Principais determinantes do preço do frete rodoviário para o transporte de soja em grãos em diferentes estados brasileiros: uma análise econométrica

The present study identifies the influence of a series of factors in order to determine operating freight rates for soybeans originally grown in the States of Goiás, Mato Grosso and Paraná, during the high seasons of 1998 to 2000 and low seasons of 1998/1999 to 2000/2001. From a multiple linear regression model, results have shown, in higher or lower degree, that the variables related to distance, number of tolls, unloading time at ports, seasonal demand for transport, quality conditions of the highways, influenced differently the rates of the freights in these states, during the periods of high and low seasons

Sistema de vendas e CRM para empresas de esquadrias de alumínio

Acompanha CD-ROMOrientador: Alessandro BrawermanMonografia (graduação) - Universidade Federal do Paraná, Setor de Educação Profissional e Tecnológica, Curso de Tecnologia em Análise e Desenvolvimento de Sistemas

Sistema de vendas e CRM para empresas de esquadrias de alumínio

Acompanha CD-ROMOrientador: Alessandro BrawermanMonografia (graduação) - Universidade Federal do Paraná, Setor de Educação Profissional e Tecnológica, Curso de Tecnologia em Análise e Desenvolvimento de Sistemas

Avaliação da altura patelar em pacientes submetidos à técnica cirúrgica de osteotomia tibial de abertura medial: Assessment of patella height in patients submitted to the surgical technique of medial opening tibial osteotomy

Objetivo: Mensurar a variação da altura patelar em pacientes submetidos à osteotomia valgizante tibial proximal com técnica de cunha de abertura medial. Métodos: Foram analisadas radiografias de membros inferiores em perfil do joelho pré e pós-operatórias de 41 pacientes com artrose unicompartimental ou lesões ligamentares do joelho e desalinhamento em varo, em que se realizou osteotomia tibial. Resultados: A medição da altura pré-operatória foi de 1,09 e de 0,93 no pós operatório, com diminuição média de 0,16, através do método Caton-Deschamps, com significância estatística (0,0000312). Portanto a altura patelar pós operatória teve a tendência de diminuição, mesmo utilizando placas com batentes e placas bloqueadas sem batente. Conclusão: A altura patelar apresentou modificações quando mensuradas pelo método de Caton-Deschamps, constatou-se redução da altura patela

Fluoxetine : an alternative in the treatment of major depression

Os autores apresentam uma revisão de literatura quanto ao uso de fluoxetina no tratamento da depressão maior. A fluoxetina é um inibidor seletivo da recaptação neuronal de serotonina na fenda sináptica, sendo tão eficaz quanto os antidepressivos tricíclicos nos quadros depressivos moderados e leves, porém com menores efeitos adversos, devido à mínima afinidade com outros receptores ali presentes. A posologia é de 20 mg diários, sendo que doses mais elevadas têm a mesma eficácia e maiores efeitos adversos, reservando-se aos casos não responsivos. Inúmeras investigações clínicas indicam que a fluoxetina é um antidepressivo bem tolerado, efetivo e seguro no tratamento da depressão maior.The authors present a review the literature concerning the use o f fluoxetine in the treatment o f major depression. Fluoxetine is one selective inhibiter o f the serotonine neuronal reuptake in the sinaptic cleft being so efficient as the tricyclic antidepressive in moderate to severe depressive conditions, but with /ess adverse efects due to a minimum affinity with other receptors presente there. The recomended dosage is 20mg daily and /arge doses have the same effectiveness with greater adverse effects beeing at reserved for monresponsive cases. Severa/ clinicai research demonstrate that fluoxetine is an effective safe and we/1 tolerated antidepressive in the treatment of major depression

Tomato floral induction and flower development are orchestrated by the interplay between gibberellin and two unrelated microRNA-controlled modules

[EN] Age-regulated microRNA156 (miR156) and targets similarly control the competence to flower in diverse species. By contrast, the diterpene hormone gibberellin (GA) and the microRNA319-regulated TEOSINTE BRANCHED/CYCLOIDEA/PCF (TCP) transcription factors promote flowering in the facultative long-day Arabidopsis thaliana, but suppress it in the day-neutral tomato (Solanum lycopersicum). We combined genetic and molecular studies and described a new interplay between GA and two unrelated miRNA-associated pathways that modulates tomato transition to flowering. Tomato PROCERA/DELLA activity is required to promote flowering along with the miR156-targeted SQUAMOSA PROMOTER BINDING-LIKE (SPL/SBP) transcription factors by activating SINGLE FLOWER TRUSS (SFT) in the leaves and the MADS-Boxgene APETALA1(AP1)/MC at the shoot apex. Conversely, miR319-targeted LANCEOLATE represses floral transition by increasing GA concentrations and inactivating SFT in the leaves and AP1/MC at the shoot apex. Importantly, the combination of high GA concentrations/responses with the loss of SPL/SPB function impaired canonical meristem maturation and flower initiation in tomato. Our results reveal a cooperative regulation of tomato floral induction and flower development, integrating age cues (miR156 module) with GA responses and miR319-controlled pathways. Importantly, this study contributes to elucidate the mechanisms underlying the effects of GA in controlling flowering time in a day-neutral species.We thank Dr C. Schommer for kindly providing tcp4-soj8/+ seeds, and Carlos Rojas for Arabidopsis flowering time analyses. This work was supported by FAPESP (grant no. 15/17892-7 and fellowships nos 15/23826-7 and 13/16949-0). The authors declare no conflict of interest.Silva, G.; Silva, E.; Correa, J.; Vicente, M.; Jiang, N.; Notini, M.; Junior, A.... (2018). 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Proceedings of the National Academy of Sciences, 103(16), 6398-6403. doi:10.1073/pnas.0601620103Liu, J., Cheng, X., Liu, P., Li, D., Chen, T., Gu, X., & Sun, J. (2017). MicroRNA319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis. PLOS Genetics, 13(5), e1006833. doi:10.1371/journal.pgen.1006833Livak, K. J., & Schmittgen, T. D. (2001). Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method. Methods, 25(4), 402-408. doi:10.1006/meth.2001.1262Livne, S., Lor, V. S., Nir, I., Eliaz, N., Aharoni, A., Olszewski, N. E., … Weiss, D. (2015). Uncovering DELLA-Independent Gibberellin Responses by Characterizing New Tomato procera Mutants. The Plant Cell, 27(6), 1579-1594. doi:10.1105/tpc.114.132795Lombardi-Crestana, S., da Silva Azevedo, M., e Silva, G. F. F., Pino, L. E., Appezzato-da-Glória, B., Figueira, A., … Peres, L. E. P. (2012). The Tomato (Solanum Lycopersicum cv. 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Self-reported adherence to physical activity recommendations compared to the IPAQ interview in patients with hypertension

Background: Physical activity (PA) is recommended as adjuvant therapy to control blood pressure (BP). The effectiveness of simple recommendations is not clear. We aimed to assess the agreement between self-report of adherence to PA in clinical routine and International Physical Activity Questionnaire (IPAQ) interview and its association with BP control. Methods: A cross-sectional study was conducted with hypertensive outpatients. Adherence to recommendation to PA was assessed by the physician and IPAQ interview. A cutoff of 150 minutes/week was used to classify active or nonactive patients. High sitting time was considered >4 hours/day. A total of 127 individuals (SBP 144.9±24.4 mmHg/DBP 82.0±12.8 mmHg) were included. Results: A total of 69 subjects (54.3%) reported to be active to their physician, whereas 81 (63.8%) were classified as active by IPAQ (6.3% active in leisure time PA). Kappa test was 0.22 (95% CI, 0.06–0.37). The rate of BP control was 45.7%. There was no association with the reported PA assessed by both methods nor with sitting time. Our results demonstrated poor agreement between self-report adherence and IPAQ interview, and neither evaluation was associated with BP control. Conclusion: Our findings underpin evidences that a simple PA recommendation has low association with BP control in clinical settings

Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure

Objective. To evaluate the expression of inflammatory markers in experimental renal failure after fetal programming. Methods. The offspring aged two and fivemonths were divided into four groups: CC (control dams, control offspring)DC (diabetic dams, control offspring)CFA (control dams, folic acid offspring, 250 mg/Kg)and DFA (diabetic dams, folic acid offspring). Gene expression of inflammatory markersMCP-1, IL-1, NOS3, TGF-beta, TNF-alpha, and VEGF was evaluated by RT-PCR. Results. MCP-1 was increased in the CFA and DFA groups at two and fivemonths of age, as well as in DC5 when compared to CC5. There was a higher expression of IL-1 in the CFA2, DFA2, and DC2 groups. There was a decrease in NOS3 and an increase in TNF-alpha in DFA5 in relation to CFA5. The gene expression of TGF-beta increased in cases that had received folic acid at two and five months, and VEGF decreased in the CFA5 and DFA5 groups. DC5 showed increased VEGF expression in comparison with CC5. Conclusions. Gestational diabetes mellitus and folic acid both change the expression of inflammatory markers, thus demonstrating that the exposure to harmful agents in adulthood has a more severe impact in cases which underwent fetal reprogramming.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundacao de Ensino e Pesquisa de Uberaba (FUNEPU)Discipline of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilDepartment of Health Sciences, Lavras Federal University, Lavras, MG, BrazilDiscipline of Physiology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilDepartment of Immunology, Institute of Biomedical Sciences IV, University of São Paulo (USP), São Paulo, SP, BrazilDepartment of General Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilWeb of Scienc