Boston Hospitality Review: Spring 2018

Table of contents: Sustainability In Hospitality? How Legality and Authenticity Impact the Rationale for Integrating Sustainable Practices By Christian E. Hardigree, J.D. -- The Digital Future of the Tourism & Hospitality Industry By Martin Zsarnoczky -- Cutting Through the Online Hospitality Clutter, Part II: Best Practices for Paid Digital Marketing By Leora Lanz and Namrata Sridhar -- Blending Theory and Practice: Experiential Learning in Hospitality Curriculum: A Case Study of Student Projects for Industry Clients By Michael Oshins and Joel Brown

Jet-related Excitation of the [CII] Emission in the Active Galaxy NGC 4258 with SOFIA

We detect widespread [CII]157.7um emission from the inner 5 kpc of the active galaxy NGC 4258 with the SOFIA integral field spectrometer FIFI-LS. The emission is found associated with warm H2, distributed along and beyond the end of southern jet, in a zone known to contain shock-excited optical filaments. It is also associated with soft X-ray hot-spots, which are the counterparts of the `anomalous radio arms' of NGC~4258, and a 1 kpc-long filament on the minor axis of the galaxy which contains young star clusters. Palomar-CWI H-alpha integral field spectroscopy shows that the filament exhibits non-circular motions within NGC 4258. Many of the [CII] profiles are very broad, with the highest line width, 455 km/s, observed at the position of the southern jet bow-shock. Abnormally high ratios of L([CII])/L(FIR) and L([CII])/L(PAH7.7um) are found along and beyond the southern jet and in the X-ray hotspots. These are the same regions that exhibit unusually large intrinsic [CII] line widths. This suggests that the [CII] traces warm molecular gas in shocks and turbulence associated with the jet. We estimate that as much as 40% (3.8 x 10^39 erg/s) of the total [CII] luminosity from the inner 5 kpc of NGC 4258 arises in shocks and turbulence (< 1% bolometric luminosity from the active nucleus), the rest being consistent with [CII] excitation associated with star formation. We propose that the highly-inclined jet is colliding with, and being deflected around, dense irregularities in a thick disk, leading to significant energy dissipation over a wide area of the galaxy.Comment: Accepted for Publication in the Astrophysical Journal Oct 29 201

Comparing eye movements recorded by search coil and infrared eye tracking

Objective: The performance of a new video-based infrared eye tracker (IR) was compared to the magnetic search coil technique (SC). Since the IR offers interesting possibilities as a diagnostic tool in neuro-ophthalmology, it was investigated whether the new device has overcome shortcomings that were reported from former IR systems. Methods: Horizontal saccades were recorded using the IR and the SC. The IR allowed eye movement recordings at different sampling rates ranging from 250Hz to 1000Hz while the SC recorded at 1000Hz. Results/Conclusions: The results show that the IR and the SC were in good agreement and produced similar results. In contrast to other studies, the influence of the sampling rate of the IR was small. The saccade main-sequences did not show significant differences. The latency times observed for both systems were mainly in the short-latency rang

Mass cannibalism in the Linear Pottery Culture at Herxheim (Palatinate, Germany)

The Early Neolithic central place at Herxheim is defined by a perimeter of elongated pits containing fragments of human bone, together with pottery imported from areas several hundred kilometres distant. This article offers a context for the centre, advancing strong evidence that the site was dedicated to ritual activities in which cannibalism played an important par

Electrothermal Finite-Element Modeling for Defect Characterization in Thin-Film Silicon Solar Modules

We present and validate a finite-element model for coupled charge and heat transport in monolithically interconnected thin-film solar modules. Using measured current-voltage (I-V) and lock-in thermography (LIT) measurements of amorphous silicon minimodules, we experimentally validate our model. The entire module volume is represented by two planes (front and back electrodes) which are coupled in vertical direction using 1-D models, leading to a large reduction of the degrees of freedom in the numerical model and contributing to an efficient solution approach. As compared to 3-D models, the vertical coupling of the charge transport is represented by local temperature-dependent I-V curves. These can be obtained by drift-diffusion calculations, single-cell measurements or, as presented here, by an analytical solar cell diode model. Inhomogeneous heat sources such as Joule's heating in the electrodes lead to nonuniform temperature distributions. The explicit temperature dependence in the local I-V curve, therefore, mediates the feedback of the thermal transport on the local electrical cell characteristics. We employ measured I-V curves under partial illumination and analytical solutions for the potential distribution to validate this approach. Further, with LIT measurements of the same modules with and without artificially induced electrical shunts, we verify the computed temperature distributions

Comparing eye movements recorded by search coil and infrared eye tracking

OBJECTIVE: The performance of a new video-based infrared eye tracker (IR) was compared to the magnetic search coil technique (SC). Since the IR offers interesting possibilities as a diagnostic tool in neuro-ophthalmology, it was investigated whether the new device has overcome shortcomings that were reported from former IR systems. METHODS: Horizontal saccades were recorded using the IR and the SC. The IR allowed eye movement recordings at different sampling rates ranging from 250 Hz to 1000 Hz while the SC recorded at 1000 Hz. RESULTS/CONCLUSIONS: The results show that the IR and the SC were in good agreement and produced similar results. In contrast to other studies, the influence of the sampling rate of the IR was small. The saccade main-sequences did not show significant differences. The latency times observed for both systems were mainly in the short-latency range

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF–TIMI 48 Trial

Background: Elderly patients with atrial fibrillation are at higher risk of both ischemic and bleeding events compared to younger patients. In a prespecified analysis from the ENGAGE AF‐TIMI 48 trial, we evaluate clinical outcomes with edoxaban versus warfarin according to age. Methods and Results: Twenty‐one thousand one‐hundred and five patients enrolled in the ENGAGE AF‐TIMI 48 trial were stratified into 3 prespecified age groups: <65 (n=5497), 65 to 74 (n=7134), and ≥75 (n=8474) years. Older patients were more likely to be female, with lower body weight and reduced creatinine clearance, leading to higher rates of edoxaban dose reduction (10%, 18%, and 41% for the 3 age groups, P<0.001). Stroke or systemic embolic event (1.1%, 1.8%, and 2.3%) and major bleeding (1.8%, 3.3%, and 4.8%) rates with warfarin increased across age groups (P trend<0.001 for both). There were no interactions between age group and randomized treatment in the primary efficacy and safety outcomes. In the elderly (≥75 years), the rates of stroke/systemic embolic event were similar with edoxaban versus warfarin (hazard ratio 0.83 [0.66–1.04]), while major bleeding was significantly reduced with edoxaban (hazard ratio 0.83 [0.70–0.99]). The absolute risk difference in major bleeding (−82 events/10 000 pt‐yrs) and in intracranial hemorrhage (−73 events/10 000 pt‐yrs) both favored edoxaban over warfarin in older patients. Conclusions: Age has a greater influence on major bleeding than thromboembolic risk in patients with atrial fibrillation. Given the higher rates of bleeding and death with increasing age, treatment of elderly patients with edoxaban provides an even greater absolute reduction in safety events over warfarin, compared to treatment with edoxaban versus warfarin in younger patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00781391

Recovering Protein-Protein and Domain-Domain Interactions from Aggregation of IP-MS Proteomics of Coregulator Complexes

Coregulator proteins (CoRegs) are part of multi-protein complexes that transiently assemble with transcription factors and chromatin modifiers to regulate gene expression. In this study we analyzed data from 3,290 immuno-precipitations (IP) followed by mass spectrometry (MS) applied to human cell lines aimed at identifying CoRegs complexes. Using the semi-quantitative spectral counts, we scored binary protein-protein and domain-domain associations with several equations. Unlike previous applications, our methods scored prey-prey protein-protein interactions regardless of the baits used. We also predicted domain-domain interactions underlying predicted protein-protein interactions. The quality of predicted protein-protein and domain-domain interactions was evaluated using known binary interactions from the literature, whereas one protein-protein interaction, between STRN and CTTNBP2NL, was validated experimentally; and one domain-domain interaction, between the HEAT domain of PPP2R1A and the Pkinase domain of STK25, was validated using molecular docking simulations. The scoring schemes presented here recovered known, and predicted many new, complexes, protein-protein, and domain-domain interactions. The networks that resulted from the predictions are provided as a web-based interactive application at http://maayanlab.net/HT-IP-MS-2-PPI-DDI/

Dairying, diseases and the evolution of lactase persistence in Europe

Update notice Author Correction: Dairying, diseases and the evolution of lactase persistence in Europe (Nature, (2022), 608, 7922, (336-345), 10.1038/s41586-022-05010-7) Nature, Volume 609, Issue 7927, Pages E9, 15 September 2022In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years(1). Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions(2,3). Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectoriesthan uniform selection since the Neolithic period. In the UK Biobank(4,5) cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.Peer reviewe