31 research outputs found

    NATO Advanced Study Institute on Confined Electrons and Photons : New Physics and Applications

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    Recyclage des cofacteurs NAD+, NADP+, ATP par des bacteries immobilisees

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    SIGLECNRS AR 10914 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

    Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active Gs-coupled receptors.

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    AbstractIn transfected CHO cells constitutively active histamine H2 receptors not only increase the basal cAMP level, but also enhance forskolin-induced cAMP production. The increased forskolin response was inhibited by inverse H2 agonists with potencies similar to those determined at basal levels. The modulation of the forskolin response was also observed after H2 receptor expression in HEK-293 and Sf9 cells or TSH receptor expression in COS-7 cells. The enhancement of forskolin-induced cAMP production seems to be a general characteristic of constitutively active Gs-coupled receptors and can be very useful to study inverse agonism at wild-type receptors
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