Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study.

OBJECTIVES: To describe the characteristics of children and adolescents affected by an outbreak of Kawasaki-like multisystem inflammatory syndrome and to evaluate a potential temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DESIGN: Prospective observational study. SETTING: General paediatric department of a university hospital in Paris, France. PARTICIPANTS: 21 children and adolescents (aged ≤18 years) with features of Kawasaki disease who were admitted to hospital between 27 April and 11 May 2020 and followed up until discharge by 15 May 2020. MAIN OUTCOME MEASURES: The primary outcomes were clinical and biological data, imaging and echocardiographic findings, treatment, and outcomes. Nasopharyngeal swabs were prospectively tested for SARS-CoV-2 using reverse transcription-polymerase chain reaction (RT-PCR) and blood samples were tested for IgG antibodies to the virus. RESULTS: 21 children and adolescents (median age 7.9 (range 3.7-16.6) years) were admitted with features of Kawasaki disease over a 15 day period, with 12 (57%) of African ancestry. 12 (57%) presented with Kawasaki disease shock syndrome and 16 (76%) with myocarditis. 17 (81%) required intensive care support. All 21 patients had noticeable gastrointestinal symptoms during the early stage of illness and high levels of inflammatory markers. 19 (90%) had evidence of recent SARS-CoV-2 infection (positive RT-PCR result in 8/21, positive IgG antibody detection in 19/21). All 21 patients received intravenous immunoglobulin and 10 (48%) also received corticosteroids. The clinical outcome was favourable in all patients. Moderate coronary artery dilations were detected in 5 (24%) of the patients during hospital stay. By 15 May 2020, after 8 (5-17) days of hospital stay, all patients were discharged home. CONCLUSIONS: The ongoing outbreak of Kawasaki-like multisystem inflammatory syndrome among children and adolescents in the Paris area might be related to SARS-CoV-2. In this study an unusually high proportion of the affected children and adolescents had gastrointestinal symptoms, Kawasaki disease shock syndrome, and were of African ancestry

Joint searches for gravitational waves and high-energy neutrinos

Many of the astrophysical sources and violent phenomena observed in our Universe are potential joint emitters of gravitational waves and high-energy cosmic radiation, in the form of photons, hadrons, and also neutrinos. This has triggered a collaborative analysis project between gravitational wave detectors and high-energy neutrino telescopes. In this article, we review some of the motivations for having pursuing science jointly and present the effort’s status

Open questions in astrophysically triggered gravitational wave searches

Sources of gravitational waves are often expected to also be observable through several other messengers, such as gamma rays, X-rays, optical, radio, and/or neutrino emission. Some of these channels are already being used in searches for gravitational waves with the LIGO-GEO600-Virgo interferometer network, and others are currently being incorporated into new searches. Astrophysical targets include gamma-ray bursts, soft-gamma repeaters, supernovae, and glitching pulsars. The simultaneous observation of electromagnetic or neutrino emission could be a crucial aspect for the first direct detection of gravitational waves. Information on the progenitor, such as trigger time, direction and expected frequency range, can enhance our ability to identify gravitational wave signatures with amplitudes close to the noise floor of the detector. Furthermore, combining gravitational waves with electromagnetic and neutrino observations will enable the extraction of scientific insight that was hidden from us before. The paper discusses the status of transient multimessenger detection efforts as well as intriguing questions that might be resolved in the future by advanced and third generation gravitational wave detector

Search for gravitational waves from compact binary coalescence in LIGO and Virgo data from S5 and VSR1

We report the results of the first search for gravitational waves from compact binary coalescence using data from the LIGO and Virgo detectors. Five months of data were collected during the concurrent S5 (LIGO) and VSR1 (Virgo) science runs. The search focused on signals from binary mergers with a total mass between 2 and 35 Msun. No gravitational waves are identified. The cumulative 90%-confidence upper limits on the rate of compact binary coalescence are calculated for non-spinning binary neutron stars, black hole-neutron star systems, and binary black holes to be 8.7x10^-3, 2.2x10^-3 and 4.4x10^-4 yr^-1 L_10^-1 respectively, where L_10 is 10^10 times the blue solar luminosity. These upper limits are compared with astrophysical expectations