Grey wolf genomic history reveals a dual ancestry of dogs

The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canisfamiliaris) lived(1-8). Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT8840,000-30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located.Peer reviewe

Les mouvements des fluides dans les végétaux

Résumé anglais par V. Conard, docteur en Médecineinfo:eu-repo/semantics/publishe

Mesure de l'assimilation du glucose: bases théoriques et applications cliniques

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

Aspects de la physiopathologie du diabète

info:eu-repo/semantics/publishe

L'épreuve d'hyperglycémie par voie intraveineuse

The A. recalls the technique of the hyperglycemic intravenous fast test. The measurement of the assimilation coefficient supplies a simple, fast and reproducible appraisal of the glucose avidity of tissues. The physiological bases of the test are discussed and the results obtained in different physiological and pathological situations are presented. © 1965 Springer-Verlag.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Psychoendocrinologie

info:eu-repo/semantics/published

Physiologie métabolique

SYL-2922 = Fascicule 2Fascicule 2 :Physiologie de l'appareil digestif3è édition 1er tirage Année Académique 1978-19793me Candidatureinfo:eu-repo/semantics/published

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3ème tirage Année Académique 1976-1977Ier Doctoratinfo:eu-repo/semantics/publishe

Physiologie pathologique: le rein

SYL-1260 = Fascicule 31e doctoratinfo:eu-repo/semantics/published

Physiopathologie: le foie

SYL-2308 = fascicule 2Année académique 1976-19771er DoctoratFascicule 2 :Le foieinfo:eu-repo/semantics/publishe