Modern Landscapes

I explore nature in order to understand something that is becoming increasingly unfamiliar. I wonder about accelerated human transactions with nature: the control of animals, land, and resources for pleasure, consumption or survival; and how these actions manifest themselves visually in the modern world. Through images, I create new ideas about my surroundings. My questions about nature are documented through my work employing subtlety to narrate stories of contemporary environments

Modern Landscapes

I explore nature in order to understand something that is becoming increasingly unfamiliar. I wonder about accelerated human transactions with nature: the control of animals, land, and resources for pleasure, consumption or survival; and how these actions manifest themselves visually in the modern world. Through images, I create new ideas about my surroundings. My questions about nature are documented through my work employing subtlety to narrate stories of contemporary environments

Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals

The ability of adult cardiomyocytes to regenerate is limited, and irreversible loss by cell death plays a crucial role in heart diseases. Autophagy is an evolutionary conserved cellular catabolic process through which long-lived proteins and damaged organelles are targeted for lysosomal degradation. Autophagy is important in cardiac homeostasis and can serve as a protective mechanism by providing an energy source, especially in the face of sustained starvation. Cellular metabolism is closely associated with cell survival, and recent evidence suggests that metabolic and autophagic signaling pathways exhibit a high degree of crosstalk and are functionally interdependent. In this review, we discuss recent progress in our understanding of regulation of autophagy and its crosstalk with metabolic signaling, with a focus on the nutrient-sensing mTOR complex1 (mTORC1) pathway