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Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure.
PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP †20 mm Hg, and 31 controls underwent MRI in central gaze and 20° to 30° abduction and adduction. Optic nerve and sheath area centroids permitted computation of midorbital lengths versus minimum paths.ResultsAverage mean deviation (±SEM) was -8.2 ± 1.2 dB in the 15 patients with POAG having interpretable perimetry. In central gaze, ON path length in POAG was significantly more redundant (104.5 ± 0.4% of geometric minimum) than in controls (102.9 ± 0.4%, P = 2.96 à 10-4). In both groups the ON became significantly straighter in adduction (28.6 ± 0.8° in POAG, 26.8 ± 1.1° in controls) than central gaze and abduction. In adduction, the ON in POAG straightened to 102.0% ± 0.2% of minimum path length versus 104.5% ± 0.4% in central gaze (P = 5.7 à 10-7), compared with controls who straightened to 101.6% ± 0.1% from 102.9% ± 0.3% in central gaze (P = 8.7 à 10-6); and globes retracted 0.73 ± 0.09 mm in POAG, but only 0.07 ± 0.08 mm in controls (P = 8.8 à 10-7). Both effects were confirmed in age-matched controls, and remained significant after correction for significant effects of age and axial globe length (P = 0.005).ConclusionsAlthough tethering and elongation of ON and sheath are normal in adduction, adduction is associated with abnormally great globe retraction in POAG without elevated IOP. Traction in adduction may cause mechanical overloading of the ON head and peripapillary sclera, thus contributing to or resulting from the optic neuropathy of glaucoma independent of IOP
Liquid Crystal-Solid Interface Structure at the Antiferroelectric-Ferroelectric Phase Transition
Total Internal Reflection (TIR) is used to probe the molecular organization
at the surface of a tilted chiral smectic liquid crystal at temperatures in the
vicinity of the bulk antiferroelectric-ferroelectric phase transition. Data are
interpreted using an exact analytical solution of a real model for
ferroelectric order at the surface. In the mixture T3, ferroelectric surface
order is expelled with the bulk ferroelectric-antiferroelectric transition. The
conditions for ferroelectric order at the surface of an antiferroelectric bulk
are presented
Soil as an Extended Composite Phenotype of the Microbial Metagenome
We use a unique set of terrestrial experiments to demonstrate how soil management practises result in emergence of distinct associations between physical structure and biological functions. These associations have a significant effect on the flux, resilience and efficiency of nutrient delivery to plants (including water). Physical structure determining the air-water balance in soil as well as transport rates is influenced by nutrient and physical interventions. Contrasting emergent soil structures exert selective pressures upon the microbiome metagenome. These selective pressures are associated with the quality of organic carbon inputs, the prevalence of anaerobic microsites and delivery of nutrients to microorganisms attached to soil surfaces. This variety results in distinctive gene assemblages characterising each state. The nature of the interactions provide evidence that soil behaves as an extended composite phenotype of the resident microbiome, responsive to the input and turnover of plant-derived organic carbon. We provide new evidence supporting the theory that soil-microbe systems are self-organising states with organic carbon acting as a critical determining parameter. This perspective leads us to propose carbon flux, rather than soil organic carbon content as the critical factor in soil systems, and we present evidence to support this view
Nonlinear Realization of N=2 Superconformal Symmetry and Brane Effective Actions
Due to the incompatibility of the nonlinear realization of superconformal
symmetry and dilatation symmetry with the dilaton as the compensator field, in
the present paper it shows an alternative mechanism of spontaneous breaking the
N=2 superconformal symmetry to the N=0 case. By using the approach of nonlinear
transformations it is found that it leads to a space-filling brane theory with
Weyl scale W(1,3) symmetry. The dynamics of the resulting Weyl scale invariant
brane, along with that of other Nambu-Goldstone fields, is derived in terms of
the building blocks of the vierbein and the covariant derivative from the
Maurer-Cartan oneforms. A general coupling of the matter fields localized on
the brane world volume to these NG fields is also constructed.Comment: 22 pages, more references and comments are adde
Gold potential of the Southwest Pacific : Papua New Guinea, Solomon Islands, Vanuatu, Fiji
For more about the East-West Center, see http://www.eastwestcenter.org/</a
Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides
Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta
position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic
fungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibition
of the growth of these fungi was exhibited for enantiomers S and R of 1-(40-chlorophenyl)-
2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activity
relationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitory
mechanism of the compounds studied. Additionally, a multiobjective optimization study of the
global antifungal profile of chlorophenyl derivatives was conducted in order to establish a rational
strategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOPDESIRE
methodology was used for this purpose providing reliable ranking models that can be
used later
Correlates of Complete Childhood Vaccination in East African Countries.
Despite the benefits of childhood vaccinations, vaccination rates in low-income countries (LICs) vary widely. Increasing coverage of vaccines to 90% in the poorest countries over the next 10 years has been estimated to prevent 426 million cases of illness and avert nearly 6.4 million childhood deaths worldwide. Consequently, we sought to provide a comprehensive examination of contemporary vaccination patterns in East Africa and to identify common and country-specific barriers to complete childhood vaccination. Using data from the Demographic and Health Surveys (DHS) for Burundi, Ethiopia, Kenya, Rwanda, Tanzania, and Uganda, we looked at the prevalence of complete vaccination for polio, measles, Bacillus Calmette-Guérin (BCG) and DTwPHibHep (DTP) as recommended by the WHO among children ages 12 to 23 months. We conducted multivariable logistic regression within each country to estimate associations between complete vaccination status and health care access and sociodemographic variables using backwards stepwise regression. Vaccination varied significantly by country. In all countries, the majority of children received at least one dose of a WHO recommended vaccine; however, in Ethiopia, Tanzania, and Uganda less than 50% of children received a complete schedule of recommended vaccines. Being delivered in a public or private institution compared with being delivered at home was associated with increased odds of complete vaccination status. Sociodemographic covariates were not consistently associated with complete vaccination status across countries. Although no consistent set of predictors accounted for complete vaccination status, we observed differences based on region and the location of delivery. These differences point to the need to examine the historical, political, and economic context of each country in order to maximize vaccination coverage. Vaccination against these childhood diseases is a critical step towards reaching the Millennium Development Goal of reducing under-five mortality by two-thirds by 2015 and thus should be a global priority
A review of wildland fire spread modelling, 1990-present 3: Mathematical analogues and simulation models
In recent years, advances in computational power and spatial data analysis
(GIS, remote sensing, etc) have led to an increase in attempts to model the
spread and behvaiour of wildland fires across the landscape. This series of
review papers endeavours to critically and comprehensively review all types of
surface fire spread models developed since 1990. This paper reviews models of a
simulation or mathematical analogue nature. Most simulation models are
implementations of existing empirical or quasi-empirical models and their
primary function is to convert these generally one dimensional models to two
dimensions and then propagate a fire perimeter across a modelled landscape.
Mathematical analogue models are those that are based on some mathematical
conceit (rather than a physical representation of fire spread) that
coincidentally simulates the spread of fire. Other papers in the series review
models of an physical or quasi-physical nature and empirical or quasi-empirical
nature. Many models are extensions or refinements of models developed before
1990. Where this is the case, these models are also discussed but much less
comprehensively.Comment: 20 pages + 9 pages references + 1 page figures. Submitted to the
International Journal of Wildland Fir
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