Examining the Relationship Between Perfect Pitch, Auditory Processing Disorders, and Autism Spectrum Disorder

In this paper, I will examine the relationship between perfect pitch, auditory processing disorders, and autism spectrum disorders and how this potential relationship affects the music education of students living with these conditions. Thorough and analytical perspectives are presented on one or more of these diagnoses, providing the opportunity to make thoughtful and relevant connections to students inside and outside of the classroom. Dohn, Garza-Villareal, Heaton, and Vust (2012) and Jiang, Liu, Wan, and Jiang (2015) discuss their research on the heightened presence of autism traits in musicians with perfect pitch and the idea of pitch processing and intonation in terms of melodic contour in autistic speakers of tonal languages, respectively. In addition, the role of auditory processing in perfect pitch possessors is explored by McKetton and Schneider (2018) and in students with autism spectrum disorder by Remington and Fairnie (2017). Each of these perspectives provides the opportunity to make connections to the music educations of students living with these conditions

Effect of perennial water on soil, vegetation and wild herbivore distribution in southeastern Zimbabwe.

Thesis (M.Sc.)-University of Natal, Pietermaritzburg, 1999.The effects of artificially supplied perennial water on soil properties, vegetation dynamics and the distribution of large herbivores was investigated in southeastern Zimbabwe. Data collection took place between March 1997 and July 1998. Water points were situated primarily on three different soil types (clay-loam, sandy-clay-loam and sand), and in four different vegetation types (Hill communities, Colophospermum mopane veld, Acacia nigrescens woodland and Albizia petersiana woodland). One water point in C. mopane veld (Bandama) had been closed two years prior to data collection, while another, in the Hill community (Manyoka), had been introduced, two years prior to data collection. Changes in physical (infiltration) and chemical (organic carbon and nutrients) properties of soils around water points were largely restricted to within 100 m of water. Chemical enrichment of the soil occurred only at water points that had been in place for more than two years. Soil surface conditions were altered to distances beyond 100 m from water. Manyoka (the new water point) was an exception, with extreme changes limited to within 100 m of water. Herbaceous and woody species composition changed in response to distance from water with changes best described by asymptotic equations. Changes in species composition of the woody component appeared to be longer lasting than changes to the herbaceous component. Most perennial grass species declined close to water, but Urochloa mosambicensis increased close to water in areas outside of the Hills. Herbaceous species diversity was adversely affected by distance from water on sandy soils (Hill communities and A. petersiana woodland), but was largely unaffected on clay-loam (A. nigrescens woodland) and sandy-clay-loam soils (C. mopane veld). Woody species composition and density was altered out to 500 m from perennial water in Acacia nigrescens woodland on clay-loam soils. Results suggest that this vegetation type may be susceptible to bush encroachment close to water. Trends in woody canopy utilisation were generally similar to trends in woody species composition, and it is proposed that the former may be used to indicate future changes in the latter. Conversion of trees to shrubs was highest at Manyoka (the new water point) indicating that woody destruction by elephants is extreme during the initial years following water introduction. Large herbivore biomass was greatest close to water (< 1 km) during the dry season but not during the wet season. Herbivore species distributions appeared to be influenced by the position of perennial water, but since all range was within easy access of water, it is unlikely that animal distributions were constrained directly by the position of surface water. It is more likely that herbivores were spatially separated on the basis of habitat type

The epoch of Queen Elizabeth II: Continuity and rupture in small states and territories

The death of Queen Elizabeth II in September 2022 after 70 years on the throne and the ascent of King Charles III precipitated much discussion about the role and relevancy of the British Monarch across the Commonwealth and more particularly whether it was time for those countries who still retained the Monarch as their head of state to move to a republican system. Change is likely, but it may well happen more slowly than commentators first thought. Indeed, the extent of influence and authority of the Crown remains significant, none more so than in the United Kingdom’s Crown Dependencies and Overseas Territories. This guest editorial introduction offers an overview of the legacy of Queen Elizabeth’s reign, the challenges facing her successor and, despite broad public debates about how decolonisation can be completed, illustrates that it is far too early in many places to dismiss or discard the continuing role of the Crown

RNA interference of gonadotropin-inhibitory hormone gene induces arousal in songbirds.

Gonadotropin-inhibitory hormone (GnIH) was originally identified in quail as a hypothalamic neuropeptide inhibitor of pituitary gonadotropin synthesis and release. However, GnIH neuronal fibers do not only terminate in the median eminence to control anterior pituitary function but also extend widely in the brain, suggesting it has multiple roles in the regulation of behavior. To identify the role of GnIH neurons in the regulation of behavior, we investigated the effect of RNA interference (RNAi) of the GnIH gene on the behavior of white-crowned sparrows, a highly social songbird species. Administration of small interfering RNA against GnIH precursor mRNA into the third ventricle of male and female birds reduced resting time, spontaneous production of complex vocalizations, and stimulated brief agonistic vocalizations. GnIH RNAi further enhanced song production of short duration in male birds when they were challenged by playbacks of novel male songs. These behaviors resembled those of breeding birds during territorial defense. The overall results suggest that GnIH gene silencing induces arousal. In addition, the activities of male and female birds were negatively correlated with GnIH mRNA expression in the paraventricular nucleus. Density of GnIH neuronal fibers in the ventral tegmental area was decreased by GnIH RNAi treatment in female birds, and the number of gonadotropin-releasing hormone neurons that received close appositions of GnIH neuronal fiber terminals was negatively correlated with the activity of male birds. In summary, GnIH may decrease arousal level resulting in the inhibition of specific motivated behavior such as in reproductive contexts

Further Development and Validation of the electronic Frailty Index using the Secure Anonymised Information Linkage Databank

Introduction Aging populations with increasing frailty have major implications for health services internationally, and evidence-based treatment becomes increasingly important. The development of an electronic Frailty Index (eFI) using routine primary care data facilitates implementation of evidence-based interventions. However, the eFI does not account for time restrictions regarding when information was recorded. Objectives and Approach Our aim is to implement and further validate the eFI using the Secure Anonymised Information Linkage (SAIL) databank, introducing refinements based on time restrictions. Our implementation of the eFI identifies frailty based on 1574 Read codes, which are mapped amongst 36 categories known as deficits. The eFI is based on the internationally established cumulative deficit model, and each deficit contributes equally to the eFI value. However, although each deficit is equally weighted, only one of them is currently time dependent. We therefore analyse the time at which each deficit is identified, and propose time dependent cut-points based on our findings. Results We were able to successfully implement the eFI using data from over 400,000 individuals from the Welsh population using data held in the SAIL databank. Our results agree with the baseline characteristics and distributions of frailty found in the original development of the eFI. We also found that the percentage of individuals identified as frail increased as the number of years of records included was increased. Furthermore, the increase in percentage year by year was almost linear for a number of the deficits. This led to the identification of time bounds for particular deficits, which could help to refine future implementations of the eFI. Conclusion/Implications Our work validates and refines the eFI, which is a particularly useful resource as it uses existing primary care data to identify frailty, meaning no additional resources are required. Furthermore, our implementation is readily available, meaning that future research related to frailty is easily reproducible and achievable by others

Routinely Identifying frailty: Implementing the electronic Frailty Index in the Secure Anonymised Information Linkage Databank

Background Aging populations with increasing frailty have major implications for health services, and evidence-based treatment becomes increasingly important. The development of the electronic Frailty Index (eFI) using routine primary care data facilitates the implementation of evidence-based interventions and care. Method Our implementation of the eFI in the Secure Anonymised Information Linkage (SAIL) databank identifies frailty based on 1574 Read codes, which are mapped amongst 36 categories known as deficits. The eFI is based on a cumulative deficit model, and each deficit contributes equally to the eFI value. Findings Although each deficit is equally weighted, only one is currently time dependent. We therefore analysed the cumulative prevalence of each deficit on a year-by-year basis. This led to the identification of time bounds for particular deficits, which will help to refine future implementations of the eFI. We also further validated the eFI using data from over 400,000 individuals held in SAIL. Conclusion The eFI is particularly useful as it uses existing data to identify frailty, meaning no additional resources are required. Furthermore, our implementation is readily available, meaning that future research related to frailty is easily achievable by others

Cognitive flexibility supports the development of cumulative cultural learning in children

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ISO LWS Spectroscopy of M82: A Unified Evolutionary Model

We present the first complete far-infrared spectrum (43 to 197 um) of M82, the brightest infrared galaxy in the sky, taken with the Long Wavelength Spectrometer of the Infrared Space Observatory (ISO). We detected seven fine structure emission lines, [OI] 63 and 145 um, [OIII] 52 and 88 um, [NII] 122 um, [NIII] 57 um and [CII] 158 um, and fit their ratios to a combination starburst and photo-dissociation region (PDR) model. The best fit is obtained with HII regions with n = 250 cm^{-3} and an ionization parameter of 10^{-3.5} and PDRs with n = 10^{3.3} cm^{-3} and a far-ultraviolet flux of G_o = 10^{2.8}. We applied both continuous and instantaneous starburst models, with our best fit being a 3-5 Myr old instantaneous burst model with a 100 M_o cut-off. We also detected the ground state rotational line of OH in absorption at 119.4 um. No excited level OH transitions are apparent, indicating that the OH is almost entirely in its ground state with a column density ~ 4x10^{14} cm^{-2}. The spectral energy distribution over the LWS wavelength range is well fit with a 48 K dust temperature and an optical depth, tau_{Dust} proportional to lambda^{-1}.Comment: 23 pages, 4 figures, accepted by ApJ, Feb. 1, 199