Synthetic Approaches to Naturally Occurring Cyclopentanes

PART I. Five synthetic routes to the prostaglandins, a group of highly substituted cyclopentanes, have been explored. The first four routes were unsuccessful but have provided interesting and useful information on a variety of substituted cyclopentanes. The fifth route has resulted in the isolation of 2-(6-cyanohexyl)-3-(oct-l-yn-3-ol) cyclopent-2-enone. The transformation of this important intermediate into the prostaglandin structure requires three further structural changes - the hydrolysis of the nitrile group, the selective reduction of the enyne system to a trans double bond and the introduction of a second oxygen function into the cyclopentane ring

Test of Lorentz Invariance in Electrodynamics Using Rotating Cryogenic Sapphire Microwave Oscillators

We present the first results from a rotating Michelson-Morley experiment that uses two orthogonally orientated cryogenic sapphire resonator-oscillators operating in whispering gallery modes near 10 GHz. The experiment is used to test for violations of Lorentz Invariance in the frame-work of the photon sector of the Standard Model Extension (SME), as well as the isotropy term of the Robertson-Mansouri-Sexl (RMS) framework. In the SME we set a new bound on the previously unmeasured $\tilde{\kappa}_{e-}^{ZZ}$ component of $2.1(5.7)\times10^{-14}$, and set more stringent bounds by up to a factor of 7 on seven other components. In the RMS a more stringent bound of $-0.9(2.0)\times 10^{-10}$ on the isotropy parameter, $P_{MM}=\delta - \beta + {1/2}$ is set, which is more than a factor of 7 improvement. More detailed description of the experiment and calculations can be found in: hep-ph/0506200Comment: Final published version, 4 pages, references adde

Evaluation Research and Institutional Pressures: Challenges in Public-Nonprofit Contracting

This article examines the connection between program evaluation research and decision-making by public managers. Drawing on neo-institutional theory, a framework is presented for diagnosing the pressures and conditions that lead alternatively toward or away the rational use of evaluation research. Three cases of public-nonprofit contracting for the delivery of major programs are presented to clarify the way coercive, mimetic, and normative pressures interfere with a sound connection being made between research and implementation. The article concludes by considering how public managers can respond to the isomorphic pressures in their environment that make it hard to act on data relating to program performance.This publication is Hauser Center Working Paper No. 23. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers

FUSE Measurements of Far Ultraviolet Extinction. I. Galactic Sight Lines

We present extinction curves that include data down to far ultraviolet wavelengths (FUV; 1050 - 1200 A) for nine Galactic sight lines. The FUV extinction was measured using data from the Far Ultraviolet Spectroscopic Explorer. The sight lines were chosen for their unusual extinction properties in the infrared through the ultraviolet; that they probe a wide range of dust environments is evidenced by the large spread in their measured ratios of total-to-selective extinction, R_V = 2.43 - 3.81. We find that extrapolation of the Fitzpatrick & Massa relationship from the ultraviolet appears to be a good predictor of the FUV extinction behavior. We find that predictions of the FUV extinction based upon the Cardelli, Clayton & Mathis (CCM) dependence on R_V give mixed results. For the seven extinction curves well represented by CCM in the infrared through ultraviolet, the FUV extinction is well predicted in three sight lines, over-predicted in two sight lines, and under-predicted in 2 sight lines. A Maximum Entropy Method analysis using a simple three component grain model shows that seven of the nine sight lines in the study require a larger fraction of grain materials to be in dust when FUV extinction is included in the models. Most of the added grain material is in the form of small (radii < 200 A) grains.Comment: Accepted for publication in the Astrophysical Journal. 31 pages with 7 figure

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.

Mutations in the charged multivesicular body protein 2B (CHMP2B) cause frontotemporal dementia (FTD). We report that mice which express FTD-causative mutant CHMP2B at physiological levels develop a novel lysosomal storage pathology characterised by large neuronal autofluorescent aggregates. The aggregates are an early and progressive pathology that occur at 3 months of age and increase in both size and number over time. These autofluorescent aggregates are not observed in mice expressing wild-type CHMP2B, or in non-transgenic controls, indicating that they are a specific pathology caused by mutant CHMP2B. Ultrastructural analysis and immuno- gold labelling confirmed that they are derived from the endolysosomal system. Consistent with these findings, CHMP2B mutation patient brains contain morphologically similar autofluorescent aggregates. These aggregates occur significantly more frequently in human CHMP2B mutation brain than in neurodegenerative disease or age-matched control brains. These data suggest that lysosomal storage pathology is the major neuronal pathology in FTD caused by CHMP2B mutation. Recent evidence suggests that two other genes associated with FTD, GRN and TMEM106B are important for lysosomal function. Our identification of lysosomal storage pathology in FTD caused by CHMP2B mutation now provides evidence that endolysosomal dysfunction is a major degenerative pathway in FTD

Seasonal variation in the correlation between anomalies of sea level and chlorophyll in the Antarctic Circumpolar Current

The Antarctic Circumpolar Current (ACC) has highly energetic mesoscale phenomena, but their impacts on phytoplankton biomass, productivity, and biogeochemical cycling are not understood well. We analyze satellite observations and an eddy‐rich ocean model to show that they drive chlorophyll anomalies of opposite sign in winter versus summer. In winter, deeper mixed layers in positive sea surface height (SSH) anomalies reduce light availability, leading to anomalously low chlorophyll concentrations. In summer with abundant light, however, positive SSH anomalies show elevated chlorophyll concentration due to higher iron level, and an iron budget analysis reveals that anomalously strong vertical mixing enhances iron supply to the mixed layer. Features with negative SSH anomalies exhibit the opposite tendencies: higher chlorophyll concentration in winter and lower in summer. Our results suggest that mesoscale modulation of iron supply, light availability and vertical mixing plays an important role in causing systematic variations in primary productivity over the seasonal cycle

Group art therapy as an adjunctive treatment for people with schizophrenia: multicentre pragmatic randomised trial

Objectives To evaluate the clinical effectiveness of group art therapy for people with schizophrenia and to test whether any benefits exceed those of an active control treatment

Performance evaluation of active wireline heave compensation systems in marine well logging environments

The basic functionality and performance of a new Schlumberger active wireline heave compensation system on the JOIDES Resolution was evaluated during the sea trial and a 3-year period of the IODP Phase II operations. A suite of software programs was developed to enable real-time monitoring of the dynamics of logging tools, and assess the efficiency of wireline heave compensation during downhole operations. The evaluation of the system effectiveness was performed under normal logging conditions as well as during stationary tests. Logging data were analyzed for their overall quality and repeatability, and to assess the reliability of high-resolution data such as formation microscanner (FMS) electrical images. This revealed that the system reduces 65–80 % of displacement or 88–98 % variance of downhole tool motion in stationary mode under heave conditions of ±0.2–1.5 m and water depths of 300–4,500 m in open holes. Under similar water/heave conditions, the compensator system reduces tool displacement by 50–60 %, or 75–84 % variance in downhole tool motion during normal logging operations. Such compensation efficiency (CE) is comparable to previous compensation systems, but using advanced and upgradeable technologies, and provides 50–85 % heave motion and heave variance attenuation. Moreover, logging down/up at low speeds (300–600 m/h) reduces the system’s CE values by 15–20 %, and logging down at higher speeds (1,000–1,200 m/h) eliminates CE values by 55–65 %. Considering the high quality of the logging data collected, it is concluded that the new system can provide an improved level of compensation over previous systems. Also, if practically feasible, future integration of downhole cable dynamics as an input feedback into the current system could further improve its compensation efficiency during logging operations

Placing Joseph Banks in the North Pacific

The South Pacific was a fulcrum of Joseph Banks's maritime world and global networks. The North Pacific was a distance and intangible fringe. This article is concerned with how Banks should be ‘placed’ in the North Pacific. It tracks how Banks's activities have been delineated in terms of languages and categories of global and local, and centre and margin, and then considers the historical and geographical specifics apposite to his connection to the North Pacific. In this setting, ideas of place (as location and assignment) and capital (as a circulatory and everyday practice of exchange and opportunism) come into view and question the distinction between science and commerce in Banks historiography. The article considers a diverse group of non-Indigenous figures – explorers, traders, cartographers, scientists, collectors – operating in the North Pacific in the 1780s and 1790s whose initiatives and missives passed across Banks's desk, and assesses their place in Banks's archive by drawing on Peter Sloterdijk's ideas about the interiorising and exteriorising logic of capital.PostprintPeer reviewe

Understanding earthquake hazards in southern California - the "LARSE" project - working toward a safer future for Los Angeles

The Los Angeles region is underlain by a network of active faults, including many that are deep and do not break the Earth’s surface. These hidden faults include the previously unknown one responsible for the devastating January 1994 Northridge earthquake, the costliest quake in U.S. history. So that structures can be built or strengthened to withstand the quakes that are certain in the future, the Los Angeles Region Seismic Experiment (LARSE) is locating hidden earthquake hazards beneath the region to help scientists determine where the strongest shaking will occur