Internet of things: Conceptual network structure, main challenges and future directions

Internet of Things (IoT) is a key technology trend that supports our digitalized society in applications such as smart countries and smart cities. In this study, we investigate the existing strategic themes, thematic evolution structure, key challenges, and potential research opportunities associated with the IoT. For this study, we conduct a Bibliometric Performance and Network Analysis (BPNA), supplemented by an exhaustive Systematic Literature Review (SLR). Specifically, in BPNA, the software SciMAT is used to analyze 14,385 documents and 30,381 keywords in the Web of Science (WoS) database, which was released between 2002 and 2019. The results reveal that 31 clusters are classified according to their importance and development, and the conceptual structures of key clusters are presented, along with their performance analysis and the relationship with other subthemes. The thematic evolution structure describes the important cluster(s) over time. For the SLR, 23 documents are analyzed. The SLR reveals key challenges and limitations associated with the IoT. We expect the results will form the basis of future research and guide decision-making in the IoT and other supporting industries.Coordenaç~ao de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Finance Code 001 and the Spanish Ministry of Science and Innovation under grants PID2019-105381 GA-100 (iScience)Consejo Nacional de Ciencia y Tecnología (CONACYT) and Direcci on General de Relaciones Exteriores (DGRI

A Rule-Learning Approach for Detecting Faults in Highly Configurable Software Systems from Uniform Random Samples

Software systems tend to become more and more configurable to satisfy the demands of their increasingly varied customers. Exhaustively testing the correctness of highly configurable software is infeasible in most cases because the space of possible configurations is typically colossal. This paper proposes addressing this challenge by (i) working with a representative sample of the configurations, i.e., a ``uniform'' random sample, and (ii) processing the results of testing the sample with a rule induction system that extracts the faults that cause the tests to fail. The paper (i) gives a concrete implementation of the approach, (ii) compares the performance of the rule learning algorithms AQ, CN2, LEM2, PART, and RIPPER, and (iii) provides empirical evidence supporting our procedure

Rough Sets: a Bibliometric Analysis from 2014 to 2018

Along almost forty years, considerable research has been undertaken on rough set theory to deal with vague information. Rough sets have proven to be extremely helpful for a diversity of computer-science problems (e.g., knowledge discovery, computational logic, machine learning, etc.), and numerous application domains (e.g., business economics, telecommunications, neurosciences, etc.). Accordingly, the literature on rough sets has grown without ceasing, and nowadays it is immense. This paper provides a comprehensive overview of the research published for the last five years. To do so, it analyzes 4,038 records retrieved from the Clarivate Web of Science database, identifying (i) the most prolific authors and their collaboration networks, (ii) the countries and organizations that are leading research on rough sets, (iii) the journals that are publishing most papers, (iv) the topics that are being most researched, and (v) the principal application domains

Data Sources as a Driver for Market‑Oriented Tourism Organizations: a Bibliometric Perspective

This paper presents a conceptual framework that accurately represents the current and future perspectives of data-driven companies in tourism by means of an analysis of the data sources used in the data-driven tourism research literature, as well as the research topics to which they are applied. For this purpose, a bibliometric analysis of data-driven tourism research is carried out. The framework of the study is all tourism-related publications whose research was based on data sources during the period 1982–2020. The results show some of the basic bibliometric performance indicators and the maps of science. The main themes of research interest are identified, and the conceptual evolution is obtained based on these maps. Three major thematic areas are identified: tourism research topics, information sources, and data analysis techniques. Based on these three thematic areas, the conceptual model of data architecture and processes of a data-driven organization in the tourism sector are obtained. An additional qualitative analysis of the three thematic areas is performedCRUE-CSIC agreement with Springer Natur

First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update

Inmunoterapia dual; Ipilimumab; NivolumabImmunoteràpia dual; Ipilimumab; NivolumabDual immunotherapy; Ipilimumab; NivolumabBackground To further characterize survival benefit with first-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone, we report updated data from the phase III CheckMate 9LA trial with a 2-year minimum follow-up. Patients and methods Adult patients were treatment naïve, with stage IV/recurrent non-small-cell lung cancer, no known sensitizing EGFR/ALK alterations, and an Eastern Cooperative Oncology Group performance status ≤1. Patients were randomized 1 : 1 to nivolumab 360 mg every 3 weeks plus ipilimumab 1 mg/kg every 6 weeks with two cycles of chemotherapy, or four cycles of chemotherapy. Updated efficacy and safety outcomes are reported, along with progression-free survival (PFS) after next line of treatment (PFS2), treatment-related adverse events (TRAEs) by treatment cycle, and efficacy outcomes in patients who discontinued all treatment components in the experimental arm due to TRAEs. Results With a median follow-up of 30.7 months, nivolumab plus ipilimumab with chemotherapy continued to prolong overall survival (OS) versus chemotherapy. Median OS was 15.8 versus 11.0 months [hazard ratio 0.72 (95% confidence interval 0.61-0.86)]; 2-year OS rate was 38% versus 26%. Two-year PFS rate was 20% versus 8%. ORR was 38% versus 25%, respectively; 34% versus 12% of all responses were ongoing at 2 years. Median PFS2 was 13.9 versus 8.7 months. Improved efficacy outcomes in the experimental versus control arm were observed across most subgroups, including by programmed death-ligand 1 and histology. No new safety signals were observed; onset of grade 3/4 TRAEs was mostly observed during the first two treatment cycles in the experimental arm. In patients who discontinued all components of nivolumab plus ipilimumab with chemotherapy treatment due to TRAEs (n = 61) median OS was 27.5 months; 56% of responders had an ongoing response ≥1 year after discontinuation. Conclusions With a 2-year minimum follow-up, nivolumab plus ipilimumab with two cycles of chemotherapy provided durable efficacy benefits over chemotherapy with a manageable safety profile and remains an efficacious first-line treatment of advanced non-small-cell lung cancer.This work was supported by Bristol Myers Squibb (Princeton, New Jersey) (no grant number). Authors received no financial support or compensation for publication of this manuscript

La acústica submarina y su desarrollo desde la creación del Instituto de Acústica

PACS: 43.30.Xm; 43.30.Yj; 43.30.Vh; 43.30.Nb; 43.30.Ma.-- Publicado en el Vol. XXXI, núm. 3-4, tercer y cuarto trimestre 2000 de la Revista de Acústica: Número especial dedicado al XXV Aniversario del Instituto de Acústica del C.S.I.C.[ES] La Acústica Submarina fue una de las líneas de la Acústica que se desarrollan en el Instituto desde los primeros tiempos. Este trabajo describe como se inició, cómo se desarrolló y el estado actual de este campo.[EN] Underwater Acoustics was one line of Acoustics first developped at the Instituto de Acústica. This paper presents a description of the activities in the underwater field, done since 1969, when the Underwater Tank was installed, up to the present times.Peer reviewe

Effects of amphetamine on development of oral candidiasis in rats

[Abstract] Experiments were conducted to evaluate the effects of amphetamine (0.4 mg/kg of body weight/day) on the development of oral candidiasis in Sprague-Dawley rats. Animals were submitted to surgical hyposalivation in order to facilitate the establishment and persistence of Candida albicans infection. Treatment with drugs (placebo or amphetamine) was initiated 7 days before C. albicans inoculation and lasted until the end of the experiments, day 15 postinoculation. Establishment of C. albicans infection was evaluated by swabbing the inoculated oral cavity with a sterile cotton applicator on days 2 and 15 after inoculation, followed by plating on YEPD (yeast extract-peptone-dextrose) agar. Tissue injury was determined by the quantification of the number and type (normal or abnormal) of papillae on the dorsal tongue per microscopic field. A semiquan- titative scale was devised to assess the degree of colonization of the epithelium by fungal hyphae. Our results show that amphetamine exacerbates C. albicans infection of the tongues of rats. Significant increases in Candida counts, the percentage of the tongue’s surface covered with clinical lesions, the percentage of abnormal papillae, and the colonization of the epithelium by fungal hyphae were found in amphetamine-treated rats compared to those found in the rats injected with a placebo. The last two parameters increased in rats treated with the placebo compared to the parameters of the untreated control rats

Author Correction: Multifunctional light beam control device by stimuli-responsive liquid crystal micro-grating structures

Correction to: Scientific Reports https://doi.org/10.1038/s41598-020-70783-8, published online 14 August 2020 This Article contains a typographical error in the Acknowledgements section. “the Ministerio de Economía y Competitividad of Spain (TEC2013-47342-C2-2-R)” should read: "the Ministerio de Economía y Competitividad of Spain (TEC2016-77242-C3-1-R)"This work was supported by the Comunidad de Madrid and FEDER Program (S2018/NMT-4326), the Ministerio de Economía y Competitividad of Spain (TEC2013-47342-C2-2-R and TEC2016-76021-C2-2-R), the FEDER/Ministerio de Ciencia, Innovación y Universidades and Agencia Estatal de Investigación (RTC2017-6321-1, PID2019-109072RB-C31 and PID2019-107270RB-C21). The authors also acknowledge the support by the Ministry of National Defense of Poland (GBMON/13-995/2018/WAT), Military University of Technology (Grant no. 23-895)

Effect of serum phosphate on parathyroid hormone secretion during hemodialysis

Effect of serum phosphate on parathyroid hormone secretion during hemodialysis.BackgroundRecent studies have demonstrated that a high concentration of phosphate directly stimulates parathyroid hormone (PTH) secretion. High serum levels of phosphate are usually observed in patients with end-stage renal disease. The aim of the present study was to evaluate whether serum phosphate concentration had an acute effect on PTH secretion in hemodialysis patients. The levels of serum phosphate were manipulated during the hemodialysis session by using a phosphate free dialysate or a dialysate with a high content of phosphate.MethodsTen stable hemodialysis patients with PTH values above 300 pg/ml were included in the study. A PTH-calcium curve was obtained during both high phosphate and phosphate free hemodialysis.ResultsThe serum phosphate concentration remained high (2.17 ± 0.18mM) throughout the high phosphate hemodialysis and decreased progressively to normal levels (1.02 ± 0.06mM) during the phosphate free hemodialysis. The serum PTH levels at maximal inhibition by hypercalcemia (minimal PTH) were greater during the high phosphate than the phosphate free hemodialysis (413 ± 79 vs. 318 ± 76 pg/ml, P < 0.003). In all patients the values of minimum PTH were greater during the high phosphorus than the phosphorus free hemodialysis. The values of maximally stimulated PTH during hypocalcemia and the set point of the PTH-calcium curve were similar during the high phosphate and the phosphate free hemodialysis.ConclusionThe maintenance of high serum phosphorus levels during hemodialysis prevented, in part, the inhibition of PTH secretion by calcium, which strongly suggests that in hemodialysis patients high serum phosphate contributes directly to the elevation of PTH levels despite normal or high serum calcium concentration

Production Trends, Collaboration, and Main Topics of the Integrative and Complementary Oncology Research Area: A Bibliometric Analysis

Background: The prevalence of cancer has increased over time worldwide. Nevertheless, the number of deaths has been reduced during the past 2 decades. Thus, one-third of the cancer patients are users of complementary and alternative therapies, looking for other types of interventions. The main aim of the present study is to understand the current status of the research in integrative and complementary oncology. Three different aspects were analyzed: production trends, country collaboration, and leading research topics. Methods: The dataset was obtained from the documents indexed under the Integrative and Complementary Medicine category of the Web of Science database from 1976 to 2017. VOSviewer and SciMAT software were employed to perform the bibliometric analysis. Results: The Journal of Ethnopharmacology, China Medical University and the People’s Republic of China are the leading producers in the field. Regarding the collaboration, the United States and China present a close connection. The scientific community is focused on the following topics: apoptosis, breast cancer, oxidative stress, chemotherapy, and nuclear factor-Kappa-B (NF-Kappa-B). Conclusions: The present article shows potentially important information that allows understanding of the past, present, and future of research in integrative and complementary oncology. It is a useful evidence-based framework on which to base future research actions and academic directions