Transthyretin familial amyloid polyneuropathy impact on health-related quality of life

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Chemical composition and anti-diabetic properties of Cytisus multiflorus

Bakground and aims: The interest on plants with potential medicinal properties has been increasing worldwide. In the Iberian Peninsula there are some endemic species known by the population for their pharmacologic activity with valorization potential that have not been yet characterized. The white Spanish broom (Cytisus multiflorus) is described as having anti-diabetic effect [1] and in a preliminary the hypoglycemic and hyper-insulinemic effect of an aqueous extract has been shown [2]. The aim of this work was to fractionate and analyse the composition of the aqueous extract of C. multiflorus flowering parts and evaluate its potential as an anti-diabetic agent. Materials and methods: The aqueous extract was primarily fractionated by SPE using water:methanol (W:Me) eluent (a 10% step-wise gradient W:Me from 100:0 to 0:100) followed by high performance liquid chromatography with diode array detector (HPLC-DAD). The most relevant fraction were analysed by LC-MS to determine the chemical composition. Total fenol content was determined by a modified Folin-Ciocalteau method and the anti-oxidant activity was evaluated by the DPPH mehod. Finally, the hipoglicemic potential was evaluated in vivo using glucose intolerant rats (GIR). Results: Eleven fractions of the bulk extract were obtained. Seven of these fractions (10, 30, 40, 50, 60, 70 e 80% Me) were found to have a relevant compounds, mostly flavonoid compounds, namely, rutin (50, 60 and 70% Me fractions), ferrulic acid (30% Me), referred as having hypoglicemic effect. The fractions obtained with 50 and 70% Me showed the highest content in phenol equivalents and the highest anti-oxidant effect were found in the 50 and 60% Me fractions. The 30 and 60% Me fraction had no effect on the post-prandial glicemia. Conclusions: The 30, 50, 60 and 70% Me fractions, due to their chemical composition and anti-oxidant effects were the most promising to have anti-diabetic effect. However, the 30 and 60% Me were found to be ineffective. The 50% Me fraction showed both a high content of flavonoid compounds and the highest anti-oxidant power which suggest that it may constitute the most promising one. The anti-diabetic properties of this fraction should be investigated. [1] Camejo-Rodrigues J. et al. (2003). J. Ethnopharmacol, 89, 199-209 [2] Célia M. Antunes, Laurinda R. Areias, Inês P. Vieira, Ana C. Costa, M. Teresa Tinoco, & Júlio Cruz-Morais (2009). Rev. Fitoterapia 9 (Supl.1): 91

Effect of oxidizing concentration on the corrosion resistance of the cerium conversion coating on galvanized steel

Ce-based conversion films have been assessed as alternatives for replacement of Cr6+-based films,which have been forbidden for their toxicity and carcinogenic properties. However, corrosion protection associated with chromate films is difficult to achieve by other surface treatments. Experimental results have revealed that to obtain the highly satisfactory results provided by chromate-based conversion coatings, it is necessary to improve the anticorrosive properties of the new chromium-free coatings. The present work deals with the effect of the oxidant concentration in the cerium-based conversion baths on the corrosion resistance of the films deposited on galvanized steel. Electrogalvanized steel sheets were exposed to cerium chloride-based baths with different concentrations of oxidant for a minute. The surface of the treated samples was analyzed by XPS and SEM-EDXS, while its corrosion resistance was investigated using electrochemical tests (EIS) conducted in a 0.05 M NaCl solution and the impedance spectra evolution analyzed as a function of the exposure time. The results showed a direct relationship between oxidant concentration and corrosion resistance. When the oxidant concentration rose from2mL.L-1 to 12mL.L-1, the corrosion resistance increased about 5 times, and this was attributed to the decrease in the Ce3+/Ce4+ relationship of the conversion film.Fil: Culcasi, José Daniel. Universidad Nacional de La Plata; ArgentinaFil: Elsner, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Di Sarli, Alejandro Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Palomino, Luis. Universidade de Sao Paulo; BrasilFil: Tomachuk, Celia Regina. Instituto de Investigaciones Energéticas y Nucleares. San Pablo; BrasilFil: Costa, Ilda. Instituto de Investigaciones Energéticas y Nucleares. San Pablo; Brasi

GASTOS SOCIAIS E DISTRIBUIÇÃO DE RENDA EM ALGUNS GOVERNOS DE ESQUERDA DA AMÉRICA LATINA

Este artigo tem o propósito de investigar se houve relação entre gastos sociais dos governos de esquerda latino-americanos em países selecionados: Brasil, Chile, Uruguai e Bolívia e melhoria das suas distribuição de renda entre 2000 e 2010. Para tanto, tomou-se como ponto de partida o artigo elaborado por Julia Sant’Anna e Fabrício Pereira da Silva – Esquerdas latino-americanas e gasto social- Há coerência entre propostas e práticas?- publicado pela Revista Debates em 2008. Nossa investigação, partindo dessa análise, é a de verificar se as ações desses governos, eminentemente de caráter emergencial, tornaram-se perenes, ou seja se impactaram em transformações na estrutura social, em especial através da verificação da evolução do Índice de Gini e do perfil da distribuição de renda nos países selecionados.As conclusões alcançadas evidenciam que a trajetória positiva dos gastos sociais nos países de esquerda selecionados foi acompanhada por avanços no Índice de Gini e no perfil da distribuição da renda

A globalização da comunicação e seus reflexos sobre a dimensão econômica, ambiental e social da sustentabilidade

O presente artigo tem como objetivo apresentar a evolução da globalização da comunicação, e mostrar como isso reflete, atualmente, na dimensão econômica, ambiental e social da sustentabilidade. Inicialmente é feito um levantamento histórico do surgimento dos meios de comunicação, desde a antiguidade, demonstrando como eles se desenvolveram até o século XXI e influenciaram também o crescimento do comércio internacional. Em seguida, é feita uma análise de como a globalização influencia a economia mundial, pela alteração de seus fluxos financeiros, passando pela abordagem ambiental, que envolve danos que podem colocar em risco toda a humanidade, e finalmente o reflexo sobre a sociedade, que faz com que a comunicação instantânea, principalmente ocasionada pela internet, altere o modo de relacionamento interpessoal, em variados aspectos

Fetal Heart Rate Fragmentation

This article was supported by National Funds through FCT– Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference UIDB/4255/2020)info:eu-repo/semantics/publishedVersio

Efeitos estéricos no mecanismo e catálise da reação cetonas biciclicas com hidroxilamina e semicarbazida

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Curso de Pós-Graduação em Físico-Químic

Treatment of cancer pain by targeting cytokines

Copyright © 2015 I. Vendrell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Inflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can be aberrantly produced by cancer and immune system cells and are of particular relevance in pain. Currently, there are very few strategies to control the release of cytokines that seems to be related to cancer pain. Nevertheless, in some cases, targeted drugs are available and in use for other diseases. In this paper, we aim to review the importance of cytokines in cancer pain and targeted strategies that can have an impact on controlling this symptom.info:eu-repo/semantics/publishedVersio

Quality Program: What Influences The Opinion Of Nursing Team

To analyze the major impact variables in the opinion of nursing staff about the Quality Program of a teaching hospital. Methods: An exploratory-descriptive study was performed with 72 nursing staff. Data were collected through self-administered questionnaire containing 24 statements about the Quality Program; and the degree of agreement of the participants was expressed in a Likert scale. The collected data were analyzed by factor analysis and Pearson's correlation coefficient. Results: The analysis grouped the statements in six factors. The Pearson's correlation coefficient defined a scale of influence of the variables within each factor, whose variable with the greatest impact in each factor is the priority issue for improving worker opinion about the Quality Program. The priority variables were to believe the Quality Program contributes to the hospital; to understand the program orientations; interest in hospital quality direction; and do not feel exhausted due to the program. Conclusion: These variables must be focused during the implementation and execution of Quality Program, as they have greater impact on improving opinion regarding the Quality Program and thus helping to increase compliance of the nursing staff to the program.14454755