Results of a FRSI material test under Space Shuttle ascent conditions in the Ames Research Center 9x7 foot supersonic wind tunnel (OS13). Space Shuttle aerothermodynamic data report

A test was conducted in the NASA/ARC 9 x 7 foot supersonic wind tunnel to verify the integrity of Felt Reusable Surface Insulation (FRSI) material in a panel flutter environment. A FRSI sample panel was subjected to the shocks, pressure gradients, and turbulence characteristics encountered at dynamic pressure 1.5 times the 3(sigma) dispersed trajectory flight conditions of the Space Shuttle. Static and fluctuating pressure data were obtained for Mach numbers ranging from 1.55 to 2.5 with dynamic pressures of 625 to 1250 psf. The FRSI panel suffered no appreciable damage as a result of the test

Results of the space shuttle vehicle ascent air data system probe calibration test using a 0.07-scale external tank forebody model (68T) in the AEDC 16-foot transonic wind tunnel (IA-310), volume 1

A recalibration of the Space Shuttle Vehicle Ascent Air Data System probe was conducted in the Arnold Engineering Development Center (AEDC) transonic wind tunnel. The purpose was to improve on the accuracy of the previous calibration in order to reduce the existing uncertainties in the system. A probe tip attached to a 0.07-scale External Tank Forebody model was tested at angles of attack of -8 to +4 degrees and sideslip angles of -4 to +4 degrees. High precision instrumentation was used to acquire pressure data at discrete Mach numbers ranging from 0.6 to 1.55. Pressure coefficient uncertainties were estimated at less than 0.0020. Data is given in graphical and tabular form

Results of the space shuttle vehicle ascent air data system probe calibration test using a 0.07-scale external tank forebody model (68T) in the AEDC 16-foot transonic wind tunnel (IA-310), volume 2

A recalibration of the Space Shuttle Vehicle Ascent Air Data System probe was conducted in the Arnold Engineering and Development Center (AEDC) transonic wind tunnel. The purpose was to improve on the accuracy of the previous calibration in order to reduce the existing uncertainties in the system. A probe tip attached to a 0.07-scale External Tank Forebody model was tested at angles of attack of -8 to +4 degrees and sideslip angles of -4 to +4 degrees. High precision instrumentation was used to acquire pressure data at discrete Mach numbers ranging from 0.6 to 1.55. Pressure coefficient uncertainties were estimated at less than 0.0020. Additional information is given in tabular form

A bi‐objective procedure to deliver actionable knowledge in sport services

The increase in retention of customer in gyms and health clubs is nowadays a challenge that requires concrete and personalized actions. Traditional data mining studies focused essentially on predictive analytics, neglecting the business domain. This work presents an actionable knowledge discovery system which uses the following pipeline (data collection, predictive model, retention interventions). In the first step, it extracts and transforms existing real data from databases of the sports facilities. In a second step, predictive models are applied to identify user profiles more susceptible to dropout, where actionable withdrawal rules are based on actionable attributes. Finally, in the third step, based on the previous actionable knowledge some of the values of the actionable attributes should be changed in order to increase retention. Simulation of scenarios is carried out, with test and control groups, where business utility and associate cost are measured. This document presents a bi-objective study in order to choose the more efficient scenarios.info:eu-repo/semantics/publishedVersio

04-ERD-052-Final Report

Generating the sequence of the human genome represents a colossal achievement for science and mankind. The technical use for the human genome project information holds great promise to cure disease, prevent bioterror threats, as well as to learn about human origins. Yet converting the sequence data into biological meaningful information has not been immediately obvious, and we are still in the preliminary stages of understanding how the genome is organized, what are the functional building blocks and how do these sequences mediate complex biological processes. The overarching goal of this program was to develop novel methods and high throughput strategies for determining the functions of ''anonymous'' human genes that are evolutionarily deeply conserved in other vertebrates. We coupled analytical tool development and computational predictions regarding gene function with novel high throughput experimental strategies and tested biological predictions in the laboratory. The tools required for comparative genomic data-mining are fundamentally the same whether they are applied to scientific studies of related microbes or the search for functions of novel human genes. For this reason the tools, conceptual framework and the coupled informatics-experimental biology paradigm we developed in this LDRD has many potential scientific applications relevant to LLNL multidisciplinary research in bio-defense, bioengineering, bionanosciences and microbial and environmental genomics

Young children’s impressionable use of teleology: the influence of question wording and questioned topic on teleological explanations for natural phenomena

There is a significant body of research on children's preconceptions concerning scientific concepts and the impact this has upon their science education. One active issue concerns the extent to which young children's explanations for the existence of natural kinds rely on a teleological rationale: for example, rain is for watering the grass, or tigers’ stripes are for camouflage. It has been argued that this teleological tendency hampers children's ability to learn about causality in the natural world. This paper investigates two factors (question wording and topic) which it is argued have led to a misestimation of children's teleological tendencies within the area natural phenomena: i.e., those that are time-constrained, natural events or process such as snow, clouds or night. Sixty-six (5- to 8-years-old) children took part in a repeated-measures experiment, answering both open- and leading-questions across 10 topics of natural phenomena. The findings indicate that children's teleological reasoning may have been overestimated as open question forms significantly reduced their tendency to answer teleologically. Moreover, the concept of teleology is more nuanced than often suggested. Consequently, young children may be more able to learn about causal explanations for the existence of natural phenomena than the literature implies

A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

International audienceRelevant preclinical mouse models are crucial to screen new therapeutic agents for acute myeloid leukemia (AML). Current in vivo models based on the use of patient samples are not easy to establish and manipulate in the laboratory. Our objective was to develop robust xenograft models of human AML using well-characterized cell lines as a more accessible and faster alternative to those incorporating the use of patient-derived AML cells. Five widely used AML cell lines representing various AML subtypes were transplanted and expanded into highly immunodeficient non-obese diabetic/LtSz-severe combined immunodeficiency IL2R gamma(null)(c) mice (for example, cell line-derived xenografts). We show here that bone marrow sublethal conditioning with busulfan or irradiation has equal efficiency for the xenotransplantation of AML cell lines. Although higher number of injected AML cells did not change tumor engraftment in bone marrow and spleen, it significantly reduced the overall survival in mice for all tested AML cell lines. On the basis of AML cell characteristics, these models also exhibited a broad range of overall mouse survival, engraftment, tissue infiltration and aggressiveness. Thus, we have established a robust, rapid and straightforward in vivo model based on engraftment behavior of AML cell lines, all vital prerequisites for testing new therapeutic agents in preclinical studies

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far