Tecnologías de la información y comunicación (TIC) y crecimiento de la empresa

Este trabajo presenta y valida, mediante un estudio cuantitativo y cualitativo, una tipología de usos y posibles ventajas estratégicas asociados a las inversiones en TIC, entendidas como plataformas de crecimiento. Nuestros resultados muestran que las empresas pueden realizar hasta tres usos o aplicaciones estratégicas de las TIC: 1) mejorar la eficiencia interna de la empresa; 2) mejorar la atención a los clientes actuales; y 3) definir nuevos mercados y nuevas oportunidades de negocio. En el trabajo se argumenta, además, que tales usos no son sustitutivos, sino complementarios

Valoración de Mapfre S.A. mediante descuento de flujos de caja

La finalidad de este trabajo de fin de grado (a partir de ahora TFG), es la de efectuar una valoración de una de las empresas más importantes cotizadas en la bolsa española, MAPFRE S.A. La valoración se va a efectuar a través del modelo de descuento de flujos de caja. Al cotizar esta compañía en el IBEX-35 disponemos de gran cantidad de información, ya que por ley sus memorias están en la Comisión Nacional del Mercado de Valores (CNMV). Después de la breve, pero necesaria introducción, donde se explica históricamente porque MAPFRE S.A. lidera en la actualidad el sector asegurador español y se sitúa dentro del Top 5 de aseguradoras multinacionales, procesaremos toda la información y obtendremos las variables que necesitamos: flujos de caja; costes de deuda y capital propio; valores que nos permitan valorar en equilibrio; etc. Para finalizar, obtendremos el valor de la empresa a través del descuento de flujo de caja, el cual contrastaremos con su cotización bursátil actual. También se incluye un análisis somero de la aplicación del método de múltiplos (PER) por comparación con las empresas del sector.The aim of this essay is to make an assessment of one of the most important companies quoted on the spanish stock exchange, MAPFRE S.A. It will be done mainly by Discount Model Cash Flow. This company quotes in IBEX-35, and for this reason we have a large of information, since for law his memoirs are in the National Securities Market Commission (CNMV). After the introduction, where it explaines historically because MAPFRE S.A. currently leads the Spanish insurance sector and is among the Top 5 of multinational insurers, we will process all the information and will obtain the variables that we need: cash flows; costs of debt and own capital; values that allow us to value in equilibrium; etc. Finally, the company is valued by Discount Model Cash Flow which we will contrast with its current quote.Departamento de Economía Financiera y ContabilidadGrado en Finanzas, Banca y Seguro

Delays in the diagnosis of oral cancer due to the quarantine of COVID-19 in Córdoba, Argentina

Coronavirus disease (COVID) 2019 has become a health challenge for the entire world. The first case of COVID in Argentina was reported on March 3rd, 2020.1 In this scenario, local authorities declared a quarantine, which effectively began on March 20th and is still ongoing. Although in recent months there have been some flexibilities, Argentinian lockdown is one of the longest isolation measures worldwide. The restrictive measures halted private and public dental care services, similar to the situation in Italy.2 The government restricted transportation between cities, only allowed in critical cases. However, people are also frightened by the increased risk of COVID infection when visiting health centers. The Oral Medicine Department (Universidad Nacional de Córdoba) remains closed since the second week of March 2020. Thus, our activities are hindered, including follow-up of oral potentially malignant disorders (OPMD) and oral cancer (OC). Due to the reduced clinical work, new visits for oral conditions were also disrupted putting those patients at risk.3 The rational use of telemedicine helped us to manage referrals.4 However, nowadays we are treating individuals that we have not seen in a long time as the result of this long-standing quarantine. We would like to report four cases showcasing the impact of lockdown in the follow-up of OPMD and early diagnosis of OC.publishedVersionFil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Medicina Oral; Argentina.Fil: Lazos, Jerónimo. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Medicina Oral; Argentina.Fil: Piemonte, Eduardo. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Medicina Oral; Argentina.Fil: Criado, Esteban. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil: Panico, René. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Medicina Oral; Argentina

Effects of indomethacin on ovarian leukocytes during the periovulatory period in the rat

We have investigated the effects of indomethacin (IM), a non-steroidal anti-inflammatory drug, and the role of prostaglandins on the accumulation of leukocytes in the rat ovary during the periovulatory period. Adult cycling rats were injected sc with 1 mg of IM in olive oil or vehicle on the morning of proestrus. Some animals were killed at 16:00 h in proestrus. On the evening (19:00 h) of proestrus, IM-treated rats were injected with 500 micrograms of prostaglandin E1 in saline or vehicle. Animals were killed at 01:30 and 09:00 h in estrus. There was an influx of macrophages, neutrophils, and eosinophils into the theca layers of preovulatory follicles, and of neutrophils and eosinophils into the ovarian medulla from 16:00 h in proestrus to 01:30 h in estrus. All these changes, except the accumulation of neutrophils in the theca layers of preovulatory follicles, were blocked by IM treatment. At 09:00 h in estrus, large clusters of neutrophils were observed in IM-treated rats, around abnormally ruptured follicles. The accumulation of leukocytes was not restored by prostaglandin supplementation, despite the inhibition of abnormal follicle rupture and restoration of ovulation in these animals. These results suggest that different mechanisms are involved in leukocyte accumulation in the ovary during the periovulatory period, and that the inhibitory effects of IM on the influx of leukocytes are not dependent on prostaglandin synthesis inhibition

Two color multichannel heterodyne interferometer set up for high spatial resolution electron density profile measurements in TJ-II

Proceedings of: 18th Topical Conference on High-Temperature Plasma Diagnostics, Wildwood, New Jersey (USA), 16-20 May 2010.Expanded-beam multichannel heterodyne interferometer has been installed on the TJ-II stellarator. Careful design of the optical system has allowed complete control on the evolution of both Gaussian beams along the interferometer, as well as the evaluation and optimization of the spatial resolution to be expected in the measurements. Five CO2 (measurement) channels and three Nd:YAG (vibration compensation) channels have been used to illuminate the plasma with a probe beam of 100 mm size. An optimum interpolation method has been applied to recover both interferometric phasefronts prior to mechanical vibration subtraction. The first results of the installed diagnostic are presented in this paper.This work was supported by Spanish Ministry of Education and Science Grant No. ENE2006-13559FTN . The authors would also like to acknowledge the help of Ernesto Garcia Ares and Jose Ramon Lopez Fernandez for setting up the signal conditioning systems

Performance and energy consumption of HPC workloads on a cluster based on Arm ThunderX2 CPU

In this paper, we analyze the performance and energy consumption of an Arm-based high-performance computing (HPC) system developed within the European project Mont-Blanc 3. This system, called Dibona, has been integrated by ATOS/Bull, and it is powered by the latest Marvell's CPU, ThunderX2. This CPU is the same one that powers the Astra supercomputer, the first Arm-based supercomputer entering the Top500 in November 2018. We study from micro-benchmarks up to large production codes. We include an interdisciplinary evaluation of three scientific applications (a finite-element fluid dynamics code, a smoothed particle hydrodynamics code, and a lattice Boltzmann code) and the Graph 500 benchmark, focusing on parallel and energy efficiency as well as studying their scalability up to thousands of Armv8 cores. For comparison, we run the same tests on state-of-the-art x86 nodes included in Dibona and the Tier-0 supercomputer MareNostrum4. Our experiments show that the ThunderX2 has a 25% lower performance on average, mainly due to its small vector unit yet somewhat compensated by its 30% wider links between the CPU and the main memory. We found that the software ecosystem of the Armv8 architecture is comparable to the one available for Intel. Our results also show that ThunderX2 delivers similar or better energy-to-solution and scalability, proving that Arm-based chips are legitimate contenders in the market of next-generation HPC systems

Patient Experience in Pancreas-Kidney Transplantation-A Methodological Approach Towards Innovation in an Established Program

Simultaneous pancreas-kidney transplantation (SPKT) leads to increased survival and quality of life, and is an alternative treatment for insulin-dependent diabetes mellitus and end-stage kidney disease. Due to the particularities of this population (often with multiple comorbidities) and of the surgery (only performed in a few centers), a comprehensive analysis of patients' experience along the SPKT process is crucial to improve patient care and add value to this procedure. Therefore, we applied a systematic and iterative methodology with the participation of both patients and professional teams working together to explore and identify unmet needs and value-adding steps along the transplant patient journey at an established pancreas transplant program. Four main steps (to comprehend, to explore, to experiment and to assess) led to several interventions around three major areas: Administration and logistics, information and communication, and perceived quality of assistance. As a result, both displacements to the hospital for diagnostic purposes and the time delay involved in joining the patient waiting list for transplantation were reduced in parallel to the administrative procedures. In conclusion, the methodological implementation of key organizational changes has great impact on overall patient experience. Further quantitative analysis from the patient's perspective will consolidate our program and may add new prototype service design components

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Lafora disease (LD) is an autosomal recessive, progressive myoclonus epilepsy, which is characterized by the accumulation of polyglucosan inclusion bodies, called Lafora bodies, in the cytoplasm of cells in the central nervous system and in many other organs. However, it is unclear at the moment whether Lafora bodies are the cause of the disease, or whether they are secondary consequences of a primary metabolic alteration. Here we describe that the major genetic lesion that causes LD, loss-of-function of the protein laforin, impairs autophagy. This phenomenon is confirmed in cell lines from human patients, mouse embryonic fibroblasts from laforin knockout mice and in tissues from such mice. Conversely, laforin expression stimulates autophagy. Laforin regulates autophagy via the mammalian target of rapamycin kinase-dependent pathway. The changes in autophagy mediated by laforin regulate the accumulation of diverse autophagy substrates and would be predicted to impact on the Lafora body accumulation and the cell stress seen in this disease that may eventually contribute to cell death

Homérica: estudiar y vivir el mundo griego (2020-2021)

Formación del alumno en la Antigüedad Clásica en doble orientación didáctica: teórica y teatral-artística, en conjunción. La teórica consiste en jornadas de conferencias y la práctica en un montaje teatral mitológico, a cargo de alumnos y profesores

A randomized, double-blind study on the efficacy of oral domperidone versus placebo for reducing SARS-CoV-2 viral load in mild-to-moderate COVID-19 patients in primary health care

15 p.-3 fig.-3 tab.Introduction:The clinical effect of domperidone against COVID-19 has been investigated in a double-blind phase III clinical trial (EudraCT number 2021-001228-17). Domperidone has shown in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential immudolatory properties through the stimulation of prolactin secretion.Patients and methods:The efficacy of oral domperidone plus standard of care (SOC; n = 87) versus placebo plus SOC (n = 86) was evaluated in a 28-day randomized double-blind multicentre study in primary health care centres. A total of 173 outpatients with mild-to-moderate COVID-19 were included. Three daily doses of 10 mg (30 mg/day) of domperidone or placebo were administered for 7 days. Reduction of viral load on day 4 was the primary efficay endpoint. It was estimated in saliva samples by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), as the cycle thresholds detected ORF1ab, N Protein and S Protein genes.Results:A significant reduction in the viral load was observed (p < 0.001) from baseline to days 4, 7 and 14 of the three genes studied with non-significant differences between domperidone and placebo groups. Twenty-three patients (13.3%) experienced adverse events, 14 patients in the domperidone group (16.1%) and 9 patients in the placebo group (10.5%). No patients needed to be hospitalized.Conclusion: Results do not prove the use of domperidone as antiviral in patients with COVID-19.This research was funded by CSIC (grant no. PIE 201980E024) and by the European Commission: NextGeneration EU (Regulation EU 2020/2094) through CSIC’s Global Health Platform (PTI Salud Global). The study sponsor was Agencia Estatal Consejo Superior de Investigaciones Científicas, M.P. (CSIC), Madrid, Spain. The sponsor was involved in the design, data interpretation, manuscript review and the decision to submit the article for publication.Peer reviewe