A Rewarding Community Psychology Practice in State Government

Finding employment as a community psychologist outside of academia or “in practice,” has remained an elusive goal for many community psychology graduates. This is not, however due to a lack of opportunities. Many employers would welcome the skills of a community psychologist, but both applicant and recruiter may not realize this initially. One of the most promising employment venues is state government service. Unfortunately, state jobs are often viewed in a pejorative fashion because of their stereotypic link to mundane, paper-pushing civil service positions. The following article counters this misperception by describing how I was able to find a number of rewarding state government positions that allowed me to utilize virtually all of my community psychology training (e.g., advocacy, organizational assessment, collaboration/consultation, communication, research, resource development, service delivery, planning, and management). Although I was never specifically hired with the job title “community psychologist,” all of my employers came to appreciate the benefits of my community psychology training. In chronological order, I present my employment history, a description of the position, and how my community psychology training was utilized in the position. It is my hope that this article will provide potential employment ideas and options for recent community psychology graduates and those looking for a career change. (Peer Reviewed

A Rewarding Community Psychology Practice in State Government

Finding employment as a community psychologist outside of academia or “in practice,” has remained an elusive goal for many community psychology graduates. This is not, however due to a lack of opportunities. Many employers would welcome the skills of a community psychologist, but both applicant and recruiter may not realize this initially. One of the most promising employment venues is state government service. Unfortunately, state jobs are often viewed in a pejorative fashion because of their stereotypic link to mundane, paper-pushing civil service positions. The following article counters this misperception by describing how I was able to find a number of rewarding state government positions that allowed me to utilize virtually all of my community psychology training (e.g., advocacy, organizational assessment, collaboration/consultation, communication, research, resource development, service delivery, planning, and management). Although I was never specifically hired with the job title “community psychologist,” all of my employers came to appreciate the benefits of my community psychology training. In chronological order, I present my employment history, a description of the position, and how my community psychology training was utilized in the position. It is my hope that this article will provide potential employment ideas and options for recent community psychology graduates and those looking for a career change. (Peer Reviewed

A first-order hyperbolic arbitrary Lagrangian Eulerian conservation formulation for non-linear solid dynamics

The paper introduces a computational framework using a novel Arbitrary Lagrangian Eulerian (ALE) formalism in the form of a system of first-order conservation laws. In addition to the usual material and spatial configurations, an additional referential (intrinsic) configuration is introduced in order to disassociate material particles from mesh positions. Using isothermal hyperelasticity as a starting point, mass, linear momentum and total energy conservation equations are written and solved with respect to the reference configuration. In addition, with the purpose of guaranteeing equal order of convergence of strains/stresses and velocities/displacements, the computation of the standard deformation gradient tensor (measured from material to spatial configuration) is obtained via its multiplicative decomposition into two auxiliary deformation gradient tensors, both computed via additional first-order conservation laws. Crucially, the new ALE conservative formulation will be shown to degenerate elegantly into alternative mixed systems of conservation laws such as Total Lagrangian, Eulerian and Updated Reference Lagrangian. Hyperbolicity of the system of conservation laws will be shown and the accurate wave speed bounds will be presented, the latter critical to ensure stability of explicit time integrators. For spatial discretisation, a vertex-based Finite Volume method is employed and suitably adapted. To guarantee stability from both the continuum and the semi-discretisation standpoints, an appropriate numerical interface flux (by means of the Rankine–Hugoniot jump conditions) is carefully designed and presented. Stability is demonstrated via the use of the time variation of the Hamiltonian of the system, seeking to ensure the positive production of numerical entropy. A range of three dimensional benchmark problems will be presented in order to demonstrate the robustness and reliability of the framework. Examples will be restricted to the case of isothermal reversible elasticity to demonstrate the potential of the new formulation

Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children

Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein (DBP). The composite genotype of two single nucleotide polymorphisms (rs7041 and rs4588) results in different DBP isotypes (Gc1f, Gc1s and Gc2). The protein configurational differences among DBP isotypes affect DBP substrate binding affinity. The aims of this study were to determine 1) Gc variant frequencies in a population from an isolated rural region of The Gambia, West Africa (n=3129) with year-round opportunity for cutaneous vitamin D synthesis and 2) the effects of Gc variants on 25OHD concentration (n=237) in a genetically representative sub-group of children (mean (SD) age: 11.9 (4.8) years). The distribution of Gc variants was Gc1f: 0.86, Gc1s: 0.11 and Gc2: 0.03. The mean (SD) concentration of 25OHD was 59.6 (12.9) nmol/L and was significantly higher in those homozygous for Gc1f compared to other Gc variants (60.7 (13.1) vs. 56.6 (12.1) nmol/L, P=0.03). Plasma 25OHD and 1,25(OH)2D concentration was significantly associated with parathyroid hormone in Gc1f-1f but not in the other Gc variants combined. This study demonstrates that different Gc variants are associated with different 25OHD concentrations in a rural Gambian population. Gc1f-1f, thought to have the highest affinity for 25OHD, had the highest 25OHD concentration compared with lower affinity Gc variants. The considerable difference in Gc1f frequency observed in Gambians compared with other non-West African populations and associated differences in plasma 25OHD concentration, may have implications for the way in which vitamin D status should be interpreted across different ancestral groups

Constraints on dark matter particles charged under a hidden gauge group from primordial black holes

In order to accommodate increasingly tighter observational constraints on dark matter, several models have been proposed recently in which dark matter particles are charged under some hidden gauge group. Hidden gauge charges are invisible for the standard model particles, hence such scenarios are very difficult to constrain directly. However black holes are sensitive to all gauge charges, whether they belong to the standard model or not. Here, we examine the constraints on the possible values of the dark matter particle mass and hidden gauge charge from the evolution of primordial black holes. We find that the existence of the primordial black holes with reasonable mass is incompatible with dark matter particles whose charge to mass ratio is of the order of one. For dark matter particles whose charge to mass ratio is much less than one, we are able to exclude only heavy dark matter in the mass range of 10^(11) GeV - 10^(16) GeV. Finally, for dark matter particles whose charge to mass ratio is much greater than one, there are no useful limits coming from primordial black holes.Comment: accepted for publication in JCA

Dark Matter Sees The Light

We construct a Dark Matter (DM) annihilation module that can encompass the predictions from a wide array of models built to explain the recently reported PAMELA and ATIC/PPB-BETS excesses. We present a detailed analysis of the injection spectrums for DM annihilation and quantitatively demonstrate effects that have previously not been included from the particle physics perspective. With this module we demonstrate the parameter space that can account for the aforementioned excesses and be compatible with existing high energy gamma ray and neutrino experiments. However, we find that it is relatively generic to have some tension between the results of the HESS experiment and the ATIC/PPB-BETS experiments within the context of annihilating DM. We discuss ways to alleviate this tension and how upcoming experiments will be able to differentiate amongst the various possible explanations of the purported excesses.Comment: 47 pages, 17 figure

Immune-related genetic enrichment in frontotemporal dementia:An analysis of genome-wide association studies

Background: Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed. Methods and findings: Using large genome-wide association studies (GWASs) (total n = 192,886 cases and controls) and recently developed tools to quantify genetic overlap/pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with FTD-related disorders—namely, FTD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)—and 1 or more immune-mediated diseases including Crohn disease, ulcerative colitis (UC), rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), and psoriasis. We found up to 270-fold genetic enrichment between FTD and RA, up to 160-fold genetic enrichment between FTD and UC, up to 180-fold genetic enrichment between FTD and T1D, and up to 175-fold genetic enrichment between FTD and CeD. In contrast, for CBD and PSP, only 1 of the 6 immune-mediated diseases produced genetic enrichment comparable to that seen for FTD, with up to 150-fold genetic enrichment between CBD and CeD and up to 180-fold enrichment between PSP and RA. Further, we found minimal enrichment between ALS and the immune-mediated diseases tested, with the highest levels of enrichment between ALS and RA (up to 20-fold). For FTD, at a conjunction false discovery rate < 0.05 and after excluding SNPs in linkage disequilibrium, we found that 8 of the 15 identified loci mapped to the human leukocyte antigen (HLA) region on Chromosome (Chr) 6. We also found novel candidate FTD susceptibility loci within LRRK2 (leucine rich repeat kinase 2), TBKBP1 (TBK1 binding protein 1), and PGBD5 (piggyBac transposable element derived 5). Functionally, we found that the expression of FTD–immune pleiotropic genes (particularly within the HLA region) is altered in postmortem brain tissue from patients with FTD and is enriched in microglia/macrophages compared to other central nervous system cell types. The main study limitation is that the results represent only clinically diagnosed individuals. Also, given the complex interconnectedness of the HLA region, we were not able to define the specific gene or genes on Chr 6 responsible for our pleiotropic signal. Conclusions: We show immune-mediated genetic enrichment specifically in FTD, particularly within the HLA region. Our genetic results suggest that for a subset of patients, immune dysfunction may contribute to FTD risk. These findings have potential implications for clinical trials targeting immune dysfunction in patients with FTD