The Time and Space: Score Analysis and reflections on WALL • E

The first hour of Wall-E is a crazily inventive, deliriously engaging and almost wordless silent comedy of the sort that Charlie Chaplin and Buster Keaton used to make. In almost 100 minutes of movie there are about 80 minutes of music. My analysis focuses mainly on the styles used by Newman and his aesthetic approach to this amazing score.https://remix.berklee.edu/graduate-studies-scoring/1008/thumbnail.jp

Moral suffering and protection of prisoners of war: the Central Tracing Agency from the Franco-Prussian war to the present

openThis study emerges from the author’s academic background combined with years of hands-on experience with the Red Cross. As a volunteer since the onset of the COVID-19 pandemic and currently overseeing missions for international cooperation, the author has long been particularly drawn to the Central Tracing Agency of the International Committee of the Red Cross. The Agency's mission to connect families, overcome physical barriers, and prioritize the alleviation of moral suffering (alongside physical suffering) has always captivated her. To gain a deeper understanding of this subject, the author recognized the necessity of historical and legal analysis. Thus, this research examines the historical developments leading to the establishment of the contemporary Central Tracing Agency, spanning from 1870 to the present day. It begins with the Basle Agency during the Franco-Prussian War and the Belgrade Agency in the Balkan War, tracing the evolution of information and aid bureaux through World Wars, with a focus on the International Prisoners of War Agency and the Central Prisoners of War Agency. The thesis highlights the continuity of the CTA’s functions from these earlier entities, showing that its core administrative responsibilities have endured, albeit in an evolved form, particularly in alleviating moral suffering and protecting prisoners of war. Central to the research is an analysis of the activities and structural adaptations, especially regarding correspondence methods, innovations in information exchange, and tracing services during conflicts. The study pays significant interest to the evolution of international humanitarian law, particularly the Geneva Conventions, assessing their impact on state roles and the distinctions between international and internal conflicts. While the 1949 Geneva Conventions require the establishment of information and aid bureaux during conflicts, the absence of a legal obligation for states to recognize the International Committee of the Red Cross’ authority is addressed, illustrating how the organization has historically filled this crucial role. Organized into six chapters, the thesis analyzes key dimensions of legal, historical, and structural evolution. Each chapter provides insights into specific periods and developments, culminating in an exploration of the CTA’s current activities. This research, drawing extensively from ICRC archives and various legal sources, aims to offer a comprehensive understanding of the CTA’s evolution and the legal frameworks that underpin its operations, contributing valuable insights into the protection of war victims, both prisoners of war and civilians.This study emerges from the author’s academic background combined with years of hands-on experience with the Red Cross. As a volunteer since the onset of the COVID-19 pandemic and currently overseeing missions for international cooperation, the author has long been particularly drawn to the Central Tracing Agency of the International Committee of the Red Cross. The Agency's mission to connect families, overcome physical barriers, and prioritize the alleviation of moral suffering (alongside physical suffering) has always captivated her. To gain a deeper understanding of this subject, the author recognized the necessity of historical and legal analysis. Thus, this research examines the historical developments leading to the establishment of the contemporary Central Tracing Agency, spanning from 1870 to the present day. It begins with the Basle Agency during the Franco-Prussian War and the Belgrade Agency in the Balkan War, tracing the evolution of information and aid bureaux through World Wars, with a focus on the International Prisoners of War Agency and the Central Prisoners of War Agency. The thesis highlights the continuity of the CTA’s functions from these earlier entities, showing that its core administrative responsibilities have endured, albeit in an evolved form, particularly in alleviating moral suffering and protecting prisoners of war. Central to the research is an analysis of the activities and structural adaptations, especially regarding correspondence methods, innovations in information exchange, and tracing services during conflicts. The study pays significant interest to the evolution of international humanitarian law, particularly the Geneva Conventions, assessing their impact on state roles and the distinctions between international and internal conflicts. While the 1949 Geneva Conventions require the establishment of information and aid bureaux during conflicts, the absence of a legal obligation for states to recognize the International Committee of the Red Cross’ authority is addressed, illustrating how the organization has historically filled this crucial role. Organized into six chapters, the thesis analyzes key dimensions of legal, historical, and structural evolution. Each chapter provides insights into specific periods and developments, culminating in an exploration of the CTA’s current activities. This research, drawing extensively from ICRC archives and various legal sources, aims to offer a comprehensive understanding of the CTA’s evolution and the legal frameworks that underpin its operations, contributing valuable insights into the protection of war victims, both prisoners of war and civilians

Russian Christian Orthodox Icons of the Mother of God

Guide is the collector\u27s supplement to the exhibit Revelation Cast in Bronze: Icons from the George Contis Collection. Exhibit dates: Sept. 15–Nov. 13, 2015 Curator: Michele Devitt Graphic designer: Ann Zlotnikhttps://ecommons.udayton.edu/ml_exhibitguides/1004/thumbnail.jp

Estrogen Receptor Expression in Pancreatic Adenocarcinoma: Time to Reconsider Evidence

Pancreatic adenocarcinoma remains a chemotherapy-resistant and refractory malignancy with high mortality, unaffected by recent progress in anticancer treatment. Expression of estrogen receptors was detected almost 50 years ago, in both benign and malignant pancreatic cells. However, early preclinical studies in pancreatic cancer led to contradictory findings, and most clinical studies failed to demonstrate an effect with tamoxifen treatment. The identification of a second form of estrogen receptor seems to provide some explanation for these discrepancies. Predominantly expressed in malignant cells and structurally different from what was considered the only estrogen receptor, estrogen receptor β was recognized as a negative prognostic factor and a possible therapeutic target in pancreatic ductal adenocarcinoma. Therefore, findings of research before the identification of estrogen receptor β should be reconsidered, and further studies should be designed to reassess the expression and effect of this specific estrogen receptor type in pancreatic cancer

Performance evaluation and relevance of the CellaVision™ DM96 system in routine analysis and in patients with malignant hematological diseases

The CellaVision™ DM96 is an automated image analysis system dedicated to locating and preclassifying the various types of white blood cells in peripheral blood smears. The system also partially characterizes of the red blood cell morphology and is able to perform platelet counts. We routinely analyzed the blood samples from 440 patients with quantitative and/or qualitative abnormalities detected by the XE-2100 Sysmex™. Only 2.6% of cells are not identified by DM96™. After classification of the unidentified cells very good correlation coefficients are observed between DM96™ and manual microscopy for most hematological parameters and accuracy is judged excellent up to 98%. For most common parameters, false positive and false negative ratios are also very good. Whatever the pathology and the number of blasts on smear, all patients were positive for blast detection on DM96™. The system is a useful tool for assisting in the diagnosis and classification of most acute or chronic leukemia. Automatic cell location and preclassification, along with unique cell views on the computer screen, could reduce the time spent performing differentials and make real-time collaboration between colleagues a natural part of the classification process. The workstation also provides an ergonomically correct and relaxed working environment. We suggest its use in routine analysis; the system could be very helpful for the accurate morphological diagnosis of samples from patients with malignant hematological disease

A relação entre a gestrinona e o transtorno do desejo sexual hipoativo durante após a menopausa: uma revisão integrativa da literatura

O transtorno de interesse e excitação sexual em mulheres (desejo sexual hipoativo) é uma das categorias que que compõe a Disfunção Sexual Feminina, que atinge mais de 70% das mulheres ao longo da vida e está intimamente relacionada com a idade das mesmas e como consequência, com o período de menopausa. Tal período é caracterizado por declínio nos níveis de estrogênio e androgênios ovarianos e como contramedida clínica, tem-se o uso de TRH e a partir da década de 70, o estudo para uso da gestrinona (derivado sintético da 19-nortesterona) em DSH. Desta forma, após levantamento de dados a análise de literaturas cientificas com o intuito de revisão em plataformas como LILACS, PubMed, Scielo, Google Acadêmico e The Lancet, ainda que haja uso da gestrinona, não se tem dados sobre seu uso a longo prazo e não estando bem estabelecida a mesma não tem indicação da Endocrine Society, SBEM, NAMS e FEBRASGO

Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice

There is considerable interest in expanding B cell-targeted therapies in human autoimmune diseases. However, clinical trials in human primary biliary cholangitis (PBC) using a chimeric antibody against human CD20 (hCD20) have showed limited efficacy. Two potential explanations for these disappointing results are the appearance of anti-drug antibodies (ADAs) and the high frequency of patients with moderate PBC or patients who had failed ursodeoxycholic acid treatment. Here, we studied a novel humanized IgG1 antibody against hCD20 and explored its efficacy in early stage PBC using a well-defined murine model. We developed a unique murine model consisting of dnTGF-βRII mice expressing hCD20 and human Fcγ receptors (hFcγRs). Beginning at 4–6 weeks of age, equivalent to stage I/II human PBC, female mice were given weekly injections of an anti-hCD20 antibody (TKM-011) or vehicle control, and monitored for liver histology as well as a broad panel of immunological readouts. After 16 weeks' treatment, we observed a significant reduction in portal inflammation, a decrease in liver-infiltrating mononuclear cells as well as a reduction in liver CD8+ T cells. Importantly, direct correlations between numbers of liver non-B cells and B cells (r = 0.7426, p = 0.0006) and between numbers of liver memory CD8+ T cells and B cells (r = 0.6423, p = 0.0054) were apparent. Accompanying these changes was a dramatic reduction in anti-mitochondrial antibodies (AMAs), interleukin (IL)-12p40 and IL-5, and elevated levels of the anti-inflammatory chemokine CXCL1/KC. In mice that developed ADAs, clinical improvements were less pronounced. Sustained treatment with B cell-targeted therapies may broadly inhibit effector pathways in PBC, but may need to be administered early in the natural history of PBC

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks