908 research outputs found
An assessment of biochar amended soilless media for nursery propagation of northern Rocky Mountain native plants
A study was conducted to better inform nursery practitioners of the potential benefits of biochar application in common nursery media for native plant propagation. Biochar – a carbon-rich, recalcitrant charred organic co-product of the bioenergy pyrolysis process – has emerged as a promising potential replacement for various components of soilless media, namely peat, perlite, and vermiculite, in nursery seedling propagation. A strong conceptual basis exists for biochar as a nursery media amendment, but empirical data on biochar-based plant propagation is limited. This greenhouse study examined the effects of biochar displacement of standard soilless nursery media at rates of 0%, 15%, 30%, and 45% (percent volume composition) on propagation of four northern Rocky Mountain native plant species: deerhorn clarkia (Clarkia pulchella Pursh.), common blanketflower (Gaillardia aristata Pursh.), ponderosa pine (Pinus ponderosa Doug.), and Idaho fescue (Festuca idahoensis Elmer). Biochar at any level generally resulted in few differences in plant growth or media chemistry. Seedling biomass production with biochar treatment was either equivalent to the standard media (control), or in the case of Festuca, was slightly less. All plant growth parameters for Festuca, except longest leaf length, resulted in significantly lower values for all the biochar treatment levels. Final seedling height in the Pinus 30% treatment group had significantly taller seedlings, but no effect on mean total biomass. For all the species, media chemistry (pH and EC) showed little variation, and no clear trends resulting from biochar treatments emerged. Significant differences were found indicating the Pinus and Gaillardia un-amended media had higher mean pH than the other biochar treatments, but the overall range of pH values was small, and did not result in any apparent negative effects on plant growth. Although few benefits of biochar incorporation were identified, this research shows that biochar can reduce watering frequency and suitably displace up to 45% standard peat, perlite, and vermiculite media without any decrease in plant biomass growth for three of the study’s four species
Thermal simulation software outputs: a conceptual data model of information presentation for building design decision-making
Building simulation outputs are inherently complex and numerous. Extracting meaningful information from them requires knowledge which mainly resides only in the hands of experts. Initiatives to address this problem tend either to provide very constrained output data interfaces or leave it to the user to customize data organisation and query. This work proposes a conceptual data model from which meaningful dynamic thermal simulation information for building design decision-making may be constructed and presented to the user. It describes how the model was generated and can become operational, with examples of its applications to practical problems. The paper therefore contains useful information for software developers to help in specifying and designing simulation outputs which better respond to building designers’ needs
Tawney and the third way
From the 1920s to the 1950s R. H. Tawney was the most influential socialist thinker in Britain. He articulated an ethical socialism at odds with powerful statist and mechanistic traditions in British socialist thinking. Tawney's work is thus an important antecedent to third way thinking. Tawney's religiously-based critique of the morality of capitalism was combined with a concern for detailed institutional reform, challenging simple dichotomies between public and private ownership. He began a debate about democratizing the enterprise and corporate governance though his efforts fell on stony ground. Conversely, Tawney's moralism informed a whole-hearted condemnation of market forces in tension with both his concern with institutional reform and modern third way thought. Unfortunately, he refused to engage seriously with emergent welfare economics which for many social democrats promised a more nuanced understanding of the limits of market forces. Tawney's legacy is a complex one, whose various elements form a vital part of the intellectual background to current third way thinking
A Treatment with a Protease Inhibitor Recombinant from the Cattle Tick (Rhipicephalus Boophilus microplus) Ameliorates Emphysema in Mice
Aims: To determine whether a serine protease inhibitor treatment can prevent or minimize emphysema in mice.Methods: C57BL/6 mice were subjected to porcine pancreatic elastase (PPE) nasal instillation to induce emphysema and were treated with a serine protease inhibitor (rBmTI-A) before (Protocol 1) and after (Protocol 2) emphysema development. in both protocols, we evaluated lung function to evaluate the airway resistance (Raw), tissue damping (Gtis) and tissue elastance (Htis). the inflammatory profile was analyzed in the bronchoalveolar lavage (BALF) and through the use of morphometry; we measured the mean linear intercept (Lm) (to verify alveolar enlargement), the volume proportion of collagen and elastic fibers, and the numbers of macrophages and metalloprotease 12 (MMP-12) positive cells in the parenchyma. We showed that at both time points, even after the emphysema was established, the rBmTI-A treatment was sufficient to reverse the loss of elastic recoil measured by Htis, the alveolar enlargement and the increase in the total number of cells in the BALF, with a primary decrease in the number of macrophages. Although, the treatment did not control the increase in macrophages in the lung parenchyma, it was sufficient to decrease the number of positive cells for MMP-12 and reduce the volume of collagen fibers, which was increased in PPE groups. These findings attest to the importance of MMP-12 in PPE-induced emphysema and suggest that this metalloprotease could be an effective therapeutic target.Laboratorios de Investigacao Medica do Hospital das Clinicas da Faculdade de Medicina da USP (LIM/HC)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Dept Med, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUNIFESP EPM, Dept Bioquim, São Paulo, BrazilUFABC, Ctr Ciencias Nat & Humanas, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUNIFESP EPM, Dept Bioquim, São Paulo, BrazilWeb of Scienc
Geographical gradient of the <em>eIF4E</em> alleles conferring resistance to potyviruses in pea (<em>Pisum</em>) germplasm
<div><p>Background</p><p>The eukaryotic translation initiation factor 4E was shown to be involved in resistance against several potyviruses in plants, including pea. We combined our knowledge of pea germplasm diversity with that of the <i>eIF4E</i> gene to identify novel genetic diversity.</p><p>Methodology/Principal findings</p><p>Germplasm of 2803 pea accessions was screened for <i>eIF4E</i> intron 3 length polymorphism, resulting in the detection of four <i>eIF4E<sup>A-B-C-S</sup></i> variants, whose distribution was geographically structured. The <i>eIF4E<sup>A</sup></i> variant conferring resistance to the P1 PSbMV pathotype was found in 53 accessions (1.9%), of which 15 were landraces from India, Afghanistan, Nepal, and 7 were from Ethiopia. A newly discovered variant, <i>eIF4E<sup>B</sup></i>, was present in 328 accessions (11.7%) from Ethiopia (29%), Afghanistan (23%), India (20%), Israel (25%) and China (39%). The <i>eIF4E<sup>C</sup></i> variant was detected in 91 accessions (3.2% of total) from India (20%), Afghanistan (33%), the Iberian Peninsula (22%) and the Balkans (9.3%). The <i>eIF4E<sup>S</sup></i> variant for susceptibility predominated as the wild type. Sequencing of 73 samples, identified 34 alleles at the whole gene, 26 at cDNA and 19 protein variants, respectively. Fifteen alleles were virologically tested and 9 alleles (<i>eIF4E<sup>A-1-2-3-4-5-6-7</sup></i>, <i>eIF4E<sup>B-1</sup></i>, <i>eIF4E<sup>C-2</sup></i>) conferred resistance to the P1 PSbMV pathotype.</p><p>Conclusions/Significance</p><p>This work identified novel <i>eIF4E</i> alleles within geographically structured pea germplasm and indicated their independent evolution from the susceptible <i>eIF4E<sup>S1</sup></i> allele. Despite high variation present in wild <i>Pisum</i> accessions, none of them possessed resistance alleles, supporting a hypothesis of distinct mode of evolution of resistance in wild as opposed to crop species. The Highlands of Central Asia, the northern regions of the Indian subcontinent, Eastern Africa and China were identified as important centers of pea diversity that correspond with the diversity of the pathogen. The series of alleles identified in this study provides the basis to study the co-evolution of potyviruses and the pea host.</p></div
lcc: an R package to estimate the concordance correlation, Pearson correlation and accuracy over time
Background and Objective: Observational studies and experiments in medicine,
pharmacology and agronomy are often concerned with assessing whether different
methods/raters produce similar values over the time when measuring a quantitative
variable. This article aims to describe the statistical package lcc, for are, that can
be used to estimate the extent of agreement between two (or more) methods over
the time, and illustrate the developed methodology using three real examples.
Methods: The longitudinal concordance correlation, longitudinal Pearson
correlation, and longitudinal accuracy functions can be estimated based on fixed
effects and variance components of the mixed-effects regression model. Inference is
made through bootstrap confidence intervals and diagnostic can be done via plots,
and statistical tests.
Results: The main features of the package are estimation and inference about the
extent of agreement using numerical and graphical summaries. Moreover, our
approach accommodates both balanced and unbalanced experimental designs or
observational studies, and allows for different within-group error structures, while
allowing for the inclusion of covariates in the linear predictor to control systematic
variations in the response. All examples show that our methodology is flexible and
can be applied to many different data types.
Conclusions: The lcc package, available on the CRAN repository, proved to be a
useful tool to describe the agreement between two or more methods over time,
allowing the detection of changes in the extent of agreement. The inclusion of
different structures for the variance-covariance matrices of random effects and
residuals makes the package flexible for working with different types of databases
A abordagem de alguns números irracionais notáveis nos livros didáticos do ensino fundamental e médio
Este texto descreve os resultados de uma pesquisa orientada pela questão ‘Como são abordados os números irracionais no ensino básico, considerando-se como fonte o livro didático?’. Em uma amostra de livros didáticos, observamos se e como são apresentados ‘o número PI’, ‘o número de Euler’ e ‘o número de Ouro’. A investigação utilizou os núcleos de significação para analisar os sentidos do discurso presente nos textos dos livros didáticos. Constatamos que os temas apontados são introduzidos por um viés empírico ou pela definição formal, porém não ocorre intercâmbio destes pólos. Observamos que o número PI é empiricamente abordado, o número de Euler é apenas citado como uma possível base dos logaritmos e fica destaca a interface artística do número de Ouro articulada a representação algébrica. Em síntese, esta opção dos livros didáticos reforça uma concepção tecnicista, limitando a compreensão da complexidade dos números irracionais no Ensino Fundamental e Médio.Palavras-chave: Livro Didático. Núcleos de Significação. Número PI. Número de Euler. Número de Ouro
Low-Cost Gas Sensors Produced by the Graphite Line-Patterning Technique Applied to Monitoring Banana Ripeness
A low-cost sensor array system for banana ripeness monitoring is presented. The sensors are constructed by employing a graphite line-patterning technique (LPT) to print interdigitated graphite electrodes on tracing paper and then coating the printed area with a thin film of polyaniline (PANI) by in-situ polymerization as the gas-sensitive layer. The PANI layers were used for the detection of volatile organic compounds (VOCs), including ethylene, emitted during ripening. The influence of the various acid dopants, hydrochloric acid (HCl), methanesulfonic acid (MSA), p-toluenesulfonic acid (TSA) and camphorsulfonic acid (CSA), on the electrical properties of the thin film of PANI adsorbed on the electrodes was also studied. The extent of doping of the films was investigated by UV-Vis absorption spectroscopy and tests showed that the type of dopant plays an important role in the performance of these low-cost sensors. The array of three sensors, without the PANI-HCl sensor, was able to produce a distinct pattern of signals, taken as a signature (fingerprint) that can be used to characterize bananas ripeness
[advances And Challenges To The Brazilian Policy Of Health Technology Management].
The Brazilian Ministry of Health has institutionalized two articulated processes in the field of health technology management: (i) the production, systematization and dissemination of health technology assessment, and (ii) the adoption of a flow for the incorporation, exclusion or alteration of new technologies by the Brazilian National Health System. Several advances have been made, such as standardization of methods; production and promotion of studies; institutional development and international cooperation in the area of health technology assessment; definition of the necessary requirements for the presentation of proposals; definition of deadlines; and expansion of the segments that compose the committee that is responsible for the analysis and recommendation. However, some difficulties remain: health technology assessment activities concentrated in the Ministry; low sustainability of the activities of production and dissemination of the assessments; low penetration of health technology assessment in health care institutions; activities of assessment/incorporation with low participation of users; non-transparent decision-making processes; and low integration of the health policy with the scientific and technological policy.46 Suppl 183-9
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