O caso do Jornal de Notícias

A evolução do jornalismo abriu espaço para o surgimento de ramos específicos, espoletando o interesse dos cidadãos por conteúdos personalizados. É neste ambiente que o jornalismo desportivo ganhou forma e uma legião de adeptos. Os meios de comunicação ao acompanharem a par e passo a realidade social, contribuíram de forma acérrima para o desenvolvimento desta especialização jornalística, dado o protagonismo conferido. O sucessivo destaque editorial é matéria de análise, uma vez que o Desporto envolve inúmeras práticas, no entanto o realce parece estar sempre confinado a uma única modalidade: o futebol. Aquele que é considerado o desporto rei aparenta assaltar as capas e os conteúdos noticiosos desportivos, relegando as demais modalidades existentes para segundo plano. É neste seguimento, que o presente estudo procura encontrar fundamentos para esta hegemonia futebolística. Será que os critérios de noticiabilidade aplicados variam de modalidade para modalidade? De forma a encontrar resposta para a questão colocada, bem como para outras que se revelam pertinentes, baseei-me na recolha e análise de dados, centrados nas capas e nas páginas da secção de Desporto de um mês do Jornal de Notícias, complementando este estudo com a realização de entrevistas, nomeadamente ao próprio protagonista, o editor, a quem cabe as tomadas de decisão editoriais, assumindo-se, por isso, como o responsável pela divisão do protagonismo desportivo. Após a análise a que me propus levar a cabo, mediante a aplicação dos vários critérios noticiosos, o futebol sedimentou a posição líder dos destaques, assumindose claramente como o privilegiado. O desporto rei demonstra gozar de uma aplicação de critérios mais amplos comparativamente com as restantes modalidades desportivas, dependentes do calendário desportivo anual para se assumirem como matéria de notícia.The evolution of journalism opened space for the emergence of specific branches, triggering the interest of citizens in personalized content. It is in this environment that Sports Journalism gained form and a legion of followers. The media, by following the social reality step by step with each other, have contributed decisively to the development of this journalistic specialisation, due to the protagonism that has been conferred. The successive editorial prominence is a matter of analysis, since that sport involves countless practices, however the emphasis always seems to be confined to a single modality: Football. The one that is regarded as the king sport seems to steal the covers and the sports news content, relegating the other existing sports to second place. It is in this context that the present study seeks to find grounds for this football hegemony. Do the applied criteria of reportability vary from modality to modality? In order to find an answer to the question raised, as well as to others that reveal to be pertinent, I based myself on a collection and analysis of data, assigned to the covers and pages of the Sports section of a single month of the Jornal de Notícias, complementing this study with interviews, namely to the protagonist himself, the editor, who is responsible for the editorials decisions, assuming, therefore, as the responsible for dividing the sports protagonism. Following the analysis that I proposed to conduct, through the application of various news benchmarks, football consolidated its leading position in terms of highlights, clearly assuming itself as the privileged one. The king sport evidences to benefit from an application of wider criteria compared to the other sports modalities, that are dependent on the annual sports calendar to be assumed as news matter

Correlations between risk factors for prostate cancer: an epidemiological analysis

Objective: To establish correlations between risk factors for prostate cancer. Method: 155 Medical records of patients with prostate cancer were analyzed regarding the tumor characteristics and risk factors. Results: The patients on average were 70 years of age, incomplete grade school (70%), exposed to pesticides (68,56%), non-smokers (93,8%), and alcohol consumption (71,2%), patients with adenocarcinoma (98,71%) and metastases (12,90%). Positive correlations (0.001) were evidenced with occupational exposure (r= 0,588), use of medications (r= 0,569) and radiation exposure (r= 0.609). No correlations were observed for diet, smoking and alcoholism. Conclusion: The data show that for associations between genetic factors and occupational exposure, with emphasis to the mutagenicity and carcinogenicity

Chromosome 1p36 deletion syndrome: a report on 4 cases

Chromosome 1p36 deletion syndrome (MIM #607872) was first described in 1997 by Shapira et al. This condition is compatible with a monosomy of the 1p36 band in the distal region of the short arm of chromosome 1 and is the most common terminal deletion in humans, with an estimated prevalence of approximately 1 in 5,000 live births. This constitutional deletion is associated with mental retardation, developmental delay, seizures, hypotonia and heart defects. The syndrome is also characterized by several distinct dysmorphic features, including large anterior fontanels, microcephaly, brachycephaly, deep-set eyes, flat nose and nasal bridge, and pointed chin. The 1p36 band is not very clearly visible using classical cytogenetics, and it is therefore difficult to detect these deletions in banded karyotypes. Fluorescence in situ hybridization (FISH) and multiplex ligation-dependent probe amplification (MLPA) analysis have increasingly been used, in addition to classical cytogenetic analysis, in children with mental retardation in order to identify this chromosomal abnormality. The authors present four patients between 1 month and 14 years of age with apparently normal karyotypes. Using molecular cytogenetic techniques, all cases showed a “pure” 1p36 deletion: three were detected by FISH (CEB108/T7, located at 1p36.3, Vysis) and are “de novo”; the fourth was detected by MLPA (P036 and P070, MRC Holland) analysis, and its origin is still unknown. The phenotypes of these patients are described and compared with other cases having this syndrome, described in the literature. We also emphasize the importance of good clinical characterization in order to establish the best cytogenetic strategy to assure accurate diagnosis

Correlations between risk factors for prostate cancer: an epidemiological analysis

Objetivo: estabelecer correlações entre fatores de risco para o câncer de próstata. Métodos: 155 prontuários de pacientes com câncer de próstata foram analisados quanto às características do tumor e aos fatores de risco. Resultados: os pacientes apresentavam em média 70 anos de idade, primário incompleto (70%), expostos a agrotóxicos (68,56%), sem hábitos para tabagismo (93,8%), e etilismo (71,2%), portadores de adenocarcinoma (98,71%) e metástases (12,90%). Correlações (0,001) positivas foram evidenciadas com exposição ocupacional (r=0,588), uso de medicamentos (r=0,569) e exposição a radiações (r=0,609). Não foram observadas correlações para dieta, tabagismo e etilismo. Conclusão: os dados apontam para associações entre fatores genéticos e exposição ocupacional, com ênfase para a mutagenicidade e carcinogenicidade. Descritores: Câncer de próstata, Fatores de risco, Mutagenicidade, Carcinogenicidade

Correlations between risk factors for prostate cancer: an epidemiological analysis

Objetivo: estabelecer correlações entre fatores de risco para o câncer de próstata. Métodos: 155 prontuários de pacientes com câncer de próstata foram analisados quanto às características do tumor e aos fatores de risco. Resultados: os pacientes apresentavam em média 70 anos de idade, primário incompleto (70%), expostos a agrotóxicos (68,56%), sem hábitos para tabagismo (93,8%), e etilismo (71,2%), portadores de adenocarcinoma (98,71%) e metástases (12,90%). Correlações (0,001) positivas foram evidenciadas com exposição ocupacional (r=0,588), uso de medicamentos (r=0,569) e exposição a radiações (r=0,609). Não foram observadas correlações para dieta, tabagismo e etilismo. Conclusão: os dados apontam para associações entre fatores genéticos e exposição ocupacional, com ênfase para a mutagenicidade e carcinogenicidade. Descritores: Câncer de próstata, Fatores de risco, Mutagenicidade, Carcinogenicidade

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Marginal microleakage in Bulk Fill resins

Abstract Introduction Despite advances and innovations in restorative dentistry, microleakage remains one of the main problems in this area. Objective To evaluate in vitro marginal microleakage of Bulk Fill resins in class II cavities, with cervical termination in the dentin. Material and method Cavities, standardized on the mesial and distal surfaces, were prepared in forty top molars and randomly assigned to four groups (n = 10), according to the resin used. G1 (control): Filtek Z350 (3M/ESPE); G2: Filtek Bulk Fill flow (3M/ESPE); G3: Surefill SDR (Dentsply); G4: X-tra (Voco). These were further subdivided into subgroups according to the strategy used to apply the adhesive (self-etch technique and conventional). After storage for 24 hours in an oven (37 °C), the samples were submitted to the thermocycling test (500 cycles: 5 °C/55 °C). They were later waterproofed, immersed in Basic Fuchsin (0.5%) and sectioned in the mesial-distal direction for evaluation using a stereo magnifying glass at 40X (Coleman) Scores from 0 to 3 were assigned according to the microinfiltration observed. The Mann-Whitney and Kruskal-Wallis tests, with a significance level of 5%, were used for statistical analysis. Result There was no statistically significant difference between the Bulk Fill resins when the total acid-etching technique was used. Only the Filtek Bulk fill flow resin presented statistically significant results when the application of the adhesive system strategy was considered, with worse results, in relation to other groups, when it the self-etching strategy was considered. Conclusion The degree of leakage of the bulk fill resins studied, in class II cavities, was not influenced by the method of application of the adhesive system (conventional or two-step self-etching bonding agent), except for the Filtek Bulk fill flow

Marginal microleakage in Bulk Fill resins

Abstract Introduction Despite advances and innovations in restorative dentistry, microleakage remains one of the main problems in this area. Objective To evaluate in vitro marginal microleakage of Bulk Fill resins in class II cavities, with cervical termination in the dentin. Material and method Cavities, standardized on the mesial and distal surfaces, were prepared in forty top molars and randomly assigned to four groups (n = 10), according to the resin used. G1 (control): Filtek Z350 (3M/ESPE); G2: Filtek Bulk Fill flow (3M/ESPE); G3: Surefill SDR (Dentsply); G4: X-tra (Voco). These were further subdivided into subgroups according to the strategy used to apply the adhesive (self-etch technique and conventional). After storage for 24 hours in an oven (37 °C), the samples were submitted to the thermocycling test (500 cycles: 5 °C/55 °C). They were later waterproofed, immersed in Basic Fuchsin (0.5%) and sectioned in the mesial-distal direction for evaluation using a stereo magnifying glass at 40X (Coleman) Scores from 0 to 3 were assigned according to the microinfiltration observed. The Mann-Whitney and Kruskal-Wallis tests, with a significance level of 5%, were used for statistical analysis. Result There was no statistically significant difference between the Bulk Fill resins when the total acid-etching technique was used. Only the Filtek Bulk fill flow resin presented statistically significant results when the application of the adhesive system strategy was considered, with worse results, in relation to other groups, when it the self-etching strategy was considered. Conclusion The degree of leakage of the bulk fill resins studied, in class II cavities, was not influenced by the method of application of the adhesive system (conventional or two-step self-etching bonding agent), except for the Filtek Bulk fill flow

Correlations between risk factors for prostate cancer: an epidemiological analysis

Objetivo: estabelecer correlações entre fatores de risco para o câncer de próstata. Métodos: 155 prontuários de pacientes com câncer de próstata foram analisados quanto às características do tumor e aos fatores de risco. Resultados: os pacientes apresentavam em média 70 anos de idade, primário incompleto (70%), expostos a agrotóxicos (68,56%), sem hábitos para tabagismo (93,8%), e etilismo (71,2%), portadores de adenocarcinoma (98,71%) e metástases (12,90%). Correlações (0,001) positivas foram evidenciadas com exposição ocupacional (r=0,588), uso de medicamentos (r=0,569) e exposição a radiações (r=0,609). Não foram observadas correlações para dieta, tabagismo e etilismo. Conclusão: os dados apontam para associações entre fatores genéticos e exposição ocupacional, com ênfase para a mutagenicidade e carcinogenicidade. Descritores: Câncer de próstata, Fatores de risco, Mutagenicidade, Carcinogenicidade

Koolen-de Vries syndrome – National Case Series with clinical and molecular characterization

Introduction: Koolen-de Vries Syndrome (KdVS) is a rare genetic condition, caused by a 17q21.31 microdeletion, or a pathogenic variant in KANSL1 gene. The clinical picture includes developmental delay (DD)/intellectual disability (ID) with expressive language particularly impaired, dysmorphisms, neonatal hypotonia, and friendly behaviour. Aim: To characterize at the molecular and clinical levels all patients in Portugal diagnosed with KdVS.N/