Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.</p

Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.</p

Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.</p

Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.</p

Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC.Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study.Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08).Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.</p

Large carnivore expansion in Europe is associated with human population density and land cover changes

Aim: The recent recovery of large carnivores in Europe has been explained as resulting from a decrease in human persecution driven by widespread rural land abandonment, paralleled by forest cover increase and the consequent increase in availability of shelter and prey. We investigated whether land cover and human population density changes are related to the relative probability of occurrence of three European large carnivores: the grey wolf (Canis lupus), the Eurasian lynx (Lynx lynx) and the brown bear (Ursus arctos).Location: Europe, west of 64 degrees longitude.Methods: We fitted multi-temporal species distribution models using >50,000 occurrence points with time series of land cover, landscape configuration, protected areas, hunting regulations and human population density covering a 24-year period (1992-2015). Within the temporal window considered, we then predicted changes in habitat suitability for large carnivores throughout Europe.Results: Between 1992 and 2015, the habitat suitability for the three species increased in Eastern Europe, the Balkans, North-West Iberian Peninsula and Northern Scandinavia, but showed mixed trends in Western and Southern Europe. These trends were primarily associated with increases in forest cover and decreases in human population density, and, additionally, with decreases in the cover of mosaics of cropland and natural vegetation.Main conclusions: Recent land cover and human population changes appear to have altered the habitat suitability pattern for large carnivores in Europe, whereas protection level did not play a role. While projected changes largely match the observed recovery of large carnivore populations, we found mismatches with the recent expansion of wolves in Central and Southern Europe, where factors not included in our models may have played a dominant role. This suggests that large carnivores' co-existence with humans in European landscapes is not limited by habitat availability, but other factors such as favourable human tolerance and policy

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.

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¡Cuidame, no me dañes con tus remedios!

La automedicación ha tomado una nueva dimensión. Hoy, es clara la relación directa entre sociedad desarrollada y consumo abusivo de fármacos, tanto en los adolescentes como en las embarazadas, comparado con décadas anteriores. Dicho hábito es la práctica mediante la cual la población reconoce por sí misma las enfermedades o síntomas, y los trata con los medicamentos disponibles, sin prescripción médica. Estudios realizados a través de la Organización Mundial de la Salud se ha observado una tendencia progresiva del uso de fármacos sin recetas en condiciones de sobreoferta, en el 65 % de embarazadas durante el segundo y tercer trimestre de embarazo. En estudios de Extensión realizados en diferentes establecimientos primarios de la localidad de Berisso, se registró un 62 % de automedicación en embarazadas con antibióticos y analgésicos antiinflamaflamtorios no esteroideos, y un 30 % de autoprescripción el mismo tipo de fármaco, pudiendo causar efectos mutantes en el niño, o alteraciones cerebrales súbitas en los recién nacidos, entre otras manifestaciones.Facultad de Odontología (FOLP

¡Cuidame, no me dañes con tus remedios!

La automedicación ha tomado una nueva dimensión. Hoy, es clara la relación directa entre sociedad desarrollada y consumo abusivo de fármacos, tanto en los adolescentes como en las embarazadas, comparado con décadas anteriores. Dicho hábito es la práctica mediante la cual la población reconoce por sí misma las enfermedades o síntomas, y los trata con los medicamentos disponibles, sin prescripción médica. Estudios realizados a través de la Organización Mundial de la Salud se ha observado una tendencia progresiva del uso de fármacos sin recetas en condiciones de sobreoferta, en el 65 % de embarazadas durante el segundo y tercer trimestre de embarazo. En estudios de Extensión realizados en diferentes establecimientos primarios de la localidad de Berisso, se registró un 62 % de automedicación en embarazadas con antibióticos y analgésicos antiinflamaflamtorios no esteroideos, y un 30 % de autoprescripción el mismo tipo de fármaco, pudiendo causar efectos mutantes en el niño, o alteraciones cerebrales súbitas en los recién nacidos, entre otras manifestaciones.Facultad de Odontología (FOLP

Un lugar de encuentro con padres para que reflexionemos juntos sobre la automedicación

La automedicación se refiere al uso de medicamentos por iniciativa propia de las personas con el propósito de tratar las enfermedades o síntomas que ellas mismas reconocen. Esta práctica constituye un riesgo para la salud. En el embarazo, los fármacos en su mayoría atraviesan la barrera placentaria y pueden ocasionar consecuencias negativas, a la madre, al futuro bebé e interferiren el desarrollo embrionario. Si nos orientamos hacia el uso racional de fármacos, la utilización apropiada demanda no solo un adecuado y amplio conocimiento de las características e indicaciones de los medicamentos sino también conocer las particularidades de las personas a las cuales se prescribe.Facultad de Odontologí