151 research outputs found
Biospecimen reporting for improved study quality (BRISQ)
- Author
- B.Chir. M.B.
- Clark M.D., Douglas
- Greenspan M.D., Renata
- Hainaut Ph.D., M.S., Pierre
- Hayes M.D., Daniel F.
- Institute National Cancer
- Jewell Ph.D., Scott D.
- Kelly Ph.D., Andrea
- Kim Paula
- Mansfield Ph.D., Elizabeth
- McShane Ph.D., Lisa M.
- Moore Ph.D., Helen M.
- Potapova Ph.D., Olga
- Riegman Ph.D., Peter
- Rubinstein Ph.D., Yaffa
- Seijo M.S., Edward
- Somiari Ph.D., Stella
- Vaught Ph.D., Jim
- Watson Peter
- Weier Ph.D., Heinz-Ulrich
- Zhu Ph.D., Claire
- Publication venue
- 'Wiley'
- Publication date
- 02/09/2010
- Field of study
Human biospecimens are subjected to collection, processing, and storage that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research that uses human tissues, it is crucial that information on the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications on biospecimen-related research and to help reassure patient contributors and the advocacy community that their contributions are valued and respected. Cancer (Cancer Cytopathol) 2011. Published 2011 by the American Cancer Society.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83764/1/20147_ftp.pd
All-sky search for long-duration gravitational wave transients with initial LIGO
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- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Abernathy M.R.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
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- Ain A.
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- Anderson S.B.
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- Babak S.
- Baiardi L.Cerboni
- Baker P.T.
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- Bassiri R.
- Basti A.
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- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
All-sky search for long-duration gravitational wave transients with initial LIGO
- Author
- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Abernathy M.R.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Ain A.
- Ajith P.
- Allen B.
- Allocca A.
- Amariutei D.V.
- Anderson S.B.
- Anderson W.G.
- Arai K.
- Araya M.C.
- Arceneaux C.C.
- Areeda J.S.
- Arnaud N.
- Arun K.G.
- Ashton G.
- Ast M.
- Aston S.M.
- Astone P.
- Aufmuth P.
- Aulbert C.
- Babak S.
- Baiardi L.Cerboni
- Baker P.T.
- Baldaccini F.
- Ballardin G.
- Ballmer S.W.
- Barayoga J.C.
- Barclay S.E.
- Barish B.C.
- Barker D.
- Barone F.
- Barr B.
- Barsotti L.
- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.C.
- Baune C.
- Bavigadda V.
- Bazzan M.
- Behnke B.
- Bejger M.
- Belczynski C.
- Bell A.S.
- Bell C.J.
- Berger B.K.
- Bergman J.
- Bergmann G.
- Berry C.P.L.
- Bersanetti D.
- Bertolini A.
- Betzwieser J.
- Bhagwat S.
- Bhandare R.
- Bilenko I.A.
- Billingsley G.
- Birch J.
- Birney R.
- Biscans S.
- Bisht A.
- Bitossi M.
- Biwer C.
- Bizouard M.A.
- Blackburn J.K.
- Blair C.D.
- Blair D.
- Blair R.M.
- Bloemen S.
- Bock O.
- Bodiya T.P.
- Boer M.
- Bogaert G.
- Bogan C.
- Bohe A.
- Bojtos P.
- Bond C.
- Bondu F.
- Bonnand R.
- Bork R.
- Boschi V.
- Bose S.
- Bozzi A.
- Bradaschia C.
- Brady P.R.
- Braginsky V.B.
- Branchesi M.
- Brau J.E.
- Briant T.
- Brillet A.
- Brinkmann M.
- Brisson V.
- Brockill P.
- Brooks A.F.
- Brown D.
- Brown D.A.
- Brown D.D.
- Brown N.M.
- Buchanan C.C.
- Buikema A.
- Bulik T.
- Bulten H.J.
- Buonanno A.
- Buskulic D.
- Buy C.
- Byer R.L.
- Cadonati L.
- Cagnoli G.
- Cahillane C.
- Calderón Bustillo J.
- Callister T.
- Calloni E.
- Camp J.B.
- Cannon K.C.
- Cao J.
- Capano C.D.
- Capocasa E.
- Carbognani F.
- Caride S.
- Casanueva Diaz J.
- Casentini C.
- Castro Gonzalez J.M.
- Caudill S.
- Cavaglià M.
- Cavalier F.
- Cavalieri R.
- Cella G.
- Cepeda C.
- Cerretani G.
- Cesarini E.
- Chakraborty R.
- Chalermsongsak T.
- Chamberlin S.J.
- Chan M.
- Chao S.
- Charlton P.
- Chassande-Mottin E.
- Chen H.Y.
- Chen Y.
- Cheng C.
- Chincarini A.
- Chiummo A.
- Cho H.S.
- Cho M.
- Chow J.H.
- Christensen N.
- Chu Q.
- Chua S.
- Chung S.
- Ciani G.
- Clara F.
- Clark J.A.
- Cleva F.
- Coccia E.
- Cohadon P.-F.
- Colla A.
- Collette C.G.
- Constancio M.
- Conte A.
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- Corbitt T.R.
- Cornish N.
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- Countryman S.T.
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- Danilishin S.L.
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- Darman N.S.
- Dattilo V.
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- Dolique V.
- Donovan F.
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- Guidi G.M.
- Guo X.
- Gupta A.
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- Gushwa K.E.
- Gustafson E.K.
- Gustafson R.
- Hacker J.J.
- Hall B.R.
- Hall E.D.
- Hammond G.
- Haney M.
- Hanke M.M.
- Hanks J.
- Hanna C.
- Hannam M.D.
- Hanson J.
- Hardwick T.
- Haris K.
- Harms J.
- Harry G.M.
- Harry I.W.
- Hart M.J.
- Hartman M.T.
- Haster C.-J.
- Haughian K.
- Heidmann A.
- Heintze M.C.
- Heitmann H.
- Hello P.
- Hemming G.
- Hendry M.
- Heng I.S.
- Hennig J.
- Heptonstall A.W.
- Heurs Michèle
- Hild S.
- Hoak D.
- Hodge K.A.
- Hofman D.
- Hollitt S.E.
- Holt K.
- Holz D.E.
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- Houston E.A.
- Howell E.J.
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- Wang Y.
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- Wei L.-W.
- Weinert M.
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- Westphal T.
- Wette K.
- Weßels P.
- Whelan J.T.
- White D.J.
- Whiting B.F.
- Williams R.D.
- Williamson A.R.
- Willis J.L.
- Willke B.
- Wimmer M.H.
- Winkler W.
- Wipf C.C.
- Wittel H.
- Woan G.
- Worden J.
- Wright J.L.
- Wu G.
- Yablon J.
- Yam W.
- Yamamoto H.
- Yancey C.C.
- Yu H.
- Yvert M.
- Zadrożny A.
- Zangrando L.
- Zanolin M.
- Zendri J.-P.
- Zevin M.
- Zhang F.
- Zhang L.
- Zhang M.
- Zhang Y.
- Zhao C.
- Zhou M.
- Zhou Z.
- Zhu X.J.
- Zucker M.E.
- Zuraw S.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
Search for Tensor, Vector, and Scalar Polarizations in the Stochastic Gravitational-Wave Background
- Author
- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Aiello L.
- Ain A.
- Ajith P.
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- Wang H.
- Wang J.Z.
- Wang W.H.
- Wang Y.F.
- Ward R.L.
- Warner J.
- Was M.
- Watchi J.
- Weaver B.
- Wei L-W.
- Weinert M.
- Weinstein A.J.
- Weiss R.
- Wen L.
- Wessel E.K.
- Westerweck J.
- Westphal T.
- Wette K.
- Weßels P.
- Whelan J.T.
- Whiting B.F.
- Whittle C.
- Wilken D.
- Williams D.
- Williams R.D.
- Williamson A.R.
- Willis J.L.
- Willke B.
- Wimmer M.H.
- Winkler W.
- Wipf C.C.
- Wittel H.
- Woan G.
- Woehler J.
- Wofford J.
- Wong K.W.K.
- Worden J.
- Wright J.L.
- Wu D.S.
- Wysocki D.M.
- Xiao S.
- Yamamoto H.
- Yancey C.C.
- Yang L.
- Yap M.J.
- Yazback M.
- Yu Hang.
- Yu Haocun.
- Yvert M.
- Zadrożny A.
- Zanolin M.
- Zelenova T.
- Zendri J-P.
- Zevin M.
- Zhang L.
- Zhang M.
- Zhang T.
- Zhang Y-H.
- Zhao C.
- Zhou M.
- Zhou Z.
- Zhu S.J.
- Zhu X.J.
- Zucker M.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2018
- Field of study
The detection of gravitational waves with Advanced LIGO and Advanced Virgo has enabled novel tests of general relativity, including direct study of the polarization of gravitational waves. While general relativity allows for only two tensor gravitational-wave polarizations, general metric theories can additionally predict two vector and two scalar polarizations. The polarization of gravitational waves is encoded in the spectral shape of the stochastic gravitational-wave background, formed by the superposition of cosmological and individually unresolved astrophysical sources. Using data recorded by Advanced LIGO during its first observing run, we search for a stochastic background of generically polarized gravitational waves. We find no evidence for a background of any polarization, and place the first direct bounds on the contributions of vector and scalar polarizations to the stochastic background. Under log-uniform priors for the energy in each polarization, we limit the energy densities of tensor, vector, and scalar modes at 95% credibility to Ω0T<5.58×10-8, Ω0V<6.35×10-8, and Ω0S<1.08×10-7 at a reference frequency f0=25 Hz. © 2018 American Physical Society
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. Hallaråker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva Rendón
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
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- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
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- A. Matoltsy
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- D. Adak
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- Y. Gottwalles
- Y. Guo
- Y. Haraguchi
- Y. Hata
- Y. Hatori
- Y. Hayashi
- Y. Ivanova
- Y. Jiao
- Y. Kamogawa
- Y. Kato
- Y. Katsube
- Y. Katsuda
- Y. Kawada
- Y. Kelfkens
- Y. Kitami
- Y. Koretsune
- Y. Koshibu
- Y. Kumai
- Y. Maruyama
- Y. Matsuura
- Y. Mizuno
- Y. Moiseeva
- Y. Mostovoy
- Y. Niijima
- Y. Nishida
- Y. Nishihata
- Y. Oba
- Y. Onuki Pearce
- Y. Orlov
- Y. Osmolovskaya
- Y. Park
- Y. Saito
- Y. Sakamoto
- Y. Samejima
- Y. Santanakorn
- Y. Sasagawa
- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
The Sample Analysis at Mars Investigation and Instrument Suite
- Author
- A. Banin
- A. Bouvier
- A. Buch
- A. Geminale
- A. Steele
- A.C. McAdam
- A.J.T. Jull
- A.J.T. Jull
- A.O. Nier
- A.O. Nier
- A.P. Zent
- A.S. McEwen
- A.S. Wong
- A.S. Yen
- Alexander A. Pavlov
- Amy C. McAdam
- Andrea Jones
- Andrew Steele
- Arnaud Buch
- B. Sherwood Lollar
- B.C. Clark
- B.C. Clark
- B.L. Ehlmann
- B.M. Jakosky
- B.M. Jakosky
- Benito Prats
- Bruce M. Jakosky
- Bruce P. Block
- C. Chyba
- C. Geffroy-Rodier
- C. Ponnamperuma
- C. Szopa
- C.D. Gillmann
- C.G. Tarsitano
- C.R. Webster
- C.R. Webster
- C.S. Cockell
- Caroline Freissinet
- Charles A. Malespin
- Charles Edmonson
- Christopher P. McKay
- Christopher R. Webster
- Christopher S. Johnson
- Cindy Gundersen
- Curt Baffes
- Cyril Szopa
- D. Bogard
- D. Meunier
- D.D. Bogard
- D.H. Garrison
- D.L. Blaney
- D.S. McKay
- D.W. Ming
- Daniel Carignan
- Daniel N. Harpold
- Daniel P. Glavin
- David Coscia
- David K. Martin
- David Sheppard
- Didier Keymeulen
- Douglas Hawk
- Douglas McLennan
- Douglas W. Ming
- E. Kaal
- E.G. Nisbet
- Eric Lyness
- Eric Raaen
- Erik Mumm
- F. Goesmann
- F. Tian
- F. Tian
- F.M. McCubbin
- Florence Tan
- Francois Raulin
- G. Klingelhofer
- G. Kminek
- G. Schwehm
- G.F. Knoll
- G.J. Flynn
- G.T. Delory
- G.V. Levin
- G.V. Levin
- G.V. Levin
- Greg Flesch
- Gregory Frazier
- H. Wanke
- H.B. Franz
- H.B. Niemann
- H.J. Melosh
- H.P. Klein
- H.R. Karlsson
- H.Y. McSween
- Heather Franz
- Heidi Manning
- I.G. Mitrofanov
- I.P. Wright
- J. Crovisier
- J. Farquhar
- J. Pollack
- J.A. Hurowitz
- J.C. Bridges
- J.C. Bridges
- J.C. Bridges
- J.C. Stern
- J.L. Bishop
- J.L. Eigenbrode
- J.L. Fox
- J.L. Fox
- J.L.Y. Bibring
- J.P. Bibring
- J.P. Bibring
- J.P. Greenwood
- J.R. Michalski
- J.S. Toporski
- James Kellogg
- James Smith
- James Wray
- Jason Feldman
- Jason P. Dworkin
- Jennifer C. Stern
- Jennifer L. Eigenbrode
- Jesse Lewis
- John Jones
- John Maurer
- K. Biemann
- K. Biemann
- K. Fast
- K. Fast
- K. Zahnle
- K. Zahnle
- K.I. Oyama
- K.J. Mathew
- Ken Arnett
- L. Becker
- L. Becker
- L. Leshin
- L. Maltagliati
- L.L. Watson
- L.R. Dartnell
- L.R. Dartnell
- Laurie A. Leshin
- Lora Bleacher
- M. Anpo
- M. Cabane
- M. Komiya
- M.A. Sephton
- M.A. Sephton
- M.B. McElroy
- M.B. McElroy
- M.D. Smith
- M.H. Acuna
- M.H. Carr
- M.H. Hecht
- M.J. Mumma
- M.M. Grady
- M.M. Grady
- M.M. Hirschmann
- M.P. Callahan
- M.P. Golombek
- M.Y. Zolotov
- Mark Cascia
- Marvin Noriega
- Mehdi Benna
- Melissa Trainer
- Michael Barciniak
- Michel Cabane
- N. Mangold
- N.J. Tosca
- O. Botta
- O. Botta
- Oliver Botta
- Oren Sheinman
- P. Ehrenfreund
- P.B. Niles
- P.R. Mahaffy
- Pamela G. Conrad
- Patrice Coll
- Patrick Jordan
- Paul R. Mahaffy
- Paul Sorensen
- Paula Everson
- R. Navarro-Gonzalez
- R. Navarro-Gonzalez
- R.C. Plumb
- R.C. Quinn
- R.E. Milliken
- R.E. Milliken
- R.E. Milliken
- R.E. Summons
- R.E. Summons
- R.K. Mohapatra
- R.L. Huguenin
- R.L. Mancinelli
- R.O. Pepin
- R.O. Pepin
- R.T. Clancy
- R.T. Clancy
- R.V. Krishnamurthy
- R.V. Morris
- R.W. Zurek
- Rafael Navarro-González
- Ray Garcia
- Richard V. Morris
- Robert A. Chalmers
- Robert Arvey
- Robert Kline-Schoder
- Robert Sternberg
- Rodger Farley
- Ryan Miller
- S. Pizzarello
- S. Schroder
- S.A. Benner
- S.K. Atreya
- S.K. Atreya
- S.K. Atreya
- S.P. Kounaves
- Samuel Teinturier
- Siamak Forouhar
- Stephen Gorevan
- Steve Battel
- Steve Woodward
- Steven Feng
- Steven Squyres
- Sushil K. Atreya
- T. Encrenaz
- T. Encrenaz
- T. Encrenaz
- T. Encrenaz
- T. Owen
- T. Owen
- T. Owen
- T. Owen
- T. Owen
- T. Owen
- T.A. Delchar
- T.B. McCord
- T.J. Millar
- T.M. McCollom
- T.M. McCollom
- T.R. Blackburn
- Therese Errigo
- Thomas J. Nolan
- Tobias Owen
- U.J. Meierhenrich
- V. Formisano
- V.A. Krasnopolsky
- V.A. Krasnopolsky
- V.A. Krasnopolsky
- V.A. Krasnopolsky
- V.A. Krasnopolsky
- Vincent Holmes
- W. Kasprzak
- W.C. Maguire
- W.V. Boynton
- William B. Brinckerhoff
- Y.P. Langevin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
On the progenitor of binary neutron star merger GW170817
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- Zevin M.
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- Zweizig J.
- Álvarez M.D.
- Publication venue
- American Astronomical Society
- Publication date
- 01/12/2017
- Field of study
On 2017 August 17 the merger of two compact objects with masses consistent with two neutron stars was discovered through gravitational-wave (GW170817), gamma-ray (GRB 170817A), and optical (SSS17a/AT 2017gfo) observations. The optical source was associated with the early-type galaxy NGC 4993 at a distance of just ∼40 Mpc, consistent with the gravitational-wave measurement, and the merger was localized to be at a projected distance of ∼2 kpc away from the galaxy's center. We use this minimal set of facts and the mass posteriors of the two neutron stars to derive the first constraints on the progenitor of GW170817 at the time of the second supernova (SN). We generate simulated progenitor populations and follow the three-dimensional kinematic evolution from binary neutron star (BNS) birth to the merger time, accounting for pre-SN galactic motion, for considerably different input distributions of the progenitor mass, pre-SN semimajor axis, and SN-kick velocity. Though not considerably tight, we find these constraints to be comparable to those for Galactic BNS progenitors. The derived constraints are very strongly influenced by the requirement of keeping the binary bound after the second SN and having the merger occur relatively close to the center of the galaxy. These constraints are insensitive to the galaxy's star formation history, provided the stellar populations are older than 1 Gyr
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
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- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
- Cullen Dan
- Cullen Lorraine
- Cunha Debora R.M.F.
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- Damratoski Brad E.
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- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
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- Driver Kimberley
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- Esmail Alisgair
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- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
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- Farrugia Leonard
- Faulkner Beverley
- Faust Saul N.
- Fedosyuk Sofiya
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- Harris Clair
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- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
- Karampatsas Konstantinos
- Kasanyinga Mwila
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- Kelly Dearbhla M.
- Kelly Debbie
- Kelly Elizabeth J.
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- Kerr David
- Kerridge Simon
- Kfouri Renato de Ávila
- Khan Liaquat
- Khozoee Baktash
- Kidd Sarah
- Killen Annabel
- Kinch Jasmin
- Kinch Patrick
- King Lloyd D.W.
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- Kingham Lucy
- Klenerman Paul
- Knapper Francesca
- Knight Julian C.
- Knott Daniel
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- Lambe Teresa
- Lang Gail
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- Larkworthy Colin W.
- Larwood Jessica P.J.
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- Li Yuanyuan
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- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
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- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
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- MacGregor Gordon
- Madhavan Meera
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- Makambwa Edson
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- McLenaghan Daniela
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- Moran Marni
- Morey Ella
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- Morrison Hazel
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- Morshead Gertraud
- Morter Richard
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- Moya Nathifa
- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
- Nugent Fay L.
- Nunes Géssika
- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
- Odam Miranda
- Oelofse Suzette
- Oguti Blanche
- Olchawski Victoria
- Oldfield Neil J.
- Oliveira Catarina
- Oliveira Marianne G.
- Oosthuizen Angela
- Osborne Piper
- Owen David R.J.
- Owen Lydia
- Owens Daniel
- Owino Nelly
- Pacurar Mihaela
- Padayachee Sherman D.
- Paiva Brenda V.B.
- Palhares Edna M.F.
- Palmer Susan
- Parkinson Sivapriyai
- Parracho Helena M.R.T.
- Parsons Karen
- Patel Bhumika
- Patel Dipak
- Patel Faeezah
- Patel Kelly
- Patrick-Smith Maia
- Payne Ruth O.
- Peng Yanchun
- Penn Elizabeth J.
- Pennington Anna
- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
- Philip Tricia
- Phillips Daniel J.
- Phillips Jennifer
- Phohu Mary Kgomotso
- Pickup Lorinda
- Pieterse Sonja
- Piper Jo
- Pipini Dimitra
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- Primeira Marcelo
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- Provstgaard-Morys Samuel
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- Pulido David
- Quaid Sheena
- Rabara Ria
- Radford Alexandra
- Radia Kajal
- Rajapaska Durga
- Rajeswaran Thurkka
- Ramasamy Maheshi N.
- Ramos Lopez Fernando
- Ramos Alberto San Francisco
- Rampling Tommy
- Rand Jade
- Ratcliffe Helen
- Rawlinson Tom
- Rea David
- Rees Byron
- Reiné Jesús
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- Ribiero Carla M.
- Ricamara Marivic
- Richter Alex
- Ritchie Adam J.
- Ritchie Neil
- Robbins Alexander J.
- Roberts Hannah
- Robinson Hannah
- Robinson Ryan E.
- Rocchetti Talita T.
- Rocha Beatriz Pinho
- Roche Sophie
- Rollier Christine
- Rose Louisa
- Ross Russell Amy L.
- Rossouw Lindie
- Royal Simon
- Rudiansyah Indra
- Ruiz Sarah
- Saich Stephen
- Sala Claudia
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- Salman Ahmed M.
- Salvador Natalia
- Salvador Stephannie
- Sampaio Milla
- Samson Annette D.
- Sanchez-Gonzalez Amada
- Sanders Helen
- Sanders Katherine
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- Santos Erika
- Satti Iman
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- Saunders Jack E.
- Sayed Aakifah
- Schim van der Loeff Ina
- Schmid Annina B.
- Schofield Ella
- Schwarzbold Alexandre V.
- Screaton Gavin
- Seddiqi Samiullah
- Segireddy Rameswara R.
- Senger Roberta
- Serrano Sonia
- Shah Rajiv
- Shaik Imam
- Sharpe Hannah E.
- Sharrocks Katherine
- Shaw Robert
- Shea Adam
- Shepherd Amy
- Shepherd James G.
- Shiham Farah
- Sidhom Emad
- Silk Sarah E.
- Silva-Junior Gilberto
- Silva-Reyes Laura
- Silveira Anderson D.
- Silveira Mariana B.V.
- Singh Nisha
- Sinha Jaisi
- Skelly Donal T.
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- Smith Catherine C.
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- Smith Nick
- Snape Matthew D.
- Soares Airanuédida
- Soares Tiago
- Solórzano Carla
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- Sorio Guilherme L.
- Sorley Kim
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- Souza Alessandra R.
- Souza Bruno S.D.F.
- Souza Cinthia M.C.D.L.
- Spencer Alexandra J.
- Spina Fernanda
- Spoors Louise
- Sprinz Eduardo
- Stafford Lizzie
- Stamford Imogen
- Starinskij Igor
- Stein Ricardo
- Steven Jill
- Stockdale Lisa
- Stockwell Lisa V.
- Strickland Louise H.
- Stuart Arabella C.
- Sturdy Ann
- Sutherland Rebecca K.
- Sutton Natalina
- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
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- Blackwell Luke
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- Buttigieg Karen R.
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- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
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- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
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- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
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- Hackett Mark
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- Harris Clair
- Harris Stephanie A.
- Harris Tara
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- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
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- Mazzella Andrea
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- McInroy Lorna
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- McLenaghan Daniela
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- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
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- Mweu Philomena
- Myasaki Celia Hatsuko
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- Naker Kush
- Nana Anusha
- Nastouli Eleni
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- Parkinson Sivapriyai
- Parracho Helena M.R.T.
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- Patel Dipak
- Patel Faeezah
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- Payne Ruth O.
- Peng Yanchun
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- Peralta Alvarez Marco Polo
- Perring James
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- Petkar Sahir
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- Schim van der Loeff Ina
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- Szigeti Anna
- Tahiri-Alaoui Abdessamad
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- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/01/2021
- Field of study
Background
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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