Measuring velocity of sound with nuclear resonant inelastic x-ray scattering

Nuclear resonant inelastic x-ray scattering is used to measure the projected partial phonon density of states of materials. A relationship is derived between the low-energy part of this frequency distribution function and the sound velocity of materials. Our derivation is valid for harmonic solids with Debye-like low-frequency dynamics. This method of sound velocity determination is applied to elemental, composite, and impurity samples which are representative of a wide variety of both crystalline and noncrystalline materials. Advantages and limitations of this method are elucidated

Importance of correlation effects in hcp iron revealed by a pressure-induced electronic topological transition

We discover that hcp phases of Fe and Fe0.9Ni0.1 undergo an electronic topological transition at pressures of about 40 GPa. This topological change of the Fermi surface manifests itself through anomalous behavior of the Debye sound velocity, c/a lattice parameter ratio and M\"ossbauer center shift observed in our experiments. First-principles simulations within the dynamic mean field approach demonstrate that the transition is induced by many-electron effects. It is absent in one-electron calculations and represents a clear signature of correlation effects in hcp Fe

Comparative evaluation of the effectiveness of a peptide-containing drug and polyoxydonium in the treatment of chronic parodontitis

Currently, the available methods of treating parodontitis are not able to have a complex effect. Therefore, in recent years, there has been an active search and development of new methods of treatment and new drugs that have a complex etiopathogenetic effect on this disease. This article provides a comparative evaluation of the classical and experimental methods of treating chronic periodontitis. Based on the reconstruction of an experimental model of chronic inflammation of periodontal tissues of the Wistar rat line, we compared methods of topical therapy by “Organosilicon Glycerohydrogel – Peptide” and “Polyoxidonium” compositions. A comparative assessment of the activity of these drugs with control groups, which were treated with “Organosilicon Glycerohydrogel” and “Metrogyl Denta”, was carried out. Previously, we carried out separate studies of the effectiveness of the use of the composition “organosilicon glycerohydrogel – peptide”, as well as the method of treatment of periodontitis, by injecting the drug “Polyoxidonium”. They have been compared with the classic treatment for this disease to obtain relevant data and results. In our opinion, the data obtained are of considerable interest. The assessment and comparison of clinical and histological data have been carried out, which showed that all drugs had a positive effect on the processes of tissue regeneration. However, the composition “Organosilicon Glycerohydrogel-peptide”, due to the characteristics of the hydrogel, which is acting as a transcutaneous conductor, showed a faster antimicrobial and pathogenetic effect, which allows a comprehensive approach to solving this problem. In comparison with the groups of “Organosilicon Glycerohydrogel” and “Polyoxidonium”, the period of clinical improvement increased by 57% in the group of “Glycerohydrogel-Peptide”, and, in the “Metrogyl Denta” group, the indicators improved by 15% approximately

The dynamics of the non-heme iron in bacterial reaction centers from Rhodobacter sphaeroides

AbstractWe investigate the dynamical properties of the non-heme iron (NHFe) in His-tagged photosynthetic bacterial reaction centers (RCs) isolated from Rhodobacter (Rb.) sphaeroides. Mössbauer spectroscopy and nuclear inelastic scattering of synchrotron radiation (NIS) were applied to monitor the arrangement and flexibility of the NHFe binding site. In His-tagged RCs, NHFe was stabilized only in a high spin ferrous state. Its hyperfine parameters (IS=1.06±0.01mm/s and QS=2.12±0.01mm/s), and Debye temperature (θD0~167K) are comparable to those detected for the high spin state of NHFe in non-His-tagged RCs. For the first time, pure vibrational modes characteristic of NHFe in a high spin ferrous state are revealed. The vibrational density of states (DOS) shows some maxima between 22 and 33meV, 33 and 42meV, and 53 and 60meV and a very sharp one at 44.5meV. In addition, we observe a large contribution of vibrational modes at low energies. This iron atom is directly connected to the protein matrix via all its ligands, and it is therefore extremely sensitive to the collective motions of the RC protein core. A comparison of the DOS spectra of His-tagged and non-His-tagged RCs from Rb. sphaeroides shows that in the latter case the spectrum was overlapped by the vibrations of the heme iron of residual cytochrome c2, and a low spin state of NHFe in addition to its high spin one. This enabled us to pin-point vibrations characteristic for the low spin state of NHFe

Study of in-medium ω\omega meson properties in Ap, pA and AA collisions

We propose to investigate the in-medium properties of vector $\omega$ mesons at the normal nuclear density in Ap(pA) collisions and at higher density in AA collisions at the ITEP accelerator facility TWAC. Using of the inverse Ap kinematics will permit us to study the $\omega$ meson production in a wide momentum interval included the not yet explored range of small meson momenta relative to the projectile nuclei where the mass modification effect in nuclear matter is expected to be the strongest. Momentum dependence of the in-medium $\omega$ meson width will be studied in the traditional pA kinematics. We intend to use the electromagnetic calorimeter for reconstruction of the $\omega$ meson invariant mass by detecting photons from the $\omega \to \pi^{0}\gamma \to 3\gamma$ decay. The model calculations and simulations with RQMD generator show feasibility of the proposed experiment. Available now intensity of the ion beams provides a possibility to collect large statistics and make decisive conclusion about the $\omega$ meson properties at density of normal nuclei. At the second stage of the investigation the $\omega$ meson properties will be studied in AA collisions at higher density. Interpretation of these measurements will be based on the results obtained in Ap(pA) interactions. Further investigation of the in-medium properties of light unflavored and charmed mesons can be performed at ITEP and at GSI(FAIR) where higher ion energies will be accessible in near future.Comment: 26 pages, 10 figures, 2 table

Dynamics of Metal Centers Monitored by Nuclear Inelastic Scattering

Nuclear inelastic scattering of synchrotron radiation has been used now since 10 years as a tool for vibrational spectroscopy. This method has turned out especially useful in case of large molecules that contain a M\"ossbauer active metal center. Recent applications to iron-sulfur proteins, to iron(II) spin crossover complexes and to tin-DNA complexes are discussed. Special emphasis is given to the combination of nuclear inelastic scattering and density functional calculations

Study of the surface microrelief of copper nanoparticles by the method of scanning probe microscopy

This work was supported by grants from the RFBR № 17-07-00407-а and № 17-32-50137-mol_nr

Application of stem cells in guided bone regeneration

Modern medicine allows us to study and develop materials and methods of restorative treatment that would be based on the immunological mechanisms of bone repair. One of the promising directions in guided bone regeneration is the use of mesenchymal stem cells. Interest in MSCs is associated with their ability to regulate the inflammatory process, and directly participate in the formation of new bone structures, thereby providing a physiological repair process. The effector impact of MSCs on the inflammatory process due to their ability to form a specific microenvironment. Low expression of MHC-II and CD80/CD86, the production of PGE2 and NO determines their low immunoconflict, and the production of TGF-b1, IDO and IL-10 has an immunomodulating effect. The ability of MSCs to differentiate into an osteogenic phenotype is accompanied with the synthesis of ALP, BSP and, subsequently, Gla-protein and OPN determine the synthesis of the extracellular matrix and its subsequent mineralization. This process is provided by the action of Runx2, which activates the differentiation of MSCs along the osteogenic pathway. These effects of MSCs were taken as the basis for the development of a new method for the treatment of bone atrophy. To accomplish the task set, a model of bone tissue atrophy and a drug containing MSCs was developed, and an experimental study was conducted to evaluate the effectiveness of the developed methodology. As the main criteria, data from clinical and laboratory studies were taken. Visual changes in the studied area were taken into account, compared with a similar area in the developed model of atrophy, the parameters of the complete blood count (CBC) were evaluated. The performed study allows us to determine the developed treatment method as capable of fully recreating the conditions of bone repair processes, taking into account the optimization of the body’s immune reactions and repair processes, without additional external influence, to obtain predictable and controllable results

Peculiarities of electronic structure and composition in ultrasound milled silicon nanowires

The combined X-ray absorption and emission spectroscopy approach was applied for the detailed electronic structure and composition studies of silicon nanoparticles produced by the ultrasound milling of heavily and lowly doped Si nanowires formed by metal-assisted wet chemical etching. The ultrasoft X-ray emission spectroscopy and synchrotron based X-ray absorption near edges structure spectroscopy techniques were utilize to study the valence and conduction bands electronic structure together with developed surface phase composition qualitative analysis. Our achieved results based on the implemented surface sensitive techniques strongly suggest that nanoparticles under studies show a significant presence of the silicon suboxides depending on the pre nature of initial Si wafers. The controlled variation of the Si nanoparticles surface composition and electronic structure, including band gap engineering, can open a new prospective for a wide range Si-based nanostructures application including the integration of such structures with organic or biological systems

Three dimensional quadratic algebras: Some realizations and representations

Four classes of three dimensional quadratic algebras of the type \lsb Q_0 , Q_\pm \rsb $=$ $\pm Q_\pm$, \lsb Q_+ , Q_- \rsb $=$ $aQ_0^2 + bQ_0 + c$, where $(a,b,c)$ are constants or central elements of the algebra, are constructed using a generalization of the well known two-mode bosonic realizations of $su(2)$ and $su(1,1)$. The resulting matrix representations and single variable differential operator realizations are obtained. Some remarks on the mathematical and physical relevance of such algebras are given.Comment: LaTeX2e, 23 pages, to appear in J. Phys. A: Math. Ge