Chitosan and hydroxyapatite based biomaterials to circumvent periprosthetic joint infections

Every year, worldwide, millions of people suffering from joint pain undergo joint replace-ment. For most patients, joint arthroplasty reduces pain and improve function, though a small fraction will experience implant failure. One of the main reasons includes prosthetic joint infection (PJI), involving the prosthesis and adjacent tissues. Few microorganisms (MO) are required to inocu-late the implant, resulting in the formation of a biofilm on its surface. Standard treatment includes not only removal of the infected prosthesis but also the elimination of necrotic bone fragments, local and/or systemic administration of antibiotics, and revision arthroplasty with a new prosthesis, immediately after the infection is cleared. Therefore, an alternative to the conventional therapeutics would be the incorporation of natural antimicrobial compounds into the prosthesis. Chitosan (Ch) is a potential valuable biomaterial presenting properties such as biocompatibility, biodegradability, low immunogenicity, wound healing ability, antimicrobial activity, and anti-inflammatory potential. Regarding its antimicrobial activity, Gram-negative and Gram-positive bacteria, as well as fungi are highly susceptible to chitosan. Calcium phosphate (CaP)-based materials are commonly utilized in orthopedic and dentistry for their excellent biocompatibility and bioactivity, particularly in the establishment of cohesive bone bonding that yields effective and rapid osteointegration. At present, the majority of CaP-based materials are synthetic, which conducts to the depletion of the natural resources of phosphorous in the future due to the extensive use of phosphate. CaP in the form of hydroxyapatite (HAp) may be extracted from natural sources as fish bones or scales, which are by-products of the fish food industry. Thus, this review aims to enlighten the fundamental characteristics of Ch and HAp biomaterials which makes them attractive to PJI prevention and bone regeneration, summarizing relevant studies with these biomaterials to the field.info:eu-repo/semantics/publishedVersio

Impact of organic acids supplementation to hardwood spent sulfite liquor as substrate for the selection of polyhydroxyalkanoates-producing organisms

The effectiveness of polyhydroxyalkanoates (PHAs) production process from a waste stream is determined by the selection of a suitable mixed microbial culture (MMC). In this work, a feedstock from the paper industry, hardwood spent sulfite liquor (HSSL), supplemented with short-chain organic acids (SCOAs) to simulate a fermented effluent, was used as substrate to enrich a MMC in PHA-storing microorganisms. A stable culture was quickly established, and during the accumulation step the selected MMC reached a maximum PHA content of 34.6% (3HB:3HV-76:24). The bacterial community was analyzed through FISH analysis. Bacteria belonging to the four main classes were identified: Betaproteobacteria (44.7 ± 2.7%), Alphaproteobacteria (13.6 ± 1.3%) and Gammaproteobacteria (2.40 ± 1.1%) and Bacteroidetes (9.20 ± 3.8%). Inside the Betaproteobacteria class, Acidovorax (71%) was the dominant genus.publishe

Hipoparatireoidismo primário em lactente - relato de caso: Primary hypoparathyroidism in infants – case report

O hipoparatireoidismo primário do lactente é uma condição rara que possui como sinal característico a hipocalcemia e hiperfosfatemia em recém-nascidos. Devido a sua raridade, há dificuldade em seu rápido diagnóstico, contribuindo, assim, para um desequilíbrio iônico, gerando os sinais e sintomas recorrentes. O aparecimento desta patologia está relacionado com alterações estruturais ou funcionais na glândula paratireoide ou como consequência de síndromes genéticas. Este relato trata-se de um lactente masculino de 01 mês de vida que após movimentos repetitivos em membros superiores e versão ocular foi admitido no Hospital Municipal Odilon Behrens, Belo Horizonte. A partir da associação entre a história clínica, o exame físico e os dados laboratoriais, sobretudo a hipocalcemia, foi constatado o hipoparatireoidismo. O objetivo deste relato de caso é apresentar os sinais e sintomas do lactente em questão assim como evidenciar o manejo adotado na conduta deste caso, tendo em vista que seu diagnóstico precoce pode evitar agravamentos como convulsões, tetania e distúrbios cardíacos

Ruptured arteriovenous fistula pseudoaneurysm treatment by balloon‐assisted direct percutaneous thrombin injection

info:eu-repo/semantics/publishedVersio

Influência do método de propagação na produção e qualidade da madeira de Tectona grandis

O principal desafio dos melhoristas é conciliar a maior produtividade florestal com a melhor qualidade da madeira para determinado uso. Deste modo, o objetivo deste estudo foi avaliar a influência do método de propagação na produção volumétrica, porcentagens de cerne e alburno e densidade da madeira de árvores jovens de teca. O estudo foi desenvolvido com materiais biológicos oriundos de plantios seminais e clonais com seis anos de idade, estabelecidos no município de Tangará da Serra, Mato Grosso, Brasil. A teca clonal apresentou melhor desenvolvimento em relação à seminal, sendo a produção volumétrica média por árvore 74,52% maior. Observaram-se valores médios para os percentuais de cerne iguais a 23,09% e 38,33% para o material seminal e clonal, respectivamente, demonstrando a superioridade da madeira dos plantios clonais. As médias de densidade, de ambos os materiais, não diferiram entre si, cujo valor médio foi de 0,470 g/cm³. Conclui-se que a teca oriunda de plantio clonal destacou-se, em relação à teca de origem seminal

Communication Design and Space Narratives

The experience with space is achieved through projects developed according to a design perspective. In addition to collaborating on the creation of spatial narratives by promoting the experience, the design also acts in the sense of enhancing accessibility in both the physical and cognitive domain. Wayfinding systems as well as informational technological systems are informative elements that communicate with citizens, fostering experiences of greater accessibility and the creation of social space. This paper discusses the concept of space from its social dimension, questioning on how spatial narratives, places, and paths can create individual or collective experiences within urban space through Communication Design by the use of technology

Radio‐cephalic fistula recovered with drainage to median basilic vein by straightening of the forearm cephalic vein: A case report

The distal arteriovenous fistula (AVF) has less complications and better patency than the proximal fistula, when it works properly. The complications of outflow of the fistula are complex, and it is necessary to analyze all solutions to solve the problem. We introduce a novel approach to solve outflow problems of a radio-cephalic AVF by straightening of the forearm cephalic vein with drainage into the median basilic vein.info:eu-repo/semantics/publishedVersio

Radio‐cephalic fistula recovered with drainage to median basilic vein by straightening of the forearm cephalic vein: A case report

The distal arteriovenous fistula (AVF) has less complications and better patency than the proximal fistula, when it works properly. The complications of outflow of the fistula are complex, and it is necessary to analyze all solutions to solve the problem. We introduce a novel approach to solve outflow problems of a radio-cephalic AVF by straightening of the forearm cephalic vein with drainage into the median basilic vein.info:eu-repo/semantics/publishedVersio

Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study

BackgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.Methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.ResultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%; p = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented (r = −0.5; p < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p < 0.05).ConclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM

Cannabis Medicinal no gerenciamento do TDAH: desafios enfrentados

INTRODUCTION: Attention deficit hyperactivity disorder is a disease characterized by lack of concentration, hyperactivity and impulsivity and disorganization. Treated through medication therapy and psychotherapy. OBJECTIVES: Address the challenges faced by patients with ADHD who use cannabis. METHODS: Integrative review, carried out based on the guiding question: "What are the main challenges faced by medicinal cannabis in people with Attention Deficit Hyperactivity Disorder?", through articles in Portuguese and English, published between 2018 and 2023, originating from the MEDLINE, HomeoIndex, IBECS databases. Data collection took place in September 2023 RESULTS: The sample consisted of 7 articles, which denoted two nuclei: Self-medication and related difficulties in individuals diagnosed with ADHD; Medicinal Cannabis and challenges faced. CONCLUSION: It is understood that there is a lack of research related to the subject addressed, which is why many patients resort to the use of cannabis, which is why early identification of the disease is necessary, in order to be able to treat it in the best possible way. way, with proven scientific methods.INTRODUÇÃO: O Transtorno de déficit de atenção e hiperatividade é uma doença caracterizada pela falta de concentração, hiperatividade e impulsividade e desorganização. Tratada por meio de terapia medicamento e psicoterapia. OBJETIVOS: Abordar os desafios enfrentados em pacientes com TDAH que fazem uso do cannabis. MÉTODOS: Revisão integrativa, realizada com base na pergunta norteadora: "Quais os principais desafios enfrentados do cannabis medicinal em pessoas com Transtorno de Déficit de Atenção e Hiperatividade?”, através de artigos em língua portuguesa e inglesa, publicados no período de 2018 a 2023, originados das bases de dados MEDLINE, HomeoIndex, IBECS. Realizou-se a coleta de dados em setembro de 2023 RESULTADOS: A amostra foi constituída por 7 artigos, que denotaram dois núcleos: Automedicação e dificuldades relacionadas em indivíduos diagnosticados com TDAH; Cannabis Medicinal e desafios enfrentados. CONCLUSÃO: Entende-se que, há escassez de pesquisas relacionadas ao assunto abordado, por isso muitos pacientes recorrem ao uso da cannabis, por isso faz-se necessário uma identificação precoce da doença, para assim poder tratá-la da melhor maneira, com métodos científicos comprovados