Chinas Partnership With Russia Seen as Serious Problem for the U.S.

As war rages in Ukraine – one which China thus far has refused to condemn – Americans are acutely concerned about the partnership between China and Russia. Around nine-in-ten U.S. adults say it's at least a somewhat serious problem for the United States, and a 62% majority say it's a very serious problem – more than say the same about any of the other six problems asked about, including China's involvement in politics in the U.S., its policies on human rights and tensions between China and Taiwan, among others.

Spotlight on Poland: Negative Views of Russia Surge, but Ratings for U.S., NATO, EU Improve

The Russian invasion of Ukraine has led to a dramatic shift in attitudes in Poland, a key European partner and one which only three decades ago was part of the former Soviet Union's Eastern Bloc. Negative attitudes among Poles towards Russia are at all-time highs since Pew Research Center began tracking opinion on this question in 2007, with virtually unanimous negative opinions of the Russian state. Currently, 94% see Russia as a major threat, up from 65% who said this in 2018, and 94% have no confidence at all in Russian President Vladimir Putin -- also an all-time high. The sharp decline in positive attitudes toward Russia has benefited Poland's western allies, specifically the United States, the North Atlantic Treaty Organization (NATO) and the European Union (Poland is a member of both NATO and the EU). Around nine-in-ten Poles have a favorable view of the U.S., NATO and the EU, all of which represent the highest shares since 2007. In terms of Poland's relationship with the U.S., the increase in favorable attitudes toward America coincides with a strong 82% confidence rating for U.S. President Joe Biden, a marked increase from the 51% who had confidence in former President Donald Trump in 2019. In addition, roughly two-thirds in Poland see having a close relationship with the U.S. as more important than having one with Russia. Only 1% want a closer relationship with Russia, while 28% volunteer that both are equally important. Just three years ago, more than half of Poles (53%) offered that both relationships are equally important

What Do Americans Know About International Affairs?

Americans know a great deal about certain global leaders and institutions. For example, nearly eight-in-ten U.S. adults can look at a photo of Kim Jong Un and correctly identify him as the leader of North Korea, and nearly two-thirds know that Boris Johnson is the current prime minister of the United Kingdom. A slim majority also know that Ukraine is not a member of the North Atlantic Treaty Organization (NATO).However, as a new Pew Research Center survey shows, Americans are less familiar with other topics. Despite the U.S. government labeling the events in Xinjiang, China, as genocide, only around one-in-five Americans are aware that it is the region in China with the most Muslims per capita. And only 41% can identify the flag of the second most populous country in the world, India

Social Media Seen as Mostly Good for Democracy Across Many Nations, But U.S. is a Major Outlier

As people across the globe have increasingly turned to Facebook, Twitter, WhatsApp and other platforms to get their news and express their opinions, the sphere of social media has become a new public space for discussing – and often arguing bitterly – about political and social issues. And in the mind of many analysts, social media is one of the major reasons for the declining health of democracy in nations around the world.However, as a new Pew Research Center survey of 19 advanced economies shows, ordinary citizens see social media as both a constructive and destructive component of political life, and overall most believe it has actually had a positive impact on democracy. Across the countries polled, a median of 57% say social media has been more of a good thing for their democracy, with 35% saying it has been a bad thing.There are substantial cross-national differences on this question, however, and the United States is a clear outlier: Just 34% of U.S. adults think social media has been good for democracy, while 64% say it has had a bad impact. In fact, the U.S. is an outlier on a number of measures, with larger shares of Americans seeing social media as divisive

Salivary Cortisol Mediates Effects of Poverty and Parenting on Executive Functions in Early Childhood

In a predominantly low-income population-based longitudinal sample of 1,292 children followed from birth, higher level of salivary cortisol assessed at ages 7, 15, and 24 months was uniquely associated with lower executive function ability and to a lesser extent IQ at age 3 years. Measures of positive and negative aspects of parenting and household risk were also uniquely related to both executive functions and IQ. The effect of positive parenting on executive functions was partially mediated through cortisol. Typical or resting level of cortisol was increased in African American relative to White participants. In combination with positive and negative parenting and household risk, cortisol mediated effects of African American ethnicity, income-to-need, and maternal education on child cognitive ability.

Policy Recommendations for Meeting the Grand Challenge to Build Financial Capability and Assets for All

This brief was created forSocial Innovation for America’s Renewal, a policy conference organized by the Center for Social Development in collaboration with the American Academy of Social Work & Social Welfare, which is leading theGrand Challenges for Social Work initiative to champion social progress. The conference site includes links to speeches, presentations, and a full list of the policy briefs

Effect of plant chemical variation and mutualistic ants on the local population genetic structure of an aphid herbivore

Plants exhibit impressive genetic and chemical diversity, not just between species but also within species, and the importance of plant intraspecific variation for structuring ecological communities is well known. When there is variation at the local population level, this can create a spatially heterogeneous habitat for specialised herbivores potentially leading to non-random distribution of individuals across host plants. Plant variation can affect herbivores directly and indirectly via a third species, resulting in variable herbivore growth rates across different host plants. Herbivores also exhibit within-species variation, with some genotypes better adapted to some plant variants than others. We genotyped aphids collected across 2 years from a field site containing ~200 patchily distributed host plants that exhibit high chemical diversity. The distribution of aphid genotypes, their ant mutualists, and other predators was assessed across the plants. We present evidence that the local distribution of aphid (Metopeurum fuscoviride) genotypes across host-plant individuals is associated with variation in the plant volatiles (chemotypes) and non-volatile metabolites (metabotypes) of their host plant tansy (Tanacetum vulgare). Furthermore, these interactions in the field were influenced by plant-host preferences of aphid-mutualist ants. Our results emphasise that plant intraspecific variation can structure ecological communities not only at the species level but also at the genetic level within species and that this effect can be enhanced through indirect interactions with a third species

Our friend in the north: the origins, evolution and appeal of the cult of St Duthac of Tain in later Middle Ages

St Duthac of Tain was one of the most popular Scottish saints of the later middle ages. From the late fourteenth century until the reformation devotion to Duthac outstripped that of Andrew, Columba, Margaret and Mungo, and Duthac's shrine in Easter Ross became a regular haunt of James IV (1488-1513) and James V (1513-42). Hitherto historians have tacitly accepted the view of David McRoberts that Duthac was one of several local saints whose emergence and popularity in the fifteenth century was part of a wider self-consciously nationalist trend in Scottish religious practice. This study looks beyond the paradigm of nationalism to trace and explain the popularity of St Duthac from the shadowy origins of the cult to its heyday in the early sixteenth century

Small RNA changes en route to distinct cellular states of induced pluripotency

MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (iPSCs), however, exactly how miRNA expression changes support the transition to pluripotency requires further investigation. Here we use a murine secondary reprogramming system to sample cellular trajectories towards iPSCs or a novel pluripotent ‘F-class’ state and perform small RNA sequencing. We detect sweeping changes in an early and a late wave, revealing that distinct miRNA milieus characterize alternate states of pluripotency. miRNA isoform expression is common but surprisingly varies little between cell states. Referencing other omic data sets generated in parallel, we find that miRNA expression is changed through transcriptional and post-transcriptional mechanisms. miRNA transcription is commonly regulated by dynamic histone modification, while DNA methylation/demethylation consolidates these changes at multiple loci. Importantly, our results suggest that a novel subset of distinctly expressed miRNAs supports pluripotency in the F-class state, substituting for miRNAs that serve such roles in iPSCs

Parent proxy-report of their children's health-related quality of life: an analysis of 13,878 parents' reliability and validity across age subgroups using the PedsQL™ 4.0 Generic Core Scales

BACKGROUND: Health-related quality of life (HRQOL) measurement has emerged as an important health outcome in clinical trials, clinical practice improvement strategies, and healthcare services research and evaluation. While pediatric patient self-report should be considered the standard for measuring perceived HRQOL, there are circumstances when children are too young, too cognitively impaired, too ill or fatigued to complete a HRQOL instrument, and reliable and valid parent proxy-report instruments are needed in such cases. Further, it is typically parents' perceptions of their children's HRQOL that influences healthcare utilization. Data from the PedsQL™ Database(SM )were utilized to test the reliability and validity of parent proxy-report at the individual age subgroup level for ages 2–16 years as recommended by recent FDA guidelines. METHODS: The sample analyzed represents parent proxy-report age data on 13,878 children ages 2 to 16 years from the PedsQL™ 4.0 Generic Core Scales Database(SM). Parents were recruited from general pediatric clinics, subspecialty clinics, and hospitals in which their children were being seen for well-child checks, mild acute illness, or chronic illness care (n = 3,718, 26.8%), and from a State Children's Health Insurance Program (SCHIP) in California (n = 10,160, 73.2%). RESULTS: The percentage of missing item responses for the parent proxy-report sample as a whole was 2.1%, supporting feasibility. The majority of the parent proxy-report scales across the age subgroups exceeded the minimum internal consistency reliability standard of 0.70 required for group comparisons, while the Total Scale Scores across the age subgroups approached or exceeded the reliability criterion of 0.90 recommended for analyzing individual patient scale scores. Construct validity was demonstrated utilizing the known groups approach. For each PedsQL™ scale and summary score, across age subgroups, healthy children demonstrated a statistically significant difference in HRQOL (better HRQOL) than children with a known chronic health condition, with most effect sizes in the medium to large effect size range. CONCLUSION: The results demonstrate the feasibility, reliability, and validity of parent proxy-report at the individual age subgroup for ages 2–16 years. These analyses are consistent with recent FDA guidelines which require instrument development and validation testing for children and adolescents within fairly narrow age groupings and which determine the lower age limit at which reliable and valid responses across age categories are achievable. Even as pediatric patient self-report is advocated, there remains a fundamental role for parent proxy-report in pediatric clinical trials and health services research