An empirical limit on the kilonova rate from the DLT40 one day cadence Supernova Survey

Binary neutron star mergers are important to understand stellar evolution, the chemical enrichment of the universe via the r-process, the physics of short gamma-ray bursts, gravitational waves and pulsars. The rates at which these coalescences happen is uncertain, but it can be constrained in different ways. One of those is to search for the optical transients produced at the moment of the merging, called a kilonova, in ongoing SN searches. However, until now, only theoretical models for kilonovae light curve were available to estimate their rates. The recent kilonova discovery AT~2017gfo/DLT17ck gives us the opportunity to constrain the rate of kilonovae using the light curve of a real event. We constrain the rate of binary neutron star mergers using the DLT40 Supernova search, and the native AT~2017gfo/DLT17ck light curve obtained with the same telescope and software system. Excluding AT~2017gfo/DLT17ck due to visibility issues, which was only discovered thanks to the aLIGO/aVirgo trigger, no other similar transients detected during 13 months of daily cadence observations of $\sim$ 2200 nearby ($<$40 Mpc) galaxies. We find that the rate of BNS mergers is lower than 0.47 - 0.55 kilonovae per 100 years per $10^{10}$ $L_{B_{\odot}}$ (depending on the adopted extinction distribution). In volume, this translates to <0.99\times 10^{-4}\,_{-0.15}^{+0.19},\rm{Mpc^{-3}}\,\rm{yr^{-1}}(SNe Ia-like extinction distribution), consistent with previous BNS coalescence rates. Based on our rate limit, and the sensitivity of aLIGO/aVirgo during O2, it is very unlikely that kilonova events are lurking in old pointed galaxy SN search datasets.Comment: 3 figures, 2 table

The discovery of the electromagnetic counterpart of GW170817: kilonova AT 2017gfo/DLT17ck

During the second observing run of the Laser Interferometer gravitational- wave Observatory (LIGO) and Virgo Interferometer, a gravitational-wave signal consistent with a binary neutron star coalescence was detected on 2017 August 17th (GW170817), quickly followed by a coincident short gamma-ray burst trigger by the Fermi satellite. The Distance Less Than 40 (DLT40) Mpc supernova search performed pointed follow-up observations of a sample of galaxies regularly monitored by the survey which fell within the combined LIGO+Virgo localization region, and the larger Fermi gamma ray burst error box. Here we report the discovery of a new optical transient (DLT17ck, also known as SSS17a; it has also been registered as AT 2017gfo) spatially and temporally coincident with GW170817. The photometric and spectroscopic evolution of DLT17ck are unique, with an absolute peak magnitude of Mr = -15.8 \pm 0.1 and an r-band decline rate of 1.1mag/d. This fast evolution is generically consistent with kilonova models, which have been predicted as the optical counterpart to binary neutron star coalescences. Analysis of archival DLT40 data do not show any sign of transient activity at the location of DLT17ck down to r~19 mag in the time period between 8 months and 21 days prior to GW170817. This discovery represents the beginning of a new era for multi-messenger astronomy opening a new path to study and understand binary neutron star coalescences, short gamma-ray bursts and their optical counterparts.Comment: ApJL in press, 4 figure

Not Only Redox: The Multifaceted Activity of Cerium Oxide Nanoparticles in Cancer Prevention and Therapy

Much information is accumulating on the effect of cerium oxide nanoparticles (CNPs) as cell-protective agents, reducing oxidative stress through their unique ability of scavenging noxious reactive oxygen species via an energy-free, auto-regenerative redox cycle, where superoxides and peroxides are sequentially reduced exploiting the double valence (Ce3+/Ce4+) on nanoparticle surface. In vitro and in vivo studies consistently report that CNPs are responsible for attenuating and preventing almost any oxidative damage and pathology. Particularly, CNPs were found to exert strong anticancer activities, helping correcting the aberrant homeostasis of cancer microenvironment, normalizing stroma-epithelial communication, contrasting angiogenesis, and strengthening the immune response, leading to reduction of tumor mass in vivo. Since these homeostatic alterations are of an oxidative nature, their relief is generally attributed to CNPs redox activity. Other studies however reported that CNPs exert selective cytotoxic activity against cancer cells and sensitize cancer cells to chemotherapy- and radiotherapy-induced apoptosis: such effects are hardly the result of antioxidant activity, suggesting that CNPs exert such important anticancer effects through additional, non-redox mechanisms. Indeed, using Sm-doped CNPs devoid of redox activity, we could recently demonstrate that the radio-sensitizing effect of CNPs on human keratinocytes is independent from the redox switch. Mechanisms involving particle dissolution with release of toxic Ce4+ atoms, or differential inhibition of the catalase vs. SOD-mimetic activity with accumulation of H2O2 have been proposed, explaining such intriguing findings only partially. Much effort is urgently required to address the unconventional mechanisms of the non-redox bioactivity of CNPs, which may provide unexpected medicinal tools against cancer

Optical follow-up of gravitational wave events during the second advanced LIGO/VIRGO observing run with the DLT40 Survey

We describe the GW follow-up strategy and subsequent results of the DLT40 during the second science run (O2) of the LVC. Depending on the information provided in the GW alert together with the localization map sent by the LVC, DLT40 would respond promptly to image the corresponding galaxies selected by our ranking algorithm in order to search for possible EM counterparts in real time. During the LVC O2 run, DLT40 followed ten GW triggers, observing between $\sim$20-100 galaxies within the GW localization area of each event. From this campaign, we identified two real transient sources within the GW localizations with an appropriate on-source time -- one was an unrelated type Ia supernova (SN~2017cbv), and the other was the optical kilonova, AT 2017fgo/SSS17a/DLT17ck, associated with the binary neutron star coalescence GW170817 (a.k.a gamma-ray burst GRB170817A). We conclude with a discussion of the DLT40 survey's plans for the upcoming LVC O3 run, which include expanding our galaxy search fields out to $D\approx$65 Mpc to match the LVC's planned three-detector sensitivity for binary neutron star mergers.Comment: 38 pages, 8 figures and 14 tables, Submitted to Ap

Consolidación y fragmentación de la investigación de la comunicación en México, 1987-1997

Este artículo expone de una manera breve y general las conclusiones del trabajo de investigación sobre los procesos de estructuración del campo de la investigación académica de la comunicación en México de 1987 a 1997. El acercamiento empírico exploratorio de este trabajo supone el acopio y la sistematización de datos sobre la producción mexicana de conocimiento sobre la comunicación y sus condiciones contextuales; sobre sus productores, tanto individuales como institucionales; y sobre sus productos objetivos, especialmente las publicaciones académicas. A partir de los resultados del análisis de toda esta información, se construyó un modelo heurístico de las determinaciones socioculturales de la estructuración del campo desde la década de 1960 hasta la de 1990, que permite formular la "doble disyuntiva" que se enfrentó en los años noventa para alcanzar la legitimación académica y social

A segmented Hybrid Photon Detector with integrated auto-triggering front-end electronics for a PET scanner

We describe the design, fabrication and test results of a segmented Hybrid Photon Detector with integrated auto-triggering front-end electronics. Both the photodetector and its VLSI readout electronics are custom designed and have been tailored to the requirements of a recently proposed novel geometrical concept of a Positron Emission Tomograph. Emphasis is put on the PET specific features of the device. The detector has been fabricated in the photocathode facility at CERN

Improved quantification of left ventricular volumes and mass based on endocardial and epicardial surface detection from cardiac MR images using level set models

The reproducibility of left ventricular (LV) volume and mass measurements based on subjective slice-by-slice tracing of LV borders is affected by image quality, and volume estimates are biased by geometric modeling. The authors developed a technique for volumetric surface detection (VoSD) and quantification of LV volumes and mass without tracing and geometric approximations. The authors hypothesized that this technique is accurate and more reproducible than the conventional methodology. Methods. Images were obtained in 24 patients in 6 to 10 slices from LV base to apex (GE 1.5 T, FIESTA). Volumetric data were reconstructed, and endocardial and epicardial surfaces were detected using the level set approach. LV volumes were obtained from voxel counts and used to compute ejection fraction (EF) and mass. Conventional measurements (MASS Analysis) were used as a reference to test the accuracy of VoSD technique (linear regression, Bland-Altman). For both techniques, measurements were repeated to compute inter- and intra-observer variability. Results. VoSD values resulted in high correlation with the reference values (EDV: r = 0.98; ESV: r = 0.99; EF: r = 0.91; mass: r = 0.98), with no significant biases (8 ml, 5 ml, 0.2% and 9 g) and narrow limits of agreement (SD: 13 ml, 10 ml, 6% and 9 g). Inter-observer variability of the VoSD technique was lower (range 3 to 5%) than that of the reference technique (5 to 11%; p &lt; 0.05). Intra-observer variability was also lower (1 to 3% vs. 7 to 10%; p &lt; 0.05). Conclusion. VoSD technique allows accurate measurements of LV volumes, EF, and mass, which are more reproducible than the conventional methodology

Effectiveness of a phone-based nurse monitoring assessment and intervention for chemotherapy-related toxicity: A randomized multicenter trial

PurposeAnticancer treatment-related toxicities can impact morbidity and mortality, hamper the administration of treatment, worsen the quality of life and increase the burden on the healthcare system. Therefore, their prompt identification is crucial. NICSO (Italian Network for Supportive Care in Cancer) conducted a nationwide randomized trial to evaluate the role of a planned, weekly phone-based nurse monitoring intervention to prevent and treat chemotherapy, targeted therapy- and immunotherapy-related toxicities. Here, we report the results from the chemotherapy arm. MethodsThis was a nationwide, randomized, open-label trial conducted among 29 Italian centers (NCT04726020) involving adult patients with breast, colon, or lung cancer and a life expectancy >= 6 months receiving adjuvant chemotherapy. Patients received either a weekly nurse monitoring phone call and an educational leaflet reporting practical advice about prevention and treatment of toxicities (experimental group) or the educational leaflet only (control group). ResultsThe addition of a nurse monitoring intervention may help reduce time spent with severe toxicities (grade >= 3), particularly those less frequently reported in clinical practice, such as fatigue. When considering grade 1-2 AEs, times with mild/moderate diarrhea, mucositis, fatigue and pain were shorter in the experimental arm. Time spent without AEs was significantly longer in the experimental arms for all the toxicities. The requirement for special medical attention was comparable between groups. ConclusionThis study suggests the need for implementing a better system of toxicity assessment and management for patients treated with adjuvant chemotherapy to promote effective preventive and/or therapeutic intervention against these events

Multi-Messenger Astronomy with Extremely Large Telescopes

The field of time-domain astrophysics has entered the era of Multi-messenger Astronomy (MMA). One key science goal for the next decade (and beyond) will be to characterize gravitational wave (GW) and neutrino sources using the next generation of Extremely Large Telescopes (ELTs). These studies will have a broad impact across astrophysics, informing our knowledge of the production and enrichment history of the heaviest chemical elements, constrain the dense matter equation of state, provide independent constraints on cosmology, increase our understanding of particle acceleration in shocks and jets, and study the lives of black holes in the universe. Future GW detectors will greatly improve their sensitivity during the coming decade, as will near-infrared telescopes capable of independently finding kilonovae from neutron star mergers. However, the electromagnetic counterparts to high-frequency (LIGO/Virgo band) GW sources will be distant and faint and thus demand ELT capabilities for characterization. ELTs will be important and necessary contributors to an advanced and complete multi-messenger network.Comment: White paper submitted to the Astro2020 Decadal Surve