Impact-Actuated Digging Tool for Lunar Excavation

NASA s plans for a lunar outpost require extensive excavation. The Lunar Surface Systems Project Office projects that thousands of tons of lunar soil will need to be moved. Conventional excavators dig through soil by brute force, and depend upon their substantial weight to react to the forces generated. This approach will not be feasible on the Moon for two reasons: (1) gravity is 1/6th that on Earth, which means that a kg on the Moon will supply 1/6 the down force that it does on Earth, and (2) transportation costs (at the time of this reporting) of $50K to$100K per kg make massive excavators economically unattractive. A percussive excavation system was developed for use in vacuum or nearvacuum environments. It reduces the down force needed for excavation by an order of magnitude by using percussion to assist in soil penetration and digging. The novelty of this excavator is that it incorporates a percussive mechanism suited to sustained operation in a vacuum environment. A percussive digger breadboard was designed, built, and successfully tested under both ambient and vacuum conditions. The breadboard was run in vacuum to more than 2..times the lifetime of the Apollo Lunar Surface Drill, throughout which the mechanism performed and held up well. The percussive digger was demonstrated to reduce the force necessary for digging in lunar soil simulant by an order of magnitude, providing reductions as high as 45:1. This is an enabling technology for lunar site preparation and ISRU (In Situ Resource Utilization) mining activities. At transportation costs of $50K to$100K per kg, reducing digging forces by an order of magnitude translates into billions of dollars saved by not launching heavier systems to accomplish excavation tasks necessary to the establishment of a lunar outpost. Applications on the lunar surface include excavation for habitats, construction of roads, landing pads, berms, foundations, habitat shielding, and ISRU

Robotic Asteroid Prospector (RAP)

This report presents the results from the nine-month, Phase 1 investigation for the Robotic Asteroid Prospector (RAP). This project investigated several aspects of developing an asteroid mining mission. It conceived a Space Infrastructure Framework that would create a demand for in space-produced resources. The resources identified as potentially feasible in the near-term were water and platinum group metals. The project's mission design stages spacecraft from an Earth Moon Lagrange (EML) point and returns them to an EML. The spacecraft's distinguishing design feature is its solar thermal propulsion system (STP) that can provide for three functions:propulsive thrust, process heat for mining and mineral processing, and electricity. The preferred propellant is water since this would allow the spacecraft to refuel at an asteroid for its return voyage to Cis-Lunar space thus reducing the mass that must be staged out of the EML point.The spacecraft will rendezvous with an asteroid at its pole, match rotation rate, and attach to begin mining operations. The team conducted an experiment in extracting and distilling water from frozen regolith simulant

Low Force Icy Regolith Penetration Technology

Recent data from the Moon, including LCROSS data, indicate large quantities of water ice and other volatiles frozen into the soil in the permanently shadowed craters near the poles. If verified and exploited, these volatiles will revolutionize spaceflight as an inexpensive source of propellants and other consumables outside Earth's gravity well. This report discusses a preliminary investigation of a method to insert a sensor through such a soiVice mixture to verify the presence, nature, and concentration of the ice. It uses percussion to deliver mechanical energy into the frozen mixture, breaking up the ice and decompacting the soil so that only low reaction forces are required from a rover or spacecraft to push the sensor downward. The tests demonstrate that this method may be ideal for a small platform in lunar gravity. However, there are some cases where the system may not be able to penetrate the icy soil, and there is some risk ofthe sensor becoming stuck so that it cannot be retracted, so further work is needed. A companion project (ISDS for Water Detection on the Lunar Surface) has performed preliminary investigation of a dielectric/thermal sensor for use with this system

Field Testing of a Pneumatic Regolith Feed System During a 2010 ISRU Field Campaign on Mauna Kea, Hawaii

Lunar In Situ Resource Utilization (ISRU) consists of a number of tasks starting with mining of lunar regolith, followed by the transfer of regolith to an oxygen extraction reactor and finally processing the regolith and storing of extracted oxygen. The transfer of regolith from the regolith hopper at the ground level to an oxygen extraction reactor many feet above the surface could be accomplished in different ways, including using a mechanical auger, bucket ladder system or a pneumatic system. The latter system is commonly used on earth when moving granular materials since it offers high reliability and simplicity of operation. In this paper, we describe a pneumatic regolith feed system, delivering feedstock to a Carbothermal reactor and lessons learned from deploying the system during the 2010 ISRU field campaign on the Mauna Kea, Hawaii

The Grizzly, March 1, 1979

Special 110th Anniversary Issue, Ursinus College 1869-1979 • Price of Permanence • Letters to the Editor: Close ties; Pledging violation; WRUC fate ; The Independent Clarifies & Apologizes • IF Council Protests Pledging Crackdown • False Alarm Suspect: State, College soften stance • Meistersingers Begin Spring Tour • Opinion: Alcohol policy on trial • Dormitory Locks to be Changed • U.C. Administrators Analyze Past, Present, and Future: Future of Ursinus; Blueprints for action • Reprint: Ursinus Adopts a War Time Program; Faculty Votes to Speed Up the Work and Close Early • Reprint: 4,157 Cigarette Packs = 1 Stereo; Murphy Alone Defeats Demas • Reprint: Dorm Lounges Opened; Slacks Rule Slackened • Reprint: Comet Disappears • Reprint: Ursinus Offered Grad Degrees • Reprint: Banana Split Rated Big Success As News Spreads Across The Country • Fraternities At Ursinus Have Interesting History • Reprint: Beta Sig Presents Bill Haley • Reprint: WSGA Is Frowning On Dungarees, Slacks For Ursinus Campus Wear • Reprint: Springsteen\u27s Rock Rocks U.C. Campus • Reprint: Barn Dance • Reprint: Fire At Olevian Hall • Reprint: Seven Arrested • Roving reporter: Suggestions for change • Sports Profile: Jan Zanger • Spring Training Opens • Wrestlers Turn In Winning Season • Bears Finish Stronghttps://digitalcommons.ursinus.edu/grizzlynews/1015/thumbnail.jp

Pneumatic Regolith Transfer Systems for In Situ Resource Utilization

This slide presentation reviews the testing of a pneumatic system for transfering regolith, to be used for In Situ Resource Utilization (ISRU). Using both the simulated microgravity of parabolic flight and ground testing, the tests demonstrated that lunar regolith can be conveyed pneumatically into a simulated ISRU oxygen production plant reactor. The ground testing also demonstrated that the regolith can be expelled from the ISRU reactor for disposal or for other resource processing

Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer

Bladder cancer is the ninth most common cause of cancer-related deaths worldwide. Although cisplatin is used routinely in treating bladder cancer, refractory disease remains lethal for many patients. The recent addition of immunotherapy has improved patient outcomes; however, a large cohort of patients does not respond to these treatments. Therefore, identification of innovative molecular targets for bladder cancer is crucial. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in both DNA repair and activation of transcription factors through reduction-oxidation (redox) regulation. High APE1/Ref-1 expression is associated with shorter patient survival time in many cancer types. In this study, we found high APE1/Ref-1 expression in human bladder cancer tissue relative to benign urothelium. Inhibition of APE1/Ref-1 redox signaling using APE1/Ref-1-specific inhibitors attenuates bladder cancer cell proliferation in monolayer, in three-dimensional cultures, and in vivo. This inhibition corresponds with an increase in apoptosis and decreased transcriptional activity of NF-κB and STAT3, transcription factors known to be regulated by APE1/Ref-1, resulting in decreased expression of downstream effectors survivin and Cyclin D1 in vitro and in vivo. We also demonstrate that in vitro treatment of bladder cancer cells with APE1/Ref-1 redox inhibitors in combination with standard-of-care chemotherapy cisplatin is more effective than cisplatin alone at inhibiting cell proliferation. Collectively, our data demonstrate that APE1/Ref-1 is a viable drug target for the treatment of bladder cancer, provide a mechanism of APE1/Ref-1 action in bladder cancer cells, and support the use of novel redox-selective APE1/Ref-1 inhibitors in clinical studies. SIGNIFICANCE: This work identifies a critical mechanism for APE1/Ref-1 in bladder cancer growth and provides compelling preclinical data using selective redox activity inhibitors of APE1/Ref-1 in vitro and in vivo

Toward Defining the Preclinical Stages of Alzheimer's Disease: Recommendations from the National Institute on Aging-Alzheimer's Association Workgroups on Diagnostic Guidelines for Alzheimer's Disease

The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the link between the pathological cascade of AD and the emergence of clinical symptoms. The National Institute on Aging and the Alzheimer's Association convened an international workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and to develop recommendations to determine the factors which best predict the risk of progression from "normal" cognition to mild cognitive impairment and AD dementia. We propose a conceptual framework and operational research criteria, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies. These recommendations are solely intended for research purposes and do not have any clinical implications at this time. It is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD, and ultimately, aid the field in moving toward earlier intervention at a stage of AD when some disease-modifying therapies may be most efficacious

Annual variation in the levels of transcripts of sex-specific genes in the mantle of the common mussel, Mytilus edulis

Mytilus species are used as sentinels for the assessment of environmental health but sex or stage in the reproduction cycle is rarely considered even though both parameters are likely to influence responses to pollution. We have validated the use of a qPCR assay for sex identification and related the levels of transcripts to the reproductive cycle. A temporal study of mantle of Mytilus edulis found transcripts of male-specific vitelline coat lysin (VCL) and female-specific vitelline envelope receptor for lysin (VERL) could identify sex over a complete year. The levels of VCL/VERL were proportional to the numbers of sperm/ova and are indicative of the stage of the reproductive cycle. Maximal levels of VCL and VERL were found in February 2009 declining to minima between July - August before increasing and re-attaining a peak in February 2010. Water temperature may influence these transitions since they coincide with minimal water temperature in February and maximal temperature in August. An identical pattern of variation was found for a cryptic female-specific transcript (H5) but a very different pattern was observed for oestrogen receptor 2 (ER2). ER2 varied in a sex-specific way with male > female for most of the cycle, with a female maxima in July and a male maxima in December. Using artificially spawned animals, the transcripts for VCL, VERL and H5 were shown to be present in gametes and thus their disappearance from mantle is indicative of spawning. VCL and VERL are present at equivalent levels in February and July-August but during gametogenesis (August to January) and spawning (March to June) VCL is present at lower relative amounts than VERL. This may indicate sex-specific control mechanisms for these processes and highlight a potential pressure point leading to reduced reproductive output if environmental factors cause asynchrony to gamete maturation or release