The Impact of Legal Status on Different Schooling Aspects of Adolescents in Germany

During the so-called refugee crisis of 2015, approximately 300,000 underage asylum seekers came to Germany. We examine whether their legal status and their subjective perception of their status are equally important for their educational integration. On the basis of rational choice theory, we hypothesize that refugees’ legal status should affect their educational outcomes. Our study finds no differences among students with different legal statuses in school placement. However, students who perceive their status as insecure report significantly worse GPA than students who feel rather secure. Concerning the objective legal status, we do find that students with an insecure legal status report better grades than those with a granted refugee status. These contrary results show the importance of additionally considering status perception in understanding and explaining educational outcomes of immigrants in further research. Educators should be aware of the potential divergence between objective and subjective status and their corresponding effects on educational trajectories. **** Note that the original PDF version of this article contained a production error, which has now been fixed. As a result, the original pagination has been adjusted. ***  Pendant la soi-disant « crise des réfugiés » de 2015, approximativement 300 000 demandeurs d’asile d’âge mineur sont arrivés en Allemagne. Nous examinons si leur statut légal et la perception subjective qu’ils ont de leur statut ont une importance égale en ce qui concerne leur intégration éducative. Nous appuyant sur la théorie du choix rationnel, nous émettons des hypothèses sur la manière dont le statut légal des réfugiés affecte leurs résultats scolaires. Notre étude ne révèle aucune divergence entre les étudiants de statuts légaux différents dans le placement scolaire. Cependant, les étudiants qui perçoivent leur statut comme précaire rapportent des moyennes significativement plus basses que ceux qui ont un plus grand sentiment de sécurité. En ce qui concerne le statut légal objectif, nous constatons que les étudiants au statut précaire rapportent de meilleures notes que ceux qui ont reçu le statut de réfugié. Ces résultats contradictoires montrent qu’il est important de tenir compte de la manière dont les immigrants perçoivent leur statut afin de comprendre et d’expliquer leurs résultats scolaires lors de recherches ultérieures. Les éducateurs devraient être conscients des potentielles divergences entre le statut objectif et le statut subjectif ainsi que leurs effets sur les trajectoires éducatives. ***Notez que la version PDF d'origine de cet article contenait une erreur de production, qui a maintenant été corrigée. En conséquence, la pagination d'origine a été ajustée.**

Integrated quantized electronics: a semiconductor quantized voltage source

The Josephson effect in superconductors links a quantized output voltage Vout = f \cdot(h/2e) to the natural constants of the electron's charge e, Planck's constant h, and to an excitation frequency f with important applications in electrical quantum metrology. Also semiconductors are routinely applied in electrical quantum metrology making use of the quantum Hall effect. However, despite their broad range of further applications e.g. in integrated circuits, quantized voltage generation by a semiconductor device has never been obtained. Here we report a semiconductor quantized voltage source generating quantized voltages Vout = f\cdot(h/e). It is based on an integrated quantized circuit of a single electron pump operated at pumping frequency f and a quantum Hall device monolithically integrated in series. The output voltages of several \muV are expected to be scalable by orders of magnitude using present technology. The device might open a new route towards the closure of the quantum metrological triangle. Furthermore it represents a universal electrical quantum reference allowing to generate quantized values of the three most relevant electrical units of voltage, current, and resistance based on fundamental constants using a single device.Comment: 15 pages, 3 figure

Baseline MELD score predicts hepatic decompensation during antiviral therapy in patients with chronic hepatitis C and advanced cirrhosis

Background and Aims: In patients with advanced liver cirrhosis due to chronic hepatitis C virus (HCV) infection antiviral therapy with peginterferon and ribavirin is feasible in selected cases only due to potentially life-threatening side effects. However, predictive factors associated with hepatic decompensation during antiviral therapy are poorly defined. Methods: In a retrospective cohort study, 68 patients with HCV-associated liver cirrhosis (mean MELD score 9.18±2.72) were treated with peginterferon and ribavirin. Clinical events indicating hepatic decompensation (onset of ascites, hepatic encephalopathy, upper gastrointestinal bleeding, hospitalization) as well as laboratory data were recorded at baseline and during a follow up period of 72 weeks after initiation of antiviral therapy. To monitor long term sequelae of end stage liver disease an extended follow up for HCC development, transplantation and death was applied (240weeks, ±SD 136weeks). Results: Eighteen patients (26.5%) achieved a sustained virologic response. During the observational period a hepatic decompensation was observed in 36.8%. Patients with hepatic decompensation had higher MELD scores (10.84 vs. 8.23, p14, respectively. Baseline MELD score was significantly associated with the risk for transplantation/death (p<0.001). Conclusions: Our data suggest that the baseline MELD score predicts the risk of hepatic decompensation during antiviral therapy and thus contributes to decision making when antiviral therapy is discussed in HCV patients with advanced liver cirrhosis

Evaluation of downscaled wind speeds and parameterised gusts for recent and historical windstorms in Switzerland

Assessments of local-scale windstorm hazard require highly resolved spatial information on wind speeds and gusts. In this study, maximum (peak) sustained wind speeds on a 3-km horizontal grid over Switzerland are obtained by dynamical downscaling from the Twentieth Century Reanalysis (20CR) employing the Weather Research and Forecasting (WRF) model. Subsequently, simulated peak gusts are derived using four wind gust parameterizations (WGPs). Evaluations against observations at 63 locations in complex terrain include four high-impact windstorms (occurring in 1919, 1935, 1990, and 1999) and 14 recent windstorms (occurring between 1993 and 2011). Peak sustained wind speeds and directions are generally well simulated, although wind speeds are mostly overestimated. In general, performance and skill measures are best for locations on the Swiss Plateau and inferior for Alpine mountain and valley locations. An independent ERA-Interim WRF downscaling configuration produces overall comparable results, implying that the 20CR ensemble mean is a reliable data set in dynamical downscaling exercises. The four evaluated WGPs largely reproduce the observed gustiness, although the timing and magnitude of the peak gusts are not regularly captured. None of the WGPs stands out as single best for the complex topography of Switzerland. Differences among the WGPs are small compared to the biases inherited from the sustained-wind part in the WGP formulations. All WGPs transform overestimated peak sustained winds into underestimated peak gusts, which points to an underrepresentation of the turbulent part in the WGP formulations. The range of simulated peak gusts from downscaling all 20CR ensemble members does not reliably include the observed peak gust, indicating limited benefit in applying an ensemble approach. Despite the limitations, we infer that with spatial optimisations of the simulation (e.g. by bias correction or adaptation of the WGP schemes), downscaling of 20CR input is an efficient option for high-resolution assessments of windstorm hazard and risk in Switzerland

Successful direct acting antiviral (DAA) treatment of HCV/HIV-coinfected patients before and after liver transplantation

Objectives The aim of this multicenter retrospective study was to investigate safety and efficacy of direct acting antiviral (DAA) treatment in the rare subgroup of patients with HCV/HIV-coinfection and advanced liver cirrhosis on the liver transplant waiting list or after liver transplantation, respectively. Methods When contacting 54 German liver centers (including all 23 German liver transplant centers), 12 HCV/HIV-coinfected patients on antiretroviral combination therapy were reported having received additional DAA therapy while being on the waiting list for liver transplantation (patient characteristics: Child-Pugh A (n = 6), B (n = 5), C (n = 1);MELD range 7-21;HCC (n = 2);HCV genotype la (n = 8), 1 b (n = 2), 4 (n = 2)). Furthermore, 2 HCV/HIV-coinfected patients were denoted having received DAA therapy after liver transplantation (characteristics: HCV genotype 1a (n = 1), 4 (n = 1)). Results Applied DAA regimens were SOF/DAC (n = 7), SOF/LDV/RBV (n = 3), SOF/RBV (n = 3), PTV/r/OBV/DSV (n = 1), or PTV/r/OBV/DSV/RBV (n = 1), respectively. All patients achieved SVR 12, in the end. In one patient, HCV relapse occurred after 24 weeks of SOF/DAC therapy;subsequent treatment with 12 weeks PTV/r/OBV/DSV achieved SVR 12. One patient underwent liver transplantation while on DAA treatment. Analysis of liver function revealed either stable parameters or even significant improvement during DAA therapy and in followup. MELD scores were found to improve in 9/13 therapies in patients on the waiting list for liver transplantation;in only 2 patients a moderate increase of MELD scores persisted at the end of follow-up. Conclusion DAA treatment was safe and highly effective in this nation-wide cohort of patients with HCV/HIV-coinfection awaiting liver transplantation or being transplanted

The SAMI Galaxy Survey: Quenching of Star Formation in Clusters I. Transition Galaxies

We use integral-field spectroscopy from the SAMI Galaxy Survey to identify galaxies that show evidence of recent quenching of star formation. The galaxies exhibit strong Balmer absorption in the absence of ongoing star formation in more than 10% of their spectra within the SAMI field of view. These Hd-strong (HDS) galaxies (HDSGs) are rare, making up only similar to 2% (25/1220) of galaxies with stellar mass log(M-*/M-circle dot) &gt; 10. The HDSGs make up a significant fraction of nonpassive cluster galaxies (15%; 17/115) and a smaller fraction (2.0%; 8/387) of the nonpassive population in low-density environments. The majority (9/17) of cluster HDSGs show evidence of star formation at their centers, with the HDS regions found in the outer parts of the galaxy. Conversely, the HDS signal is more evenly spread across the galaxy for the majority (6/8) of HDSGs in low-density environments and is often associated with emission lines that are not due to star formation. We investigate the location of the HDSGs in the clusters, finding that they are exclusively within 0.6R(200) of the cluster center and have a significantly higher velocity dispersion relative to the cluster population. Comparing their distribution in projected phase space to those derived from cosmological simulations indicates that the cluster HDSGs are consistent with an infalling population that has entered the central 0.5r(200,3D) cluster region within the last similar to 1 Gyr. In the eight of nine cluster HDSGs with central star formation, the extent of star formation is consistent with that expected of outside-in quenching by ram pressure stripping. Our results indicate that the cluster HDSGs are currently being quenched by ram pressure stripping on their first passage through the cluster

Soluble Serum CD81 Is Elevated in Patients with Chronic Hepatitis C and Correlates with Alanine Aminotransferase Serum Activity

Aim: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed a case-control study to investigate whether soluble CD81 in the exosomal serum fraction is associated with HCV replication and inflammatory activity. Patients and Methods: Four cohorts were investigated, patients with chronic hepatitis C (n = 37), patients with chronic HCV infection and persistently normal ALT levels (n = 24), patients with long term sustained virologic response (SVR, n = 7), and healthy volunteers (n = 23). Concentration of soluble CD81 was assessed semi-quantitatively after differential centrifugation ranging from 200 g to 100,000 g in the fifth centrifugation fraction by immunoblotting and densitometry. Results: Soluble CD81 was increased in patients with chronic hepatitis C compared to healthy subjects (p = 0.03) and cured patients (p = 0.017). Patients with chronic HCV infection and persistently normal ALT levels and patients with long term SVR had similar soluble CD81 levels as healthy controls (p>0.2). Overall, soluble CD81 levels were associated with ALT levels (r = 0.334, p = 0.016) and severe liver fibrosis (p = 0.027). Conclusion: CD81 is increased in the exosomal serum fraction in patients with chronic hepatitis C and appears to be associated with inflammatory activity and severity of fibrosis

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P<0.001); there was no difference between serum miR-21 in patients with CHC and CHC-associated HCC. Serum miR-21 levels correlated with histological activity index (HAI) in the liver (r = −0.494, P = 0.00002), alanine aminotransferase (ALT) (r = −0.309, P = 0.007), aspartate aminotransferase (r = −0.495, P = 0.000007), bilirubin (r = −0.362, P = 0.002), international normalized ratio (r = −0.338, P = 0.034) and γ-glutamyltransferase (r = −0.244, P = 0.034). Multivariate analysis revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21 discriminated between minimal and mild-severe necroinflammation (AUC = 0.758) with a sensitivity of 53.3% and a specificity of 95.2%. Conclusions/Significance: The serum miR-21 level is a marker for necroinflammatory activity, but does not differ between patients with HCV and HCV-induced HCC