1,246 research outputs found
Where to Go: Examining Enforcement of Intra-European Union Arbitration Awards in the United States and United Kingdom Post-Achmea
Letter to the Editor: 1H, 15N, and 13C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis
International audienceNo abstract availabl
Resummed Photon Spectra for WIMP Annihilation
We construct an effective field theory (EFT) description of the hard photon
spectrum for heavy WIMP annihilation. This facilitates precision predictions
relevant for line searches, and allows the incorporation of non-trivial energy
resolution effects. Our framework combines techniques from non-relativistic
EFTs and soft-collinear effective theory (SCET), as well as its multi-scale
extensions that have been recently introduced for studying jet substructure. We
find a number of interesting features, including the simultaneous presence of
SCET and SCET modes, as well as collinear-soft modes
at the electroweak scale. We derive a factorization formula that enables both
the resummation of the leading large Sudakov double logarithms that appear in
the perturbative spectrum, and the inclusion of Sommerfeld enhancement effects.
Consistency of this factorization is demonstrated to leading logarithmic order
through explicit calculation. Our final result contains both the exclusive and
the inclusive limits, thereby providing a unifying description of these two
previously-considered approximations. We estimate the impact on experimental
sensitivity, focusing for concreteness on an SU(2) triplet fermion dark
matter - the pure wino - where the strongest constraints are due to a search
for gamma-ray lines from the Galactic Center. We find numerically significant
corrections compared to previous results, thereby highlighting the importance
of accounting for the photon spectrum when interpreting data from current and
future indirect detection experiments.Comment: 55+25 pages, 11+2 figures; v3, updated an expression in the appendix
to make it applicable at higher order - no impact on the results in this wor
Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study
Background Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic non-cancer pain who had been prescribed opioids, including their reasons for use and perceived effectiveness of cannabis; associations between amount of cannabis use and pain, mental health, and opioid use; the effect of cannabis use on pain severity and interference over time; and potential opioid-sparing effects of cannabis. Methods The Pain and Opioids IN Treatment study is a prospective, national, observational cohort of people with chronic non-cancer pain prescribed opioids. Participants were recruited through community pharmacies across Australia, completed baseline interviews, and were followed up with phone interviews or self-complete questionnaires yearly for 4 years. Recruitment took place from August 13, 2012, to April 8, 2014. Participants were asked about lifetime and past year chronic pain conditions, duration of chronic non-cancer pain, pain self-efficacy, whether pain was neuropathic, lifetime and past 12-month cannabis use, number of days cannabis was used in the past month, and current depression and generalised anxiety disorder. We also estimated daily oral morphine equivalent doses of opioids. We used logistic regression to investigate cross-sectional associations with frequency of cannabis use, and lagged mixed-effects models to examine temporal associations between cannabis use and outcomes. Findings 1514 participants completed the baseline interview and were included in the study from Aug 20, 2012, to April 14, 2014. Cannabis use was common, and by 4-year follow-up, 295 (24%) participants had used cannabis for pain. Interest in using cannabis for pain increased from 364 (33%) participants (at baseline) to 723 (60%) participants (at 4 years). At 4-year follow-up, compared with people with no cannabis use, we found that participants who used cannabis had a greater pain severity score (risk ratio 1·14, 95% CI 1·01-1·29, for less frequent cannabis use; and 1·17, 1·03-1·32, for daily or near-daily cannabis use), greater pain interference score (1·21, 1·09-1·35; and 1·14, 1·03-1·26), lower pain self-efficacy scores (0·97, 0·96-1·00; and 0·98, 0·96-1·00), and greater generalised anxiety disorder severity scores (1·07, 1·03-1·12; and 1·10, 1·06-1·15). We found no evidence of a temporal relationship between cannabis use and pain severity or pain interference, and no evidence that cannabis use reduced prescribed opioid use or increased rates of opioid discontinuation. Interpretation Cannabis use was common in people with chronic non-cancer pain who had been prescribed opioids, but we found no evidence that cannabis use improved patient outcomes. People who used cannabis had greater pain and lower self-efficacy in managing pain, and there was no evidence that cannabis use reduced pain severity or interference or exerted an opioid-sparing effect. As cannabis use for medicinal purposes increases globally, it is important that large well designed clinical trials, which include people with complex comorbidities, are conducted to determine the efficacy of cannabis for chronic non-cancer pain
Molecular Gas in the z=1.2 Ultraluminous Merger GOODS J123634.53+621241.3
We report the detection of CO(2-1) emission from the z=1.2 ultraluminous
infrared galaxy (ULIRG) GOODS J123634.53+621241.3 (also known as the
sub-millimeter galaxy GN26). These observations represent the first discovery
of high-redshift CO emission using the new Combined Array for Research in
Millimeter-Wave Astronomy (CARMA). Of all high-redshift (z>1) galaxies within
the GOODS-North field, this source has the largest far-infrared (FIR) flux
observed in the Spitzer 70um and 160um bands. The CO redshift confirms the
optical identification of the source, and the bright CO(2-1) line suggests the
presence of a large molecular gas reservoir of about 7x10^10 M(sun). The
infrared-to-CO luminosity ratio of L(IR)/L'(CO) = 80+/-30 L(sun) (K Km/s
pc^2)^-1 is slightly smaller than the average ratio found in local ULIRGs and
high-redshift sub-millimeter galaxies. The short star-formation time scale of
about 70 Myr is consistent with a starburst associated with the merger event
and is much shorter than the time scales for spiral galaxies and estimates made
for high-redshift galaxies selected on the basis of their B-z and z-K colors.Comment: Accepted for publication in ApJ Letter
Transient disruption of M1 during response planning impairs subsequent offline consolidation
Transcranial magnetic stimulation (TMS) was used to probe the involvement of the left primary motor cortex (M1) in the consolidation of a sequencing skill. In particular we asked: (1) if M1 is involved in consolidation of planning processes prior to response execution (2) whether movement preparation and movement execution can undergo consolidation independently and (3) whether sequence consolidation can occur in a stimulus specific manner. TMS was applied to left M1 while subjects prepared left hand sequential finger responses for three different movement sequences, presented in an interleaved fashion. Subjects also trained on three control sequences, where no TMS was applied. Disruption of subsequent consolidation was observed, but only for sequences where subjects had been exposed to TMS during training. Further, reduced consolidation was only observed for movement preparation, not movement execution. We conclude that left M1 is causally involved in the consolidation of effective response planning for left hand movements prior to response execution, and mediates consolidation in a sequence specific manner. These results provide important new insights into the role of M1 in sequential memory consolidation and sequence response planning
What makes you not a Buddhist? : a preliminary mapping of values
This study sets out to establish which Buddhist values contrasted with or were shared by adolescents from a non-Buddhist population. A survey of attitude toward a variety of Buddhist values was fielded in a sample of 352 non-Buddhist schoolchildren aged between 13 and 15 in London. Buddhist values where attitudes were least positive concerned the worth of being a monk/nun or meditating, offering candles & incense on the Buddhist shrine, friendship on Sangha Day, avoiding drinking alcohol, seeing the world as empty or impermanent and Nirvana as the ultimate peace. Buddhist values most closely shared by non-Buddhists concerned the Law of Karma, calming the mind, respecting those deserving of respect, subjectivity of happiness, welfare work, looking after parents in old age and compassion to cuddly animals. Further significant differences of attitude toward Buddhism were found in partial correlations with the independent variables of sex, age and religious affiliation. Correlation patterns paralleled those previously described in theistic religions. Findings are applied to spiritual, moral, social and cultural development and for the teaching of religious to pupils of no faith adherence. The study recommends that quantitative psychometrics employed to conceptualize Buddhist values by discriminant validity in this study could be extended usefully to other aspects of the study of Buddhism, particularly in quest of validity in the conceptualization of Buddhist identity within specifically Buddhist populations
A classification of chronic pain for ICD-11.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450869
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