9 research outputs found
Quantitative analysis of opioids and cannabinoids in wastewater samples
Wastewater-based epidemiology is an innovative approach that uses the analysis of human excretion products in wastewater to obtain information about exposure to drugs in defined population groups. We developed and validated an analytical method for the simultaneous determination of opioids (morphine, oxycodone, hydrocodone, oxymorphone and hydromorphone), and cannabinoids (Δ9-tetrahydrocannabinol, 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) and THCCOOH-glucuronide) in raw-influent wastewater samples by ultra-high performance liquid chromatography-tandem mass spectrometry. Method validation included linearity (5–1 000 ng/L for opioids, 10–1 000 ng/L for cannabinoids), imprecision (\u3c21.2%), accuracy (83%–131%), matrix effect (from –35.1% to –14.7%) and extraction efficiency (25%–84%), limit of detection (1–5 ng/L) and quantification (5–10 ng/L) and auto-sampler stability (no loss detected). River and wastewater samples were collected in triplicate from different locations in New York City and stored at −20 °C until analysis. Water from sewage overflow location tested positive for morphine (10.7 ng/L), oxycodone (4.2–23.5 ng/L), oxymorphone (4.8 ng/L) and hydromorphone (4.2 ng/L). Raw influent wastewater samples tested positive for morphine (133.0–258.3 ng/L), oxycodone (31.1–63.6 ng/L), oxymorphone (16.0–56.8 ng/L), hydromorphone (6.8–18.0 ng/L), hydrocodone (4.0–12.8 ng/L) and THCCOOH (168.2–772.0 ng/L). This method is sensitive and specific for opioids and marijuana determination in wastewater samples
Editorial: Current Analytical Trends in Drug Testing in Clinical and Forensic Toxicology
Editorial on the Research Topic: Current Analytical Trends in Drug Testing in Clinical and Forensic Toxicology
The articles included in this collection cover novel analytical approaches, including
chromatographic and spectrometric methods, and sample preparation techniques for the
investigation and analysis of several classes of compounds. These compounds include novel
psychoactive substances (NPS) as well as other drugs and substances within the scope of clinical
and forensic toxicology, and other fields, such as doping control.
Current trends in bioanalysis require the constant development of novel analytical tools, which
includes efficient sample collection procedures and adequate sample preparation protocols in order
to maximize compound detection, even at trace levels. Taking into account that the number of
substances possibly present in a sample are increasing, efficient multi-analyte methods are usually
necessary.info:eu-repo/semantics/publishedVersio