Fatores associados à sintomas de distúrbios osteomusculares em professores da rede pública municipal de Cuiabá-MT

Introduction: Work-related musculoskeletal disorders are injuries resulting from the excessive use of the musculoskeletal system. This study analyzed musculoskeletal symptoms and associated factors in primary school teachers in the municipal public network in Cuiabá, Mato Grosso.Methods: A cross-sectional study was conducted with 326 teachers. Data collection instruments included the Vocal Production Condition, Self-Reporting Questionnaire, and Nordic Musculoskeletal Questionnaire. The dependent variable was the presence or absence of musculoskeletal symptoms. Bivariate analysis using chi-square test and prevalence ratios with 95% confidence intervals, as well as multiple analysis using Poisson regression model, were performed.Results: In the multiple analysis, it was found that the presence of musculoskeletal symptoms was significantly associated (p<0.05) with the following risk factors: common mental disorders (PRa=1.45), regularly lifting weights (PRa=1.26), and performing intense physical effort (PRa=1.22). Additionally, a significant association was identified between these symptoms and contracted teachers (PRa=0.82), as well as an interaction between performing intense physical effort and regularly lifting weights (PRa=0.75), which acted as protective factors for symptom presence.Conclusion: It is concluded that work characteristics were important risk factors for the development of musculoskeletal symptoms in the last twelve months. The results of this study are believed to provide a basis for decision-making by managers and stakeholders in implementing preventive measures in the work environment of these teachers.Introducción: Los trastornos musculoesqueléticos relacionados con el trabajo son lesiones relacionadas con daños por uso excesivo del sistema musculoesquelético. El objetivo fue analizar los síntomas musculo esqueléticos y los factores asociados en profesores de enseñanza básica de escuelas públicas municipales de la ciudad de Cuiabá, Mato Grosso, Brasil.Métodos: Estudio transversal, la muestra era de 326 docentes. Para la recolección de datos se utilizaron los instrumentos: Condición de Producción Vocal, Self-Reporting Questionnaire y el Cuestionario Nórdico Musculoesquelético. Se realizó un análisis bivariado, mediante la prueba de chi-cuadrado y razones de prevalencia con intervalos de confianzas de 95% y un análisis múltiple con el modelo de regresión de Poisson.Resultados: En el análisis múltiple se demostró que la presencia de síntomas musculo esqueléticos se asoció significativamente (p<0,05) con los siguientes factores de riesgo: tener trastornos mentales comunes (RPa=1,45), cargar peso con frecuencia (RPa=1,26) y realizar un esfuerzo físico intenso (RPa= 1,22). Además, se identificó asociación significativa entre estos síntomas y los docentes contratados (RPa= 0,82), así como para la interacción realizar esfuerzo físico intenso y cargar peso con frecuente (RPa=0,75), siendo estos factores protectores para la presencia de síntomas.Conclusión: Se concluyó que las características del trabajo demostraron ser importantes factores de riesgo para el desarrollo de síntomas musculoesqueléticos en los últimos doce meses. Y se cree que los resultados de este estudio pueden subsidiar a los gestores y responsables de acciones preventivas en el ambiente de trabajo de estos docentes.Introdução: Os distúrbios osteomusculares relacionados ao trabalho são lesões relacionadas a danos do uso excessivo do sistema musculoesquelético. O objetivo foi analisar os sintomas osteomusculares e os fatores associados em professores do ensino fundamental da rede pública municipal na cidade de Cuiabá, Mato Grosso.Metodologia: Estudo transversal, a amostra foi de 326 professores. Para coleta de dados foram utilizados os instrumentos: Condição de Produção Vocal, Self-Reporting Questionnaire e o Nordic Musculoskeletal Questionnaire. A variável dependente foi à presença ou não de sintomas osteomusculares. Foi realizada uma análise bivariada, utilizando teste qui-quadrado e razões de prevalências com intervalos de confianças 95% e uma análise múltipla com o modelo de regressão de Poisson. Resultados: Na análise múltipla, foi evidenciado que a presença de sintomas osteomusculares, foi significativamente associada (p<0,05) com os seguintes fatores de risco: possuir transtornos mentais comuns (RPa=1,45), carregar peso com frequência (RPa=1,26) e realizar esforço físico intenso (RPa= 1,22). Além disso, foi identificada associação significativa, entre estes sintomas e professores contratados (RPa= 0,82), assim como para a interação realizar esforço físico intenso e carregar peso com frequência (RPa=0,75), sendo estes, fatores de proteção para a presença de sintomas.Conclusão: Conclui-se que as características de trabalho demostraram ser importantes fatores de risco para o acometimento dos sintomas osteomusculares nos últimos doze meses. E acredita-se que, os resultados deste estudo podem subsidiar gestores e responsáveis para ações preventivas no ambiente laboral destes professores

Salvar o fogo

Resenha do romance Salvar o fogo, escrito por Itamar Vieira Junior, publicado em 2023 pela editora Todavia

A Contribuição do Movimento Escolinhas de Arte no Ensino de Arte em Santa Catarina

Este artigo busca contribuir com as reflexões e encaminhamentos em torno da importância da organização da História do Ensino de Arte em Santa Catarina. Oferece um olhar que trás a marca pessoal de quem vivenciou parte desta história, sendo constituído por múltiplos olhares e fragmentos que revelam a história do Movimento Escolinhas de Arte e seus desdobramentos em nosso estado, com ênfase na criação da Escolinha de Arte de Florianópolis

O olho que se faz olhar: os sentidos do espaço estético do Colégio de Aplicação da UFSC para alunos do ensino fundamental

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em Psicologia.Esta dissertação teve como objetivo investigar os sentidos do "Espaço Estético do Colégio de Aplicação da UFSC" para alunos de 8ª série do Colégio de Aplicação, visando analisar como estes significam o processo de alfabetização estético-artístico-visual a que foram submetidos. Investigar também se, como e de que maneira este espaço provoca mudanças no olhar estético de quem por ali transita. Os aportes teóricos da Psicologia Histórico-Cultural de Lev Semenovich Vygotski e interlocutores, bem como a proposta Triangular do Ensino de Arte de Ana Mae Barbosa são fundamentações para a realização do presente estudo. Na dinâmica de investigação, foram utilizados como procedimentos para a coleta de informações: entrevistas com onze alunos, observações in loco e documentos, sendo a análise de conteúdo utilizada para a análise, interpretação e compreensão das informações obtidas. Constatou-se a importância de espaços estéticos, artísticos, didáticos e pedagógicos em contextos escolares por possibilitarem o acesso ao universo da produção estético-artístico-visual, criando condições para que alunos e comunidade escolar vivenciem experiências significativas através da exposição da produção, da fruição dessas formas e das reflexões provenientes da relação arte-vida, expandindo, na dialogia com o outro, valores e conceitos culturais, estéticos, artísticos visuais e éticos. Considerando que a função da escola é não apenas a de socializar conhecimentos científicos, mas também a de possibilitar a constituição de sujeitos críticos, criativos e transformadores da realidade, de forma que os alunos possam interpretar o mundo e nele deliberadamente intervir, buscamos com esta pesquisa contribuir para a construção de uma escola em que a dimensão ética e estética seja valorizada, onde a expressividade do sujeito seja permitida e onde o conhecimento já sistematizado seja tratado de forma histórica e em sua condição polissêmica

Mental disorders in pregnancy and newborn conditions: longitudinal study with pregnant women attended in primary care

This study aimed to determine the presence and association of possible mental disorders diagnoses in primary care pregnant women and newborns' conditions. This is a longitudinal study with pregnant women (18-39 years), in the second and third trimesters of pregnancy, attended at primary care facilities in the metropolitan region of Sao Paulo (February to August/2014). The following tools were used: sociodemographic questionnaireMental Disorders in Primary Care Assessment tooland an interview with information and mother's perception of the behavior of newborns. Of the 300 pregnant women interviewed, 76 had possible diagnosis of mental disorders, 46 women had depression/dysthymia and 58 anxiety/panic symptoms. Low birth weight and prematurity was observed in 14 and 19 newborns, respectively, and there was no association with the probable diagnosis of mental disordersthe possible presence of mental disorders was associated with the mother's perception of newborns behavior. Pregnant women attended at low risk prenatal care showed relevant frequency of mental disordersthus, the identification of these changes during pregnancy can also contribute to a better understanding of the mother-and-child dynamics and in the quality of family care.O objetivo do estudo foi verificar a presença e a associação entre diagnósticos prováveis de transtornos mentais em gestantes da atenção básica e condições dos recém-nascidos. Estudo longitudinal com gestantes (18 a 39 anos), no segundo e terceiro trimestres da gravidez, assistidas na atenção básica da região Metropolitana de São Paulo (fevereiro a agosto/2014). Foram aplicados: questionário sociodemográfico, instrumento para Avaliação de Transtornos Mentais na Atenção Primária e entrevista sobre informações e percepção do comportamento do recém-nascido. Das 300 gestantes entrevistadas, 76 apresentaram diagnóstico provável de transtorno mental, sendo que 46 apresentavam sintomas de depressão/distimia e 58, ansiedade/pânico. Observou-se baixo peso ao nascer e prematuridade em 14 e 19 dos recém-nascidos, respectivamente, e não foi verificada associação com diagnósticos prováveis de transtorno mental; a presença destes associou-se com a percepção materna de alterações no comportamento do recém-nascido. Gestantes em acompanhamento de pré-natal de baixo risco apresentam frequência relevante de transtornos mentais, logo, a identificação dessas alterações na gestação pode colaborar para melhor compreensão da dinâmica do binômio mãe-filho e na qualidade na assistência à família.Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat, R Botucatu 598, BR-04023062 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, R Botucatu 598, BR-04023062 Sao Paulo, SP, BrazilWeb of Scienc

Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells

BCR-ABL kinase activates downstream signaling pathways, including the PI3K-Akt/mTOR and the MAPK pathway. IRS1 has been previously described as constitutively phosphorylated and associated with BCR-ABL in K562 cells, suggesting that IRS1 has role in the BCR-ABL signaling pathways. in this study, we analyzed the effect of IRS1 silencing, by shRNA-lentiviral delivery, in K562 cells, a CML cell line that presents the BCR-ABL. IRS1 silencing decreased cell proliferation and colony formation in K562 cells, which correlates with the delay of these cells at the G0/G1 phase and a decrease in the S phase of the cell cycle. Furthermore, IRS1 silencing in K562 cells resulted in a decrease of Akt, P70S6K and ERK1/2 phosphorylation. Nevertheless, apoptosis was unaffected by IRS1 knockdown and no alterations were found in the phosphorylation of BAD and in the expression of BCL2 and BAX. BCR-ABL and CRKL phosphorylation levels remained unaffected upon IRS1 silencing, and no synergistic effect was observed with imatinib treatment and IRS1 knockdown, indicating that IRS1 is downstream from BCR-ABL in conclusion, we demonstrated that inhibition of IRS1 is capable of inducing the downregulation of Akt/mTOR and MAPK pathways and further decreasing proliferation, and clonogenicity and induces to cell cycle delay at G0/G1 phase in BCR-ABL cells. (C) 2011 Elsevier B.V. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Campinas, Hematol & Hemotherapy Ctr, UNICAMP, Hemoctr,Inst Nacl Ciencia & Tecnol Sangue, BR-13083878 Campinas, SP, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilWeb of Scienc

Higher fiber intake is associated with lower blood pressure levels in patients with type 1 diabetes

Objective: The present investigation sought to evaluate the potential association between dietary fiber intake and blood pressure (BP) in adult patients with type 1 diabetes (T1D). Subjects and methods: A cross-sectional study was carried out in 111 outpatients with T1D from Porto Alegre, Brazil. Patients were predominantly male (56%) and white (88%), with a mean age of 40 ± 10 years, diabetes duration of 18 ± 9 years, BMI 24.8 ± 3.85 kg/m2, and HbA1c 9.0 ± 2.0%. After clinical and laboratory evaluation, dietary intake was evaluated by 3-day weighed-diet records, whose reliability was confirmed by 24-h urinary nitrogen output. Patients were stratified into two groups according to adequacy of fiber intake in relation to American Diabetes Association (ADA) recommendations: below recommended daily intake (< 14g fiber/1000 kcal) or at/above recommended intake (≥ 14g/1000 kcal). Results: Patients in the higher fiber intake group exhibited significantly lower systolic (SBP) (115.9 ± 12.2 vs 125.1 ± 25.0 mmHg, p = 0.016) and diastolic blood pressure (DBP) (72.9 ± 9.2 vs 78.5 ± 9.3 mmHg, p = 0.009), higher energy intake (2164.0 ± 626.0 vs 1632.8 ± 502.0 kcal, p < 0.001), and lower BMI (24.4 ± 3.5 vs 26.2 ± 4.8, p = 0.044). Linear regression modelling, adjusted for age, energy intake, sodium intake, and BMI, indicated that higher fiber intake was associated with lower SBP and DBP levels. No significant between-group differences were observed with regard to duration of diabetes, glycemic control, insulin dosage, or presence of hypertension, nephropathy, or retinopathy. Conclusion: We conclude that fiber consumption meeting or exceeding current ADA recommendations is associated with lower SBP and DBP in patients with T1D

Identification of protein-coding and non-coding RNA expression profiles in CD34+ and in stromal cells in refractory anemia with ringed sideroblasts

<p>Abstract</p> <p>Background</p> <p>Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcriptional activity in the human genome. Non-coding RNAs (ncRNAs) transcribed from intronic regions of genes are involved in a number of processes related to post-transcriptional control of gene expression, and in the regulation of exon-skipping and intron retention. Characterization of ncRNAs in progenitor cells and stromal cells of MDS patients could be strategic for understanding gene expression regulation in this disease.</p> <p>Methods</p> <p>In this study, gene expression profiles of CD34⁺cells of 4 patients with MDS of refractory anemia with ringed sideroblasts (RARS) subgroup and stromal cells of 3 patients with MDS-RARS were compared with healthy individuals using 44 k combined intron-exon oligoarrays, which included probes for exons of protein-coding genes, and for non-coding RNAs transcribed from intronic regions in either the sense or antisense strands. Real-time RT-PCR was performed to confirm the expression levels of selected transcripts.</p> <p>Results</p> <p>In CD34⁺cells of MDS-RARS patients, 216 genes were significantly differentially expressed (q-value ≤ 0.01) in comparison to healthy individuals, of which 65 (30%) were non-coding transcripts. In stromal cells of MDS-RARS, 12 genes were significantly differentially expressed (q-value ≤ 0.05) in comparison to healthy individuals, of which 3 (25%) were non-coding transcripts.</p> <p>Conclusions</p> <p>These results demonstrated, for the first time, the differential ncRNA expression profile between MDS-RARS and healthy individuals, in CD34⁺cells and stromal cells, suggesting that ncRNAs may play an important role during the development of myelodysplastic syndromes.</p

Technical and environmental assessment of coated urea production with a natural polymeric suspension in spouted bed to reduce nitrogen losses

Urea is the most used nitrogen fertilizer in the world, but should be supplied to the plants in a controlled way to make it as efficient as possible. Otherwise, nitrogen losses due to volatilization and leaching can reach up to 70%. The production of coated urea with slow-release polymers can be a good alternative not just to reduce the nitrogen losses but also to avoid the greenhouse gases emissions related to the high consumption of this fertilizer. Therefore, the aim of this study is to evaluate the technical and environmental aspects of coated urea production in a spouted bed to control the nitrogen volatilization. The influence of the operating conditions in the coating performance was evaluated using a central composite rotational design and the environmental performance was determined using a life cycle assessment. The coating performance results showed that coated urea particle growth ranged from 0.8 to 4.4%, the coating efficiency presented results between 17 and 47% and the nitrogen volatilization reduction was significant (11–50%). The highest nitrogen volatilization reduction was obtained for suspension flow rate equal to 15 mL/min and air temperature equal to 85 °C. The daily volatilized nitrogen release profile and the microscopic analysis showed that the coating film was effective in controlling nitrogen release contained within the particle. The environmental analyses demonstrated that coated urea had a lower impact than uncoated, for most of the impact categories under study, indicating that the coating process is also appropriate to reduce the environmental impacts of urea fertilization.publishe