The Work Agentic Capabilities (WAC) questionnaire: validation of a new measure

Agentic capabilities refer to the basic capabilities of mind that, according to social cognitive theory, allow people to proactively influence their functioning and external context. This study presents a new scale, namely the Work Agentic Capabilities (WAC) questionnaire, that consists of 28 items and measures forethought capability, self-regulation capability, self-reflection capability and vicarious capability in the organizational context. Accordingly, an exploratory (N = 290) and a confirmatory factor analysis (N = 300) demonstrated a four-factor structure. Agentic capabilities were positively correlated with psychological capital and its dimensions (i.e., self-efficacy, hope, optimism and resiliency), positive job attitudes (work engagement and job satisfaction), proactive organizational behaviours (job crafting and organizational citizenship behaviours), perceived job performance, and promotion prospects. Finally, we discuss meaningful differences in the mean values of agentic capabilities associated with sociodemographic and organizational variables. Results suggest that the WAC questionnaire can be reliably used to measure agentic capabilities.Las capacidades agénticas aluden a aquellas capacidades de la mente que según la teoría social cognitiva permiten a las personas influir de un modo proactivo en su funcionamiento y en el contexto externo. El presente estudio presenta una nueva escala, el cuestionario de Capacidades Agénticas en el Trabajo (WAC, por sus siglas en inglés), compuesto de 28 ítems que mide la capacidad de previsión, autorregulación, autorreflexión y vicaria en el contexto organizativo. Un estudio con análisis factorial exploratorio (N = 290) y confirmatorio (N = 300) descubrió una estructura de cuatro factores. Las capacidades agénticas correlacionaban positivamente con el capital psicológico y sus dimensiones (es decir, autoeficacia, esperanza, optimismo y resiliencia), las actitudes laborales positivas (engagement y satisfacción en el trabajo), la percepción del desempeño laboral y las perspectivas de promoción. Por último abordamos las diferencias significativas de los valores medios de las capacidades agénticas asociadas a las variables sociodemográficas y organizativas. Los resultados indican que el cuestionario WAC puede utilizarse de modo fiable para medir las capacidades agénticas

Bringing social interaction at the core of organizational neuroscience

Organizations are composed of individuals working together for achieving specific goals, and interpersonal dynamics do exert a strong influence on workplace behaviour. Nevertheless, the dual and multiple perspective of interactions has been scarcely considered by Organizational Neuroscience (ON), the emerging field of study that aims at incorporating findings from cognitive and brain sciences into the investigation of organizational behaviour. This perspective article aims to highlight the potential benefits of adopting experimental settings involving two or more participants (the so-called "second person" approach) for studying the neural bases of organizational behaviour. Specifically, we stress the idea that moving beyond the individual perspective and capturing the dynamical relationships occurring within dyads or groups (e.g., leaders and followers, salespersons and clients, teams) might bring novel insights into the rising field of ON. In addition, designing research paradigms that reliably recreate real work and life situations might increase the generalizability and ecological validity of its results. We start with a brief overview of the current state of ON research and we continue by describing the second-person approach to social neuroscience. In the last paragraph, we try and outline how this approach could be extended to ON. To this end, we focus on leadership, group processes and emotional contagion as potential targets of interpersonal ON research

Microvesicles secreted from equine amniotic cells and their potential role in in vitro cell tendon repair

The regenerative mechanisms ascribed to mesenchymal stem cells (MSCs) are classified into 3 categories: differentiating into damaged cell types, supplying nutrients, and improving survival/functions of the endogenous cells via paracrine actions. However, because of the inhospitable microenvironment of the injured tissues, a proportion of the implanted MSCs may quickly die, suggesting that other mechanisms might be present. This notion is supported by the overlapping beneficial effect (in terms of time of healing) resulted  after the injection of AMCs or of amniotic mesenchymal cells - conditioned medium (AMC-CM)  in equine spontaneous injured tendons and ligaments. Microvesicles (MVs) released by cells are an integral component of the cell-to-cell communication network involved in tissue regeneration.In the present study, MVs secreted by AMCs were investigated with Nanosigth instrument and TEM. Then, the in vitro incorporation of MVs into equine tendon cells was studied by a dose-response curve. Lastly, the ability of MVs to counteract an in vitro inflammatory process induced by lipolysaccaride on tendon cells was studied evaluating the expression of pro-inflammatory genes like metallopeptidase (MPP) 1 and 13, and prostaglandin-endoperoxide synthase 2 (COX2). Results demonstrated that AMCs secreted MVs ranging in size from 100 to 1000 nm with a prevalence of 100-200 nm large MVs. Tendon cells were able to uptake them with an inverse relationship between concentration and time. The greatest incorporation was detectable at 40x106 MVs/ml after 72h. MVs induced down-regulation of MMP1 and MMP13, suggesting that they may have contributed, along with soluble factors, to in vivo tendon regeneration

Italian Validation of the 12-Item Version of the Burnout Assessment Tool (BAT-12)

The Burnout Assessment Tool (BAT) has shown satisfactory validity evidence in several countries, with the 23-item version of the instrument reporting adequate psychometric properties also in the Italian context. This paper is aimed to present results from the Italian validation of the 12-item version of the BAT. Based on a sample of 2277 workers, our results supported the factorial validity of a higher-order model represented by 4 first-order factors corresponding to the core dimensions of burnout, namely exhaustion, mental distance, and emotional and cognitive impairment. The measure invariance of the BAT-12 between data collected before and during the COVID-19 pandemic was supported. However, ANCOVA results suggest a higher score on the second-order burnout factor on data collected during the COVID-19 pandemic in comparison with earlier data. In line with the JD-R model, the BAT-12 total score reported a positive association with job demands (i.e., workload, time pressure, and role conflict) and a negative association with job resources (i.e., job autonomy, coworkers' support) and personal resources (i.e., optimism, social self-efficacy, and task self-efficacy). Additionally, the BAT-12 showed a negative association with work engagement components (i.e., vigor, dedication, and absorption) and positive job attitudes (i.e., job satisfaction, affective commitment). All in all, our results identify the Italian version of the BAT-12 as a brief and reliable tool for measuring burnout among workers

Whole-Exome and Transcriptome Sequencing Expands the Genotype of Majewski Osteodysplastic Primordial Dwarfism Type II

Microcephalic Osteodysplastic Primordial Dwarfism type II (MOPDII) represents the most common form of primordial dwarfism. MOPD clinical features include severe prenatal and postnatal growth retardation, postnatal severe microcephaly, hypotonia, and an increased risk for cerebrovascular disease and insulin resistance. Autosomal recessive biallelic loss-of-function genomic variants in the centrosomal pericentrin (PCNT) gene on chromosome 21q22 cause MOPDII. Over the past decade, exome sequencing (ES) and massive RNA sequencing have been effectively employed for both the discovery of novel disease genes and to expand the genotypes of well-known diseases. In this paper we report the results both the RNA sequencing and ES of three patients affected by MOPDII with the aim of exploring whether differentially expressed genes and previously uncharacterized gene variants, in addition to PCNT pathogenic variants, could be associated with the complex phenotype of this disease. We discovered a downregulation of key factors involved in growth, such as IGF1R, IGF2R, and RAF1, in all three investigated patients. Moreover, ES identified a shortlist of genes associated with deleterious, rare variants in MOPDII patients. Our results suggest that Next Generation Sequencing (NGS) technologies can be successfully applied for the molecular characterization of the complex genotypic background of MOPDII

Nuclear emulsion techniques for muography

Nuclear emulsions are currently being used in the field of muography, more specifically muon radiography of volcanic edifices and fault regions. The peculiar features of such detector for cosmic muons demand appropriate data processing and analysis techniques. The paper shows the current development status of readout devices and analysis techniques developed by some research groups that established a collaborative network in Italy and Japan. An overview is given of nuclear emulsion-based detectors, from the detection principles to detector operation and set-up techniques, in connection with the expectations in terms of geophysics information. Two systems for readout are presented, one developed in the first decade of the 21st century and one that is entering duty now. The evolution in terms of data quality and speed is discussed. Finally, the most relevant data processing steps that allow working out muon absorption maps from nuclear emulsion data are described

muography of 1949 fault in la palma canary islands spain

Muography (muon radiography) is a new geophysical technique that allows investigation of inner structures of an edifice with a very detailed spatial resolution. It has been recently used for several volcanoes and different geoscientific targets. In 2011 Tanaka et al. succeeded to find hidden ancient seismic faults. In 1949 there was a volcanic activity of the Cumbre Vieja, La Palma, Canary Islands, Spain and a 1km long fault suddenly appeared during the active period. The fault might be the sign of a large scale land collapse. In order to get additional information, investigations by several geophysical exploration techniques are needed. We consider that muography can be applied to study the shallow part of the fault and it can clarify some important parameters: the bulk density, the width of the low density zone, and the depth. Previous investigations allowed detecting two ancient seismic faults that have 20m-wide mechanically fractured zone consisting of highly damaged rocks. The 1949 fault might be the result of large scale land slide and the slide length might be just a few meter. Therefore the expected width of the fault is only a few meter. In order to detect such narrow fault, the muon detector should have as high spatial resolution as possible. In addition, it is difficult to get continuous power supply near the fault. Nuclear emulsions are a kind of photographic films that have high sensitivity for high energy charged particles. They also have high spatial resolution for high energy muon paths and do not need any power supply to be operated. We placed an emulsion detector having 0.19 m 2 effective area near the 1949 fault. The exposure started on January 2014 and lasted 106 days. All the emulsion films were developed and they are under analysis. We also estimated the expected performance of this test exposure. Assuming a very simple model, we evaluated the detectable region as a function of the low density zone width and of the depth from the ground surface as well

Flat band separation and robust spin-Berry curvature in bilayer kagome metals

Kagome materials have emerged as a setting for emergent electronic phenomena that encompass different aspects of symmetry and topology. It is debated whether the XV$_6$Sn$_6$ kagome family (where X is a rare earth element), a recently discovered family of bilayer kagome metals, hosts a topologically non-trivial ground state resulting from the opening of spin-orbit coupling gaps. These states would carry a finite spin-Berry curvature, and topological surface states. Here, we investigate the spin and electronic structure of the XV$_6$Sn$_6$ kagome family. We obtain evidence for a finite spin-Berry curvature contribution at the center of the Brillouin zone, where the nearly flat band detaches from the dispersing Dirac band because of spin-orbit coupling. In addition, the spin-Berry curvature is further investigated in the charge density wave regime of ScV$_6$Sn$_6$, and it is found to be robust against the onset of the temperature-driven ordered phase. Utilizing the sensitivity of angle resolved photoemission spectroscopy to the spin and orbital angular momentum, our work unveils the spin-Berry curvature of topological kagome metals, and helps to define its spectroscopic fingerprint.Comment: 21 pages, 4 figure

muography with nuclear emulsions stromboli and other projects

The muon radiography is a novel imaging technique to probe the volcanoes interior, using the capability of high energy cosmic ray muons to penetrate large thicknesses of rock. In this way it is possible to derive a 2D density map along the muon trajectory of volcanic edifices and deduce information on the variations in the rock density distribution, like those expected from dense lava conduits, or low density magma supply paths. This method is applicable also to study geological objects as glaciers, faults, oil underground reservoirs, engineering constructions, where a density contrast is present. Nuclear emulsions are well suited to be employed in this context for their excellent angular resolution; they are compact and robust detectors, able to work in harsh environments without need of power supply. On the other side, a long exposure time is required for a reasonable detector surface (~10 m 2 ) in order to collect a sufficient statistics of muons, and a quasi-real time analysis of the emulsion data is rather difficult due to the scanning time needed by the optical microscopes. Such drawback is on the way to be overcome thanks to a recent R&D program on ultra-fast scanning systems. Muon radiography technique, even if limited to the summit part of the volcano edifice, represents an important tool of investigation, at higher spatial resolution, complementary to the conventional geophysics techniques. The first successful result in this field was obtained by a Japanese group that observed in 2007 the conduit structure of Mt. Asama. Since 2010, other interesting volcanoes have been probed with the same method: Stromboli in 2011, Mt. Teide in 2012 and La Palma in 2014. Here we discuss the muon imaging technique reporting the nuclear emulsion detector design exposed at Stromboli and results of the data analysis