts raise issues for modelers in particular areas of biology, as for example, the study of tumor growth in the presence of different tissues

Vaccination strategy on a geographic network

We considered a mathematical model describing the propagation of an epidemic on a geographical network. The initial growth rate of the disease is the maximal eigenvalue of the epidemic matrix formed by the susceptibles and the graph Laplacian representing the mobility. We use matrix perturbation theory to analyze the epidemic matrix and define a vaccination strategy, assuming the vaccination reduces the susceptibles. When the mobility is small compared to the local disease dynamics, it is best to vaccinate the vertex of least degree and not vaccinate neighboring vertices. Then the epidemic grows on the vertex corresponding to the largest eigenvalue. When the mobility is comparable to the local disease dynamics, the most efficient strategy is to vaccinate the whole network because the disease grows uniformly. However, if only a few vertices can be vaccinated then which ones do we choose? We answer this question, and show that it is most efficient to vaccinate along the eigenvector corresponding to the largest eigenvalue of the Laplacian. We illustrate these general results on a 7 vertex graph, a grid, and a realistic example of the french rail network

Cómo rinden los estudiantes peruanos en Comunicación y Matemática : Resultados de la Evaluación Nacional 2001. Cuarto grado de secundaria

Muestra concretamente los resultados de las áreas de Matemática y Comunicación en la evaluación nacional 2011 y muestra la magnitud de las deficiencias en los aprendizajes de los estudiantes escolares. También evidencian las grandes diferencias en los rendimientos entre los diferentes grupos de poblaciones estudiantiles

Multiplus: a modular high-performance multiprocessor

The MULTIPLUS project is currently under development at NCE/UFRJ, Brazil, aims at the study of parallel processing problems in MIMD environments. The project includes the development of a parallel shared-memory architecture and a UNIX-like operating operating system called MULTIPLIX. The MULTIPLUS achitecture uses an inverted n-cube multistage network to interconnect clusters of processing nodes designed around a double-bus system. As a consequence, the architecture is partitionable and modular. It cas easily and efficiently supportconfigurations ranging from workstations to powerful parallel supercomputers with up to 2048 processing nodes. The MULTIPLix operating system provides MULTIPLUS with an efficient computing environment for parallel scientific applications. MULTIPLIX uses the concept of thread, implements busy-waiting synchronization primitives very efficiently and carefully considers data locality and scientific processing requirements in the policies adopted for memory management and thread scheduling.O projeto MULTIPLUS, que está atualmente em desenvolvimento no NCE/UFRJ, objetiva o estudo de problemas de processamento paralelo em ambiente MIMD. O projeto inclui o desenvolvimento de uma arquitetura paralela com memória compartilhada e um sistema operacional tipo UNIX chamado MULTIPLIX. A arquitetura do MULTIPLUS usa uma rede de interconexão multiestágio do tipo n-cubo invertido para interligar clusters de nós de processamento projetados em torno de um sistema de barramento duplo. Como consequência a arquitetura é patrocinável e modular. Ela pode suportar eficientemente configurações cobrindo um espectro que vai desde estações de trabalho até poderosos supercomputadores contendo 2048 nós de processamento trabalhando em paralelo. O sistema operacional MULTIPLIX provê o MULTIPLUS com um ambiente eficiente de computação para aplicações científicas paralelas.O MULTIPLIX usa o conceito de "thread", implementa primitivas de sincronização de espera ocupara muito eficientemente e considera fortemente aspectos de localidade dos dados e requisitos de processamento científico nas políticas adotadas para gerenciamento de memória e escalonamento de "threads"

A Mathematical Model to Optimize the Neoadjuvant Chemotherapy Treatment Sequence for Triple-Negative Locally Advanced Breast Cancer

Background: Triple-negative locally advanced breast cancer is an aggressive tumor type. Currently, the standard sequence treatment is applied, administering anthracyclines first and then a taxane plus platinum. Clinical studies for all possible treatment combinations are not practical or affordable, but mathematical modeling of the active mitotic cell population is possible. Our study aims to show the regions with the tumor’s most substantial cellular population variation by utilizing all possible values of the parameters () that define the annihilatory drug capacity according to the proposed treatment. Method: A piecewise linear mathematical model was used to analyze the cell population growth by applying four treatments: standard sequences of 21 days (SS21) and 14 days (SS14), administering anthracyclines first, followed by a taxane plus platinum, and inverted sequences of 21 days (IS21) and 14 days (IS14), administering a taxane plus platinum first then anthracyclines. Results: The simulation showed a higher effect of IS14 over SS14 when the rate of drug resistance was larger in the cell population during DNA synthesis (G1 and S) compared to cells in mitosis (G2 and M). However, if the proportion of resistant cells in both populations was equivalent, then treatments did not differ. Conclusions: When resistance is considerable, IS14 is more efficient than SS14, reducing the tumor population to a minimum

Urea nitrogen in the urine of dairy cows fed with crambe meal in replacement of dietary soybean meal

Todos os textos, informa??es e resultados apresentados s?o de inteira responsabilidade dos autores.Objetivou-se avaliar a concentra??o de nitrog?nio ureico na urina de vacas F1 Holand?s x Zebu, alimentadas com farelo de crambe em substitui??o ao farelo de soja. O experimento foi realizado na Fazenda Experimental da EPAMIG (Empresa de Pesquisa Agropecu?ria de Minas Gerais), situada na cidade de Felixl?ndia, Minas Gerais. Foram utilizadas 20 vacas mult?paras, no ter?o m?dio de lacta??o. O ensaio teve dura??o de 27 dias, sendo os 20 primeiros para adapta??o. Os tratamentos se basearam na substitui??o do farelo de soja pelo farelo de crambe no concentrado, nos n?veis de 0, 25, 50, 75 e 100%. Foram coletadas amostras de urina no 24? e 25? dia para an?lise de ureia. Houve diminui??o nos n?veis de ureia urin?ria (P?0,05) com o aumento de inclus?o do farelo de crambe.The objective was to evaluate the concentration of urea nitrogen in the urine of F1 Holstein x Zebu cows, fed crambe meal replacing soybean meal. The experiment was conducted at the Experimental Farm of EPAMIG (Agricultural Research Company of Minas Gerais), located in the city of Felixl?ndia, Minas Gerais. They were used 20 multiparous cows in mid lactation. The experiment lasted 27 days with the first 20 for adaptation. The treatments were based on replacing soybean meal with crambe meal in the concentrate at levels of 0, 25, 50, 75 and 100%. Blood samples were collected at 24 and 25 days for urea analysis. There was a negative linear behavior (P?0.05) increased with the inclusion of crambe meal

The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; MéxicoFil: Arrieta Bolaños, Esteban. Universitat Essen; AlemaniaFil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; AlemaniaFil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; MéxicoFil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; MéxicoFil: López Gil, Concepción. Instituto Mexicano del Seguro Social; MéxicoFil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; MéxicoFil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; MéxicoFil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; MéxicoFil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; AlemaniaFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; MéxicoFil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; MéxicoFil: Díaz López, Rosario. Hospital Central Militar, Mexico City; MéxicoFil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; MéxicoFil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; MéxicoFil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; MéxicoFil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; MéxicoFil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; MéxicoFil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; MéxicoFil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentin

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality