Eta-mesic nuclei

In this contribution we report on theoretical studies of $\eta$ nuclear quasi-bound states in few- and many-body systems performed recently by the Jerusalem-Prague Collaboration [1-5]. Underlying energy-dependent $\eta N$ interactions are derived from coupled-channel models that incorporate the $N^*(1535)$ resonance. The role of self-consistent treatment of the strong energy dependence of subthreshold $\eta N$ amplitudes is discussed. Quite large downward energy shift together with rapid decrease of the $\eta N$ amplitudes below threshold result in relatively small binding energies and widths of the calculated $\eta$ nuclear bound states. We argue that the subthreshold behavior of $\eta N$ scattering amplitudes is crucial to conclude whether $\eta$ nuclear states exist, in which nuclei the $\eta$ meson could be bound and if the corresponding widths are small enough to allow detection of these $\eta$ nuclear states in experiment.Comment: 7 pages, 5 figures; presented at HADRON2017, Sept. 25-29, 2017, Salamanca (Spain); prepared for Proceedings of Scienc

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in various context-dependent ways, including increased metastatic potential, expansion of cancer stem cell subpopulations, chemo-resistance and disease recurrence. One of the hallmarks of EMT is resistance of tumor cells to anoikis. This resistance contributes to metastasis and is a defining property not only of EMT but also of cancer stem cells. Here, we review the mechanistic coupling between EMT and resistance to anoikis. The discussion focuses on several key aspects. First, we provide an update on new pathways that lead from the loss of E-cadherin to anoikis resistance. We then discuss the relevance of transcription factors that are crucial in wound healing in the context of oncogenic EMT. Next, we explore the consequences of the breakdown of cell-polarity complexes upon anoikis sensitivity, through the Hippo, Wnt and transforming growth factor β (TGF-β) pathways, emphasizing points of crossregulation. Finally, we summarize the direct regulation of cell survival genes through EMT-inducing transcription factors, and the roles of the tyrosine kinases focal adhesion kinase (FAK) and TrkB neurotrophin receptor in EMT-related regulation of anoikis. Emerging from these studies are unifying principles that will lead to improvements in cancer therapy by reprogramming sensitivity of anoikis

Latest results for the antikaon-nucleon optical potential

The key question of this letter is whether the K-nucleus optical potential is deep, as it is prefered by the phenomenological fits to kaonic atoms data, or shallow, as it comes out from unitary chiral model calculations. The current experimental situation is reviewed.Comment: 3 pages, 1 figure. Presented at the 21st European Conference on the Few-Body problems in Physics (EFB21), Salamanca, Spain, August 29 - September 3, 201

Antikaons and hyperons in nuclear matter with saturation

We evaluate the antikaon and hyperon spectral functions in a self-consistent and covariant many-body approach. The computation is based on coupled-channel dynamics derived from the chiral SU(3) Lagrangian. A novel subtraction scheme is developed that avoids kinematical singularities and medium-induced power divergencies all together. Scalar and vector mean fields are used to model nuclear binding and saturation. The effect of the latter is striking for the antikaon spectral function that becomes significantly more narrow at small momenta. Attractive mass shifts of about 30 and 40 MeV are predicted for the Lambda(1405) and Sigma(1385) resonances. Once scalar and vector mean fields for the nucleon are switched on the Lambda(1520) resonances dissolves almost completely in nuclear matter. All together only moderate attraction is predicted for the nuclear antikaon systems at saturation density. However, at larger densities we predict a sizable population of soft antikaon modes that arise from the coupling of the antikaon to a highly collective Lambda(1115) nucleon-hole state. This may lead to the formation of exotic nuclear systems with strangeness and antikaon condensation in compact stars at moderate densities.Comment: 49 pages, 13 figures, The revised manuscript contains additional material at twice nuclear saturation density. An unexpected and novel mechanism is unravelled that may have dramatic implications on the formation of exotic nuclear systems with strangeness and antikaon condensation in compact star

Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up

Clinical studies have confirmed that renal oncocytoma (RO) is a benign neoplasm with excellent prognosis. In diagnostically challenging cases of renal oncocytic epithelial neoplasms, fluorescent in-situ hybridization (FISH) is increasingly being used and its ability to distinguish RO from chromophobe renal cell carcinoma (ChRCC) has been documented. In this study, we evaluated the differential diagnostic contribution of FISH in cases of RO

Elastic Pion Scattering on the Deuteron in a Multiple Scattering Model

Pion elastic scattering on deuterium is studied in the KMT multiple scattering approach developed in momentum space. Using a Paris wave function and the same methods and approximations as commonly used in pion scattering on heavier nuclei excellent agreement with differential cross section data is obtained for a wide range of pion energies. Only for $T_{\pi}>250$ MeV and very backward angles, discrepancies appear that are reminiscent of disagreements in pion scattering on $^3$He, $^3$H, and $^4$He. At low energies the second order corrections have been included. Polarization observables are studied in detail. While tensor analyzing powers are well reproduced, vector analyzing powers exhibit dramatic discrepancies.Comment: 25 pages LATEX and 9 postscript figures in a self-extracting uufile archiv

Separable potential model for K−NK^{-}N interactions at low energies

The effective separable meson-baryon potentials are constructed to match the equivalent chiral amplitudes up to the second order in external meson momenta. We fit the model parameters (low energy constants) to the threshold and low energy $K^{-}p$ data. In the process, the $K^{-}$-proton bound state problem is solved exactly in the momentum space and the 1s level characteristics of the kaonic hydrogen are computed simultaneously with the available low energy $K^{-}p$ cross sections. The model is also used to describe the $\pi \Sigma$ mass spectrum and the energy dependence of the $K^{-}n$ amplitude.Comment: 31 pages, v2 - added corrections to make it compatible with the published versio

Pion interaction with the trinucleon up to the eta production threshold

Pion elastic, charge exchange scattering and induced eta production on the trinucleon systems are investigated in a coupled-channels approach in momentum space with Fadeev wave functions. The channel $\pi N \rightarrow \eta N$ is included using an isobar model with S-, P-, and D-wave resonances. While the coherent reactions like $^3$He($\pi,\pi)^3$He can be reasonably well reproduced up to $T_{\pi}$=500 MeV, large discrepancies appear for the incoherent processes, $^3$He($\pi^-,\pi^0)^3$H and $^3$He($\pi^-,\eta)^3$H at backward angles and energies above $\Delta$-resonance. In the forward direction the $(\pi,\eta)$ calculations underestimate the experimental measurements very close to threshold but agreement with the data improves with increasing pion energy. Predictions are made for the asymmetries of the various reactions on polarized $^3$He.Comment: 40 pages, 12 figures (available from the authors), Mainz preprint MKPH-T-92-1

The A(Kstop−,π±Σ∓)A′A(K^-_{stop},\pi^\pm\Sigma^\mp)A' reaction on p-shell nuclei

This letter is concerned with the study of the $K^-_{stop}A\rightarrow \pi^\pm\Sigma^\mp A'$ reaction in p-shell nuclei, i.e., $^{6,7}Li$, $^9Be$, $^{13}C$ and $^{16}O$. The $\pi^\pm\Sigma^\mp / K^-_{stop}$ emission rates are reported as a function of $A$. These rates are discussed in comparison with previous findings. The ratio $\pi^-\Sigma^+/\pi^+\Sigma^-$ in p-shell nuclei is found to depart largely from that on hydrogen, which provides support for large in-medium effects possibly generated by the sub-threshold $\Lambda(1405)$. The continuum momentum spectra of prompt pions and free sigmas are also discussed as well as the $\pi^\pm\Sigma^\mp$ missing mass behavior and the link with the reaction mechanism. The apparatus used for the investigation is the FINUDA spectrometer operating at the DA$\Phi$NE $\phi$-factory (LNF-INFN, Italy).Comment: 14 pages, 5 figures, accepted for publication in Phys. Lett.

Correlated Λd\Lambda d pairs from the Kstop−A→ΛdA′K^{-}_{stop} A \to \Lambda d A' reaction

Correlated $\Lambda d$ pairs emitted after the absorption of negative kaons at rest $K^{-}_{stop}A\to \Lambda d A'$ in light nuclei $^6Li$ and $^{12}C$ are studied. $\Lambda$-hyperons and deuterons are found to be preferentially emitted in opposite directions. The $\Lambda d$ invariant mass spectrum of $^6Li$ shows a bump whose mass is 3251$\pm$6 MeV/c$^2$. The bump mass (binding energy), width and yield are reported. The appearance of a bump is discussed in the realm of the [$\bar{K}3N$] clustering process in nuclei. The experiment was performed with the FINUDA spectrometer at DA$\Phi$NE (LNF).Comment: 13 pages, 5 figures, accepted for publication in Phys. Lett.