Drawing Elena Ferrante's Profile. Workshop Proceedings, Padova, 7 September 2017

Elena Ferrante is an internationally acclaimed Italian novelist whose real identity has been kept secret by E/O publishing house for more than 25 years. Owing to her popularity, major Italian and foreign newspapers have long tried to discover her real identity. However, only a few attempts have been made to foster a scientific debate on her work. In 2016, Arjuna Tuzzi and Michele Cortelazzo led an Italian research team that conducted a preliminary study and collected a well-founded, large corpus of Italian novels comprising 150 works published in the last 30 years by 40 different authors. Moreover, they shared their data with a select group of international experts on authorship attribution, profiling, and analysis of textual data: Maciej Eder and Jan Rybicki (Poland), Patrick Juola (United States), Vittorio Loreto and his research team, Margherita Lalli and Francesca Tria (Italy), George Mikros (Greece), Pierre Ratinaud (France), and Jacques Savoy (Switzerland). The chapters of this volume report the results of this endeavour that were first presented during the international workshop Drawing Elena Ferrante's Profile in Padua on 7 September 2017 as part of the 3rd IQLA-GIAT Summer School in Quantitative Analysis of Textual Data. The fascinating research findings suggest that Elena Ferrante\u2019s work definitely deserves \u201cmany hands\u201d as well as an extensive effort to understand her distinct writing style and the reasons for her worldwide success

Sulle tracce di Elena Ferrante: questioni di metodo e primi risultati

This chapter illustrates the implementation of quantitative analysis methods on a corpus of modern Italian novels aimed to shed light on the identity of Elena Ferrante, the pen name of a very successful novelist whose real identity is still unknown. After a review of previous attempts conducted according to different approaches (based on lexical, contextual and thematic factors), in order to offset the impact of diatopic varieties of Italian the seven novels written by Elena Ferrante have been compared to 39 novels written by ten authors from Campania (Ferrante\u2019s region of origin) according to two methods: correspondence analysis and intertextual distance. Both methods show that Elena Ferrante\u2019s novels are more similar to Domenico Starnone\u2019s works than to the novels of any other author included in the corpus. In addition, a lexical analysis shows that, compared to the other authors, Ferrante and Starnone share the greatest number of lexical items used exclusively in their novels. Conclusively, the qualitative and quantitative approaches used in this study confirm that a similarity emerges between the novels published by Ferrante and Starnone after the early 1990s and paves the way to further research based on larger corpora of fiction as well as non-fictional texts

EVOLUZIONE DELLA LINGUA E STATICITÀ DELLA NORMA NELL'ITALIANO CONTEMPORANEO: GLI AUSILIARI NEI COSTRUTTI CON VERBI MODALI

Tra i fenomeni che vengono attribuiti alla recente evoluzione dell'italiano (e che vengono stigmatizzati dalle grammatiche normative) vi è l'uso generalizzato dell'ausiliare avere nei tempi composti dei verbi modali, anche quando il verbo modale regge un verbo all'infinito che nei tempi composti richiede l'ausiliare essere. Studi recenti hanno già mostrato che, nell'uso, l'impiego di avere è prevalente rispetto all'uso di essere e che si tratta di un fenomeno che percorre tutta la storia dell'italiano. Queste conclusioni sono state confermate e rafforzate dall'analisi di un corpus formato da 116 romanzi italiani pubblicati a partire dal secondo dopoguerra

Noise reduction in muon tomography for detecting high density objects

The muon tomography technique, based on multiple Coulomb scattering of cosmic ray muons, has been proposed as a tool to detect the presence of high density objects inside closed volumes. In this paper a new and innovative method is presented to handle the density fluctuations (noise) of reconstructed images, a well known problem of this technique. The effectiveness of our method is evaluated using experimental data obtained with a muon tomography prototype located at the Legnaro National Laboratories (LNL) of the Istituto Nazionale di Fisica Nucleare (INFN). The results reported in this paper, obtained with real cosmic ray data, show that with appropriate image filtering and muon momentum classification, the muon tomography technique can detect high density materials, such as lead, albeit surrounded by light or medium density material, in short times. A comparison with algorithms published in literature is also presented

A diachronic-comparative analysis for the identification of the most powerful prognostic index for localized diffuse large B-cell lymphoma

BACKGROUND: In the rituximab era, the conventional International Prognostic index (IPI) lost at least in part its predictive power, while the National Comprehensive Cancer Network-IPI (NCCN-IPI) seems to be a new and valid prognosticator. However, it has not yet been evaluated in patients with localized disease and it has not been compared with the modified IPI (mIPI) of the pre-rituximab era. In order to evaluate the different prognosticators and to assess the importance of rituximab and radiotherapy (RT), we carried out the so far largest retrospective analysis of patients with localized diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS: We retrospectively assessed clinical and therapeutical data of 1405 patients treated in from 1987 to 2012 in 10 cancer centers in Italy and 1 in Austria. RESULTS: All patients underwent an anthracycline containing polychemotherapy and 254 additional rituximab. The median follow-up was 5.7 years (range 0.1-23 years). The 5-year overall survival (OS) was 75%, being significantly superior in those who underwent additional rituximab, while RT consolidation did not improve the outcome of those who received immunochemotherapy. Patients with extranodal disease benefited from the addition of rituximab, while RT did not improve OS of the immunochemotherapy subgroup. In the pre-rituximab era, the mIPI showed a better performance than the others. In rituximab-treated patients, the NCCN-IPI had the highest discriminant value and the 5-years OS varied significantly (P < 0.001) between the three risk groups and was 98% in low-risk patients, 82% in those with a low-intermediate risk and 57% among high-intermediate and high-risk cases. CONCLUSIONS: The NCCN-IPI is so far the best prognosticator for patients with localized DLBCL who underwent R-CHOP(-like). The addition of rituximab is indispensable regardless of the risk category and site of involvement, while the addition of RT should be reserved to those cases who are ineligible to rituximab

A multicenter retrospective clinical study of CD5/CD10-negative chronic B cell leukemias.

CD5-negative chronic B cell lymphoproliferative disorders in leukemic phase (B-CLPD) are heterogeneous and relatively uncommon pathologies that often lack a histopathological definition because of the absence of accessible pathological tissue. We describe the clinical features and evolution-related variables of 156 patients with CD5/CD10-negative B-CLPD (median age 66 years, range 25-86). The median follow-up was 51 months (range 6-216), and overall 3- and 5-year survival was respectively 87 and 76%; 50 patients needed therapy at diagnosis, 56 during follow-up, and 50 remained untreated until the last control. A combined clinical, histological, cytomorphological, immunophenotypical, and cytogenetic diagnostic approach allowed the complete classification of only a minority of patients as being affected by splenic marginal zone or lymphoplasmacytic lymphoma; the majority of cases remained unclassifiable. Multivariate analysis showed that the clinicohematological variables adversely related to overall survival were serum LDH levels and age, whereas high serum LDH levels, hemoglobin levels of <11 g/dl, and splenomegaly related to treatment-free time (in "wait and see" cases); only splenomegaly related to time to progression (in treated patients). In conclusion, our retrospective study describes the clinical features and variables related to evolution in a large group of patients with CD5/CD10-negative chronic B-cell lymphoid leukemias and underlines the fact that a probable lymphoplasmacytic or marginal zone normal cell origin can be supposed in such leukemic forms, but never surely demonstrated

Persistent Unresolved Inflammation in the Mecp2-308 Female Mutated Mouse Model of Rett Syndrome

Rett syndrome (RTT) is a rare neurodevelopmental disorder usually caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). Several Mecp2 mutant mouse lines have been developed recapitulating part of the clinical features. In particular, Mecp2-308 female heterozygous mice, bearing a truncating mutation, are a validated model of the disease. While recent data suggest a role for inflammation in RTT, little information on the inflammatory status in murine models of the disease is available. Here, we investigated the inflammatory status by proteomic 2-DE/MALDI-ToF/ToF analyses in symptomatic Mecp2-308 female mice. Ten differentially expressed proteins were evidenced in the Mecp2-308 mutated plasma proteome. In particular, 5 positive acute-phase response (APR) proteins increased (i.e., kininogen-1, alpha-fetoprotein, mannose-binding protein C, alpha-1-antitrypsin, and alpha-2-macroglobulin), and 3 negative APR reactants were decreased (i.e., serotransferrin, albumin, and apolipoprotein A1). CD5 antigen-like and vitamin D-binding protein, two proteins strictly related to inflammation, were also changed. These results indicate for the first time a persistent unresolved inflammation of unknown origin in the Mecp2-308 mouse model

statistics biomedicine and scientific fraud

A consistent fraction of published data on scientific journals is not reproducible mainly due to insufficient knowledge of statistical methods. Here, we discuss on the use of proper statistical tools in biomedical research and statistical pitfalls potentially undermining the scientific validity of published data. Apart from unaware errors, a growing concern exists regarding data fabrication and scientific misconduct. Indeed, the social impact of false scientific data can be largely unpredictable and devastating, as shown by the worldwide dramatic effects on vaccinations coverage following a retracted paper published on a highly authoritative medical journal. Unfortunately, statistics shows a quite limited power in detecting false science, although a few statistical tools, such as the Benford's law, are known. Taken together, statistics in biomedical sciences i) is a powerful tool to interpret experimental data; ii) has limited power in detecting false science; and iii) first and foremost, is not the result of a simple "click of a mouse", but should be the result of accurate research planning by experienced and knowledgeable users

Germination in developing seeds of Bixa orellana

Com este trabalho objetivou-se investigar a aquisição da capacidade germinativa e o estabelecimento da dormência em sementes em desenvolvimento de Bixa orellana L. (urucum). Foram caracterizados 7 estádios de desenvolvimento das sementes, baseados nas características morfológicas, massa fresca, massa seca e teor de umidade dos frutos e das sementes. Sementes imaturas de B. orellana não germinaram durante os estádios iniciais de seu desenvolvimento. As sementes adquiriram a capacidade germinativa máxima quando os níveis de umidade declinaram para valores em torno de 60%. Nessa fase, as sementes apresentaram acúmulo máximo de massa seca. A dormência foi estabelecida quando as sementes exibiam um conteúdo de água em torno de 10%.The objective of this work was to investigate the acquisition of germination capacity and the onset of dormancy in developing seeds of Bixa orellana L. (annatto). Seven stages of development were characterized with regard to morphology, fresh and dry mass and moisture content of the fruits and seeds. Immature seeds of B. orellana did not germinate during early stages of their development. The seeds achieved their maximum germination capacity after the moisture content had declined to around 60%. In this phase the seeds presented maximum dry mass. The onset of dormancy occurred when the seeds exhibited water contents around 10%