Extraction of silymarin compounds from milk thistle (Silybum marianum) seed using hot, liquid water as the solvent

High-value specialty chemicals are usually obtained from natural products by extracting with generally regarded as safe (GRAS) solvents. Because organic solvents are quite often used, high operating and disposal costs occur. When compared to traditional solvents, water is an interesting alternative because of its low operating and disposal costs. Milk thistle contains compounds (taxifolin, silychristin, silydianin, silybinin A, and silybinin B) that display hepatoxic protection properties. This paper examines the batch extraction of silymarin compounds from milk thistle seed meal in 50°C, 70°C, 85°C and 100°C water as a function of time. For taxifolin, silychristin, silybinin A, and silybinin B, extraction with 100°C water resulted in the highest yields. After 210 min of extraction at 100°C, the yield of taxifolin was 1.2 mg/g of seed while the yields of silychristin, silybinin A, and silybinin B were 5.0, 1.8 and 3.3 mg/g of seed, respectively. The ratios of the extracted compounds, and particularly the ratios at long extraction times, showed that the more polar compounds (taxifolin and silychristin) were preferentially extracted at 85°C, while the less polar silybinin was preferentially extracted at 100°C

Age and helium content of the open cluster NGC 6791 from multiple eclipsing binary members. I. Measurements, methods, and first results

Earlier measurements of the masses and radii of the detached eclipsing binary V20 in the open cluster NGC 6791 were accurate enough to demonstrate that there are significant differences between current stellar models. Here we improve on those results and add measurements of two additional detached eclipsing binaries, the cluster members V18 and V80. The enlarged sample sets much tighter constraints on the properties of stellar models than has hitherto been possible, thereby improving both the accuracy and precision of the cluster age. We employed (i) high-resolution UVES spectroscopy of V18, V20 and V80 to determine their spectroscopic effective temperatures, [Fe/H] values, and spectroscopic orbital elements, and (ii) time-series photometry from the Nordic Optical Telescope to obtain the photometric elements. The masses and radii of the V18 and V20 components are found to high accuracy, with errors on the masses in the range 0.27-0.36% and errors on the radii in the range 0.61-0.92%. V80 is found to be magnetically active, and more observations are needed to determine its parameters accurately. The metallicity of NGC 6791 is measured from disentangled spectra of the binaries and a few single stars to be [Fe/H]= +0.29 \pm 0.03 (random) \pm 0.07 (systematic). The cluster reddening and apparent distance modulus are found to be E(B - V) = 0.160 \pm 0.025 and (m - M)V = 13.51 \pm 0.06 . A first model comparison shows that we can constrain the helium content of the NGC 6791 stars, and thus reach a more accurate age than previously possible. It may be possible to constrain additional parameters, in particular the C, N, and O abundances. This will be investigated in paper II.Comment: Accepted for publication in A&

All-optical 160 Gbit/s RZ data retiming system incorporating a pulse shaping fibre Bragg grating

We characterize a 160Gbit/s retimer based on flat-topped pulses shaped using a superstructured fibre Bragg grating. The benefits of using shaped rather than conventional pulse forms in terms of timing jitter reduction are confirmed by bit-error-rate measurements

Multi-site H-bridge breathers in a DNA--shaped double strand

We investigate the formation process of nonlinear vibrational modes representing broad H-bridge multi--site breathers in a DNA--shaped double strand. Within a network model of the double helix we take individual motions of the bases within the base pair plane into account. The resulting H-bridge deformations may be asymmetric with respect to the helix axis. Furthermore the covalent bonds may be deformed distinctly in the two backbone strands. Unlike other authors that add different extra terms we limit the interaction to the hydrogen bonds within each base pair and the covalent bonds along each strand. In this way we intend to make apparent the effect of the characteristic helicoidal structure of DNA. We study the energy exchange processes related with the relaxation dynamics from a non-equilibrium conformation. It is demonstrated that the twist-opening relaxation dynamics of a radially distorted double helix attains an equilibrium regime characterized by a multi-site H-bridge breather.Comment: 27 pages and 10 figure

The CORALIE survey for southern extra-solar planets. X. A Hot Jupiter orbiting HD73256

Recent radial-velocity measurements obtained with the CORALIE spectrograph on the 1.2-m Euler Swiss telescope at La Silla unveil the presence of a new Jovian-mass Hot Jupiter around HD 73256. The 1.85-M_Jup planet moves on an extremely short-period (P=2.5486 d), quasi-circular orbit. The best Keplerian orbital solution is presented together with an unsuccessful photometric planetary-transit search performed with the SAT Danish telescope at La Silla. Over the time span of the observations, the photometric follow-up of the candidate has nevertheless revealed a P=14-d photometric periodicity corresponding to the rotational period of the star. This variation as well as the radial-velocity jitter around the Keplerian solution are shown to be related to the fair activity level known for HD 73256.Comment: 7 pages, 7 figures. Accepted in A&

Snapshots of Urban and Rural Food Environments: EPOCH-Based Mapping in a High-, Middle-, and Low-Income Country from a Non-Communicable Disease Perspective

A changing food environment is implicated as a primary contributor to the increasing levels of non-communicable diseases (NCDs). This study aimed to generate snapshots of selected external food environments to inform intervention strategies for NCD prevention in three countries: Uganda (low income), South Africa (middle income) and Sweden (high income), with one matched pair of urban–rural sites per country. Fifty formal and informal food retail outlets were assessed, and descriptive and comparative statistical analyses were performed. We found that formal food retail outlets in these countries had both positive and negative traits, as they were the main source of basic food items but also made unhealthy food items readily available. The Ugandan setting had predominantly informal outlets, while the Swedish setting had primarily formal outlets and South Africa had both, which fits broadly into the traditional (Uganda), mixed (South Africa) and modern (Sweden) conceptualized food systems. The promotion of unhealthy food products was high in all settings. Uganda had the highest in-community advertising, followed by South Africa and Sweden with the lowest, perhaps related to differences in regulation and implementation. The findings speak to the need to address contextual differences in NCD-related health interventions by incorporating strategies that address the food environment, and for a critical look at regulations that tackle key environment-related factors of food on a larger scale

Quasiperiodic Envelope Solitons

We analyse nonlinear wave propagation and cascaded self-focusing due to second-harmonic generation in Fibbonacci optical superlattices and introduce a novel concept of nonlinear physics, the quasiperiodic soliton, which describes spatially localized self-trapping of a quasiperiodic wave. We point out a link between the quasiperiodic soliton and partially incoherent spatial solitary waves recently generated experimentally.Comment: Submitted to PRL. 4 pages with 5 figure

Sub-kHz-level relative stabilization of an intracavity doubled continuous wave optical parametric oscillator using Pound-Drever-Hall scheme

We report the relative frequency stabilization of an intracavity frequency doubled singly resonant optical parametric oscillator on a Fabry-Perot\'etalon. The red/orange radiation produced by the frequency doubling of the intracavity resonant idler is stabilized using the Pound-Drever-Hall locking technique. The relative frequency noise of this orange light, when integrated from 1 Hz to 50 kHz, corresponds to a standard deviation of 700 Hz. The frequency noise of the pump laser is shown experimentally to be transferred to the non resonant signal beam

Light Curves of Core-Collapse Supernovae with Substantial Mass Loss using the New Open-Source SuperNova Explosion Code (SNEC)

We present the SuperNova Explosion Code (SNEC), an open-source Lagrangian code for the hydrodynamics and equilibrium-diffusion radiation transport in the expanding envelopes of supernovae. Given a model of a progenitor star, an explosion energy, and an amount and distribution of radioactive nickel, SNEC generates the bolometric light curve, as well as the light curves in different wavelength bands assuming black body emission. As a first application of SNEC, we consider the explosions of a grid of 15 M_⊙ (at zero-age main sequence) stars whose hydrogen envelopes are stripped to different extents and at different points in their evolution. The resulting light curves exhibit plateaus with durations of ∼20 − 100 days if & 1.5 − 2 M_⊙ of hydrogen-rich material is left and no plateau if less hydrogen-rich material is left. The shorter plateau lengths are unlike the Type IIP supernova light curves typically observed in nature. This suggests that, at least for zero-age main sequence masses . 20 M_⊙, hydrogen mass loss occurs as an all or nothing process, perhaps pointing to the important role binary interactions play in observed mass-stripped supernovae (i.e., Type Ib/c events). These light curves are also unlike what is typically seen for Type IIL supernovae, arguing that simply varying the amount of mass loss cannot explain these events. The most stripped models begin to show double-peaked light curves similar to what is often seen for Type IIb supernovae, confirming previous work that these supernovae can come from progenitors that have a small amount of hydrogen and a radius of ∼ 500 R_⊙