Digital inclusion - the vision, the challenges and the way forward

This paper considers the vision and aspiration of digital inclusion, and then examines the current reality. It looks beyond the rhetoric to provide an analysis of the status quo, a consideration of some facilitators and challenges to progress and some suggestions for moving forward with renewed energy and commitment. The far-reaching benefits of digital inclusion and the crucial role it plays in enabling full participation in our digital society are considered. At the heart of the vision of universal digital inclusion is the deceptively simple goal to ensure that everyone is able to access and experience the wide-ranging benefits and transformational opportunities and impacts it offers. The reality is a long way from the vision: inequality of access still exists despite many national campaigns and initiatives to reduce it. The benefits and beneficiaries of a digital society are not just the individual but all stakeholders in the wider society. Research evidence has shown that the critical success factors for successful digital participation are (i) appropriate design and (ii) readily available and on-going ICT (Information and Communication Technology) support in the community. Challenges and proven solutions are presented. The proposition of community hubs in local venues to provide user-centred ICT support and learning for older and disabled people is presented. While the challenges to achieve digital inclusion are very considerable, the knowledge of how to achieve it and the technologies which enable it already exist. Harnessing of political will is necessary to make digital inclusion a reality rather than a vision. With the cooperation and commitment of all stakeholders actualisation of the vision of a digitally inclusive society, while challenging, can be achieved and will yield opportunities and rewards that eclipse the cost of implementation

Mesoscale monitoring of the soil freeze/thaw boundary from orbital microwave radiometry

A technique was developed for mapping the spatial extent of frozen soils from the spectral characteristics of the 10.7 to 37 GHz radiobrightness. Through computational models for the spectral radiobrightness of diurnally heated freesing soils, a distinctive radiobrightness signature was identified for frozen soils, and the signature was cast as a discriminant for unsupervised classification. In addition to large area images, local area spatial averages of radiobrightness were calculated for each radiobrightness channel at 7 meteorologic sites within the test region. Local area averages at the meteorologic sites were used to define the preliminary boundaries in the Freeze Indicator discriminate. Freeze Indicator images based upon Nimbus 7, Scanning Multichannel Microwave Radiometer (SMMR) data effectively map temporal variations in the freeze/thaw pattern for the northern Great Plains at the time scale of days. Diurnal thermal gradients have a small but measurable effect upon the SMMR spectral gradient. Scale-space filtering can be used to improve the spatial resolution of a freeze/thaw classified image

Phenotypic selection exerted by a seed predator is replicated in space and time and among prey species

Although consistent phenotypic selection arising from biotic interactions is thought to be the primary cause of adaptive diversification, studies documenting such selection are relatively few. Here we analyze 12 episodes of phenotypic selection exerted by a predispersal seed predator, the red crossbill (Loxia curvirostra complex), on five species of pines (Pinus). We find that even though the intensity of selection for some traits increased with the strength of the interaction (i.e., proportion of seeds eaten), the relative strength of selection exerted by crossbills on cone and seed traits is replicated across space and time and among species. Such selection (1) can account for repeated patterns of conifer cone evolution and escalation in seed defenses with time and (2) suggests that variation in selection is less the result of variation intrinsic to pairwise biotic interactions than, for example, variation in relative densities of the interacting species, community context, and abiotic factorsNational Science Foundation (DEB-0212271 and DEB-0344503), the Robert B. Berry Endowed Chair, and the Ministry of Science and Innovation of Spain (CGL2010- 15687) for financial support for our researc

Birkhoff Normal form for Gravity Water Waves

We consider the gravity water waves system with a one-dimensional periodic interface in infinite depth, and present the proof of the rigorous reduction of these equations to their cubic Birkhoff normal form (Berti et al. in Birkhoff normal form and long-time existence for periodic gravity Water Waves. arXiv:1810.11549, 2018). This confirms a conjecture of Zakharov\u2013Dyachenko (Phys Lett A 190:144\u2013148, 1994) based on the formal Birkhoff integrability of the water waves Hamiltonian truncated at degree four. As a consequence, we also obtain a long-time stability result: periodic perturbations of a flat interface that are of size \u3b5 in a sufficiently smooth Sobolev space lead to solutions that remain regular and small up to times of order \u3b5 123

Static versus dynamic fluctuations in the one-dimensional extended Hubbard model

The extended Hubbard Hamiltonian is a widely accepted model for uncovering the effects of strong correlations on the phase diagram of low-dimensional systems, and a variety of theoretical techniques have been applied to it. In this paper the world-line quantum Monte Carlo method is used to study spin, charge, and bond order correlations of the one-dimensional extended Hubbard model in the presence of coupling to the lattice. A static alternating lattice distortion (the ionic Hubbard model) leads to enhanced charge density wave correlations at the expense of antiferromagnetic order. When the lattice degrees of freedom are dynamic (the Hubbard-Holstein model), we show that a similar effect occurs even though the charge asymmetry must arise spontaneously. Although the evolution of the total energy with lattice coupling is smooth, the individual components exhibit sharp crossovers at the phase boundaries. Finally, we observe a tendency for bond order in the region between the charge and spin density wave phases.Comment: Corrected typos. (10 pages, 9 figures

Large time existence for 3D water-waves and asymptotics

We rigorously justify in 3D the main asymptotic models used in coastal oceanography, including: shallow-water equations, Boussinesq systems, Kadomtsev-Petviashvili (KP) approximation, Green-Naghdi equations, Serre approximation and full-dispersion model. We first introduce a ``variable'' nondimensionalized version of the water-waves equations which vary from shallow to deep water, and which involves four dimensionless parameters. Using a nonlocal energy adapted to the equations, we can prove a well-posedness theorem, uniformly with respect to all the parameters. Its validity ranges therefore from shallow to deep-water, from small to large surface and bottom variations, and from fully to weakly transverse waves. The physical regimes corresponding to the aforementioned models can therefore be studied as particular cases; it turns out that the existence time and the energy bounds given by the theorem are always those needed to justify the asymptotic models. We can therefore derive and justify them in a systematic way.Comment: Revised version of arXiv:math.AP/0702015 (notations simplified and remarks added) To appear in Inventione

Resistance Mechanisms to Novel Therapies in Myeloma

The number of novel therapies for the treatment of multiple myeloma (MM) is rapidly increasing with proteasome inhibitors, immunomodulatory agents and monoclonal antibodies being the most well-known therapeutic classes whilst histone deacetylase inhibitors, selective inhibitors of nuclear export and CAR-T cells amongst others also being actively investigated. However, in parallel with the development and application of these novel myeloma therapies is the emergence of novel mechanisms of resistance, many of which remain elusive, particularly for more recently developed agents. Whilst resistance mechanisms have been best studied for proteasome inhibitors, particularly Bortezomib, class effects do not universally apply to all proteasome inhibitors, and within-class differences in efficacy, toxicity and resistance mechanisms have been observed. Immunomodulatory agents share the common cellular target cereblon and thus resistance patterns relate to cereblon expression and its pathway components. However, the cell surface antigens to which monoclonal antibodies are directed means these agents frequently exhibit unique within-class differences in clinical efficacy and resistance patterns. Despite the progressive biological elucidation of resistance mechanisms to these novel therapies, attempts to specifically exploit these processes lag considerably behind and until such approaches become available, resistance to these therapies will remain a concern