IL-6 and IL-1 beta responses to a carbohydrate-electrolyte drink in orienteering athletes

Background: This study was conducted to determine acute effects of carbohydrate-electrolyte (CHO-E) found in sports drinks, ingested just before an orienteering competition, on the levels of plasma IL-6 and IL-1 beta cytokine.Material and methods: The study was conducted in a randomized, double-blind design, including 23 elite orienteering athletes who volunteered to participate. Following the collection of resting specimens of blood, the experimental group (n = 12) was administered a sports drink containing CHO-E, while the placebo group (n = 11) was administered 500 ml of plain water. The subjects were asked to finish the orienteering competition.Result: IL-1 beta level in the 24th hour after the competition was found to be significantly lower than in precompetition and 2 hours after the competition in the placebo group (p 0.05).Conclusion: A drink containing CHO-E might have stopped muscle contraction-associated cytokine production by increasing the tissue stability of the muscles, compensating the loss of fluid and electrolytes from athletes' bodies

Atypical right diaphragmatic hernia (hernia of Morgagni), spigelian hernia and epigastric hernia in a patient with Williams syndrome: a case report

<p>Abstract</p> <p>Introduction</p> <p>Williams syndrome is rare genetic disorder resulting in neurodevelopmental problems. Hernias of the foramen of Morgagni are rare diaphragmatic hernias and they mostly present on the right side, in the anterior mediastinum. They are usually asymptomatic and are difficult to diagnose, especially in patients with learning disabilities.</p> <p>Case presentation</p> <p>This 49-year-old woman with Williams syndrome, cognitive impairment and aortic stenosis presented to physicians with right-sided chest pain. She had previously undergone repair of her right spigelian and epigastric hernia. Her abdominal examination was unremarkable. Chest X-ray suggested right-sided diaphragmatic hernia and pleural effusion for which she received treatment. The computed tomography scan showed a diaphragmatic hernia with some collapse/consolidation of the adjacent lung. Furthermore, the patient had aortic stenosis and was high risk for anaesthesia (ASA grade 3). She underwent successful laparoscopic repair of her congenital diaphragmatic hernia leading to a quick and uneventful postoperative recovery.</p> <p>Conclusion</p> <p>These multiple hernias suggest that patients with Williams syndrome may have some connective tissue disorder which makes them prone to develop hernias especially associated with those parts of the body which may have intracavity pressure variations like the abdomen. Diaphragmatic hernia may be the cause of chest pain in these patients. A computed tomography scan helps in early diagnosis, and laparoscopic repair helps in prevention of further complications, and leads to quick recovery especially in patients with learning disabilities. In the presence of significant comorbidities, a less invasive operative procedure with quick recovery becomes advisable.</p

Optical waveguides written deep inside silicon by Femtosecond Laser

[No abstract available

Effect of grain and secondary phase morphologies in the mechanical and damping behavior of Al7075 alloys

The present study evaluates the role of the microstructure in the static and dynamic mechanical behavior of as-cast Al7075 alloy promoted by ultrasonic treatment (US) during solidification. The characterization of samples revealed that US treatment promoted grain and intermetallics refinement, changed the shape of the intermetallic phases (equilibrium phases of soluble M and/or T (Al, Cu, Mg, Zn) and their insoluble Al-Cu-Fe compounds) and lead to their uniform distribution along the grain boundaries. Consequently, the mechanical properties and damping capacity above critical strain values were enhanced by comparison with values obtained for castings produced without US vibration. This results suggest that the grain and secondary phases refinement by US can be a promising solution to process materials to obtain high damping and high strength characteristics.This research was supported by FEDER/COMPETE funds and by national funds through FCT - Portuguese Foundation for Science and Technology and was developed on the aim of the research Post-Doctoral grant SFRH/BPD/76680/2011. Also, this work has been supported by the FCT in the scope of the project: UID/EEA/04436/2013.info:eu-repo/semantics/publishedVersio

Keeping the Vimentin Network under Control: Cell–Matrix Adhesion–associated Plectin 1f Affects Cell Shape and Polarity of Fibroblasts

Mature focal adhesions and fibrillar adhesions act as anchorage sites for vimentin filaments, with plectin isoform 1f being the crucial linker protein. Plectin serves as a nucleation and assembly center for the de novo formation of vimentin networks. Anchored vimentin creates a resilient cage-like core structure that affects cell shape

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

10.1091/mbc.E12-05-0377Molecular Biology of the Cell24121-30MBCE

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

The PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase (PI3K) activation. PTEN expression has been shown to be decreased in colorectal cancer. Little is known however as to the specific cellular role of PTEN in human intestinal epithelial cells. The aim of this study was to investigate the role of PTEN in human colorectal cancer cells.Caco-2/15, HCT116 and CT26 cells were infected with recombinant lentiviruses expressing a shRNA specifically designed to knock-down PTEN. The impact of PTEN downregulation was analyzed on cell polarization and differentiation, intercellular junction integrity (expression of cell-cell adhesion proteins, barrier function), migration (wound assay), invasion (matrigel-coated transwells) and on tumor and metastasis formation in mice. Electron microscopy analysis showed that lentiviral infection of PTEN shRNA significantly inhibited Caco-2/15 cell polarization, functional differentiation and brush border development. A strong reduction in claudin 1, 3, 4 and 8 was also observed as well as a decrease in transepithelial resistance. Loss of PTEN expression increased the spreading, migration and invasion capacities of colorectal cancer cells in vitro. PTEN downregulation also increased tumor size following subcutaneous injection of colorectal cancer cells in nude mice. Finally, loss of PTEN expression in HCT116 and CT26, but not in Caco-2/15, led to an increase in their metastatic potential following tail-vein injections in mice.Altogether, these results indicate that PTEN controls cellular polarity, establishment of cell-cell junctions, paracellular permeability, migration and tumorigenic/metastatic potential of human colorectal cancer cells

Societal-level versus individual-level predictions of ethical behavior: a 48-society study of collectivism and individualism

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed

7th Drug hypersensitivity meeting: part two

No abstract availabl

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients