Valuable? A roadmap for valuing and evaluating archives of science

<p>Slides from a presentation at the annual meeting of UNIVERSEUM (an European network for university heritage), Trondheim (Norway) 2012. </p> <p>The presentation outlines our preliminary ideas about the evaluation of materials which accumulate during the career of research scientists and the need for a quantitative methodology. </p

Biogeochemistry of fatty acids in a river-dominated Mediterranean ecosystem (Rhône River prodelta, Gulf of Lions, France): Origins and diagenesis

International audienceMajor rivers transfer high loads of continental particulate organic matter to deltaic environments, where the impact on the biogeochemistry and productivity of coastal sediments depends on the sources and lability of these inputs. Our aims are to provide new insights into the reactivity of riverine inputs in coastal environments and to delineate the parameters controlling their fate in these dynamic systems. Sediment cores were collected from a Mediterranean deltaic system (the Rhône prodelta and its adjacent shelf) during a period of moderate river discharge (Spring 2007) and analyzed for their fatty acid composition. Sediment properties were also described using biochemical bulk analyses (organic carbon and lipids), granulometry and profiles of redox potential. Based on the bulk compositional changes and hierarchical clustering of the fatty acid biomarkers, we determined the principal sources of organic matter and their spatial distribution. Fatty acids were primarily of continental origin in the prodelta, shifting to a higher contribution from marine sources in the shelf area. Fatty acids derived from both continental and marine sources were efficiently degraded in the sediments by microbial decay processes in the upper oxic layer. Degradation rate constants calculated from the down-core decreases in concentrations indicate that fatty acid degradation was enhanced in sediments influenced by the Rhône River. The most important parameters affecting fatty acid preservation were the inherent stability of individual molecular components and their physical association with mineral matrices, the source and freshness of the inputs, and the depositional environment (redox condition, accumulation rates)

STATE-CIVIL SOCIETY NETWORKS FOR POLICY IMPLEMENTATION IN DEVELOPING COUNTRIES -super-1

The emphasis in this article is on the trends which speak of governance rather than government. Governance refers to the role of citizens in the policy process and how groups within a society organize to make and implement decisions on matters of great concern. The focus is on democratic governance as taking place through networks in developing countries. These networks are referred to as state-civil society networks and are defined as cross-sectoral collaborations in which the view is not of individuals, per se, but rather of individual actors who are seen as a connected and interdependent whole. Three case studies of such state-civil society networks provide some preliminary lessons which suggest four situational variables for the emergence and success of these networks. These include: regime type, level of trust, legal framework and regulations, and the nature of the policy to be implemented. They also suggest some effective mechanisms and processes based on ad hoc vs formalizedmechanisms, initiation of the network and coordinating linkages. Copyright 1999 by The Policy Studies Organization.

Risk of COVID-19 after natural infection or vaccinationResearch in context

Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health