Sound Governance and Sound Law

A Review of Administrative Law: Rethinking Judicial Control of Bureaucracy by Christopher F. Edley, Jr

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

Genes as Tags: The Tax Implications of Widely Available Genetic Information

This paper examines how progress in genetics\u27 specifically, the proliferation of knowledge about the human genome\u27 may influence the feasibility and desirability of a tax that is based on individual human endowments or ability. The paper explores various forms that such a genetic endowment tax-and-transfer regime might take and identifies some of the benefits and costs of such a regime. The authors take no position on whether a genetic endowment tax would be desirable or not. However, one contribution of the paper is to observe that current law in the U.S., which restricts the use of genetic information by insurers and employers, is equivalent to a form of genetic endowment tax. The paper also notes that, in the absence of a government-mandated transfer policy with respect to genetic endowments, private insurance markets may arise to fill the gap, allowing individuals to purchase insurance against the possibility of a bad genetic draw

Breaking Ranks: How the Rankings Industry Rules Higher Education and What to Do about It

Some colleges will do anything to improve their national ranking. That can be bad for their students—and for higher education.Since U.S. News & World Report first published a college ranking in 1983, the rankings industry has become a self-appointed judge, declaring winners and losers among America\u27s colleges and universities. In this revealing account, Colin Diver shows how popular rankings have induced college applicants to focus solely on pedigree and prestige, while tempting educators to sacrifice academic integrity for short-term competitive advantage. By forcing colleges into standardized best-college hierarchies, he argues, rankings have threatened the institutional diversity, intellectual rigor, and social mobility that is the genius of American higher education. As a former university administrator who refused to play the game, Diver leads his readers on an engaging journey through the mysteries of college rankings, admissions, financial aid, spending policies, and academic practices. He explains how most dominant college rankings perpetuate views of higher education as a purely consumer good susceptible to unidimensional measures of brand value and prestige. Many rankings, he asserts, also undermine the moral authority of higher education by encouraging various forms of distorted behavior, misrepresentation, and outright cheating by ranked institutions. The recent Varsity Blues admissions scandal, for example, happened in part because affluent parents wanted to get their children into elite schools by any means necessary. Explaining what is most useful and important in evaluating colleges, Diver offers both college applicants and educators a guide to pursuing their highest academic goals, freed from the siren song of the best-college illusion. Ultimately, he reveals how to break ranks with a rankings industry that misleads its consumers, undermines academic values, and perpetuates social inequality.https://scholarship.law.bu.edu/books/1343/thumbnail.jp