ALMA Cycle 1 Observations of the HH46/47 Molecular Outflow: Structure, Entrainment and Core Impact

We present ALMA Cycle 1 observations of the HH46/47 molecular outflow using combined 12m array and ACA observations. The improved angular resolution and sensitivity of our multi-line maps reveal structures that help us study the entrainment process in much more detail and allow us to obtain more precise estimates of outflow properties than previous observations. We use 13CO(1-0) and C18O(1-0) emission to correct for the 12CO(1-0) optical depth to accurately estimate the outflow mass, momentum and kinetic energy. This correction increases the estimates of the mass, momentum and kinetic energy by factors of about 9, 5 and 2, respectively, with respect to estimates assuming optically thin emission. The new 13CO and C18O data also allow us to trace denser and slower outflow material than that traced by the 12CO maps, and they reveal an outflow cavity wall at very low velocities (as low as 0.2km/s with respect to the cores central velocity). Adding with the slower material traced only by 13CO and C18O, there is another factor of 3 increase in the mass estimate and 50% increase in the momentum estimate. The estimated outflow properties indicate that the outflow is capable of dispersing the parent core within the typical lifetime of the embedded phase of a low-mass protostar, and that it is responsible for a core-to-star efficiency of 1/4 to 1/3. We find that the outflow cavity wall is composed of multiple shells associated with a series of jet bow-shock events. Within about 3000AU of the protostar the 13CO and C18O emission trace a circumstellar envelope with both rotation and infall motions, which we compare with a simple analytic model. The CS(2-1) emission reveals tentative evidence of a slowly-moving rotating outflow, which we suggest is entrained not only poloidally but also toroidally by a disk wind that is launched from relatively large radii from the source.Comment: Accepted for publication in ApJ. 26 pages, 20 figure

COVID-19 model-based practice changes in managing a large prostate cancer practice: following the trends during a month-long ordeal

Coronavirus (COVID-19) has been a life-changing experience for both individuals and institutions. We describe changes in our practice based on real-time assessment of various national and international trends of COVID-19 and its effectiveness in the management of our resources. Initial risk assessment and peak resource requirement using the COVID-19 Hospital Impact Model for Epidemics (CHIME) and McKinsey models. Strengths, weaknesses, opportunities, and threats (SWOT) analysis of our practice\u2019s approach during the pandemic. Based on CHIME the community followed 60% social distancing, the number of expected new patients hospitalized at maximum surge would be 401, with 100 patients requiring ventilator support. In contrast, when the community followed 15% social distancing, the maximum surge of hospitalized new patients would be 1823 and 455 patients would require a ventilator. on April 15, the expected May requirement of ICU beds at peak would be 68, with 61 patients needing ventilators. The estimated surge numbers improved throughout April, and on April 22 the expected ICU bed peak in May would be 11.7, and those requiring ventilator would be 10.5. Simultaneously, within a month, our surgical waitlist grew from 585 to over 723 patients. Our SWOT analysis revealed our internal strengths and inherent weakness, relevant to the pandemic. A graded and a guarded response to this type of situation is crucial in managing patients in a large practice

uvbyCa H beta CCD Photometry of Clusters. VII. The Intermediate-Age Anticenter Cluster Melotte 71

CCD photometry on the intermediate-band uvbyCa H beta system is presented for the anticenter, intermediate-age open cluster, Melotte 71. Restricting the data to probable single members of the cluster using the color-magnitude diagram and the photometric indices alone generates a sample of 48 F dwarfs on the unevolved main sequence. The average E(b-y) = 0.148 +/- 0.003 (s.e.m.) or E(B-V) = 0.202 +/- 0.004 (s.e.m.), where the errors refer to internal errors alone. With this reddening, [Fe/H] is derived from both m1 and hk, using H beta and b-y as the temperature index, with excellent agreement among the four approaches and a final weighted average of [Fe/H] = -0.17 +/- 0.02 (s.e.m.) for the cluster, on a scale where the Hyades has [Fe/H] = +0.12. When adjusted for the higher reddening estimate, the previous metallicity estimates from Washington photometry and from spectroscopy are now in agreement with the intermediate-band result. From comparisons to isochrones of appropriate metallicity, the cluster age and distance are determined as 0.9 +/- 0.1 Gyr and (m-M) = 12.2 +/- 0.1 or (m-M)_0 = 11.6 +/- 0.1. At this distance from the sun, Mel 71 has a galactocentric distance of 10.0 kpc on a scale where the sun is 8.5 kpc from the galactic center. Based upon its age, distance, and elemental abundances, Mel 71 appears to be a less populous analog to NGC 3960.Comment: Accepted for Astronomical Journal. 38 page latex file includes 11 figures and short version of data table. Full table will appear in online AJ or may be requested from author

A multi-wavelength analysis for interferometric (sub-)mm observations of protoplanetary disks: radial constraints on the dust properties and the disk structure

Theoretical models of grain growth predict dust properties to change as a function of protoplanetary disk radius, mass, age and other physical conditions. We lay down the methodology for a multi-wavelength analysis of (sub-)mm and cm continuum interferometric observations to constrain self-consistently the disk structure and the radial variation of the dust properties. The computational architecture is massively parallel and highly modular. The analysis is based on the simultaneous fit in the uv-plane of observations at several wavelengths with a model for the disk thermal emission and for the dust opacity. The observed flux density at the different wavelengths is fitted by posing constraints on the disk structure and on the radial variation of the grain size distribution. We apply the analysis to observations of three protoplanetary disks (AS 209, FT Tau, DR Tau) for which a combination of spatially resolved observations in the range ~0.88mm to ~10mm is available (from SMA, CARMA, and VLA), finding evidence of a decreasing maximum dust grain size (a_max) with radius. We derive large a_max values up to 1 cm in the inner disk between 15 and 30 AU and smaller grains with a_max~1 mm in the outer disk (R > 80AU). In this paper we develop a multi-wavelength analysis that will allow this missing quantity to be constrained for statistically relevant samples of disks and to investigate possible correlations with disk or stellar parameters.Comment: 19 pages, 15 figures, accepted for publication in A&

The Circumstellar Disk and Asymmetric outflow of the EX Lup Outburst System

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations at 0.3 arcsec-resolution of EX Lup, the prototype of the EXor class of outbursting pre-main sequence stars. The circumstellar disk of EX Lup is resolved for the first time in 1.3mm continuum emission and in the $J$=2--1 spectral line of three isotopologues of CO. At the spatial resolution and sensitivity achieved, the compact dust continuum disk shows no indications of clumps, fragments, or asymmetries above 5-sigma level. Radiative transfer modeling constrains the characteristic radius of the dust disk to 23 au and a total dust mass of 1.0$\times$10$^{-4}$ M$_\odot$ (33 M_earth), similar to other EXor sources. The $^{13}$CO and C$^{18}$O line emission trace the disk rotation and are used to constrain the disk geometry, kinematics, and a total gas disk mass of 5.1$\times$10$^{-4}$ M$_\odot$. The $^{12}$CO emission extends out to a radius of 200 au and is asymmetric, with one side deviating from Keplerian rotation. We detect blue-shifted, $^{12}$CO arc-like emission located 0.8 arcsec to the north-west, and spatially disconnected from the disk emission. We interpret this extended structure as the brightened walls of a cavity excavated by an outflow, which are more commonly seen in FUor sources. Such outflows have also been seen in the borderline FU/EXor object V1647 Ori, but not towards EXor objects. Our detection provides evidence that the outflow phenomenon persists into the EXor phase, suggesting that FUor and EXor objects are a continuous population in which outflow activity declines with age, with transitional objects such as EX Lup and V1647 Ori

On the structure of the transition disk around TW Hya

For over a decade, the structure of the inner cavity in the transition disk of TW Hydrae has been a subject of debate. Modeling the disk with data obtained at different wavelengths has led to a variety of proposed disk structures. Rather than being inconsistent, the individual models might point to the different faces of physical processes going on in disks, such as dust growth and planet formation. Our aim is to investigate the structure of the transition disk again and to find to what extent we can reconcile apparent model differences. A large set of high-angular-resolution data was collected from near-infrared to centimeter wavelengths. We investigated the existing disk models and established a new self-consistent radiative-transfer model. A genetic fitting algorithm was used to automatize the parameter fitting. Simple disk models with a vertical inner rim and a radially homogeneous dust composition from small to large grains cannot reproduce the combined data set. Two modifications are applied to this simple disk model: (1) the inner rim is smoothed by exponentially decreasing the surface density in the inner ~3 AU, and (2) the largest grains (>100 um) are concentrated towards the inner disk region. Both properties can be linked to fundamental processes that determine the evolution of protoplanetary disks: the shaping by a possible companion and the different regimes of dust-grain growth, respectively. The full interferometric data set from near-infrared to centimeter wavelengths requires a revision of existing models for the TW Hya disk. We present a new model that incorporates the characteristic structures of previous models but deviates in two key aspects: it does not have a sharp edge at 4 AU, and the surface density of large grains differs from that of smaller grains. This is the first successful radiative-transfer-based model for a full set of interferometric data.Comment: 22 pages, 12 figures, accepted for publication in Astronomy & Astrophysic

Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series

The largest kindred with inherited prion disease P102L, historically Gerstmann-Sträussler-Scheinker syndrome, originates from central England, with émigrés now resident in various parts of the English-speaking world. We have collected data from 84 patients in the large UK kindred and numerous small unrelated pedigrees to investigate phenotypic heterogeneity and modifying factors. This collection represents by far the largest series of P102L patients so far reported. Microsatellite and genealogical analyses of eight separate European kindreds support multiple distinct mutational events at a cytosine-phosphate diester-guanidine dinucleotide mutation hot spot. All of the smaller P102L kindreds were linked to polymorphic human prion protein gene codon 129M and were not connected by genealogy or microsatellite haplotype background to the large kindred or each other. While many present with classical Gerstmann-Sträussler-Scheinker syndrome, a slowly progressive cerebellar ataxia with later onset cognitive impairment, there is remarkable heterogeneity. A subset of patients present with prominent cognitive and psychiatric features and some have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease. We show that polymorphic human prion protein gene codon 129 modifies age at onset: the earliest eight clinical onsets were all MM homozygotes and overall age at onset was 7 years earlier for MM compared with MV heterozygotes (P = 0.02). Unexpectedly, apolipoprotein E4 carriers have a delayed age of onset by 10 years (P = 0.02). We found a preponderance of female patients compared with males (54 females versus 30 males, P = 0.01), which probably relates to ascertainment bias. However, these modifiers had no impact on a semi-quantitative pathological phenotype in 10 autopsied patients. These data allow an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals, with the identification of two genetic modifiers

Molecular Gas Clumps from the Destruction of Icy Bodies in the β\beta Pictoris Debris Disk

Many stars are surrounded by disks of dusty debris formed in the collisions of asteroids, comets and dwarf planets. But is gas also released in such events? Observations at submm wavelengths of the archetypal debris disk around $\beta$ Pictoris show that 0.3% of a Moon mass of carbon monoxide orbits in its debris belt. The gas distribution is highly asymmetric, with 30% found in a single clump 85AU from the star, in a plane closely aligned with the orbit of the inner planet, $\beta$ Pic b. This gas clump delineates a region of enhanced collisions, either from a mean motion resonance with an unseen giant planet, or from the remnants of a collision of Mars-mass planets

First Results from High Angular Resolution ALMA Observations Toward the HL Tau Region

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations from the 2014 Long Baseline Campaign in dust continuum and spectral line emission from the HL Tau region. The continuum images at wavelengths of 2.9, 1.3, and 0.87 mm have unprecedented angular resolutions of 0.075 arcseconds (10 AU) to 0.025 arcseconds (3.5 AU), revealing an astonishing level of detail in the circumstellar disk surrounding the young solar analogue HL Tau, with a pattern of bright and dark rings observed at all wavelengths. By fitting ellipses to the most distinct rings, we measure precise values for the disk inclination (46.72pm0.05 degrees) and position angle (+138.02pm0.07 degrees). We obtain a high-fidelity image of the 1.0 mm spectral index ($\alpha$), which ranges from $\alpha\sim2.0$ in the optically-thick central peak and two brightest rings, increasing to 2.3-3.0 in the dark rings. The dark rings are not devoid of emission, we estimate a grain emissivity index of 0.8 for the innermost dark ring and lower for subsequent dark rings, consistent with some degree of grain growth and evolution. Additional clues that the rings arise from planet formation include an increase in their central offsets with radius and the presence of numerous orbital resonances. At a resolution of 35 AU, we resolve the molecular component of the disk in HCO+ (1-0) which exhibits a pattern over LSR velocities from 2-12 km/s consistent with Keplerian motion around a ~1.3 solar mass star, although complicated by absorption at low blue-shifted velocities. We also serendipitously detect and resolve the nearby protostars XZ Tau (A/B) and LkHa358 at 2.9 mm.Comment: 11 pages, 5 figures, 2 tables, accepted for publication in the Astrophysical Journal Letter