Modelling distributed lag effects in mortality and air pollution studies: the case of Santiago

Most of the epidemiological literature on air pollution and mortality deals only with single or dual pollutant models whose results are hard to interpret and of questionable value from the policy perspective. In addition, much of the existing literature deals only with the very short-term effects of air pollution whereas policy makers need to know when, whether and to what extent pollution-induced increases in mortality counts are reversed. This involves modelling the infinite distributed lag effects of air pollution. Borrowing from econometrics this paper presents a method by which the infinite distributed lag effects can be estimated parsimoniously but plausibly estimated. The paper presents a time series study into the relationship between ambient levels of air pollution and daily mortality counts for Santiago employing this technique which confirms that the infinite lag effects are highly significant. It is also shown that day to day variations in NO2 concentrations and in the concentrations of both fine and coarse particulates are associated with short-term variations in death rates. These findings are made in the context of a model that simultaneously includes six different pollutants. Evidence is found pointing to the operation of a very short term harvesting effect

Cool dwarfs in wide multiple systems. Paper 6: A curious quintuple system of a compact Sun-like triple and a close pair of an M dwarf and a very cool white dwarf at a wide separation

The system WDS 16329+0315 is an old, nearby quintuple physical system in the thick Galactic disc formed by a close-resolved, triple primary of solar metallicity, namely HD 149162, and a very wide, common proper motion, secondary pair, formed by the mid-M dwarf G-17-23 and the white dwarf LSPM J1633+0311S. We present an exhaustive astrometric and photometric data compilation of the system, including Gaia DR2 parallaxes and proper motions, and the first analysis of the nature of the faintest component. LSPM J1633+0311S (HD 149162 C) is a very cool white dwarf with an effective temperature of only about 5500 K, near the coolest end of the grid of theoretical models.Comment: The Observatory, in press, to appear in December 201

A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli

This is the author accepted manuscript. The final version is available fromFerrata Storti Foundation via the DOI in this recordThe regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry, which has been utilised to monitor simultaneously platelet activation and oxygen radical generation. This technique has been used to investigate the redox-dependence of human and mouse platelets. Using selective peptide inhibitors of NOXs on human platelets and genetically modified mouse platelets (NOX1-/- or NOX2-/-), we discovered that:1) intracellular but not extracellular superoxide anion generated by NADPH oxidases (NOXs) is critical for platelet activation by collagen; 2) superoxide dismutation to hydrogen peroxide is required for thrombin-dependent activation; 3) NOX1 is the main source of oxygen radicals in response to collagen, while NOX2 is critical for activation by thrombin; 4) two platelet modulators, namely oxidised low density lipoproteins (oxLDL) and amyloid peptide β (Aβ), require activation of both NOX1 and NOX2 to pre-activate platelets. This study provides new insights on the redox dependence of platelet activation. It suggests the possibility of selectively inhibiting platelet agonists by targeting either NOX1 (for collagen) or NOX2 (for thrombin). Selective inhibition of either NOX1 or NOX2 impairs the potentiatory effect of tested platelet modulators (oxLDL and Aβ), but does not completely abolish platelet haemostatic function. This information offers new opportunities for the development of disease specific antiplatelet drugs with limited bleeding side effects by selectively targeting one NOX isoenzyme.British Heart Foundatio

Curiosity driven search: When is relevance irrelevant?

Classical information search behaviour models based on work-task scenarios fail to explain common leisure search scenarios motivated by a hedonistic need rather than a defined information need. This paper presents work into such unstructured search driven by curiosity. In order to explore this hedonistic catalyst, a social media search application was designed in which the search experience is triggered by the user's spatio-temporal context during their exploration rather than query-response based information retrieval. We report a study with real users and a simulated casual-leisure search task where results indicated that relevance is not relevant for some searches

Early fever detection on COVID-19 infection using thermoelectric module generators

In 2020 the COVID-19 pandemic has suddenly stopped society and changed human interaction. In this work, a thermoelectric generator wearable device for early fever detection symptoms is presented as a possible solution to avoid higher propagation of this disease. To identify a possible fever symptom, numerical and parametric simulations are developed using a highquality-refined hexahedral mesh. At first, a 2-pair-leg thermoelectric module has undergone simulations to establish temperature conditions, open-circuit voltage, and power output generation; and secondly, these previous results are extrapolated for a larger thermoelectric module containing 28 pair-leg of N-P type material. The numerical study shows that a maximum value of electrical power of 60.70 mW was reached for 28-pair-leg N-P type thermocouples under a constant temperature difference of 20 K

Curiosity driven search experiences

Casual-Leisure Search describes any behaviour that allows people to express and satisfy hedonistic needs rather than information needs as part of the information-seeking process. For example, individuals who search their social media universe for hours after a long day at work may do so out of curiosity, to relax or for fun (e.g. exploring for the experience). Studies have shown that classical information seeking (IS) and interactive information retrieval models (IIR) have failed to represent them because they were created observing people in work related scenarios, and assuming that search is always a rational decision making process and with an extrinsic utilitarian value. The research described in this PhD work investigates IIR from the perspective of the psychological curiosity and leisure information seeking behaviour. Traditional search engines focus the user experience on satisfying users with topically relevant information (i.e. quick lookup search and then moving on), but they are limited supporting the discovery of unknown information because they fail to entice and engage users exploration as proxy to seek enjoyment both in leisure and work scenarios. The research described increases understanding of the role that curiosity plays in IIR and investigates the merits of incorporating the characteristics and function of human curiosity in the design of IIR systems. The research is grounded by the theoretical understanding of how human curiosity works. A review of appropriate psychological curiosity literature offers a means to critique existing IIR tools and a basis from which to start designing novel curiosity driven search tools. In the first experimental work, this research compared IIR behaviour between a standard query response paradigm and a curiosity driven search map prototype using social media content, and attempts to learn lessons from the behaviour that people show in everyday casual-leisure search scenarios. In the second experiment, this research contrast IIR behaviour between standard query-response paradigm and a curious adaptation of query-response paradigm using search notifications or recommendations for news reading in a social media leisure search scenario. The tools are evaluated to determine the usefulness of incorporating curiosity in the design of IIR systems, to learn about the effect in user engagement, how users exploration is increase when motivated by a hedonistic need, and then elaborate a set of design recommendations to enhance the search experience in leisure scenarios

Cauchy completeness in elementary logic

The inverse of the distance between two structures A not equal B of finite type sis naturally measured by the smallest integer q such that a sentence of quantifier rank q-1 is satisfied by A but not by B. In this way the space Str of structures of type tau is equipped with a pseudometric. The induced topology coincides with the elementary topology of Str(tau). Using the rudiments of the theory of uniform spaces, in this elementary note we prove the convergence of every Cauchy net of structures, for any type tau.6141153115