245 research outputs found
Dynamical Generation of Extended Objects in a Dimensional Chiral Field Theory: Non-Perturbative Dirac Operator Resolvent Analysis
We analyze the dimensional Nambu-Jona-Lasinio model non-perturbatively.
In addition to its simple ground state saddle points, the effective action of
this model has a rich collection of non-trivial saddle points in which the
composite fields \sigx=\lag\bar\psi\psi\rag and \pix=\lag\bar\psi
i\gam_5\psi\rag form static space dependent configurations because of
non-trivial dynamics. These configurations may be viewed as one dimensional
chiral bags that trap the original fermions (``quarks") into stable extended
entities (``hadrons"). We provide explicit expressions for the profiles of
these objects and calculate their masses. Our analysis of these saddle points
is based on an explicit representation we find for the diagonal resolvent of
the Dirac operator in a \{\sigx, \pix\} background which produces a
prescribed number of bound states. We analyse in detail the cases of a single
as well as two bound states. We find that bags that trap fermions are the
most stable ones, because they release all the fermion rest mass as binding
energy and become massless. Our explicit construction of the diagonal resolvent
is based on elementary Sturm-Liouville theory and simple dimensional analysis
and does not depend on the large approximation. These facts make it, in our
view, simpler and more direct than the calculations previously done by Shei,
using the inverse scattering method following Dashen, Hasslacher, and Neveu.
Our method of finding such non-trivial static configurations may be applied to
other dimensional field theories
KELT-25 b and KELT-26 b: A Hot Jupiter and a Substellar Companion Transiting Young A Stars Observed by TESS
We present the discoveries of KELT-25 b (TIC 65412605, TOI-626.01) and KELT-26 b (TIC 160708862, TOI-1337.01), two transiting companions orbiting relatively bright, early A stars. The transit signals were initially detected by the KELT survey and subsequently confirmed by Transiting Exoplanet Survey Satellite (TESS) photometry. KELT-25 b is on a 4.40 day orbit around the V = 9.66 star CD-24 5016 (Teff=8280-180+440 K, M โ = 2.18-0.11+0.12 M oห), while KELT-26 b is on a 3.34 day orbit around the V = 9.95 star HD 134004 (Teff = 8640-240+500 K, M โ = 1.93-0.16+0.14 M oห), which is likely an Am star. We have confirmed the substellar nature of both companions through detailed characterization of each system using ground-based and TESS photometry, radial velocity measurements, Doppler tomography, and high-resolution imaging. For KELT-25, we determine a companion radius of R P = 1.64-0.043+0.039 R J and a 3ฯ upper limit on the companion\u27s mass of โผ64 M J. For KELT-26 b, we infer a planetary mass and radius of M P = 1.41-0.51+0.43MJ and R P = 1.94-0.058+0.060 R J. From Doppler tomographic observations, we find KELT-26 b to reside in a highly misaligned orbit. This conclusion is weakly corroborated by a subtle asymmetry in the transit light curve from the TESS data. KELT-25 b appears to be in a well-aligned, prograde orbit, and the system is likely a member of the cluster Theia 449
The Sloan Digital Sky Survey Quasar Catalog V. Seventh Data Release
We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar
Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which
contains 105,783 spectroscopically confirmed quasars, represents the conclusion
of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS
objects that have luminosities larger than M_i = -22.0 (in a cosmology with H_0
= 70 km/s/Mpc Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission
line with FWHM larger than 1000 km/s or have interesting/complex absorption
features, are fainter than i > 15.0 and have highly reliable redshifts. The
catalog covers an area of 9380 deg^2. The quasar redshifts range from 0.065 to
5.46, with a median value of 1.49; the catalog includes 1248 quasars at
redshifts greater than four, of which 56 are at redshifts greater than five.
The catalog contains 9210 quasars with i < 18; slightly over half of the
entries have i< 19. For each object the catalog presents positions accurate to
better than 0.1" rms per coordinate, five-band (ugriz) CCD-based photometry
with typical accuracy of 0.03 mag, and information on the morphology and
selection method. The catalog also contains radio, near-infrared, and X-ray
emission properties of the quasars, when available, from other large-area
surveys. The calibrated digital spectra cover the wavelength region 3800-9200
Ang. at a spectral resolution R = 2000 the spectra can be retrieved from the
SDSS public database using the information provided in the catalog. Over 96% of
the objects in the catalog were discovered by the SDSS. We also include a
supplemental list of an additional 207 quasars with SDSS spectra whose archive
photometric information is incomplete.Comment: Accepted, to appear in AJ, 7 figures, electronic version of Table 2
is available, see
http://www.sdss.org/dr7/products/value_added/qsocat_dr7.htm
The Astropy Problem
The Astropy Project (http://astropy.org) is, in its own words, "a community
effort to develop a single core package for Astronomy in Python and foster
interoperability between Python astronomy packages." For five years this
project has been managed, written, and operated as a grassroots,
self-organized, almost entirely volunteer effort while the software is used by
the majority of the astronomical community. Despite this, the project has
always been and remains to this day effectively unfunded. Further, contributors
receive little or no formal recognition for creating and supporting what is now
critical software. This paper explores the problem in detail, outlines possible
solutions to correct this, and presents a few suggestions on how to address the
sustainability of general purpose astronomical software
US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report
This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in
Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Measurement of the charge asymmetry in top-quark pair production in protonโproton collisions at โs = 7 TeV
The difference in angular distributions between top quarks and antiquarks, commonly referred to as the charge asymmetry, is measured in pp collisions at the LHC with the CMS experiment. The data sample corresponds to an integrated luminosity of 1.09 fb[superscript โ1] at a centre-of-mass energy of 7 TeV. Top-quark pairs are selected in the final state with an electron or muon and four or more jets. At least one jet is identified as originating from b-quark hadronization. The charge asymmetry is measured in two variables, one based on the pseudorapidities (ฮท) of the top quarks and the other on their rapidities (y). The results A[ฮท over C] = โ0.017 ยฑ 0.032 (stat.)[+0.025 over โ0.036] (syst.) and A[y over C] = โ0.013 ยฑ 0.028 (stat.)[+0.029 over โ0.031] (syst.) are consistent within uncertainties with the standard-model predictions.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
PhagoSight: an open-source MATLABยฎ package for the analysis of fluorescent neutrophil and macrophage migration in a zebrafish model
Neutrophil migration in zebrafish larvae is increasingly used as a model to study the response of these leukocytes to different determinants of the cellular inflammatory response. However, it remains challenging to extract comprehensive information describing the behaviour of neutrophils from the multi-dimensional data sets acquired with widefield or confocal microscopes. Here, we describe PhagoSight, an open-source software package for the segmentation, tracking and visualisation of migrating phagocytes in three dimensions. The algorithms in PhagoSight extract a large number of measurements that summarise the behaviour of neutrophils, but that could potentially be applied to any moving fluorescent cells. To derive a useful panel of variables quantifying aspects of neutrophil migratory behaviour, and to demonstrate the utility of PhagoSight, we evaluated changes in the volume of migrating neutrophils. Cell volume increased as neutrophils migrated towards the wound region of injured zebrafish. PhagoSight is openly available as MATLABยฎ m-files under the GNU General Public License. Synthetic data sets and a comprehensive user manual are available from http://www.phagosight.org
Exposure to Apoptotic Activated CD4+ T Cells Induces Maturation and APOBEC3G- Mediated Inhibition of HIV-1 Infection in Dendritic Cells
Dendritic cells (DCs) are activated by signaling via pathogen-specific receptors or exposure to inflammatory mediators. Here we show that co-culturing DCs with apoptotic HIV-infected activated CD4+ T cells (ApoInf) or apoptotic uninfected activated CD4+ T cells (ApoAct) induced expression of co-stimulatory molecules and cytokine release. In addition, we measured a reduced HIV infection rate in DCs after co-culture with ApoAct. A prerequisite for reduced HIV infection in DCs was activation of CD4+ T cells before apoptosis induction. DCs exposed to ApoAct or ApoInf secreted MIP-1ฮฑ, MIP-1ฮฒ, MCP-1, and TNF-ฮฑ; this effect was retained in the presence of exogenous HIV. The ApoAct-mediated induction of co-stimulatory CD86 molecules and reduction of HIV infection in DCs were partially abrogated after blocking TNF-ฮฑ using monoclonal antibodies. APOBEC3G expression in DCs was increased in co-cultures of DCs and ApoAct but not by apoptotic resting CD4+ T cells (ApoRest). Silencing of APOBEC3G in DC abrogated the HIV inhibitory effect mediated by ApoAct. Sequence analyses of an env region revealed significant induction of G-to-A hypermutations in the context of GG or GA dinucleotides in DNA isolated from DCs exposed to HIV and ApoAct. Thus, ApoAct-mediated DC maturation resulted in induction of APOBEC3G that was important for inhibition of HIV-infection in DCs. These findings underscore the complexity of differential DC responses evoked upon interaction with resting as compared with activated dying cells during HIV infection
Arousal of Cancer-Associated Stroma: Overexpression of Palladin Activates Fibroblasts to Promote Tumor Invasion
Background: Cancer-associated fibroblasts, comprised of activated fibroblasts or myofibroblasts, are found in the stroma surrounding solid tumors. These myofibroblasts promote invasion and metastasis of cancer cells. Mechanisms regulating the activation of the fibroblasts and the initiation of invasive tumorigenesis are of great interest. Upregulation of the cytoskeletal protein, palladin, has been detected in the stromal myofibroblasts surrounding many solid cancers and in expression screens for genes involved in invasion. Using a pancreatic cancer model, we investigated the functional consequence of overexpression of exogenous palladin in normal fibroblasts in vitro and its effect on the early stages of tumor invasion. Principal Findings: Palladin expression in stromal fibroblasts occurs very early in tumorigenesis. In vivo, concordant expression of palladin and the myofibroblast marker, alpha smooth muscle actin (a-SMA), occurs early at the dysplastic stages in peri-tumoral stroma and progressively increases in pancreatic tumorigenesis. In vitro introduction of exogenous 90 kD palladin into normal human dermal fibroblasts (HDFs) induces activation of stromal fibroblasts into myofibroblasts as marked by induction of a-SMA and vimentin, and through the physical change of cell morphology. Moreover, palladin expression in the fibroblasts enhances cellular migration, invasion through the extracellular matrix, and creation of tunnels through which cancer cells can follow. The fibroblast invasion and creation of tunnels results from the development o
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