Körperproportionen der Leistungsstärkstenjuniorenruderer im bezug auf Wettkampfniveau,den Stil des Ruderns und die Bootsgattung

The performance of elite rowers is, beside others, determined by their physical characteristics. Anthropometric data for adult rowers emphasise the importance of body mass and body size for rowing performance. Little is known concerning the importance of proportional length development. At the 1997 World Junior Rowing Championships anthropometric measurements (body mass and 6 length dimensions) were performed on 383 elite male junior rowers. Based on these measurements several proportional length dimensions were calculated. Data on boat type were obtained by questionnaire and data on competition level were based on the results obtained during the championship. The results indicate that these rowers were heavier (Mean = 82.2±7.4 kg) and taller (Mean = 187.4±5.8 cm) and had a larger sitting height (Mean=96.8±3.2 cm) and longer legs (Mean= 90.7±3.8 cm) than a reference population. Finalists had significantly larger length dimensions than non-finalists and sweep rowers had in general larger length dimensions than scullers. No differences existed when the length dimensions were expressed proportional to the stature of the rowers. It can be concluded that elite junior rowers have larger length dimensions compared to less successful rowers, but these top athletes do not differentiate from the sub-elite athletes regarding proportional length development. Differences could be observed between sweep rowers and scullers with larger length dimensions in favour of sweep rowers.Uvod Natjecateljska uspješnost vrhunskih veslača određena je, između ostaloga, i njihovim tjelesnim karakteristikama. S biološkog stajališta možemo kod sportaša olimpijske i svjetske razine kvalitete očekivati optimalnu ekspresiju utjecaja nasljeđa, sportske pripreme, prehrane i socio-kulturnih faktora. Ispitivanje obilježja tih sportaša može pomoći kineziolozima, znanstvenicima i trenerima, u razumijevanju vrhunskog sportskog uspjeha time što im pruža informacije korisne za oblikovanje strategija za objašnjenje i predviđanje sportskih rezultata. U prošlosti su se antropometrijske studije bavile uglavnom veslačima seniorima, a manje juniorima. Te antropometrijske studije naglašavaju važnost tjelesne mase i veličine tijela za uspješnost u veslanju. Smatra se da osobitu prednost veslačima donose duži udovi zbog toga što su to duže poluge i što omogućuju veću radnu snagu. Duge noge pojačavaju potisnu fazu (provlak) veslačkog zaveslaja. Štoviše, veći veslači imaju veći presjek mišića i veći apsolutni energetski kapacitet. Proučavanje longitudinalnih dimenzija do sada je bilo uglavnom ograničeno na varijablu “visina tijela ili stas”. Samo je nekoliko studija o proporcijama longitudinalnih dimenzija vrhunskih veslača, pa se malo zna o važnosti longitudinalnih proporcija tijela veslača. Cilj je ove studije bio trostruk: (1) opisati razvojne proporcijske longitudinalne dimenzije juniora veslača u usporedbi s flamanskim mladićima, (2) usporediti tjelesne proporcije veslača prema različitim kvalitetnim natjecateljskim razinama, načinu veslanja i kategorijama čamca i (3) ustanoviti model antropometrijskog profila za veslače juniore. Metode Uzorak ispitanika činila su 383 veslača juniora, u dobi od 17,8 ± 0,7 godina, raspon godina od 15,1 do 18,6. Ispitanici su nastupili na FISA svjetskom ju-niorskom veslačkom prvenstvu 1997 godine. Istraživanjem je obuhvaćeno 90% sudionika (bez kormilara), od toga 83% pobjednika i osvajača meda-lja te 89% finalista. Svi su trenirali 7-10 puta tjedno (10-15 sati). Potpuni opis uzorka i mjerenja može se naći u članku Bourgois i suradnici (1998). Za ovaj članak upotrijebljene su sljedeće tjelesne dimenzije: tjelesna visina, sjedeća visina, duljina nadlaktice, duljina podlaktice, duljina šake i duljina potkoljenice. Mjerenja su provedena u standardnim uvjetima prema postupcima koje su opisali Claessens i suradnici (1998). Na temelju tih mjera izračunate su proporcijske longitudinalne dimenzije. Pregled varijabli prikazan je u tablici 1. Podaci o vrsti čamca prikupljeni su upitnikom, a podaci o kvalitetnoj razini temeljili su se na rezultatima postignutima na prvenstvu. Međunarodna juniorska veslačka natjecanja standardizirana su na stazi od 2 000 m i podijeljena su u discipline veslanja jednim veslom (rimen) i veslanja na pariće (skul). Te se veslačke tehnike međusobno dosta razlikuju – veslač u čamcu rimen, dakle, vesla samo jednim veslom, dok skuleri koriste dva kraća vesla koja povlače istodobno. Izračunati su parametri deskriptivne statistike (aritmetička sredina, standardna devijacija i raspon) za sve varijable i za ukupni uzorak veslača. Za usporedbu proporcijskih odnosa između rimen veslača i skul veslača te finalista i onih koji se nisu plasirali u finale upotrijebljen je Studentov t-test za nezavisne uzorke. Analiza varijance (ANOVA) i post-hoc Tukeyjev test primijenjeni su da bi se otkrile razlike u proporcionalnosti među veslačima u raznim vrstama čamaca. Za statističke analize korišten je računalni program Statistical Analysis System. Svi su testovi bili dvostruki, a značajnom se smatrala razlika na razini od p<0.05. Rezultati Deskriptivna statistika prikazana je u tablici 3. U tablici su uspoređene proporcije veslača u rimenu i skulu. Rimen veslači bili su značajno viši i teži od skulera. Kada su se longitudinalne dimenzije dovele u proporcijski odnos prema tjelesnoj visini, nisu primijećene značajne razlike između te dvije vrste veslača. Slični su se rezultati dobili i u usporedbi finalista i ne-finalista (tablica 5). Prema rezultatima analize varijance (tablica 6) razlike između dva stila veslanja (rimen nasuprot skul) nađene su između dvojca sa (2+) i četverca sa (4+), s jedne strane, te samca (1x), četverca na pariće (4x) i dvojca bez (2-), s druge strane. Sportaši koji veslaju u dvojcu sa (2+) i četvercu sa (4+) bili su, u prosjeku, teži i viši od veslača u samcu (1x), četvercu na pariće (4x) i dvojcu bez (2-). Nisu dobivene razlike u proporcijskim odnosima longitudinalnih dimenzija prema vrsti čamaca. U tablici 7 predstavljen je model profila proporcijskih odnosa longitudinalnih dimenzija za veslače juniore koji su nastupili na FISA svjetskom juniorskom veslačkom prvenstvu. Rasprava i zaključak Rezultati pokazuju da su promatrani veslači teži i viši te da imaju veću sjedeću visinu i duže noge od opće populacije. Finalisti su imali značajno veće longitudinalne dimenzije od ne-finalista, a rimen veslači su općenito imali veće longitudinalne dimenzije od skulera. Nisu, međutim, dobivene razlike kada su longitudinalne dimenzije postavljene u proporcijski odnos prema tjelesnoj visini. Veslanje je sport izdržljivosti i longitudinalne dimenzije su nedvojbeno povezane s uspješnošću. Duge noge pojačavaju potisak u fazi provlaka tijekom veslačkog zaveslaja, što znači da su veslači s dugim nogama u biomehaničkoj prednosti. Usporedba tjelesnih proporcija izmjerenih veslača juniora s vrijednostima o kojima su izvijestili drugi autori (Carter i dr., 1982; Rodriguez, 1986) otkriva da veslači juniori imaju manju sjedeću visinu u odnosu na ukupnu tjelesnu visinu ili stas (Valoisov indeks) (51,6%) i veću duljinu nogu u odnosu na stas (48,4%) od normativne usporedne skupine (Ostyn i dr., 1980) (52,1% i 47,9%) i od teških olimpijskih veslača (Carter i dr, 1982) (52,1% i 47,.9%). Nisu dobivene razlike između veslača juniora i vrhunskih lakih veslača (51,5% i 48,5%). Može se zaključiti da su kvalitetniji veslači uglavnom viši i, povezano s tom razlikom, imaju veće longitudinalne dimenzije od manje uspješnih veslača, ali se oni ne razlikuju međusobno kada se te vrijednosti izraze proporcionalno u odnosu na njihovu tjelesnu visinu. Uočene su razlike između rimen veslača i skul veslača – rimen veslači su višega stasa i imaju veće apsolutne vrijednosti longitudinalnih dimenzija. Uz to što je izrađen profil veslača juniora, rezultati ove studije mogu pomoći trenerima i kineziolozima da steknu bolji uvid u to koje su morfološke karakteristike povezane s uspješnošću u veslanju. Rezultati se također mogu primijeniti za određenje antropometrijskog profila veslača i kao instrument za selekciju dječaka talentiranih za veslanje.Die Leistung der leistungsstärksten Ruderer ist unter anderem von ihren körperlichen Eigenschaften bestimmt. Körperbaudaten für erwachsene Ruderer stellen den Nachdruck auf die Wichtigkeit des Körpergewichts und der Körperhöhe für das Rudern. Es bleibt noch unklar, wie wichtig die proportionale Längenzunahme ist. Während der Junioren Weltmeisterschaften im 1997 wurden die Körperbau-Messungen (Körpergewicht und 6 Extremitätenlängen) auf 383 leistungsstärksten Junioren-Ruderer vorgenommen. Auf Grund dieser Messungen einige proportionale Extremitätenlängen wurden berechnet. Die Angaben über die Bootsgat-tung wurden einem Fragebogen entnommen, während die Angaben über dem Wettkampf-Niveau auf den während der Meisterschaft gewonnenen Ergebnissen basierten. Den Ergebnissen nach wogen diese Ruderer mehr (Mittelwert = 82,2±7,4 kg), sie waren größer (Mittelwert = 187,4±5,8 cm) und hatten eine größere Sitzhöhe (Mittelwert = 96,8±3,2 cm) und längere Beine (Mittelwert = 90,7±3,8 cm) als die Referenz-Grundgesamtheit. Die Finalisten hatten bedeutend größere Extremitätenlängenwerte als die Nicht-Finalisten, während die Riemenruderer im allgemeinen größere Extremitätenlängenwerte hatten als die Skuller. Keine Unterschiede waren zu merken, wenn die Extremitätenlängenwerte proportional der Körperhöhe der Ruderer dargestellt wurden. Daraus lässt sich schließen, dass die leistungsstärksten Junioren größere Extremitätenlängenwerte haben im Vergleich zu den weniger erfolgreichen Ruderern, aber diese Spitzensportler unterscheiden sich keineswegs von weniger erfolgreichen Sportlern im Bezug auf die proportionale Längenzunahme. Die Unterschiede sind bei den Riemenruderern und den Skullern zu merken, wobei die Skuller größere Extremitätenlängenwerte aufzeigen

Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease

BACKGROUND: Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long-term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. METHODS AND RESULTS: Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology. We applied a placental pathology severity score to relate placental abnormalities to neurological outcome. Postnatal, presurgical magnetic resonance imaging was used to analyze brain volumes, gyrification, and brain injuries. Placental analyses revealed the following abnormalities: maternal vascular malperfusion lesions in 46%, nucleated red blood cells in 37%, chronic inflammatory lesions in 35%, delayed maturation in 30%, and placental weight below the 10th percentile in 28%. Severity of placental pathology was negatively correlated with cortical gray matter, deep gray matter, brainstem, cerebellar, and total brain volumes (r=-0.25 to -0.31, all P&lt;0.05). When correcting for postmenstrual age at magnetic resonance imaging in linear regression, this association remained significant for cortical gray matter, cerebellar, and total brain volume (adjusted R2=0.25-0.47, all P&lt;0.05). CONCLUSIONS: Placental pathology occurs frequently in neonates with severe congenital heart disease and may contribute to impaired brain development, indicated by the association between placental pathology severity and reductions in postnatal cortical, cerebellar, and total brain volumes.</p

Observer Variation of 2-Deoxy-2-[F-18]fluoro-d-Glucose-Positron Emission Tomography in Mediastinal Staging of Non-Small Cell Lung Cancer as a Function of Experience, and its Potential Clinical Impact

Purpose: To test the extent of variation among nuclear medicine physicians with respect to staging non-small cell lung cancer with positron emission tomography (PET). Procedures: Two groups of nuclear medicine physicians with different levels of PET experience reviewed 30 PET scans. They were requested to identify and localize suspicious mediastinal lymph nodes (MLN) using standardized algorithms. Results were compared between the two groups, between individuals, and with expert reading. Results: Overall we found good interobserver agreement (kappa 0.65). Experience with PET translated into a better ability to localize MLN stations (68 % vs. 51%, respectively), and experienced readers appeared to be more familiar with translating PET readings into clinically useful statements. Conclusions: Although our results suggest that clinical experience with PET increases observers _ ability to read and interpret results from PET adequately, there is room for improvement. Experience with PET does not necessarily improve the accuracy of image interpretation

Agent-based control of a neighborhood: a generic approach by coupling Modelica with Python

The research of optimal control in residential building clusters is approached from different disciplines: building simulation and control engineering. Control engineers focus mainly on the research and development of sophisticated optimal control strategies combined with high-level simulation tools but less accurate building models for fast prototyping of new control strategies. On the other hand, building simulation experts develop detailed building models which provide realistic and accurate building representations, however often in a simulation environment which is less suited for control. This paper proposes several methodologies to extend building and cluster models in Modelica, an objectoriented modelling and simulation language, with a Python control layer in order to bridge the gap between both disciplines. Co-simulation tries to leverage the advantages of both approaches by enabling the combination of both in an integrated simulation and keeping the development of the building models and control strategies separate. Control algorithms developed in Python can then easily be tested on detailed models in Modelica. As such, the Modelica simulation model is used as an emulator or virtual test bed. These integrated co-simulations can provide new insights in the behavior of building clusters when using sophisticated control algorithms.status: publishe

Interobserver agreement on captopril renography for assessing renal vascular disease

Captopril-stimulated renography is widely used to screen selected groups of hypertensive patients for renal vascular disease. Evaluation of the test is a complex task. Lack of interobserver agreement on the assessment and interpretation of renographic parameters may contribute to differences in sensitivity and specificity between studies. Methods: Three experienced nuclear medicine physicians evaluated 658 renograms of 503 hypertensive patients suspected of having renal vascular disease from a large Dutch multicenter study (the Dutch Renal Artery Stenosis Intervention Cooperative [DRASTIC] study). Interobserver agreement on several renographic parameters was assessed by the K statistic and the intraclass correlation coefficient (ICC). Results: The interobserver agreement on the time to excretion was high: The pooled ICC was 0.90. The pooled K was ≥0.65 for the pattern of the time-activity curves, the visual aspect of the scintigraphic images (visible uptake and kidney size), and the judgment on the presence of renal artery stenosis. However, the interobserver agreement on cortical retention and pelvic retention by visual inspection of the images was rather low (pooled K = 0.46 and 0.52, respectively). Pelvic retention was found to complicate the interpretation of renography. Conclusion: Interobserver agreement on most of the renographic parameters was satisfactory, but the assessment of cortical retention was more difficult, in particular, in the presence of pelvic retention. Captopril renography should be interpreted with caution if pelvic retention is suspected. Interobserver variability offers one of several explanations for the differences in diagnostic test performance that are found between studies

Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease

BACKGROUND: Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long-term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. METHODS AND RESULTS: Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology. We applied a placental pathology severity score to relate placental abnormalities to neurological outcome. Postnatal, presurgical magnetic resonance imaging was used to analyze brain volumes, gyrification, and brain injuries. Placental analyses revealed the following abnormalities: maternal vascular malperfusion lesions in 46%, nucleated red blood cells in 37%, chronic inflammatory lesions in 35%, delayed maturation in 30%, and placental weight below the 10th percentile in 28%. Severity of placental pathology was negatively correlated with cortical gray matter, deep gray matter, brainstem, cerebellar, and total brain volumes (r=-0.25 to -0.31, all P&lt;0.05). When correcting for postmenstrual age at magnetic resonance imaging in linear regression, this association remained significant for cortical gray matter, cerebellar, and total brain volume (adjusted R2=0.25-0.47, all P&lt;0.05). CONCLUSIONS: Placental pathology occurs frequently in neonates with severe congenital heart disease and may contribute to impaired brain development, indicated by the association between placental pathology severity and reductions in postnatal cortical, cerebellar, and total brain volumes.</p

Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents

In 1991, WHO recognized the resurgence of tuberculosis as a global health problem. Although modern chemotherapy is effective against the causative pathogen Mycobacterium tuberculosis, the current drug regimens have failed to eradicate the disease. The success of the pathogen, partially attributed to drug resistance, necessitates the development of novel anti-tuberculosis drugs. Benzo[j]phenanthridine-7,12-diones, tetracyclic derivatives of the natural product benz[g]isoquinoline-5,10-dione, were conveniently synthesized via palladium-catalyzed intramolecular cyclization of N-methanesulfonyl-3-bromo-2-(arylamino)methyl-1,4-naphthoquinones. Here we report on the bioactivity of eight benzo[j]phenanthridine-7,12-dione derivatives as candidate drug molecules against M. tuberculosis and on their cytotoxicity on C3A human hepatocytes. The strongest antimicrobial activity (as detected by growth inhibition of bacteria, using luminometry and BACTEC 460-TB) and lowest cytotoxicity was found for 3-methylbenzo[j]phenanthridine-7,12-dione 5e, which was also effective in targeting intracellular M. tuberculosis (in murine J774 macrophages) and was not genotoxic for C3A hepatocytes</p

Quality of life in a real-world cohort of advanced breast cancer patients:a study of the SONABRE Registry

Purpose We aimed to evaluate quality of life (QoL) using the European Quality of Life Five-Dimensions questionnaire (EQ-5D-3L) in a real-world cohort of Dutch advanced breast cancer (ABC) patients. Secondary, we reported differences in QoL between subgroups of patients based on age, comorbidity, tumor-, and treatment characteristics, and assessed the association of duration of metastatic disease and time to death with QoL. Methods ABC patients who attended the outpatient clinic between October 2010 and May 2011 were asked to fill out the EQ-5D-3L questionnaire. Patient-, disease-, and treatment characteristics were obtained from the medical files. Health-utility scores were calculated. Subgroups were described and compared for utility scores by parametric and non-parametric methods. Results A total of 92 patients were included with a median utility score of 0.691 (Interquartile range [IQR] 0.244). Patients &gt;= 65 years had significantly worse median utility scores than younger patients; 0.638 versus 0.743, respectively (p = 0.017). Moreover, scores were significantly worse for patients with versus those without comorbidity (medians 0.620 versus 0.725,p = 0.005). Utility scores did not significantly differ between subgroups of tumor type, type of systemic treatment, number of previous palliative treatment(s), or number or location of metastatic site(s). The remaining survival was correlated with utility scores (correlation coefficient (r) = 0.260,p = 0.0252), especially in the subgroup &lt;65 years (r = 0.340,p = 0.0169), whereas there was no significant correlation with time since metastatic diagnosis (r = - 0.106,p = 0.3136). Conclusion Within this real-world cross-sectional study, QoL was significantly associated with age, comorbidity, and remaining survival duration. The observation of a lower QoL in ABC patients, possibly indicating the last period of life, may assist clinical decision-making on timing of cessation of systemic antitumor therapy.</p

Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease

Background Neonates with congenital heart disease are at risk for impaired brain development in utero, predisposing children to postnatal brain injury and adverse long‐term neurodevelopmental outcomes. Given the vital role of the placenta in fetal growth, we assessed the incidence of placental pathology in fetal congenital heart disease and explored its association with total and regional brain volumes, gyrification, and brain injury after birth. Methods and Results Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology. We applied a placental pathology severity score to relate placental abnormalities to neurological outcome. Postnatal, presurgical magnetic resonance imaging was used to analyze brain volumes, gyrification, and brain injuries. Placental analyses revealed the following abnormalities: maternal vascular malperfusion lesions in 46%, nucleated red blood cells in 37%, chronic inflammatory lesions in 35%, delayed maturation in 30%, and placental weight below the 10th percentile in 28%. Severity of placental pathology was negatively correlated with cortical gray matter, deep gray matter, brainstem, cerebellar, and total brain volumes (r=−0.25 to −0.31, all P<0.05). When correcting for postmenstrual age at magnetic resonance imaging in linear regression, this association remained significant for cortical gray matter, cerebellar, and total brain volume (adjusted R2=0.25–0.47, all P<0.05). Conclusions Placental pathology occurs frequently in neonates with severe congenital heart disease and may contribute to impaired brain development, indicated by the association between placental pathology severity and reductions in postnatal cortical, cerebellar, and total brain volumes