Activating STAT3 Alpha for Promoting Healing of Neurons

A method of promoting healing of injured or diseased neurons involves pharmacological activation of the STAT3 alpha protein. Usually, injured or diseased neurons heal incompletely or not at all for two reasons: (1) they are susceptible to apoptosis (cell death); and (2) they fail to engage in axogenesis that is, they fail to re-extend their axons to their original targets (e.g., muscles or other neurons) because of insufficiency of compounds, denoted neurotrophic factors, needed to stimulate such extension. The present method (see figure) of treatment takes advantage of prior research findings to the effect that the STAT3 alpha protein has anti-apoptotic and pro-axogenic properties

Subpixel-Scale Topography Retrieval of Mars Using Single-Image DTM Estimation and Super-Resolution Restoration

We propose using coupled deep learning based super-resolution restoration (SRR) and single-image digital terrain model (DTM) estimation (SDE) methods to produce subpixel-scale topography from single-view ESA Trace Gas Orbiter Colour and Stereo Surface Imaging System (CaSSIS) and NASA Mars Reconnaissance Orbiter High Resolution Imaging Science Experiment (HiRISE) images. We present qualitative and quantitative assessments of the resultant 2 m/pixel CaSSIS SRR DTM mosaic over the ESA and Roscosmos Rosalind Franklin ExoMars rover’s (RFEXM22) planned landing site at Oxia Planum. Quantitative evaluation shows SRR improves the effective resolution of the resultant CaSSIS DTM by a factor of 4 or more, while achieving a fairly good height accuracy measured by root mean squared error (1.876 m) and structural similarity (0.607), compared to the ultra-high-resolution HiRISE SRR DTMs at 12.5 cm/pixel. We make available, along with this paper, the resultant CaSSIS SRR image and SRR DTM mosaics, as well as HiRISE full-strip SRR images and SRR DTMs, to support landing site characterisation and future rover engineering for the RFEXM22

DNA diet profiles with high‐resolution animal tracking data reveal levels of prey selection relative to habitat choice in a crepuscular insectivorous bird

Given the global decline of many invertebrate food resources, it is fundamental to understand the dietary requirements of insectivores. We give new insights into the functional relationship between the spatial habitat use, food availability, and diet of a crepuscular aerial insectivore, the European Nightjar (Caprimulgus europaeus) by relating spatial use data with high‐throughput sequencing (HTS) combined with DNA metabarcoding. Our study supports the predictions that nightjars collect a substantial part of their daily nourishment from foraging locations, sometimes at considerable distance from nesting sites. Lepidopterans comprise 65% of nightjars' food source. Nightjars tend to select larger species of Lepidoptera (>19 mm) which suggests that nightjars optimize the efficiency of foraging trips by selecting the most energetically favorable—larger—prey items. We anticipate that our findings may shed additional light on the interactions between invertebrate communities and higher trophic levels, which is required to understand the repercussions of changing food resources on individual‐ and population‐level processes

The Apparent Host Galaxy of PKS 1413+135: HST, ASCA and VLBA Observations

PKS 1413+135 (z=0.24671) is one of very few radio-loud AGN with an apparent spiral host galaxy. Previous authors have attributed its nearly exponential infrared cutoff to heavy absorption but have been unable to place tight limits on the absorber or its location in the optical galaxy. In addition, doubts remain about the relationship of the AGN to the optical galaxy given the observed lack of re-emitted radiation. We present new HST, ASCA and VLBA observations which throw significant new light on these issues. The HST observations reveal an extrremely red color (V-H = 6.9 mag) for the active nucleus of PKS 1413+135, requiring both a spectral turnover at a few microns due to synchrotron aging and a GMC-sized absorber. We derive an intrinsic column N_H = 4.6^{+2.1}_{-1.6} times 10^{22}cm^{-2} and covering fraction f = 0.12^{+0.07}_{-0.05}. As the GMC is likely in the disk of the optical galaxy, our sightline is rather unlikely (P ~ 2 times 10^{-4}). The properties of the GMC typical of GMCs in our own galaxy. The HI absorber appears centered 25 milliarcseconds away from the nucleus, while the X-ray and nearly all of the molecular absorbers must cover the nucleus, implying a complicated geometry and cloud structure, with a molecular core along our line of sight to the nucleus. Interestingly, the HST/NICMOS data require the AGN to be decentered relative to the optical galaxy by 13 +/- 4 milliarcseconds. This could be interpreted as suggestive of an AGN location far in the background compared to the optical galaxy, but it can also be explained by obscuration and/or nuclear structure, which is more consistent with the observed lack of multiple images.Comment: 27 pages, 8 figures; accepted to A

Are blackcaps sylvia atricapilla differential distance migrants by sex?

Aims: To investigate if male and female blackcaps show differences in the amplitude of migratory movements. Methods: The extent of movements of male and female British blackcaps were analysed using ringing recovery records. Furthermore, through a literature review and the collection of original field data, the sex-ratios of blackcap samples taken at several latitudes in Europe and Africa were compared. Results: There were no differences between British male and female blackcaps in relation to wintering latitude or distance moved during migration. Sex-ratios of blackcap samples were quite even across a wide range of latitudes. However, there was a significantly larger proportion of females in samples of birds that wintered in Africa. Conclusions: Laboratory data and morphological studies have yielded inconclusive results in relation to the question of whether or not European blackcaps are differential distance migrants. The results from the present study suggest that British blackcaps are not differential distance migrants. Furthermore, there is, at best, only a weak latitudinal segregation of the sexes of blackcaps wintering in Europe and Africa. The slightly higher proportion of males in European samples, when compared to Africa, could result from a differential behaviour of males and females in some blackcap populations, or simply result from differences in the sex-ratios of blackcap populations breeding and wintering in different areas. An absence of a pronounced latitudinal segregation in the size-monomorphic blackcap is interesting, and contrasts with the pattern found in more sexually dimorphic species, such as the chiffchaff Phylloscopus collybita or the robin Erithacus rubecula

Multi-scale habitat selection throughout the annual cycle of a long-distance avian migrant

Long-distance migrants are constrained by widely separated hospitable habitats in geographically isolated locations, making them vulnerable to environmental change, both through natural and anthropogenic causes. Knowledge about their resource selection decisions is imperative to understand the drivers of their declines. The distinct periods within an annual cycle, when individuals experience different environmental circumstances, are inextricably linked through carry-over effects which can have important consequences for the individual, and consequently the population. In this study, we employ precise archival GPS-tracking data of European Nightjars (Caprimulgus europaeus) and high-resolution global land cover data to examine habitat selection during the sedentary wintering and breeding periods, as well as during autumn and spring migration, using a correlational approach. We demonstrate how nightjars use general habitat characteristics, such as landscape diversity, for high-order habitat selection, while resource selection at a finer spatial scale is reliant on fine-scale variables related to a habitat’s suitability, such as surface area of grassland and shrubland. We show that nightjars favour spatially diverse landscapes, which allows them to minimize time spent searching for optimal habitats. The considerable variation in the drivers of habitat selection between and within seasons shows how anthropogenic land-use change can have an array of different impacts on migrants by influencing large- and fine-scale habitat selection. This study shows the advantages of an individual based GPS-tracking approach, combined with high spatial resolution remote sensing data, and highlights the need for full annual-cycle research on scale dependent habitat selection of long-distance avian migrants

Differential migration of chiffchaffs Phylloscopus collybita and P. ibericus in Europe and Africa

Differential migration is a widespread, but poorly understood, phenomenon in birds. In this paper, we present the first detailed field study of differential migration in the Old World warbler (Sylviidae) family. We studied two chiffchaff Phylloscopus [collybita ] semispecies: the common chiffchaff P. [c. ] collybita and the Iberian chiffchaff P. [c. ] ibericus. Using data collected at several latitudes in Europe and Africa, we present convincing evidence for differential distance migration of sexes in chiffchaffs, with females moving further than males. Interestingly, while there was a pronounced gradient in the sex-ratios in Europe and North Africa (with an increasing proportion of females with declining latitude), no clear pattern was found south of the Sahara, where sex-ratios were more male-biased than predicted by a simple latitude model. This suggests that, amongst the chiffchaffs wintering in West Africa, a large proportion is composed by Iberian birds, and provides support to previous suggestions that Iberian chiffchaffs are long distance migrants. Results from detailed studies in Senegal also show that chiffchaffs display differential timing of spring migration, with males leaving the winter quarters considerably earlier than females. The results are discussed in the framework of the three main (non-mutually exclusive) hypotheses attempting to explain the latitudinal segregation of the sexes. Given the relative failure of standard comparative studies to discriminate between competing single-factor hypotheses to explain differential migration, it is argued that the chiffchaff species complex might be particularly suited to study this issue using a new approach suggested by Cristol et al. (1999): detailed (further) comparisons between closely related species (such as the common and the Iberian chiffchaffs) could help identifying the key factors to be incorporated into optimality models that can predict relative distance of migration of different sex or age classes

Role of Gas6 Receptors in Platelet Signaling during Thrombus Stabilization and Implications for Antithrombotic Therapy

Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing “outside-in” signaling and platelet granule secretion. Gas6, through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the β3 integrin, thereby amplifying outside-in signaling via αIIbβ3. Blocking the Gas6-R–αIIbβ3 integrin cross-talk might be a novel approach to the reduction of thrombosis