Processo De Preparação De Novos Trialcoxissilanos Com Grupos Reativos Derivados Da Uréia

Compreendendo a síntese de novos agentes sililantes a partir da reação do precursor do tipo trialcoxissilano com várias aminas alifáticas de cadeia carbônica de diferentes tamanhos, pela rota sintética em meio homogêneo e em condições anidras, onde acontece, a formação de uma nova função química, formando um derivado da ureia do tipo -NH-C=O-NH-.BR9903110 (B1); BR9903110 (A)C07F7/18C07F7/18BR19999903110C07F7/18C07F7/1

Intake analysis of hematopoietic micronutrients and anemia : prevalence in Brazilian female older-adults

Objetivos: Este estudo teve como objetivo avaliar a ingestão de micronutrientes relacionados à hematopoiese e determinar a prevalência de anemia em pacientes do sexo feminino com idade superior a 60 anos residentes na periferia do Distrito Federal. Material e Métodos: Para cada paciente, foi determinada a média da ingestão diária de ferro, vitamina B12 e ácido fólico por meio da análise dietética dos registros alimentares estimados de três dias alternados, seguida pela determinação das dosagens séricas de cobalamina livre e homocisteína. O diagnóstico de anemia foi estabelecido pela dosagem de hemoglobina total. Resultados: Encontrou-se uma prevalência de anemia em 9,8% das idosas estudadas. Não foi observada diferença significativa no consumo de ferro e ácido fólico entre pacientes anêmicas e não-anêmicas. No entanto, o consumo médio de vitamina B12 entre as pacientes não-anêmicas mostrou-se 2,6 vezes superior à ingestão média observada no grupo anêmico (p < 0,05). Dosagens séricas de cobalamina e homocisteína mostraram-se aumentadas entre portadoras de anemia. Conclusões: Nossos dados sugerem que a deficiência na ingestão de vitamina B12 constitui fator predisponente ao desenvolvimento de anemia em pacientes idosos. ____________________________________________________________________________________ ABSTRACTAim: This study aimed to estimate the average intake of hematopoiesis related micro-nutrients and to assess the prevalence of anemia in elder female subjects aged 60 years or older residing in the outskirts of the Brazilian Federal District. Material and Methods: Mean daily consumption of iron, folic acid and vitamin B12 were determined for each patient by means of dietary analysis of food registries, followed by evaluation of free serum cobalamin and homocysteine. Anemia diagnosis was established by quantification of total hemoglobin. Results: Prevalence was found to assault 9.8% of elderly studied. No significant difference has been observed in folic acid and iron intakes between anemic and non-anemic subjects. On the other hand, mean consumption of vitamin B12 was 2.6 times higher among anemic patients (p < 0.05). Accordingly, serum cobalamin and homocysteine dosages have shown marked increase in the anemic group. Conclusions: Our findings suggest that deficiency in vitamin B12 intake constitutes a predisposing factor to the onset of anemia in the elderly

Accuracy of air temperature forecasts and its use for prediction of the reference evapotranspiration

The objective of this study was to verify the quality of the short-term forecasts made by some web sites, as well as the potential of its use in estimating reference evapotranspiration (ETo). For the period 2012-2013, every 4-days, the maximum (Tmax) and minimum (Tmin) air temperature forecasts for horizons of 24, 48, 72 and 96 hours provided by public sites for Uberlandia-MG were collected and used for calculating the reference evapotranspiration (ETo) by the Hargreaves-Samani (HS) calibrated equation. The sites www.accuweather.com (WEATHER); www.cemig.com.br (CEMIG); jornaldotempo.uol.com.br; (JORNAL) and www.climatempo.com.br (CLIMA) were evaluated. For the same period, the meteorological data were taken at the National Institute of Meteorology (www.inmet.gov.br). The performance of the Tmax and Tmin forecasts as well as the ETo estimates were made by regression analysis, the mean bias error (MBE), root mean square error (RMSE) and t-test. For all sites, there was a better performance in the prediction of Tmin when compared to Tmax, especially by a reduction in errors (MBE and RMSE) and an increase in coefficients b and R2. For ETo, the site CLIMA had lowest MBE and RMSE (0.9 mm d-1) following by the WEATHER and JORNAL. On the other hand, the site CEMIG presented higher values for MBE (-1.3 mm d-1) and RMSE (1.6 mm d-1). There was no worsening with an increase of the forecast horizon in these indices, except for R² values. The site CLIMA was the only one that did not differ significantly from the ETo values observed.  The results of diagnostic verification procedures indicate the potential use of air temperature forecasts in irrigation management

Planejamento Estratégico em uma Universidade Federal: os principais benefícios e desafios da construção do Plano de Desenvolvimento Institucional a partir da percepção dos gestores

Diante de um cenário dinâmico e competitivo, o Planejamento Estratégico torna-se indispensável a uma organização, pois possibilita o seu autoconhecimento. A Administração Pública, que tem como foco não o lucro, mas o bem estar social e a continuidade de serviços, deve também adotar modelos gerenciais visando à melhoria da gestão de recursos públicos e a entrega de resultados à sociedade. Este artigo tem como objetivos avaliar os principais benefícios e desafios enfrentados na construção e revisão do Plano de Desenvolvimento Institucional na Universidade Federal do Amazonas a partir da percepção dos gestores envolvidos, bem como conceituar o Planejamento Estratégico no setor público, examinar e descrever os PDIs produzidos pela instituição. Para esse trabalho sugere-se uma pesquisa de abordagem qualitativa, de natureza básica, do tipo exploratória e descritiva, realizada por meio de um estudo de caso com utilização de pesquisa bibliográfica e pesquisa documental como métodos. Os resultados da pesquisa indicam que os principais benefícios incluem alinhar a atuação dos gestores, definir objetivos e metas, proporcionar o envolvimento da comunidade acadêmica e colaborar para a tomada de decisão. Os grandes desafios enfrentados dizem respeito à dinâmica de grupos, dentre os quais se destacam os conflitos de ideias, a efetiva participação dos envolvidos e o alinhamento de propostas, que torna essencial uma boa comunicação entre os setores envolvidos e a capacitação da equipe condutora do processo

Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure ratethe inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-beta-D-glucosaminidase activities. The levels of TNF-alpha, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilUniv Fed Rural Pernambuco, Dept Chem, Recife, PE, BrazilUniv Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilWeb of Scienc

O uso de antimicrobianos na Atenção Primária à Saúde / The use of antimicrobials in primary health care

A resistência aos antimicrobianos é um problema mundial de saúde pública, aumentando consideravelmente a mortalidade e morbidade por doenças e complicações infecciosas que, anteriormente, eram tratáveis com antibióticos ou antimicrobianos quimioterápicos. Esse fenômeno é, em parte, induzido pelo uso indiscriminado dos medicamentos disponíveis, o qual, no contexto brasileiro, se estende aos diferentes níveis de atenção do Sistema Único de Saúde (SUS). Nesse sentido, a Atenção Primária à Saúde (APS) tem uma contribuição importante para o fortalecimento desse fenômeno, já que é responsável por atender um alto número de infecções frequentes, sendo a porta de entrada preferencial do sistema de saúde brasileiro. Com base nessas considerações, o presente artigo tem por objetivo discutir o uso de antimicrobianos na APS

Effects of n-3 fatty acids and exercise on oxidative stress parameters in type 2 diabetic : a randomized clinical trial

Background: The relationship between diabetes and oxidative stress has been previously reported. Exercise represents a useful non-pharmacological strategy for the treatment in type 2 diabetic (T2DM) patients, but high intensity exercise can induce a transient inflammatory state and increase oxidative stress. Nutritional strategies that may contribute to the reduction of oxidative stress induced by acute exercise are necessary. The aim of this study was to examine if n-3 PUFA supplementation intervention can attenuate the inflammatory response and oxidative stress associated with high intensity exercise in this population. As a primary outcome, lipoperoxidation measurements (TBARS and F2-isoprostanes) were selected. Methods: Thirty T2DM patients, without chronic complications, were randomly allocated into two groups: placebo (gelatin capsules) or n-3 PUFA (capsules containing 180 mg of eicosapentaenoic acid and 120 mg of docosahexaenoic acid). Blood samples were collected fasting before and after 8 weeks supplementation. In the beginning and at the end of protocol, an acute exercise was performed (treadmill), and new blood samples were collected before and immediately after the exercise for measurements of oxidative stress and high-sensitivity C-reactive protein (hs-CRP). Results: After the supplementation period, a decrease in triglycerides levels was observed only in n-3 PUFA supplementation group (mean difference and 95% CI of 0.002 (0.000–0.004), p = 0.005). Supplementation also significantly reduced TRAP levels after exercise (mean difference and 95% CI to 9641 (− 20,068–39,351) for − 33,884 (− 56,976 - -10,793), p = 0.004, Cohen’s d effect size = 1.12), but no significant difference was observed in n-3 PUFA supplementation group in lipoperoxidation parameters as TBARS (mean difference and 95% CI to − 3.8 (− 10–2.4) for − 2.9 (− 1.6–7.4) or F2-isoprostanes (mean difference and 95% CI -0.05 (− 0.19–0.10) for − 0.02 (− 0.19–0.16), p > 0.05 for both. Conclusion: PUFA n-3 supplementation reduced triglycerides as well as TRAP levels after exercise, without a significant effect on inflammatory and oxidative stress markers. This study is registered at ClinicalTrials.gov with the registration number of NCT03182712

Geo-environmental mapping using physiographic analysis: constraints on the evaluation of land instability and groundwater pollution hazards in the Metropolitan District of Campinas, Brazil

Geo-environmental terrain assessments and territorial zoning are useful tools for the formulation and implementation of environmental management instruments (including policy-making, planning, and enforcement of statutory regulations). They usually involve a set of procedures and techniques for delimitation, characterisation and classification of terrain units. However, terrain assessments and zoning exercises are often costly and time-consuming, particularly when encompassing large areas, which in many cases prevent local agencies in developing countries from properly benefiting from such assessments. In the present paper, a low-cost technique based on the analysis of texture of satellite imagery was used for delimitation of terrain units. The delimited units were further analysed in two test areas situated in Southeast Brazil to provide estimates of land instability and the vulnerability of groundwater to pollution hazards. The implementation incorporated procedures for inferring the influences and potential implications of tectonic fractures and other discontinuities on ground behaviour and local groundwater flow. Terrain attributes such as degree of fracturing, bedrock lithology and weathered materials were explored as indicators of ground properties. The paper also discusses constraints on- and limitations of- the approaches taken