255 research outputs found
Gluino Contribution to the 3-loop QCD beta function in the Minimal Supersymmetric Standard Model
We deduce the gluino contribution to the three-loop QCD \beta function within
the minimal supersymmetric Standard Model (MSSM) from its standard QCD
expression. The result is a first step in the computation of the full MSSM
three-loop \beta function. In addition, in the case of a light gluino it
provides the strong three-loop SUSY correction to the extrapolation of the
strong coupling constant from the low energy regime to the Z region and up to
the squark threshold.Comment: 11 pages, RevTex, 4 Postscript figur
Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release
Ethosuximide is the drug of choice for treating generalized absence seizures, but its mechanism of action is still a matter of debate. It has long been thought to act by disrupting a thalamic focus via blockade of T-type channels and, thus, generation of spike-wave activity in thalamocortical pathways. However, there is now good evidence that generalized absence seizures may be initiated at a cortical focus and that ethosuximide may target this focus. In the present study we have looked at the effect ethosuximide on glutamate and GABA release at synapses in the rat entorhinal cortex in vitro, using two experimental approaches. Whole-cell patch-clamp studies revealed an increase in spontaneous GABA release by ethosuximide concurrent with no change in glutamate release. This was reflected in studies that estimated global background inhibition and excitation from intracellularly recorded membrane potential fluctuations, where there was a substantial rise in the ratio of network inhibition to excitation, and a concurrent decrease in excitability of neurones embedded in this network. These studies suggest that, in addition to well-characterised effects on ion channels, ethosuximide may directly elevate synaptic inhibition in the cortex and that this could contribute to its anti-absence effects. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'
"I'm still me - I'm still here!" Understanding the person's sense of self in the provision of self-management support for people with progressive neurological long-term conditions
Purpose: There is increasing interest in tailoring self-management support, but little detail is available on the relevance and impact of such approaches for people with progressive neurological conditions. The aim of this study was to draw on individuals' experiences to inform the practice of self-management support for these groups.
Method: Community rehabilitation service users were purposively recruited and took part in in-depth qualitative interviews. Interviews were audio-recorded and transcribed. Data analysis was iterative and interpretative, taking a phenomenological approach. Strategies to enhance rigor were auditability, peer review, and researcher reflexivity.
Results: The sample consisted of 10 adults (age 20-79 years) who were living with a range of progressive neurological conditions. Individuals demonstrated resourcefulness in developing practice-based self-management strategies. Beyond practical strategies, interviewees' experiences were signified by reflecting on and upholding a sense of identity and a desire for purpose against the background of losses and gains over time. Linking with this overarching theme of 'Sense of self' were aspects of 'My body and mind', 'Time', 'Space', 'Relationships', and 'What I do'.
Conclusions: Self-management approaches for individuals with progressive neurological conditions will benefit from incorporating ways of recognizing, articulating, and supporting the person's sense of identity and purpose.
Implications for rehabilitation: Self-management approaches for people with progressive neurological conditions need to take account of individuals' wishes to contribute, connect with others, and be valued as a person. Person-centred self-management support can be realized through a broader approach than solely managing disease progression. The experiences and words of people with progressive neurological conditions can be used to inform meaningful evaluation of self-management support to drive service delivery by measuring what really matters. Rehabilitation practitioners need to adapt their conceptualisations of goal setting to account for how people with progressive neurological conditions themselves interpret 'progress' and 'improvement'. Person-centred conversation that values who the person is can be an effective starting point for self-management interventions in people with progressive neurological conditions
Status of the T20 experiment at VEPPâ3
Using a gaseous polarized deuterium and the 2 GeV electron beam at 2 GeV beam energy the tensor analyzing power, T20, for the NN potential will be measured with the elastic dâ(e,e) reaction at VEPPâ3, Novosibirsk. A description and progress report of the experiment is given. (AIP)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87524/2/530_1.pd
Electron scattering from polarized deuterium at VEPPâ3
The status, results, and future plans for the experiment measuring the tensor analyzing power of the deuteron using a tensorâpolarized internal target at the VEPPâ3 electron storage ring in Novosibirsk are presented. © 1995 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87517/2/713_1.pd
A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2
The A-dependence of the quasielastic A(e,e'p) reaction has been studied at
SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and
6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the
average probability that the struck proton escapes from the nucleus A without
interaction. Several calculations predict a significant increase in T with
momentum transfer, a phenomenon known as Color Transparency. No significant
rise within errors is seen for any of the nuclei studied.Comment: 5 pages incl. 2 figures, Caltech preprint OAP-73
Are publicly available internet resources enabling women to make informed fertility preservation decisions before starting cancer treatment: an environmental scan?
Background To identify publicly available internet resources and assess their likelihood to support women making informed decisions about, and between, fertility preservation procedures before starting their cancer treatment. Methods A survey of publically available internet resources utilising an environmental scan method. Inclusion criteria were applied to hits from searches of three data sources (November 2015; repeated June 2017): Google (Chrome) for patient resources; repositories for clinical guidelines and projects; distribution email lists to contact patient decision aid experts. The Data Extraction Sheet applied to eligible resources elicited: resource characteristics; informed and shared decision making components; engagement health services. Results Four thousand eight hundred fifty one records were identified; 24 patient resources and 0 clinical guidelines met scan inclusion criteria. Most resources aimed to inform women with cancer about fertility preservation procedures and infertility treatment options, but not decision making between options. There was a lack of consistency about how health conditions, decision problems and treatment options were described, and resources were difficult to understand. Conclusions Unless developed as part of a patient decision aid project, resources did not include components to support proactively womenâs fertility preservation decisions. Current guidelines help people deliver information relevant to treatment options within a single disease pathway; we identified five additional components for patient decision aid checklists to support more effectively peopleâs treatment decision making across health pathways, linking current with future health problems
Inclusive Electron Scattering from Nuclei at
The inclusive A(e,e') cross section for was measured on H,
C, Fe, and Au for momentum transfers from 1-7 (GeV/c). The scaling
behavior of the data was examined in the region of transition from y-scaling to
x-scaling. Throughout this transitional region, the data exhibit -scaling,
reminiscent of the Bloom-Gilman duality seen in free nucleon scattering.Comment: 4 pages, RevTeX; 4 figures (postscript in .tar.Z file
Measurement of the Neutron Spin Structure Function with a Polarized ^3He Target
Results are reported from the HERMES experiment at HERA on a measurement of
the neutron spin structure function in deep inelastic scattering
using 27.5 GeV longitudinally polarized positrons incident on a polarized
He internal gas target. The data cover the kinematic range
and . The integral evaluated at a fixed of is . Assuming Regge behavior at low , the first
moment is .Comment: 4 pages TEX, text available at
http://www.krl.caltech.edu/preprints/OAP.htm
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