581 research outputs found
Fluctuation of intratumor biological variables as a function of menstrual timing of surgery for breast cancer in premenopausal patients
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Probing the origin of the dark material on Iapetus
Among the icy satellites of Saturn, Iapetus shows a striking dichotomy
between its leading and trailing hemispheres, the former being significantly
darker than the latter. Thanks to the VIMS imaging spectrometer on-board
Cassini, it is now possible to investigate the spectral features of the
satellites in Saturn system within a wider spectral range and with an enhanced
accuracy than with previously available data. In this work, we present an
application of the G-mode method to the high resolution, visible and near
infrared data of Phoebe, Iapetus and Hyperion collected by Cassini/VIMS, to
search for compositional correlations. We also present the results of a
dynamical study on the efficiency of Iapetus in capturing dust grains
travelling inward in Saturn system to evaluate the viability of
Poynting-Robertson drag as the physical mechanism transferring the dark
material to the satellite. The results of spectroscopic classification are used
jointly with the ones of the dynamical study to describe a plausible physical
scenario for the origin of Iapetus' dichotomy. Our work shows that mass
transfer from the outer Saturnian system is an efficient mechanism,
particularly for the range of sizes hypothesised for the particles composing
the newly discovered outer ring around Saturn. Both spectral and dynamical data
indicate Phoebe as the main source of the dark material. However, we suggest a
multi-source scenario where now extinct prograde satellites and the disruptive
impacts that generated the putative collisional families played a significant
role in supplying the original amount of dark material.Comment: 20 pages, 4 tables, 11 figures, major revision (manuscript extended
and completed, figures added and corrected, new results added), minor
revision and finalization of author list, moderate revision (update of the
manuscript following reviewer's feedback and discovery of the new Saturnian
outer ring
Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours
Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen.
Between 1982 and 1990, 321 elderly patients (range 70-92 years, median age 77) with operable breast cancer (T1 in 219, T2 in 77, T3 in one and T4b in 24 patients) and clinically uninvolved axillary nodes underwent surgery without axillary dissection and received adjuvant tamoxifen. All patients had surgery performed under local anaesthesia. Tamoxifen was given after surgery at the dose of 20 mg daily, indefinitely. With a median follow-up of 67 months (range 42-141), 17 patients developed local relapse, 14 ipsilateral axillary recurrence, five ipsilateral breast cancer, five contralateral breast cancer, 13 second primary and 23 developed distant metastases. The cumulative probability of developing a local, axillary and distant recurrence at 72 months was estimated to be 5.4%, 4.3% and 6.2%, respectively. Out of 244 patients who did not develop any relapse, 83 (25.8%) died from intercurrent disease. The 72 month relapse-free survival rate was 76%. This experience suggests that elderly patients with small tumours without clinical axillary involvement may be satisfactorily treated with conservative surgery and tamoxifen. The importance of axillary dissection is controversial owing to a high response rate to hormonal therapy and an increased death rate due to concomitant diseases
Contribution of vascular endothelial growth factor to the Nottingham prognostic index in node-negative breast cancer
The prognostic contribution of intratumour VEGF, the most important factor in tumour-induced angiogenesis, to NPI was evaluated by using flexible modelling in a series of 226 N-primary breast cancer patients in which steroid receptors and cell proliferation were also accounted for. VEGF provided an additional prognostic contribution to NPI mainly within ER-poor tumours. © 2001 Cancer Research Campaignhttp://www.bjcancer.co
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Marco Polo: near Earth object sample return mission
Marco Polo is a joint European-Japanese mission of sample return from a Near Earth Object. The Marco Polo proposal was submitted to ESA on July 2007 in the framework of the Cosmic Vision 2015-2025 context, and on October 2007 passed the first evaluation process. The primary objectives of this mission is to visit a primitive NEO, belonging to a class that cannot be related to known meteorite types, to characterize it at multiple scales, and to bring samples back to Earth. Marco Polo will give us the first opportunity for detailed laboratory study of the most primitive materials that formed the planets. This will allow us to improve our knowledge on the processes which governed the origin and early evolution of the Solar System, and possibly of the life on Earth
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Marco Polo: A near Earth object sample return mission
From Introduction:
MARCO POLO is a joint European-Japanese sample return mission to a Near-Earth Object. In late 2007 this mission was selected by ESA, in the framework of COSMIC VISION 2015-2025, for an assessment scheduled to last until mid 2009.
This Euro-Asian mission will go to a primitive Near-Earth Object (NEO), such as a C or D type asteroid. The spacecraft will rendezvous with the object, and over an extended period scientifically characterize it at multiple scales and bring samples back to Earth for detailed scientific investigation
Rosetta-Alice Observations of Exospheric Hydrogen and Oxygen on Mars
The European Space Agency's Rosetta spacecraft, en route to a 2014 encounter
with comet 67P/Churyumov-Gerasimenko, made a gravity assist swing-by of Mars on
25 February 2007, closest approach being at 01:54UT. The Alice instrument on
board Rosetta, a lightweight far-ultraviolet imaging spectrograph optimized for
in situ cometary spectroscopy in the 750-2000 A spectral band, was used to
study the daytime Mars upper atmosphere including emissions from exospheric
hydrogen and oxygen. Offset pointing, obtained five hours before closest
approach, enabled us to detect and map the HI Lyman-alpha and Lyman-beta
emissions from exospheric hydrogen out beyond 30,000 km from the planet's
center. These data are fit with a Chamberlain exospheric model from which we
derive the hydrogen density at the 200 km exobase and the H escape flux. The
results are comparable to those found from the the Ultraviolet Spectrometer
experiment on the Mariner 6 and 7 fly-bys of Mars in 1969. Atomic oxygen
emission at 1304 A is detected at altitudes of 400 to 1000 km above the limb
during limb scans shortly after closest approach. However, the derived oxygen
scale height is not consistent with recent models of oxygen escape based on the
production of suprathermal oxygen atoms by the dissociative recombination of
O2+.Comment: 17 pages, 8 figures, accepted for publication in Icaru
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