Resultados oncológicos en enfermedad N1 posterior a la prostatectomía radical

ResumenAntecedentesLa prostatectomía radical+linfadenectomía pélvica puede mejorar la supervivencia libre de progresión y supervivencia cáncer-específica en la enfermedad ganglionar.ObjetivoAnalizar las características de los pacientes con enfermedad ganglionar en el análisis histopatológico de la prostatectomía radical.Material y métodosEstudio retrospectivo de pacientes sometidos a prostatectomía radical con enfermedad ganglionar metastásica de 1988 a 2015.ResultadosSe incluyeron 25 pacientes, de 66.5 años (DE±6.5); antígeno prostático específico medio de 20.17ng/dL (RIC: 18); con una mediana de seguimiento en 63 meses (RIC: 86). Clasificación de riesgo por D’Amico, 15 (60%) pacientes de alto, 8 (32%) intermedio y 2 (8%) de riesgo bajo. Se encontraron márgenes positivos en 15 casos (60%); estadio tumoral T2 en 4 (16%), T3A en 3 (12%), T3B en 17 (68%) y T4 en 1 (4%); cantidad de ganglios positivos, uno en 14 (56%), 2 en 3 (12%) y más de 2 en 8 (32%) casos. Recibieron radioterapia 3 pacientes (16%) y bloqueo hormonal 24 (96%). La supervivencia libre de progresión fue de 105 meses y la supervivencia cáncer-específica fue del 86 y 45% a 5 y 10 años respectivamente. El HR para progresión bioquímica fue significativo en márgenes positivos (HR: 9.5, IC95%: 0.99-91.5, p=0.50) y ≥2 ganglios positivos (HR: 8.5, IC95%: 1.1-61.9, p=0.34). La afectación≥2 ganglios predijo progresión con una OR de 7.2 (IC95% 1.06-48.6, p=0.043).ConclusionesLa supervivencia media a 5 años es superior al 80%. El número de ganglios positivos podría ser un factor predictor de progresión bioquímica.AbstractBackgroundRadical prostatectomy+pelvic lymph node dissection can improve progression-free survival and cancer-specific survival in lymph node disease.AimTo analyze the characteristics of patients with lymph node disease in the histopathologic findings of the radical prostatectomy and lymph node dissection.Material and methodsA retrospective study was carried out on patients that underwent radical prostatectomy with metastatic lymph node disease within the time frame of 1988 to 2015.ResultsThe study included 25 patients with a mean 66.5 years of age (SD±6.5), a mean prostate-specific antigen of 20.17ng/dl (IQR: 18), and a median follow-up period of 63 months (IQR: 86). According to the D’Amico classification, 15 (60%) patients were high-risk, 8 (32%) were intermediate-risk, and 2 (8%) were low-risk. Positive margins were found in 15 cases (60%); 4 (16%) patients had T2 tumor stage, 3 (12%) had T3A, 17 (68%) had T3B, and one patient (4%) had T4. Fourteen (56%) patients had one positive lymph node, 3 (12%) patients had 2 positive lymph nodes, and 8 (32%) patients had more than 2 positive lymph nodes. Three (16%) patients received radiotherapy and 24 (96%) underwent hormone blockade. Progression-free survival was 105 months and cancer-specific survival was 86% at 5 years and 45% at ten years. The HR for biochemical progression was significant in positive margins (HR: 9.5, 95% CI: 0.99-91.5, P=.50) and when there were≥2 positive lymph nodes (HR: 8.5, 95% CI: 1.1-61.9, P=0.34). Involvement of≥2 lymph nodes predicted progression with an odds ratio of 7.2 (95% CI: 1.06-48.6, P=.043).ConclusionsThe average 5-year survival was above 80%. The number of positive lymph nodes could be a predictive factor for biochemical progression

Structural disorder in plant proteins : where plasticity meets sessility

Plants are sessile organisms. This intriguing nature provokes the question of how they survive despite the continual perturbations caused by their constantly changing environment. The large amount of knowledge accumulated to date demonstrates the fascinating dynamic and plastic mechanisms, which underpin the diverse strategies selected in plants in response to the fluctuating environment. This phenotypic plasticity requires an efficient integration of external cues to their growth and developmental programs that can only be achieved through the dynamic and interactive coordination of various signaling networks. Given the versatility of intrinsic structural disorder within proteins, this feature appears as one of the leading characters of such complex functional circuits, critical for plant adaptation and survival in their wild habitats. In this review, we present information of those intrinsically disordered proteins (IDPs) from plants for which their high level of predicted structural disorder has been correlated with a particular function, or where there is experimental evidence linking this structural feature with its protein function. Using examples of plant IDPs involved in the control of cell cycle, metabolism, hormonal signaling and regulation of gene expression, development and responses to stress, we demonstrate the critical importance of IDPs throughout the life of the plant

Contrasting Phaseolus crop water use patterns and stomatal dynamics in response to terminal drought

Terminal drought stress affects more than half of the areas planted with common bean (Phaseolus vulgaris), the main food legume globally, generating severe yield losses. Phenotyping water deficit responses and water use are central strategies to develop improved terminal drought resilience. The exploration and exploitation of genetic diversity in breeding programs are gaining importance, with a particular interest in related species with great adaptation to biotic and abiotic factors. This is the case with tepary beans (Phaseolus acutifolius), a bean that evolved and was domesticated in arid conditions and is considered well adapted to drought and heat stress. Under greenhouse conditions, using one genotype of tepary beans (resistant to drought) and two of common beans (one resistant and one susceptible to terminal drought), we evaluated phenotypic differences in traits such as water use efficiency (WUE), transpiration efficiency, rate of photosynthesis, photosynthetic efficiency, stomatal density, stomatal index, stomatal size, and the threshold for transpiration decline under well-watered and terminal drought conditions. Our results indicate two different water use strategies in drought-resistant genotypes: one observed in common bean aimed at conserving soil water by closing stomata early, inhibiting stomatal development, and limiting growth; and the other observed in tepary bean, where prolonged stomatal opening and higher carbon fixation, combined with no changes in stomata distribution, lead to higher biomass accumulation. Strategies that contribute to drought adaptation combined with other traits, such as greater mobilization of photoassimilates to the formation of reproductive structures, confer bean drought resistance and are useful targets in breeding programs

DES13S2cmm: the first superluminous supernova from the Dark Energy Survey

We present DES13S2cmm, the first spectroscopically-confirmed superluminous supernova (SLSN) from the Dark Energy Survey (DES). We briefly discuss the data and search algorithm used to find this event in the first year of DES operations, and outline the spectroscopic data obtained from the European Southern Observatory (ESO) Very Large Telescope to confirm its redshift (z = 0.663 +/- 0.001 based on the host-galaxy emission lines) and likely spectral type (type I). Using this redshift, we find M_U_peak = -21.05 +0.10 -0.09 for the peak, rest-frame U-band absolute magnitude, and find DES13S2cmm to be located in a faint, low metallicity (sub-solar), low stellar-mass host galaxy (log(M/M_sun) = 9.3 +/- 0.3); consistent with what is seen for other SLSNe-I. We compare the bolometric light curve of DES13S2cmm to fourteen similarly well-observed SLSNe-I in the literature and find it possesses one of the slowest declining tails (beyond +30 days rest frame past peak), and is the faintest at peak. Moreover, we find the bolometric light curves of all SLSNe-I studied herein possess a dispersion of only 0.2-0.3 magnitudes between +25 and +30 days after peak (rest frame) depending on redshift range studied; this could be important for 'standardising' such supernovae, as is done with the more common type Ia. We fit the bolometric light curve of DES13S2cmm with two competing models for SLSNe-I - the radioactive decay of 56Ni, and a magnetar - and find that while the magnetar is formally a better fit, neither model provides a compelling match to the data. Although we are unable to conclusively differentiate between these two physical models for this particular SLSN-I, further DES observations of more SLSNe-I should break this degeneracy, especially if the light curves of SLSNe-I can be observed beyond 100 days in the rest frame of the supernova.Comment: Accepted by MNRAS (2015 January 23), 13 pages, 6 figures, 2 table

First Observation of the Cabibbo-suppressed Decays Xi_c+ -> Sigma+ pi- pi+ and Xi_c+ -> Sigma- pi+ pi+ and Measurement of their Branching Ratios

We report the first observation of two Cabibbo-suppressed decay modes, Xi_c+ -> Sigma+ pi- pi+ and Xi_c+ -> Sigma- pi+ pi+. We observe 59+/-14 over a background of 87, and 22+/-8 over a background of 13 events, respectively, for the signals. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, chiefly from a 600GeV/c Sigma- beam. The branching ratios of the decays relative to the Cabibbo--favored Xi_c+ -> Xi- pi+ pi+ are measured to be B(Xi_c+ -> Sigma+ pi- pi+)/B(Xi_c+ -> Xi- pi+ pi+) = 0.48+/-0.20, and B(Xi_c+ -> Sigma- pi+ pi+)/B(Xi_c+ -> Xi- pi+ pi+) = 0.18+/-0.09, respectively. We also report branching ratios for the same decay modes of the Lambda_c+ relative to Lambda_c+ -> p K- pi+.Comment: 15 pages, 5 figures, version 2 as accepted in PL

Nuclear Dependence Of Charm Production

Using data taken by SELEX during the 1996-1997 fixed target run at Fermilab, we study the production of charmed hadrons on copper and carbon targets with ∑ -, p, π -, and π + beams. Parametrizing the dependence of the inclusive production cross section on the atomic number A as A α, we determine α for D +, D 0, D s +, D +(2010), Λ c +, and their respective anti-particles, as a function of their transverse momentum p t and scaled longitudinal momentum x F . Within our statistics there is no dependence of α on x F for any charm species for the interval 0.1<x F <1.0. The average value of α for charm production by pion beams is α meson=0.850±0.028. This is somewhat larger than the corresponding average α baryon=0.755±0.016 for charm production by baryon beams (∑ -, p). © 2009 Springer-Verlag/Società Italiana di Fisica.644637644Cobbaert, H., (1987) Phys. Lett. B, 191, p. 456. , 10.1016/0370-2693(87)90639-3 1987PhLB.191.456CCobbaert, H., (1988) Phys. Lett. B, 206, p. 546. , 10.1016/0370-2693(88)91627-9Cobbaert, H., (1988) Phys. Lett. B, 213, p. 395. , 10.1016/0370-2693(88)91783-2 1988PhLB.213.395CLeitch, M.J., (2000) Phys. Rev. Lett., 84, p. 3256. , 10.1103/PhysRevLett.84.3256 2000PhRvL.84.3256L arXiv:nucl-ex/9909007Alessandro, B., Alexa, C., Arnaldi, R., Atayan, M., Baglin, C., Baldit, A., Beole, S., Willis, N., Charmonium production and nuclear absorption in p-A interactions at 450 GeV (2004) European Physical Journal C, 33 (1), pp. 31-40. , DOI 10.1140/epjc/s2003-01539-yAbt, I., (2009) Eur. Phys. J. C, 60, p. 525. , 10.1140/epjc/s10052-009-0965-7 2009EPJC.60.525A arXiv:0812.0734 [hep-ex]Heller, K.J., (1977) Phys. Rev. D, 16, p. 2737. , 10.1103/PhysRevD.16.2737 1977PhRvD.16.2737HSkubic, P., (1978) Phys. Rev. D, 18, p. 3115. , 10.1103/PhysRevD.18.3115 1978PhRvD.18.3115SAleev, A.N., (1987) Sov. J. Nucl. Phys., 46, p. 657. , [Yad. Fiz. 46, 1127 (1987)]Vecko, M., (1989) Czech. J. Phys. B, 39, p. 297. , 10.1007/BF01597781 1989CzJPh.39.297VAdamovich, M., (1992) Phys. Lett. B, 284, p. 453. , 10.1016/0370-2693(92)90460-L 1992PhLB.284.453AAlves, G.A., (1993) Phys. Rev. Lett., 70, p. 722. , 10.1103/PhysRevLett.70.722 1993PhRvL.70.722AAlves, G.A., (1994) Phys. Rev. D, 49, p. 4317. , 10.1103/PhysRevD.49.R4317 1994PhRvD.49.4317ALeitch, M.J., (1994) Phys. Rev. Lett., 72, p. 2542. , 10.1103/PhysRevLett.72.2542 1994PhRvL.72.2542LAdamovich, M., (1997) Nucl. Phys. B, 495, p. 3. , 10.1016/S0550-3213(97)00223-X 1997NuPhB.495.3AApanasevich, L., (1997) Phys. Rev. D, 56, p. 1391. , 10.1103/PhysRevD.56.1391 1997PhRvD.56.1391A arXiv:hep-ex/9702014Abt, I., (2007) Eur. Phys. J. C, 52, p. 531. , 10.1140/epjc/s10052-007-0427-z 2007EPJC.52.531A arXiv:0708.1443 [hep-ex]Duffy, M.E., (1985) Phys. Rev. Lett., 55, p. 1816. , 10.1103/PhysRevLett.55.1816 1985PhRvL.55.1816DVogt, R., The A dependence of open charm and bottom production (2003) International Journal of Modern Physics E, 12 (2), pp. 211-269. , DOI 10.1142/S0218301303001272Lourenco, C., Wohri, H.K., Heavy-flavour hadro-production from fixed-target to collider energies (2006) Physics Reports, 433 (3), pp. 127-180. , DOI 10.1016/j.physrep.2006.05.005, PII S0370157306001815Frawley, A.D., Ullrich, T., Vogt, R., (2008) Phys. Rept., 462, p. 125. , 10.1016/j.physrep.2008.04.002 2008PhR.462.125F arXiv:0806.1013 [nucl-ex]Russ, J.S., (1998) Proceedings of the 29th International Conference on High Energy Physics II World Scientific Singapore, 1259. , A. Astbury (eds), et al. arXiv:hep-ex/9812031Russ, J.S., (1998) Proceedings of the 29th International Conference on High Energy Physics, 2, p. 1259. , ed. by A. Astbury, et al. (World Scientific, Singapore) arXiv:hep-ex/9812031Engelfried, J., (1999) Nucl. Instrum. Methods A, 431, p. 53. , 10.1016/S0168-9002(99)00043-1 1999NIMPA.431.53E arXiv:hep-ex/9811001Kushnirenko, A., Alkhazov, G., Atamantchouk, A.G., Balatz, M.Y., Bondar, N.F., Cooper, P.S., Dauwe, L.J., Vishnyakov, V.E., Precision measurements of the ∧c+ and D 0 lifetimes (2001) Physical Review Letters, 86 (23), pp. 5243-5246. , DOI 10.1103/PhysRevLett.86.5243Garcia, F.G., (2002) Phys. Lett. B, 528, p. 49. , 10.1016/S0370-2693(01)01484-8 2002PhLB.528.49S arXiv:hep-ex/0109017Kaya, M., (2003) Phys. Lett. B, 558, p. 34. , 10.1016/S0370-2693(03)00246-6 2003PhLB.558.34S arXiv:hep-ex/0302039Brodsky, S.J., Kopeliovich, B., Schmidt, I., Soffer, J., (2006) Phys. Rev. D, 73, p. 113005. , 2006PhRvD.73k3005B arXiv:hep-ph/0603238Adamovich, M.I., (2003) Eur. Phys. J. C, 26, p. 357. , 10.1140/epjc/s2002-01073-6 2003EPJC.26.357WA. Blanco-Covarrubias, et al. (SELEX Collaboration), in preparatio

Chitosan/silver nanocomposites: Synergistic antibacterial action of silver nanoparticles and silver ions

Two groups of participants, men and women, reached in seated position for a plastic block that was presented on a table at different distances. When the distance was expressed in extrinsic units (centimeters), women changed their modes of action for reaching for the block at closer distances than men because their body sizes were smaller than those of men. When the distance was expressed in intrinsic units; that is, as the ratio between the distance of the block and the arm length of each participant, both men and women allocated their modes of action to reach for the block in a comparable way along the different distances. However, at the ? distance 1.1 differences were observed in the performance of men and women. The choice of mode of action shifted in critical points where the relationship between the distance of the block and arm length induced the appearance of a different mode of action. The choice of the mode of action varied more at and at distances around the absolute critical boundary of the arm-only mode of action. These findings suggest that the relation between the subject´s body scale, his or her biomechanical restrictions, and the scale of the environment, contributes to the choice of mode of action. " 2013, Sociedad Mexicana de Analisis de la Conducta. All rights reserved.",,,,,,,,,"http://hdl.handle.net/20.500.12104/40034","http://www.scopus.com/inward/record.url?eid=2-s2.0-84919773090&partnerID=40&md5=fcc112852925dfb8c8c4c0bbbc0aa2d4",,,,,,"1",,"Revista Mexicana de Analisis de la Conducta",,"

Choice of modes of action and intrinsic metric in an arm reaching task [Elección de modos de acción y métrica intrínseca en una tarea de alcance con el brazo]

Two groups of participants, men and women, reached in seated position for a plastic block that was presented on a table at different distances. When the distance was expressed in extrinsic units (centimeters), women changed their modes of action for reaching for the block at closer distances than men because their body sizes were smaller than those of men. When the distance was expressed in intrinsic units; that is, as the ratio between the distance of the block and the arm length of each participant, both men and women allocated their modes of action to reach for the block in a comparable way along the different distances. However, at the π distance 1.1 differences were observed in the performance of men and women. The choice of mode of action shifted in critical points where the relationship between the distance of the block and arm length induced the appearance of a different mode of action. The choice of the mode of action varied more at and at distances around the absolute critical boundary of the arm-only mode of action. These findings suggest that the relation between the subject’s body scale, his or her biomechanical restrictions, and the scale of the environment, contributes to the choice of mode of action. © 2013, Sociedad Mexicana de Analisis de la Conducta. All rights reserved

Crop biotechnology for improving drought tolerance : targets, approaches, and outcomes

Human population growth and climate change threaten our food and water security. The increasing frequency of extreme drought events will cause major crop yield losses. To mitigate this threat to global food security, we need to rapidly select and/or develop new ‘climate‐ready’ crop varieties that can withstand and flourish under water deficit, enabling the sustained and sustainable production of higher yields to support human life on Earth. In this article, we identify the current targets for crop plant improvement under drought, working from the ground up, with modifications in rooting, shoot, stomatal, and photosynthetic systems, and finally nutrient transport and sink strength. We argue that by using a holistic approach to crop development, prudently incorporating the natural variation available in crop wild relatives and cultivars with cutting‐edge tools, such as molecular breeding and transgenics, we may be able to produce high‐yielding crops under a range of conditions to meet our needs in a changing world

Estimating the 'reachability' of a line: An affordance perception approach [Estimando la 'alcanzabilidad' de una línea: Una aproximación a la percepción de acción]

Two experiments were conducted to assess the perception of 'reachability' of horizontal lines at different heights in humans. In Experiment 1, participants were asked whether the lines were reachable using their arms, and in Experiment 2 the estimation was made using a pole that was sized at the maximum extension of the participants' arms in vertical position. Two conditions were arranged for both experiments: participants estimated whether the lines were reachable while sitting in a small chair (Low Support Condition) or while sitting in a tall chair (High Support Condition). For data analysis we used a body-scaled or intrinsic metric that is expressed as the ratio of the height of stimuli with respect to the participants' maximum arm extension or respect to the pole's extension. This measurement evaluated the accuracy of the participants' estimation. Results showed that subjects estimated the reachability of the lines more accurately when using their arms (Experiment 1) than when using the pole (Experiment 2); nevertheless, participants had less confidence of their estimations at heights close to the absolute critical boundary. Findings are discussed in terms of the behavioral meaning of stimuli, the intrinsic metric in the affordance perception, and their contribution for the experimental analysis of behavior