On the global uniqueness for the Einstein-Maxwell-scalar field system with a cosmological constant. Part 3: Mass inflation and extendibility of the solutions

This paper is the third part of a trilogy dedicated to the following problem: given spherically symmetric characteristic initial data for the Einstein-Maxwell-scalar field system with a cosmological constant $\Lambda$, with the data on the outgoing initial null hypersurface given by a subextremal Reissner-Nordstrom black hole event horizon, study the future extendibility of the corresponding maximal globally hyperbolic development as a "suitably regular" Lorentzian manifold. In the first part of this series we established the well posedness of the characteristic problem, whereas in the second part we studied the stability of the radius function at the Cauchy horizon. In this third and final paper we show that, depending on the decay rate of the initial data, mass inflation may or may not occur. When the mass is controlled, it is possible to obtain continuous extensions of the metric across the Cauchy horizon with square integrable Christoffel symbols. Under slightly stronger conditions, we can bound the gradient of the scalar field. This allows the construction of (non-isometric) extensions of the maximal development which are classical solutions of the Einstein equations. Our results provide evidence against the validity of the strong cosmic censorship conjecture when $\Lambda>0$.Comment: 48 pages, 5 figures; v2: some presentation changes, mostly in the Introduction; v3: substantial changes in Section 5; v4: expanded Introduction; some presentation changes; matches final published versio

On the global uniqueness for the Einstein-Maxwell-scalar field system with a cosmological constant. Part 2: Structure of the solutions and stability of the Cauchy horizon

This paper is the second part of a trilogy dedicated to the following problem: given spherically symmetric characteristic initial data for the Einstein-Maxwell-scalar field system with a cosmological constant $\Lambda$, with the data on the outgoing initial null hypersurface given by a subextremal Reissner-Nordstrom black hole event horizon, study the future extendibility of the corresponding maximal globally hyperbolic development as a "suitably regular" Lorentzian manifold. In the first paper of this sequence, we established well posedness of the characteristic problem with general initial data. In this second paper, we generalize the results of Dafermos on the stability of the radius function at the Cauchy horizon by including a cosmological constant. This requires a considerable deviation from the strategy followed by Dafermos, focusing on the level sets of the radius function instead of the red-shift and blue-shift regions. We also present new results on the global structure of the solution when the free data is not identically zero in a neighborhood of the origin. In the third and final paper, we will consider the issue of mass inflation and extendibility of solutions beyond the Cauchy horizon.Comment: 44 pages, 13 figures; v2: a few small changes; v3: a paragraph was added in the Introduction, minor clarifications were made thoughout, the list of references was expanded, matches final published versio

Genomic blueprints of sponge-prokaryote symbiosis are shared by low abundant and cultivatable Alphaproteobacteria

Marine sponges are early-branching, filter-feeding metazoans that usually host complex microbiomes comprised of several, currently uncultivatable symbiotic lineages. Here, we use a low-carbon based strategy to cultivate low-abundance bacteria from Spongia officinalis. This approach favoured the growth of Alphaproteobacteria strains in the genera Anderseniella, Erythrobacter, Labrenzia, Loktanella, Ruegeria, Sphingorhabdus, Tateyamaria and Pseudovibrio, besides two likely new genera in the Rhodobacteraceae family. Mapping of complete genomes against the metagenomes of S. officinalis, seawater, and sediments confirmed the rare status of all the above-mentioned lineages in the marine realm. Remarkably, this community of low-abundance Alphaproteobacteria possesses several genomic attributes common to dominant, presently uncultivatable sponge symbionts, potentially contributing to host fitness through detoxification mechanisms (e.g. heavy metal and metabolic waste removal, degradation of aromatic compounds), provision of essential vitamins (e.g. B6 and B12 biosynthesis), nutritional exchange (especially regarding the processing of organic sulphur and nitrogen) and chemical defence (e.g. polyketide and terpenoid biosynthesis). None of the studied taxa displayed signs of genome reduction, indicative of obligate mutualism. Instead, versatile nutrient metabolisms along with motility, chemotaxis, and tight-adherence capacities - also known to confer environmental hardiness - were inferred, underlying dual host-associated and free-living life strategies adopted by these diverse sponge-associated Alphaproteobacteria.PTDC/MAR-BIO/1547/2014; full PhD scholarship from the Erasmus Mundus Programme/SALAM EMA2 lot7/SALA1206422info:eu-repo/semantics/publishedVersio

An integrative assessment to determine the genotoxic hazard of estuarine sediments: combining cell and whole-organism responses

The application of the Comet assay in environmental monitoring remains challenging in face of the complexity of environmental stressors, e.g., when dealing with estuarine sediments, that hampers the drawing of cause-effect relationships. Although the in vitro Comet assay may circumvent confounding factors, its application in environmental risk assessment (ERA) still needs validation. As such, the present work aims at integrating genotoxicity and oxidative DNA damage induced by sediment-bound toxicants in HepG2 cells with oxidative stress-related effects observed in three species collected from an impacted estuary. Distinct patterns were observed in cells exposed to crude mixtures of sediment contaminants from the urban/industrial area comparatively to the ones from the rural/riverine area of the estuary, with respect to oxidative DNA damage and oxidative DNA damage. The extracts obtained with the most polar solvent and the crude extracts caused the most significant oxidative DNA damage in HepG2 cells, as measured by the formamidopyrimidine-DNA glycosylase (FPG)-modified Comet assay. This observation suggests that metals and unknown toxicants more hydrophilic than polycyclic aromatic hydrocarbons may be important causative agents, especially in samples from the rural part of the estuary, where oxidative DNA damage was the most significant. Clams, sole, and cuttlefish responded differentially to environmental agents triggering oxidative stress, albeit yielding results accordant with the oxidative DNA damage observed in HepG2 cells. Overall, the integration of in vivo biomarker responses and Comet assay data in HepG2 cells yielded a comparable pattern, indicating that the in vitro FPG-modified Comet assay may be an effective and complementary line-of-evidence in ERA even in particularly challenging, natural, scenarios such as estuarine environments

Thrombus aspiration in patients with ST-elevation myocardial infarction: results of a national registry of interventional cardiology.

BACKGROUND: We aimed to evaluate the impact of thrombus aspiration (TA) during primary percutaneous coronary intervention (P-PCI) in 'real-world' settings. METHODS: We performed a retrospective study, using data from the National Registry of Interventional Cardiology (RNCI 2006-2012, Portugal) with ST-elevation myocardial infarction (STEMI) patients treated with P-PCI. The primary outcome, in-hospital mortality, was analysed through adjusted odds ratio (aOR) and 95% confidence intervals (95%CI). RESULTS: We assessed data for 9458 STEMI patients that undergone P-PCI (35% treated with TA). The risk of in-hospital mortality with TA (aOR 0.93, 95%CI:0.54-1.60) was not significantly decreased. After matching patients through the propensity score, TA reduced significantly the risk of in-hospital mortality (OR 0.58, 95%CI:0.35-0.98; 3500 patients). CONCLUSIONS: The whole cohort data does not support the routine use of TA in P-PCI, but the results of the propensity-score matched cohort suggests that the use of selective TA may improve the short-term risks of STEMI.info:eu-repo/semantics/publishedVersio

Análise de QTL 'S correlacionados à produção de leite em búfalos (Bubalus bubalis).

Disponível também on-line